Perspectives of Autologous Mesenchymal Stem-Cell Transplantation in Macular Hole Surgery: A Review of Current Findings

The main treatment available for idiopathic macular holes is represented by pars plana vitrectomy with internal limiting membrane peeling. However, late-stage macular holes are affected by a higher risk of surgical failure. Although adjuvant techniques can be employed, a satisfactory functional recovery is difficult to achieve in refractory macular holes. Given their neuroprotective and antiapoptotic properties, mesenchymal stem cells (MSCs) may represent an appealing approach to treat these extreme cases. The purpose of this review is to highlight the findings regarding healing mechanisms exerted by mesenchymal stem cells and preliminary application in cases of refractory macular holes. When compared with MSCs, MSC-derived exosomes may represent a feasible alternative, given their reduced risk of undesired proliferation and easiness of use.

• Publication year

  2019

• Venue

  Journal of Ophthalmology

• Publication date

  2019-02-24

• Fields of study

  Medicine

• Identifiers
  DOI 10.1155/2019/3162478PMID 30918717PMCID 6409040
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Stemming retinal regeneration with pluripotent stem cells

  2019cited by this paper
• Cell-Based Therapy for Degenerative Retinal Disease.

  2019cited by this paper
• Visual Recovery after Macular Hole Surgery and Related Prognostic Factors

  2018cited by this paper
• Effects of mesenchymal stem cells and their exosomes on the healing of large and refractory macular holes

  2018cited by this paper
• Comparative analysis of large macular hole surgery using an internal limiting membrane insertion versus inverted flap technique

  2018cited by this paper
• Microstructural changes in the fovea following autologous internal limiting membrane transplantation surgery for large macular holes

  2018cited by this paper
• Ethical and Safety Issues of Stem Cell-Based Therapy

  2018cited by this paper
• Effects of Mesenchymal Stem Cell-Derived Exosomes on Experimental Autoimmune Uveitis

  2017cited by this paper
• Intravitreal use of bone marrow mononuclear fraction containing CD34+ stem cells in patients with atrophic age-related macular degeneration

  2017cited by this paper
• Vision Loss after Intravitreal Injection of Autologous "Stem Cells" for AMD.

  2017cited by this paper
• Stem Cell Ophthalmology Treatment Study (SCOTS): bone marrow-derived stem cells in the treatment of Leber's hereditary optic neuropathy

  2016cited by this paper
• Exosomes derived from MSCs ameliorate retinal laser injury partially by inhibition of MCP-1

  2016cited by this paper
• CD73 Pathway Contributes to the Immunosuppressive Ability of Mesenchymal Stem Cells in Intraocular Autoimmune Responses

  2016cited by this paper
• Donor and host photoreceptors engage in material transfer following transplantation of post-mitotic photoreceptor precursors

  2016cited by this paper
• Dental pulp stem cells: a novel cell therapy for retinal and central nervous system repair

  2016cited by this paper
• Stem Cell Ophthalmology Treatment Study (SCOTS): improvement in serpiginous choroidopathy following autologous bone marrow derived stem cell treatment

  2016cited by this paper
• Internal limiting membrane translocation for refractory macular holes

  2016cited by this paper
• TREATMENT OF PERSISTENTLY OPEN MACULAR HOLES WITH HEAVY SILICONE OIL (DENSIRON 68) VERSUS C2F6. A PROSPECTIVE RANDOMIZED STUDY

  2016cited by this paper
• VITRECTOMY FOR REFRACTORY MACULAR HOLE.

  2015cited by this paper
• Improvement of ischaemic macular oedema after intravitreal injection of autologous bone marrow‐derived haematopoietic stem cells

  2015cited by this paper
• Neuroprotective effects of intravitreally transplanted adipose tissue and bone marrow-derived mesenchymal stem cells in an experimental ocular hypertension model.

  2015cited by this paper
• Stem cell based therapies for age-related macular degeneration: The promises and the challenges.

  2015cited by this paper
• Vitrectomy for idiopathic macular hole.

