New strategies in immune tolerance induction

No abstract is available for this paper.

• Publication year

  2007

• Venue

  Cell Biochemistry and Biophysics

• Publication date

  Unknown publication date

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1385/CBB:40:3:27PMID 15289641
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Graft-versus-host disease

  2007influential reference
• Regulatory T cells

  2006cited by this paper
• Isolation of a functional cDNA encoding the RT1.Au MHC class I heavy chain by a novel PCR-based method

  2004cited by this paper
• Role of CD4+CD25+ regulatory T cells from naive host thymus in the induction of acquired transplant tolerance by immunization with allo-major histocompatibility complex peptide.1

  2003cited by this paper
• Immature rat myeloid dendritic cells generated in low-dose granulocyte macrophage-colony stimulating factor prolong donor-specific rat cardiac allograft survival

  2003cited by this paper
• Thymic dendritic cells traffic to thymi of allogeneic recipients and prolong graft survival.

  2002cited by this paper
• Modulation of LIGHT-HVEM Costimulation Prolongs Cardiac Allograft Survival

  2002cited by this paper
• Blockade of LIGHT/LTbeta and CD40 signaling induces allospecific T cell anergy, preventing graft-versus-host disease.

  2002cited by this paper
• Effect of mixed hematopoietic chimerism on cardiac allograft survival in cynomolgus monkeys1

  2002cited by this paper
• BLOCKING THE CD80 AND CD86 COSTIMULATION MOLECULES: LESSONS TO BE LEARNED FROM ANIMAL MODELS

  2002cited by this paper
• Blockade of LIGHT/LTβ and CD40 signaling induces allospecific T cell anergy, preventing graft-versus-host disease

  2002cited by this paper
• Dendritic Cells, Tolerance Induction and Transplant Outcome

  2002cited by this paper
• CD25+CD4+ Regulatory T Cells Prevent Graft Rejection: CTLA-4- and IL-10-Dependent Immunoregulation of Alloresponses1

  2002cited by this paper
• THE CD154-CD40 COSTIMULATORY PATHWAY IN TRANSPLANTATION

  2002influential reference
• Vaccines: Spinning molecular immunology into successful immunotherapy

  2002cited by this paper
• Both CD4+CD25+ and CD4+CD25− Regulatory Cells Mediate Dominant Transplantation Tolerance1

  2002cited by this paper
• Regulatory T Cells Induced by 1α,25-Dihydroxyvitamin D3 and Mycophenolate Mofetil Treatment Mediate Transplantation Tolerance1

  2001cited by this paper
• Regulatory T Cells Induced by 1 ,25-Dihydroxyvitamin D3 and Mycophenolate Mofetil Treatment Mediate Transplantation Tolerance

  2001cited by this paper
• IL-10 Is Required for Regulatory T Cells to Mediate Tolerance to Alloantigens In Vivo1

  2001cited by this paper
• Induction of Transplant Tolerance with Immunodominant Allopeptide‐pulsed Host Lymphoid and Myeloid Dendritic Cells

  2001cited by this paper
• Costimulatory blockade for induction of mixed chimerism and renal allograft tolerance in nonhuman primates.

  2001influential reference
• Mixed chimerism and transplantation tolerance.

  2001cited by this paper
• Indirect allorecognition in acquired thymic tolerance: induction of donor-specific permanent acceptance of rat islets by adoptive transfer of allopeptide-pulsed host myeloid and thymic dendritic cells.

  2001cited by this paper
• Mixed allogeneic chimerism. Past, present, and prospects for the future.

  2001cited by this paper
• Role of reentry of in vivo alloMHC peptide-activated T cells into the adult thymus in acquired systemic tolerance.

  2001cited by this paper
• Antigen-Specific Inhibition of Effector T Cell Function in Humans after Injection of Immature Dendritic Cells

  2001cited by this paper
• Mechanisms Involved in the Establishment of Tolerance Through Costimulatory Blockade and BMT: Lack of Requirement for CD40L‐Mediated Signaling for Tolerance or Deletion of Donor‐reactive CD4+ Cells

  2001cited by this paper
• Importance of ICOS–B7RP-1 costimulation in acute and chronic allograft rejection

  2001cited by this paper
• Mechanisms of acquired thymic tolerance: induction of transplant tolerance by adoptive transfer of in vivo allomhc peptide activated syngeneic T cells.

