Androgen deficiency, diabetes, and the metabolic syndrome in men

No abstract is available for this paper.

• Publication year

  2007

• Venue

  Current Opinion in Endocrinology, Diabetes & Obesity

• Publication date

  2007-06-01

• Fields of study

  Medicine

• Identifiers
  DOI 10.1097/MED.0b013e32814db856PMID 17940444
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Introduction The Aging Male

  2008cited by this paper
• Epidemiology: testosterone and the metabolic syndrome

  2007cited by this paper
• Contrasting Testosterone Concentrations in Type 1 and Type 2 DiabetesTomar R, Mohanty P, Dhindsa S, et al (State Univ of New York at Buffalo; Kaleida Health, Buffalo, NY) Diabetes Care 29:1120–1122, 2006§

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• Testosterone replacement therapy improves insulin resistance, glycaemic control, visceral adiposity and hypercholesterolaemia in hypogonadal men with type 2 diabetes.

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• Sex differences of endogenous sex hormones and risk of type 2 diabetes: a systematic review and meta-analysis.

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• Inflammatory process in type 2 diabetes: The role of cytokines.

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• Relative androgen deficiency in relation to obesity and metabolic status in older men

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• Expression of Hypothalamic KiSS-1 System and Rescue of Defective Gonadotropic Responses by Kisspeptin in Streptozotocin-Induced Diabetic Male Rats

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• The age related decrease in testosterone is significantly exacerbated in obese men with the metabolic syndrome. What are the implications for the relatively high incidence of erectile dysfunction observed in these men?

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• Hyperglycemia and insulin resistance in men with prostate carcinoma who receive androgen‐deprivation therapy

  2006cited by this paper
• Androgen-replacement therapy depresses the ex vivo production of inflammatory cytokines by circulating antigen-presenting cells in aging type-2 diabetic men with partial androgen deficiency.

  2006cited by this paper
• Low sex hormone-binding globulin, total testosterone, and symptomatic androgen deficiency are associated with development of the metabolic syndrome in nonobese men.

  2006cited by this paper
• Prevalence of hypogonadism in males aged at least 45 years: the HIM study

  2006cited by this paper
• The effect of changes in adiposity on testosterone levels in older men: longitudinal results from the Massachusetts Male Aging Study.

  2006cited by this paper
• Diabetes and cardiovascular disease during androgen deprivation therapy for prostate cancer.

  2006cited by this paper
• Body mass index, waist circumference and waist to hip ratio and change in sex steroid hormones: the Massachusetts Male Ageing Study

  2006cited by this paper
• Diabetes, Hyperglycemia, and Inflammation in Older Individuals

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• Association of specific symptoms and metabolic risks with serum testosterone in older men.

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• EFFECT OF BODY WEIGHT ON TESTOSTERONE/ESTRADIOL RATIO IN OLIGOZOOSPERMIC PATIENTS

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• Inflammatory Process in Type 2 Diabetes

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• Association of hypogonadism and type II diabetes in men attending an outpatient erectile dysfunction clinic

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• Androgen receptor null male mice develop late-onset obesity caused by decreased energy expenditure and lipolytic activity but show normal insulin sensitivity with high adiponectin secretion.

  2005cited by this paper
• Increasing insulin resistance is associated with a decrease in Leydig cell testosterone secretion in men.

  2005cited by this paper
• The association of total antioxidant capacity with sex hormones

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• Endogenous sex hormones and metabolic syndrome in aging men.

  2005cited by this paper
• Androgens, insulin resistance and vascular disease in men

  2005cited by this paper
• Protective effect of testosterone on early apoptotic damage induced by streptozotocin in rat pancreas.

  2005cited by this paper
• The Effect of Testosterone Supplement on Insulin Sensitivity, Glucose Effectiveness, and Acute Insulin Response After Glucose Load in Male Type 2 Diabetics

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• Diabetes mellitus is associated with subnormal serum levels of free testosterone in men

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• Molecular Mechanism of Suppression of Testicular Steroidogenesis by Proinflammatory Cytokine Tumor Necrosis Factor Alpha

  2004cited by this paper
• Changes in sex hormone‐binding globulin and testosterone during weight loss and weight maintenance in abdominally obese men with the metabolic syndrome

  2004cited by this paper
• The associations of endogenous testosterone and sex hormone-binding globulin with glycosylated hemoglobin levels, in community dwelling men. The Tromsø Study.

  2004cited by this paper
• Partial androgen deficiency in aging type 2 diabetic men and its relationship to glycemic control.

