Compression of morbidity in a progeroid mouse model through the attenuation of myostatin/activin signalling

Khalid Alyodawi,W. Vermeij,S. Omairi,O. Kretz,M. Hopkinson,Francesca Solagna,Barbara Joch,Renata M. C. Brandt,S. Barnhoorn,Nicole van Vliet,Y. Ridwan,J. Essers,R. Mitchell,Taryn Morash,A. Pasternack,O. Ritvos,A. Matsakas,H. Collins‐Hooper,T. Huber,J. Hoeijmakers,K. Patel

Published 2019 in Journal of Cachexia, Sarcopenia and Muscle

ABSTRACT

One of the principles underpinning our understanding of ageing is that DNA damage induces a stress response that shifts cellular resources from growth towards maintenance. A contrasting and seemingly irreconcilable view is that prompting growth of, for example, skeletal muscle confers systemic benefit.

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