Updates on Approaches for Studying Atherosclerosis.

Atherosclerosis is initiated and propagated over decades with no overt clinical symptoms. The complexity and chronicity of its pathophysiological process have been a major challenge to fully define molecular mechanisms and explore more effective therapeutic targets. This Recent Highlights series summarizes ATVB articles published in 2017 and 2018 on the traditional animal model systems and new approaches that have become powerful tools for studying pathogenesis and mechanisms of atherosclerosis.

• Publication year

  2019

• Venue

  Arteriosclerosis, Thrombosis and Vascular Biology

• Publication date

  2019-04-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1161/ATVBAHA.119.312001PMID 30917052PMCID PMC6438191
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Promoters to Study Vascular Smooth Muscle: Mistaken Identity?

  2019cited by this paper
• Statin Safety and Associated Adverse Events: A Scientific Statement From the American Heart Association

  2019cited by this paper
• IL-35 (Interleukin-35) Suppresses Endothelial Cell Activation by Inhibiting Mitochondrial Reactive Oxygen Species-Mediated Site-Specific Acetylation of H3K14 (Histone 3 Lysine 14)

  2018cited by this paper
• Brown Adipocyte-Specific PPAR&ggr; (Peroxisome Proliferator-Activated Receptor &ggr;) Deletion Impairs Perivascular Adipose Tissue Development and Enhances Atherosclerosis in Mice

  2018cited by this paper
• Endothelial FN (Fibronectin) Deposition by &agr;5&bgr;1 Integrins Drives Atherogenic Inflammation

  2018cited by this paper
• Carotid Artery Remodeling Is Segment Specific: An In Vivo Study by Vessel Wall Magnetic Resonance Imaging

  2018cited by this paper
• Renin-Angiotensin System and Cardiovascular Functions

  2018cited by this paper
• STK25 Regulates Cardiovascular Disease Progression in a Mouse Model of Hypercholesterolemia

  2018cited by this paper
• 2016 Jeffrey M. Hoeg Award Lecture: Immune Checkpoints in Atherosclerosis Toward Immunotherapy for Atheroprotection

  2018cited by this paper
• Diabetic Vascular Calcification Mediated by the Collagen Receptor Discoidin Domain Receptor 1 via the Phosphoinositide 3-Kinase/Akt/Runt-Related Transcription Factor 2 Signaling Axis

  2018cited by this paper
• Myeloid β-Catenin Deficiency Exacerbates Atherosclerosis in Low-Density Lipoprotein Receptor-Deficient Mice

  2018cited by this paper
• Dickkopf 3 ) Alters Atherosclerotic Plaque Phenotype Involving Vascular Progenitor and Fibroblast Differentiation Into Smooth Muscle Cells

  2018cited by this paper
• Statin Pretreatment and Microembolic Signals in Large Artery Atherosclerosis: A Systematic Review and Meta-Analysis

  2018cited by this paper
• CSL112 (Apolipoprotein A-I [Human]) Enhances Cholesterol Efflux Similarly in Healthy Individuals and Stable Atherosclerotic Disease Patients

  2018cited by this paper
• Impact of Gut Microbiota and Diet on the Development of Atherosclerosis in Apoe−/− Mice

  2018cited by this paper
• IgE to the Mammalian Oligosaccharide Galactose-α-1,3-Galactose Is Associated With Increased Atheroma Volume and Plaques With Unstable Characteristics—Brief Report

  2018cited by this paper
• Limited Macrophage Positional Dynamics in Progressing or Regressing Murine Atherosclerotic Plaques—Brief Report

  2018cited by this paper
• Evaluation of the Pleiotropic Effects of Statins: A Reanalysis of the Randomized Trial Evidence Using Egger Regression—Brief Report

  2018cited by this paper
• Macrophage-Associated Lipin-1 Enzymatic Activity Contributes to Modified Low-Density Lipoprotein–Induced Proinflammatory Signaling and Atherosclerosis

  2018cited by this paper
• RGC-32 (Response Gene to Complement 32) Deficiency Protects Endothelial Cells From Inflammation and Attenuates Atherosclerosis

  2018cited by this paper
• Classical Pathway of Complement Activation: Longitudinal Associations of C1q and C1-INH With Cardiovascular Outcomes The CODAM Study (Cohort on Diabetes and Atherosclerosis Maastricht)—Brief Report

  2018cited by this paper
• Sortilin and Its Multiple Roles in Cardiovascular and Metabolic Diseases.