  2004cited by this paper
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  2004cited by this paper
• Blood testosterone threshold for androgen deficiency symptoms.

  2004cited by this paper
• Association of bioavailable, free, and total testosterone with insulin resistance: influence of sex hormone-binding globulin and body fat.

  2004cited by this paper
• Monocytic Expression Behavior of Cytokines in Diabetic Patients upon Inflammatory Stimulation

  2004cited by this paper
• Reversal of the hypogonadotropic hypogonadism of obese men by administration of the aromatase inhibitor testolactone.

  2003cited by this paper
• Interactions of androgens, green tea catechins and the antiandrogen flutamide with the external glucose‐binding site of the human erythrocyte glucose transporter GLUT1

  2003cited by this paper
• Hypogonadism and diabetes

  2003cited by this paper
• Follow-up report on the diagnosis of diabetes mellitus.

  2003cited by this paper
• Androgen receptor gene repeats and indices of obesity in older adults

  2003cited by this paper
• Testosterone supplementation in men with type 2 diabetes, visceral obesity and partial androgen deficiency

  2003cited by this paper
• Seasonal variation of testosterone and waist to hip ratio in men: the Tromsø study.

  2003cited by this paper
• Impact of obesity on hypogonadism in the andropause.

  2002cited by this paper
• Sex steroid hormones, upper body obesity, and insulin resistance.

  2002cited by this paper
• Endogenous sex hormones and the development of type 2 diabetes in older men and women: the Rancho Bernardo study.

  2002cited by this paper
• The CAG repeat polymorphism in the androgen receptor gene modulates body fat mass and serum concentrations of leptin and insulin in men

  2002cited by this paper
• American Association of Clinical Endocrinologists Medical Guidelines for clinical practice for the evaluation and treatment of hypogonadism in adult male patients--2002 update.

  2002cited by this paper
• Insulin-dependent diabetes in men is associated with hypothalamo-pituitary derangement and with impairment in semen quality.

  2002cited by this paper
• American Association of Clinical Endocrinologists Medical Guidelines for clinical practice for the evaluation and treatment of hypogonadism in adult male patients--2002 update.

  2002cited by this paper
• Androgen replacement therapy in the aging male--a critical evaluation.

  2001cited by this paper
• Testosterone, sex hormone-binding globulin, and the development of type 2 diabetes in middle-aged men: prospective results from the Massachusetts Male Aging Study

  2000cited by this paper
• Central Action of Insulin Regulates Pulsatile Luteinizing Hormone Secretion in the Diabetic Sheep Model1

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• Interleukin-1 inhibits Leydig cell steroidogenesis without affecting steroidogenic acute regulatory protein messenger ribonucleic acid or protein levels.

  1998cited by this paper
• The length and location of CAG trinucleotide repeats in the androgen receptor N-terminal domain affect transactivation function.

  1994cited by this paper
• Level of sex hormone-binding globulin is positively correlated with insulin sensitivity in men with type 2 diabetes.

  1993cited by this paper
• Attenuated luteinizing hormone (LH) pulse amplitude but normal LH pulse frequency, and its relation to plasma androgens in hypogonadism of obese men.

  1993cited by this paper
• Obesity, body fat distribution and sex hormones in men.

  1993cited by this paper
• Genetic variation at five trimeric and tetrameric tandem repeat loci in four human population groups.

  1992cited by this paper
• Influence of diabetes on the gonadotropin response to the negative feedback effect of testosterone and hypothalamic neurotransmitter turnover in adult male rats.

  1991cited by this paper
• Effect of obesity and body fat distribution on sex hormones and insulin in men.

  1991cited by this paper
• Pulsatile LH secretion in streptozotocin-induced diabetes in the rat.

  1991cited by this paper
• Visceral fat accumulation in men is positively associated with insulin, glucose, and C-peptide levels, but negatively with testosterone levels.

  1990cited by this paper
• Endogenous sex hormone levels in older adult men with diabetes mellitus.

  1990cited by this paper
• Partial reversal of the hypogonadotropic hypogonadism of obese men by administration of corticosuppressive doses of dexamethasone.

  1988cited by this paper
• Relationships of plasma estradiol, testosterone, and sex hormone-binding globulin with lipoproteins, apolipoproteins, and high density lipoprotein subfractions in men.

  1987cited by this paper
• The effect of streptozotocin-induced diabetes on the neuroendocrine-male reproductive tract axis of the adult rat.

  1987cited by this paper
• Altered Responses to Androgen in Diabetic Male Rats

  1984cited by this paper
• Increased estrogen production in obese men.