  2001cited by this paper
• A Discrete Subpopulation of Dendritic Cells Transports Apoptotic Intestinal Epithelial Cells to T Cell Areas of Mesenteric Lymph Nodes

  2000cited by this paper
• Suppressor Effector Function of CD4+CD25+ Immunoregulatory T Cells Is Antigen Nonspecific

  2000cited by this paper
• Dendritic cells and prospects for transplantation tolerance.

  2000cited by this paper
• Characterization of Peripheral Regulatory CD4+ T Cells That Prevent Diabetes Onset in Nonobese Diabetic Mice1

  2000cited by this paper
• Major histocompatibility complex class I peptide-pulsed host dendritic cells induce antigen-specific acquired thymic tolerance to islet cells.

  2000cited by this paper
• Regulatory T cells: key controllers of immunologic self-tolerance.

  2000cited by this paper
• Immunologic Self-Tolerance Maintained by Cd25+Cd4+Regulatory T Cells Constitutively Expressing Cytotoxic T Lymphocyte–Associated Antigen 4

  2000influential reference
• Mixed hematopoietic chimerism induces long-term tolerance to cardiac allografts in miniature swine.

  2000cited by this paper
• Immature dendritic cells generated with low doses of GM‐CSF in the absence of IL‐4 are maturation resistant and prolong allograft survival in vivo

  2000cited by this paper
• The control of T cell responses by dendritic cell subsets.

  2000cited by this paper
• Induction of Interleukin 10–Producing, Nonproliferating Cd4+ T Cells with Regulatory Properties by Repetitive Stimulation with Allogeneic Immature Human Dendritic Cells

  2000cited by this paper
• Cytotoxic T Lymphocyte–Associated Antigen 4 Plays an Essential Role in the Function of Cd25+Cd4+ Regulatory Cells That Control Intestinal Inflammation

  2000cited by this paper
• Culture of bone marrow cells in GM‐CSF plus high doses of lipopolysaccharide generates exclusively immature dendritic cells which induce alloantigen‐ specific CD4 T cell anergy in vitro

  2000cited by this paper
• Cd40 Ligand (Cd154) Triggers a Short-Term Cd4+ T Cell Activation Response That Results in Secretion of Immunomodulatory Cytokines and Apoptosis

  2000cited by this paper
• Mixed chimerism as an approach to transplantation tolerance.

  2000cited by this paper
• Immunotherapy of NOD mice with bone marrow-derived dendritic cells.

  1999cited by this paper
• NOD mice have a generalized defect in their response to transplantation tolerance induction.

  1999cited by this paper
• Mechanism of acquired thymic tolerance induced by a single major histocompatibility complex class I peptide with the dominant epitope: differential analysis of regulatory cytokines in the lymphoid and intragraft compartments.

  1999cited by this paper
• Induction of immunologic tolerance for transplantation.

  1999cited by this paper
• Human Dendritic Cells Mediate Cellular Apoptosis via Tumor Necrosis Factor–Related Apoptosis-Inducing Ligand (Trail)

  1999cited by this paper
• Long-term survival and function of intrahepatic islet allografts in rhesus monkeys treated with humanized anti-CD154.

  1999cited by this paper
• Long-term outcome and alloantibody production in a non-myeloablative regimen for induction of renal allograft tolerance.

  1999cited by this paper
• Cutting edge: thymic selection and autoreactivity are regulated by multiple coreceptors involved in T cell activation.

  1999cited by this paper
• Treatment with humanized monoclonal antibody against CD154 prevents acute renal allograft rejection in nonhuman primates

  1999cited by this paper
• CD8+TCR+ and CD8+TCR- cells in whole bone marrow facilitate the engraftment of hematopoietic stem cells across allogeneic barriers.

  1999cited by this paper
• Prevention of renal allograft rejection in primates by blocking the B7/CD28 pathway.

  1999cited by this paper
• CD4+ CD45RB low-density cells from untreated mice prevent acute allograft rejection.