  2015cited by this paper
• Stem Cell Ophthalmology Treatment Study (SCOTS) for retinal and optic nerve diseases: a preliminary report

  2015cited by this paper
• TEMPORAL INVERTED INTERNAL LIMITING MEMBRANE FLAP TECHNIQUE VERSUS CLASSIC INVERTED INTERNAL LIMITING MEMBRANE FLAP TECHNIQUE: A Comparative Study

  2015cited by this paper
• Molecular Mechanisms Mediating Retinal Reactive Gliosis Following Bone Marrow Mesenchymal Stem Cell Transplantation

  2015cited by this paper
• Quality of life in patients with retinitis pigmentosa submitted to intravitreal use of bone marrow-derived stem cells (Reticell -clinical trial)

  2015cited by this paper
• Retinal pigment epithelium transplantation: concepts, challenges, and future prospects

  2015cited by this paper
• Autologous Internal Limiting Membrane Fragment Transplantation for Large, Chronic, and Refractory Macular Holes

  2015cited by this paper
• Cellular strategies for retinal repair by photoreceptor replacement.

  2015cited by this paper
• Protective Effects of Human iPS‐Derived Retinal Pigmented Epithelial Cells in Comparison with Human Mesenchymal Stromal Cells and Human Neural Stem Cells on the Degenerating Retina in rd1 mice

  2015cited by this paper
• Stem Cell Ophthalmology Treatment Study (SCOTS) for retinal and optic nerve diseases: a case report of improvement in relapsing auto-immune optic neuropathy

  2015cited by this paper
• Autologous transplantation of the internal limiting membrane for refractory macular holes.

  2014cited by this paper
• Exosomes/miRNAs as mediating cell-based therapy of stroke

  2014cited by this paper
• Long-term therapeutic effects of mesenchymal stem cells compared to dexamethasone on recurrent experimental autoimmune uveitis of rats.

  2014cited by this paper
• Perfluoro-n-Octane–Assisted Single-Layered Inverted Internal Limiting Membrane Flap Technique for Macular Hole Surgery

  2014cited by this paper
• Intravitreal autologous bone marrow CD34+ cell therapy for ischemic and degenerative retinal disorders: preliminary phase 1 clinical trial findings.

  2014cited by this paper
• INVERTED INTERNAL LIMITING MEMBRANE FLAP TECHNIQUE FOR SURGICAL REPAIR OF MYOPIC MACULAR HOLES

  2014cited by this paper
• Mesenchymal stem cell: an efficient mass producer of exosomes for drug delivery.

  2013cited by this paper
• The effect of mesenchymal stem cells on dynamic changes of T cell subsets in experimental autoimmune uveoretinitis

  2013cited by this paper
• Efficacy of inverted internal limiting membrane flap technique for the treatment of macular hole in high myopia.

  2013cited by this paper
• Long-term neuroprotective effects of NT-4-engineered mesenchymal stem cells injected intravitreally in a mouse model of acute retinal injury.

  2013cited by this paper
• Resolution of macular oedema associated with retinitis pigmentosa after intravitreal use of autologous BM-derived hematopoietic stem cell transplantation

  2013cited by this paper
• Bone marrow mesenchymal stem cells protect against retinal ganglion cell loss in aged rats with glaucoma

  2013cited by this paper
• Macular hole surgery prognostic success rates based on macular hole size.

  2012cited by this paper
• Generation of retinal cells from pluripotent stem cells.

  2012cited by this paper
• Safety of Cell Therapy with Mesenchymal Stromal Cells (SafeCell): A Systematic Review and Meta-Analysis of Clinical Trials

  2012cited by this paper
• Cell replacement and visual restoration by retinal sheet transplants.

  2012cited by this paper
• Effect of In Vitro Exposure of Corticosteroid Drugs, Conventionally Used in AMD Treatment, on Mesenchymal Stem Cells

  2012cited by this paper
• Role of mesenchymal stem cells in neurogenesis and nervous system repair.

  2011cited by this paper
• Intraocular Transplantation of Human Adipose-Derived Mesenchymal Stem Cells in a Rabbit Model of Experimental Retinal Holes

  2011cited by this paper
• Mesenchymal Stem Cells

  2011cited by this paper
• Transplantation of BDNF-secreting mesenchymal stem cells provides neuroprotection in chronically hypertensive rat eyes.

