The association of metabolic syndrome and its components with serum prostate-specific antigen levels.

Metabolic syndrome (MetS) can increase the risk of prostate cancer. Prostate-specific antigen (PSA) is the marker for prostate cancer puncture screening. The aim of our study was to investigate the association between MetS and its components with PSA levels. Data were obtained from 482 943 healthy men who underwent routine health check-ups from January 2010 to December 2017. We used linear regression analysis to evaluate the effects of MetS and its components on PSA levels. To explore the cumulative effect of MetS components, analysis of variance trend analysis was carried out. The PSA levels in the group with MetS were significantly lower than those without MetS (P=0.001). In the multivariate regression model, age (P<0.001) and hypertension (P<0.001) were correlated positively with PSA levels; nevertheless, obesity (P<0.001), hypertriglyceridemia (P<0.001), hyperglycemia (P<0.001), and low high-density lipoprotein cholesterol level (P<0.001) had a negative correlation. In addition, after adjustment for age, increasing sums of positive MetS components were associated with a linear decrease in PSA levels (P<0.001). In conclusion, MetS, obesity, hypertriglyceridemia, hyperglycemia, and low high-density lipoprotein cholesterol levels are associated with decreased PSA levels. For patients with PSA levels at the critical value of prostate puncture, the effect of these diseases in reducing PSA levels should be taken into account.

• Publication year

  2020

• Venue

  European Journal of Cancer Prevention

• Publication date

  2020-01-01

• Fields of study

  Medicine

• Identifiers
  DOI 10.1097/CEJ.0000000000000508PMID 30913093
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• syndrome in men.

  2019cited by this paper
• Meta-analysis of metabolic syndrome and prostate cancer

  2017cited by this paper
• Actual lowering effect of metabolic syndrome on serum prostate‐specific antigen levels is partly concealed by enlarged prostate: results from a large‐scale population‐based study

  2017cited by this paper
• Prostate‐specific antigen lowering effect of metabolic syndrome is influenced by prostate volume

  2016cited by this paper
• Dissecting the association between metabolic syndrome and prostate cancer risk: analysis of a large clinical cohort.

  2015cited by this paper
• Metabolic Syndrome and Breast Cancer: Is There a Link?

  2014cited by this paper
• Prevalence and Determinants of Metabolic Syndrome among Adults in a Rural Area of Northwest China

  2014cited by this paper
• Relationships between Prostate-Specific Antigen, Prostate Volume, and Components of Metabolic Syndrome in Healthy Korean Men

  2012cited by this paper
• Metabolic factors and risk of thyroid cancer in the Metabolic syndrome and Cancer project (Me-Can)

  2011cited by this paper
• The illusion of prostate‐specific antigen decline in patients with metabolic syndrome and insulin resistance

  2011cited by this paper
• Prevalence of the Metabolic Syndrome among rural original adults in NingXia, China

  2010cited by this paper
• Metabolic Factors and the Risk of Pancreatic Cancer: A Prospective Analysis of almost 580,000 Men and Women in the Metabolic Syndrome and Cancer Project

  2010cited by this paper
• The Association of Metabolic Syndrome and Its Components with Serum Prostate-Specific Antigen Levels in a Korean-Screened Population

  2010influential reference
• Harmonizing the metabolic syndrome: a joint interim statement of the International Diabetes Federation Task Force on Epidemiology and Prevention; National Heart, Lung, and Blood Institute; American Heart Association; World Heart Federation; International Atherosclerosis Society; and International As

  2009cited by this paper
• Relationship between serum prostate-specific antigen levels and components of metabolic syndrome in healthy men.

  2008cited by this paper
• The association between metabolic syndrome and prostate‐specific antigen levels

  2008cited by this paper
• Endogenous testosterone and serum lipids in middle-aged men.

  2008cited by this paper
• Androgen deficiency, diabetes, and the metabolic syndrome in men

  2007cited by this paper
• Obesity Is Negatively Associated with Prostate-Specific Antigen in U.S. Men, 2001-2004

  2007cited by this paper
• Obesity-related plasma hemodilution and PSA concentration among men with prostate cancer.

  2007cited by this paper
• Prostate-specific antigen values in diabetic and nondiabetic US men, 2001-2002.

  2006cited by this paper
• Metabolic syndrome predicts prostate cancer in a cohort of middle-aged Norwegian men followed for 27 years.

  2006cited by this paper
• Association of specific symptoms and metabolic risks with serum testosterone in older men.

  2006cited by this paper
• Metabolic syndrome.

  2005cited by this paper
• Increasing insulin resistance is associated with a decrease in Leydig cell testosterone secretion in men.

  2005cited by this paper
• Observed effect of age and body mass index on total and complexed PSA: analysis from a national screening program.

  2005cited by this paper
• Is obesity a risk factor for prostate cancer, and does it even matter? A hypothesis and different perspective.

  2002cited by this paper
• Endogenous sex hormone levels in older adult men with diabetes mellitus.

  1990cited by this paper

• Metabolic syndrome as an independent determinant of prostate volume in elderly males over 60 years

  2026cites this paper
• Exposure to heavy metal elements may significantly increase serum prostate-specific antigen levels with overdosed dietary zinc.

  2024cites this paper
• Association of TyG index with prostate-specific antigen (PSA) in American men: results from NHANES, 2003–2010

  2023cites this paper
• CLINICAL COURSE OF PROSTATE CANCER AND FACTORS THAT DETERMINE IT

  2023cites this paper
• Total Prostate Specific Antigen in Prostate Cancer Screening in Hyperglycemic Individuals.

  2022cites this paper
• Spray Deposited ZnO Nanograins for Enzyme-Free Detection of Sarcosine

  2021cites this paper
• Clinical factors affecting prostate-specific antigen levels in prostate cancer patients undergoing radical prostatectomy: a retrospective study

  2021cites this paper
• Reply to: Comment to: The association of metabolic syndrome and its components with serum prostate-specific antigen levels.

  2021cites this paper
• Metabolic syndrome and chronic prostatitis

  2020cites this paper
• Metabolic syndrome biomarkers and prostate cancer risk in the UK Biobank

  2020cites this paper
• Diabetes Medications, Prostate-Specific Antigen Values, and the Chemoprevention of Prostate Cancer.

  2019cites this paper