  1999cited by this paper
• Inhibition of CD40 signaling pathway in antigen presenting cells by T suppressor cells.

  1999cited by this paper
• Long-term survival and function of intrahepatic islet allografts in baboons treated with humanized anti-CD154.

  1999cited by this paper
• Combined histocompatibility leukocyte antigen-matched donor bone marrow and renal transplantation for multiple myeloma with end stage renal disease: the induction of allograft tolerance through mixed lymphohematopoietic chimerism.

  1999cited by this paper
• Indirect allorecognition in acquired thymic tolerance: induction of donor-specific tolerance to rat cardiac allografts by allopeptide-pulsed host dendritic cells.

  1999cited by this paper
• Dendritic cells as regulators of immune reactivity: implications for transplantation.

  1999cited by this paper
• Antigen capture, processing, and presentation by dendritic cells: recent cell biological studies.

  1999cited by this paper
• CD4+CD25+ Immunoregulatory T Cells Suppress Polyclonal T Cell Activation In Vitro by Inhibiting Interleukin 2 Production

  1998cited by this paper
• CD40 and CD154 in cell-mediated immunity.

  1998cited by this paper
• Comparative studies of specific acquired systemic tolerance induced by intrathymic inoculation of a single synthetic Wistar-Furth (RT1U) allo-MHC class I (RT1.AU) peptide or WAG (RT1U)-derived class I peptide.

  1998cited by this paper
• Engagement of Cytotoxic T Lymphocyte–associated Antigen 4 (CTLA-4) Induces Transforming Growth Factor β (TGF-β) Production by Murine CD4+ T Cells

  1998cited by this paper
• Monocyte-derived dendritic cell precursors facilitate tolerance to heart allografts after total lymphoid irradiation.

  1998cited by this paper
• CD4+CD25+ T cells inhibit both the induction and effector function of autoreactive T cells and represent a unique lineage of immunoregulatory cells.

  1998cited by this paper
• In vivo depletion of host CD4+ and CD8+ cells permits engraftment of bone marrow stem cells and tolerance induction with minimal conditioning.

  1997cited by this paper
• Induction of peripheral T cell tolerance in vivo requires CTLA-4 engagement.

  1997cited by this paper
• Targeted Expression of Major Histocompatibility Complex (MHC) Class II Molecules Demonstrates that Dendritic Cells Can Induce Negative but Not Positive Selection of Thymocytes In Vivo

  1997influential reference
• Fas ligand (CD95L) and B7 expression on dendritic cells provide counter-regulatory signals for T cell survival and proliferation.

  1997cited by this paper
• Preclinical studies of allograft tolerance in rhesus monkeys: a novel anti-CD3-immunotoxin given peritransplant with donor bone marrow induces operational tolerance to kidney allografts.

  1997cited by this paper
• CTLA4-Ig and anti-CD40 ligand prevent renal allograft rejection in primates.

  1997cited by this paper
• Blockade of the CD40-CD40 ligand pathway potentiates the capacity of donor-derived dendritic cell progenitors to induce long-term cardiac allograft survival.

  1997cited by this paper
• Induction of high levels of allogeneic hematopoietic reconstitution and donor-specific tolerance without myelosuppressive conditioning

  1997cited by this paper
• Induction of allograft nonresponsiveness after intrathymic inoculation with donor class I allopeptides. I. Correlation of graft survival with antidonor IgG antibody subclasses.

  1997cited by this paper
• Induction of allograft nonresponsiveness after intrathymic inoculation with donor class I allopeptides. II. Evidence for persistent chronic rejection despite high levels of donor microchimerism.

  1997cited by this paper
• Long-term acceptance of skin and cardiac allografts after blocking CD40 and CD28 pathways

  1996cited by this paper
• Acquired systemic tolerance to rat cardiac allografts induced by intrathymic inoculation of synthetic polymorphic MHC class I allopeptides.

  1996cited by this paper
• CD28 expression is not essential for positive and negative selection of thymocytes or peripheral T cell tolerance.

  1996cited by this paper
• Costimulatory molecule-deficient dendritic cell progenitors (MHC class II+, CD80dim, CD86-) prolong cardiac allograft survival in nonimmunosuppressed recipients.