  1979cited by this paper
• Interaction of steroids with the transport system of glucose in human erythrocytes

  1975cited by this paper

• Impact of noninsulin-dependent diabetes mellitus (level of control) on sex hormone profile and erectile function

  2025influential citation
• Low testosterone levels in men at age 31 associates with future risk of prediabetes and type 2 diabetes: A birth cohort study.

  2025cites this paper
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  2024cites this paper
• The Fatty Liver Index, the Strongest Risk Factor for Low Testosterone Level

  2023cites this paper
• Phenotyping obesity: A focus on metabolically healthy obesity and metabolically unhealthy normal weight

  2023cites this paper
• Hypogonadism: a neglected comorbidity in young and middle-aged HIV-positive men on effective combination antiretroviral therapy

  2022cites this paper
• Relationship between Serum Testosterone Level and Carotid Intima-Media Thickness among Korean Men and Postmenopausal Women

  2022cites this paper
• Modification of testosterone levels with Piptadeniastrum africanum and Cordia plathytyrsa may influence metabolic parameters in Wistar rats

  2022cites this paper
• Clinical Aspects of Genetic and Non-Genetic Cardiovascular Risk Factors in Familial Hypercholesterolemia

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• Association Between Metabolic Syndrome and Risk of Renal Cell Cancer: A Meta-Analysis

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• The Role of Diet in the Pathogenesis of Erectile Dysfunction

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• Association of Metabolic Obesity Phenotypes and Total Testosterone in Chinese Male Population

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• MicroRNA regulation of the proliferation and apoptosis of Leydig cells in diabetes

  2021cites this paper
• The association of metabolic syndrome and its components with serum prostate-specific antigen levels.

  2020cites this paper
• Association of Metabolic Obesity Phenotypes and Total Testosterone in Middle-aged and Elderly Male Population

  2020cites this paper
• Pharmacology and perspectives in erectile dysfunction in man.

  2020cites this paper
• Gut Microbiological Disorders Reduce Semen Utilization Rate in Duroc Boars

  2020cites this paper
• Biomarkers and Non-Calcified Coronary Artery Plaque Progression in Older Men Treated with Testosterone.

  2019cites this paper
• The efficacy of chronic zinc oxide nanoparticles using on testicular damage in the streptozotocin-induced diabetic rat model.

  2019cites this paper
• Obesity, endocrine disruption and male infertility

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• Effects of Eryngium Caucasicum Extract on Testosterone, Inflammation and Oxidative Status of Nicotinamide-Streptozotocin Induced Type-2 Diabetes in Male Rats

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  2018cites this paper
• Cholesterol: A Gatekeeper of Male Fertility?

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• A new 2% testosterone gel formulation: a comparison with currently available topical preparations

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  2018cites this paper
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• Testosterone Replacement Therapy and Components of the Metabolic Syndrome.

  2017cites this paper
• Effect of total terpenes of Cornus officinalis Sieb . on hypogonadism in streptozotocin ( STZ )-induced diabetic rats

  2017cites this paper
• The prevalence of the metabolic syndrome in a farm worker community in the Boland district, South Africa

  2017cites this paper
• The Effects of Androgen Replacement Therapy on Glycemic Control in a Case with Klinefelter Syndrome and Poorly Controlled Diabetes

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• Low testosterone levels are related to oxidative stress, mitochondrial dysfunction and altered subclinical atherosclerotic markers in type 2 diabetic male patients

  2017cites this paper
• Positive Correlation between Androgen Receptor CAG Repeat Length and Metabolic Syndrome in a Korean Male Population

  2017cites this paper
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  2017cites this paper
• Taurine Improves Sexual Function in Streptozotocin-Induced Diabetic Rats.

  2017cites this paper
• Early testosterone replacement attenuates intracellular calcium dyshomeostasis in the heart of testosterone-deprived male rats.

  2017cites this paper
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  2017cites this paper
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  2016cites this paper
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  2016cites this paper
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  2016cites this paper
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  2016influential citation
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  2015cites this paper
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  2015influential citation
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• Low testosterone and the metabolic syndrome: a high‐risk combination

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• Diabetes mellitus link with hypogonadism in male patients with type 2 diabetes mellitus aged 40-50 years

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  2014influential citation
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  2012cites this paper
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  2011cites this paper
• Hypogonadism and subnormal total testosterone levels in men with type 2 diabetes mellitus.

  2011cites this paper
• Age, obesity and inflammation at baseline predict the effects of testosterone administration on the metabolic syndrome

  2011cites this paper
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  2011cites this paper
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