  2011cited by this paper
• Mesenchymal stem cells ameliorate experimental autoimmune uveoretinitis by comprehensive modulation of systemic autoimmunity.

  2011cited by this paper
• Axial length and outcomes of macular hole surgery assessed by spectral-domain optical coherence tomography.

  2011cited by this paper
• Inverted internal limiting membrane flap technique for large macular holes.

  2010cited by this paper
• Mesenchymal stem cells for the treatment of neurodegenerative disease.

  2010cited by this paper
• Mesenchymal stem cells rescue cardiomyoblasts from cell death in an in vitro ischemia model via direct cell-to-cell connections

  2010cited by this paper
• Neuroprotective effects of intravitreal mesenchymal stem cell transplantation in experimental glaucoma.

  2010cited by this paper
• Directed differentiation of human embryonic stem cells into functional retinal pigment epithelium cells.

  2009cited by this paper
• Protective Effects of Human iPS-Derived Retinal Pigment Epithelium Cell Transplantation in the Retinal Dystrophic Rat

  2009cited by this paper
• Induced pluripotent stem cells for retinal degenerative diseases: a new perspective on the challenges

  2009cited by this paper
• Correlation between foveal structure and visual outcome following macular hole surgery: a spectral optical coherence tomography study

  2008cited by this paper
• Mesenchymal Stem Cell Transplantation for Neurodegenerative Diseases

  2008cited by this paper
• Transplantation of bone marrow-derived mesenchymal stem cells rescue photoreceptor cells in the dystrophic retina of the rhodopsin knockout mouse

  2007cited by this paper
• Transplantation of the RPE in AMD.

  2007cited by this paper
• Retreatment of full-thickness macular hole: predictive value of optical coherence tomography

  2007cited by this paper
• Human Embryonic Stem Cell–Derived Cells Rescue Visual Function in Dystrophic RCS Rats

  2006cited by this paper
• Mesenchymal stem cells participate in angiogenesis and improve heart function in rat model of myocardial ischemia with reperfusion.

  2006cited by this paper
• SUCCESSFUL TREATMENT OF PERSISTENT MACULAR HOLES USING “HEAVY SILICONE OIL” AS INTRAOCULAR TAMPONADE

  2006cited by this paper
• Secretion of Angiogenic and Antiapoptotic Factors by Human Adipose Stromal Cells

  2004cited by this paper
• VITRECTOMY FOR CHRONIC MACULAR HOLES

  2004cited by this paper
• Rescue of retinal degeneration by intravitreally injected adult bone marrow-derived lineage-negative hematopoietic stem cells.

  2004cited by this paper
• Outcome of transplantation of autologous retinal pigment epithelium in age-related macular degeneration: a prospective trial.

  2004cited by this paper
• Local Delivery of Marrow-Derived Stromal Cells Augments Collateral Perfusion Through Paracrine Mechanisms

  2004cited by this paper
• Surgery for idiopathic full-thickness macular hole: two-year results of a randomized clinical trial comparing natural history, vitrectomy, and vitrectomy plus autologous serum: Morfields Macular Hole Study Group RAeport no. 1.

  2004cited by this paper
• Derivation and Comparative Assessment of Retinal Pigment Epithelium from Human Embryonic Stem Cells Using Transcriptomics

  2004cited by this paper
• Autologous peripheral retinal pigment epithelium translocation in patients with subfoveal neovascular membranes

  2003cited by this paper
• Differentiation of Marrow Stromal Cells into Photoreceptors in the Rat Eye

  2003cited by this paper
• Differential expression of stem cell mobilization-associated molecules on multi-lineage cells from adipose tissue and bone marrow.

  2003cited by this paper
• Macular hole size as a prognostic factor in macular hole surgery

  2002cited by this paper
• Transplantation of autologous retinal pigment epithelium in eyes with foveal neovascularization resulting from age-related macular degeneration: a pilot study.

  2002cited by this paper
• Long-term follow-up of unoperated macular holes.