  1996cited by this paper
• Functions of CD40 and its ligand, gp39 (CD40L).

  1996cited by this paper
• Pathogenesis of post-thymectomy autoimmune gastritis. Identification of anti-H/K adenosine triphosphatase-reactive T cells.

  1996cited by this paper
• Genomic organization and sequence of the rat major histocompatibility complex class Ia gene RT1.Au

  1995cited by this paper
• Transplantation tolerance to rat cardiac and islet allografts by posttransplant intrathymic inoculation of soluble alloantigens.

  1995cited by this paper
• T cell costimulatory pathways: promising novel targets for immunosuppression and tolerance induction.

  1995cited by this paper
• Donor-specific unresponsiveness to murine cardiac allografts induced by intrathymic-soluble alloantigens is dependent on alternate pathway of antigen presentation.

  1995cited by this paper
• Bone marrow-derived dendritic cell progenitors (NLDC 145+, MHC class II+, B7-1dim, B7-2-) induce alloantigen-specific hyporesponsiveness in murine T lymphocytes.

  1995cited by this paper
• Mechanisms of acquired thymic tolerance in experimental autoimmune encephalomyelitis: thymic dendritic-enriched cells induce specific peripheral T cell unresponsiveness in vivo

  1995cited by this paper
• TREATMENT OF ACUTE GRAFT‐VERSUS-HOST DISEASE WITH METHYLPREDNISOLONE AND CYCLOSPORINE WITH OR WITHOUT AN ANTI‐INTERLEUKIN-2 RECEPTOR MONOCLONAL ANTIBODY: A Multicenter Phase III Study

  1995cited by this paper
• Granulocyte/macrophage colony-stimulating factor-stimulated hepatic dendritic cell progenitors prolong pancreatic islet allograft survival.

  1995cited by this paper
• Mechanisms of acquired thymic unresponsiveness to renal allografts. Thymic recognition of immunodominant allo-MHC peptides induces peripheral T cell anergy.

  1994cited by this paper
• Effectiveness of intrathymic inoculation of soluble antigens in the induction of specific unresponsiveness to rat islet allografts without transient recipient immunosuppression.

  1994cited by this paper
• Induction of specific tolerance by intrathymic injection of recipient muscle cells transfected with donor class I major histocompatibility complex.

  1994cited by this paper
• Thymic recognition of class II major histocompatibility complex allopeptides induces donor-specific unresponsiveness to renal allografts.

  1993cited by this paper
• Induction of donor-specific tolerance to rat cardiac and small bowel allografts by intrathymic inoculation of donor T-cells.

  1993cited by this paper
• Prevention of graft-versus-host disease and bone marrow rejection: kinetics of induction of tolerance by UVB modulation of accessory cells and T cells in the bone marrow inoculum.

  1993cited by this paper
• Induction of specific unresponsiveness to rat islet allografts by intrathymic UVB donor spleen cells.

  1993cited by this paper
• Tolerance induction to rat islet allografts by intrathymic inoculation of donor spleen cells.

  1993cited by this paper

• Donor-Specific Regulatory T Cell-Mediated Immune Tolerance in an Intrahepatic Murine Allogeneic Islet Transplantation Model with Short-Term Anti-CD154 mAb Single Treatment

  2020cites this paper
• Eosinophils from Murine Lamina Propria Induce Differentiation of Naïve T Cells into Regulatory T Cells via TGF-β1 and Retinoic Acid

  2015cites this paper
• Induction of immune tolerance in mice with a novel mucosal nanoemulsion adjuvant and self-antigen.

  2012cites this paper
• Tolerance-Inducing Strategies in Islet Transplantation

  2012cites this paper
• Combination of donor splenocyte transfusion with blockade of &ggr;c signal synergizes to inhibit alloreactive T‐cell proliferation and induces apoptosis

  2011influential citation
• Endothelial cell‐matrix interactions determine maturation of dendritic cells

  2007cites this paper
• Cell therapy and the safety of embryonic stem cell-derived grafts.

  2007cites this paper
• Therapeutic potential of stem cells in diabetes.

  2006cites this paper
• Soluble HLA-G in heart transplantation: their relationship to rejection episodes and immunosuppressive therapy.

  2006cites this paper