  2001cited by this paper
• Visual and anatomical results of surgery for long standing macular holes

  2000cited by this paper
• The process of closure of experimental retinal holes in rabbit eyes

  2000cited by this paper
• Morphological changes of retinal pigment epithelial and glial cells at the site of experimental retinal holes

  2000cited by this paper
• Clinical course of macular holes: the Eye Disease Case-Control Study.

  1999cited by this paper
• Regulation of intercellular adhesion molecule‐1 (CD54) gene expression

  1999cited by this paper
• Retinal detachment associated with a macular hole in severely myopic eyes.

  1999cited by this paper
• Plasmin enzyme-assisted vitrectomy in traumatic pediatric macular holes.

  1998cited by this paper
• Treatment of reopened macular hole after vitrectomy by laser and outpatient fluid-gas exchange.

  1998cited by this paper
• Macular hole.

  1998cited by this paper
• Entfernung der Membrana limitans interna bei Makulalöchern Klinische und morphologische Befunde *

  1997cited by this paper
• [Removal of the internal limiting membrane in macular holes. Clinical and morphological findings].

  1997cited by this paper
• Outpatient postoperative fluid-gas exchange after early failed vitrectomy surgery for macular hole.

  1997cited by this paper
• Closure of persistent macular holes with human recombinant transforming growth factor-beta 2.

  1996cited by this paper
• Bilateral visual function after macular hole surgery.

  1996cited by this paper
• Closure of persistent macular holes with human recombinant transforming growth factor-beta 2.

  1996cited by this paper
• Bilaterality of idiopathic macular holes

  1996cited by this paper
• Surgical treatment of full-thickness macular holes using autologous serum

  1996cited by this paper

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• Therapeutic potential of mesenchymal stem cells in ocular degenerative disorders.

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  2025cites this paper
• Rekindling Vision: Innovative Strategies for Treating Retinal Degeneration

  2025cites this paper
• TUpdates on surgical and nonsurgical innovations for macular hole treatment.

  2025cites this paper
• Extracellular vesicle-based protein and RNA delivery.

  2025cites this paper
• Intravitreal allogeneic mesenchymal stem cells: a non-randomized phase II clinical trial for acute non-arteritic optic neuropathy

  2023cites this paper
• Intravitreal Administration Effect of Adipose-Derived Mesenchymal Stromal Cells Combined with Anti-VEGF Nanocarriers, in a Pharmaceutically Induced Animal Model of Retinal Vein Occlusion

  2022cites this paper
• Exosomes: a new way of protecting and regenerating optic nerve after injury

  2022cites this paper
• Management of refractory and recurrent macular holes: A comprehensive review.

  2022cites this paper
• Mesenchymal Stem Cell-Based Therapy for Retinal Degenerative Diseases: Experimental Models and Clinical Trials

  2021cites this paper
• Retinopathy predicts stroke but not myocardial infarction in type 2 diabetes: the Fremantle Diabetes Study Phase II

  2020cites this paper
• Characteristics and regulation of mesenchymal stem cell plasticity by the microenvironment — specific factors involved in the regulation of MSC plasticity

  2020cites this paper
• Myopic Traction Maculopathy: Diagnostic and Management Strategies

  2020cites this paper
• Corneal Biomechanics After Intrastromal Ring Surgery: Optomechanical In Silico Assessment

  2020cites this paper
• Effect of Mesenchymal Stem Cell-Derived Exosomes on Retinal Injury: A Review of Current Findings

  2020cites this paper
• Physiology-like crystalline lens modelling for children.

  2020cites this paper
• Literature Review of Surgical Treatment in Idiopathic Full-Thickness Macular Hole

  2020cites this paper
• The relationship between carotid disease and retinopathy in diabetes: a systematic review

  2020cites this paper
• Incomplete fluid-air exchange technique for idiopathic macular hole surgery.

  2019cites this paper
• The role of intracranial pressure in glaucoma and therapeutic implications

  2019cites this paper
• Measurement and application of patient similarity in personalized predictive modeling based on electronic medical records

  2019cites this paper