  2018cited by this paper
• Acute Loss of Apolipoprotein E Triggers an Autoimmune Response That Accelerates Atherosclerosis

  2018cited by this paper
• Lp(a) [Lipoprotein(a)]-Related Risk of Heart Failure Is Evident in Whites but Not in Other Racial/Ethnic Groups: The Multi-Ethnic Study of Atherosclerosis

  2018cited by this paper
• Molecular Ultrasound Imaging of Junctional Adhesion Molecule A Depicts Acute Alterations in Blood Flow and Early Endothelial Dysregulation

  2018cited by this paper
• Comparative Effects of PCSK9 (Proprotein Convertase Subtilisin/Kexin Type 9) and Statins on Postprandial Triglyceride-Rich Lipoprotein Metabolism

  2018cited by this paper
• Testosterone Protects Against Atherosclerosis in Male Mice by Targeting Thymic Epithelial Cells—Brief Report

  2018cited by this paper
• SREBF1/MicroRNA-33b Axis Exhibits Potent Effect on Unstable Atherosclerotic Plaque Formation In Vivo

  2018cited by this paper
• Fibronectin Containing Extra Domain A Induces Plaque Destabilization in the Innominate Artery of Aged Apolipoprotein E–Deficient Mice

  2018cited by this paper
• Follicular B Cells Promote Atherosclerosis via T Cell–Mediated Differentiation Into Plasma Cells and Secreting Pathogenic Immunoglobulin G

  2018cited by this paper
• Association of Circulating Chemerin With Subclinical Parameters of Atherosclerosis

  2018cited by this paper
• Telomerase Mediates Lymphocyte Proliferation but Not the Atherosclerosis-Suppressive Potential of Regulatory T-Cells

  2018cited by this paper
• Selective EGFR (Epidermal Growth Factor Receptor) Deletion in Myeloid Cells Limits Atherosclerosis—Brief Report

  2018cited by this paper
• Bempedoic Acid Lowers Low-Density Lipoprotein Cholesterol and Attenuates Atherosclerosis in Low-Density Lipoprotein Receptor–Deficient (LDLR+/− and LDLR−/−) Yucatan Miniature Pigs

  2018cited by this paper
• Deficiency of Dab2 (Disabled Homolog 2) in Myeloid Cells Exacerbates Inflammation in Liver and Atherosclerotic Plaques in LDLR (Low-Density Lipoprotein Receptor)-Null Mice—Brief Report

  2018cited by this paper
• Settlement of Stenotic Site and Enhancement of Risk Factor Load for Atherosclerosis in Left Anterior Descending Coronary Artery by Myocardial Bridge

  2018cited by this paper
• Visualization of Monocytic Cells in Regressing Atherosclerotic Plaques by Intravital 2-Photon and Positron Emission Tomography–Based Imaging—Brief Report

  2018cited by this paper
• nSMase2 (Type 2-Neutral Sphingomyelinase) Deficiency or Inhibition by GW4869 Reduces Inflammation and Atherosclerosis in Apoe−/− Mice

  2018cited by this paper
• DKK3 (Dickkopf 3) Alters Atherosclerotic Plaque Phenotype Involving Vascular Progenitor and Fibroblast Differentiation Into Smooth Muscle Cells

  2018cited by this paper
• Exogenous Insulin Infusion Can Decrease Atherosclerosis in Diabetic Rodents by Improving Lipids, Inflammation, and Endothelial Function

  2018cited by this paper
• Recent Highlights of ATVB: Lipoproteins

  2018cited by this paper
• Genetic Deletion of IL-19 (Interleukin-19) Exacerbates Atherogenesis in Il19−/−×Ldlr−/− Double Knockout Mice by Dysregulation of mRNA Stability Protein HuR (Human Antigen R)

  2018cited by this paper
• Consideration of Sex Differences in Design and Reporting of Experimental Arterial Pathology Studies-Statement From ATVB Council.

  2018cited by this paper
• Diet, Microbes, and Murine Atherosclerosis.

  2018cited by this paper
• USP20 (Ubiquitin-Specific Protease 20) Inhibits TNF (Tumor Necrosis Factor)-Triggered Smooth Muscle Cell Inflammation and Attenuates Atherosclerosis

  2018cited by this paper
• Endothelial-Specific Cre Mouse Models: Is Your Cre CREdibile?

  2018cited by this paper
• Palmitoylethanolamide Promotes a Proresolving Macrophage Phenotype and Attenuates Atherosclerotic Plaque Formation

  2018cited by this paper
• Highlight on Endothelial Activation and Beyond.

  2018cited by this paper
• Ablation of Myeloid ADK (Adenosine Kinase) Epigenetically Suppresses Atherosclerosis in ApoE−/− (Apolipoprotein E Deficient) Mice

  2018cited by this paper
• Translating Evidence of HDL and Plaque Regression.

  2018cited by this paper
• Deletion of BMAL1 in Smooth Muscle Cells Protects Mice From Abdominal Aortic Aneurysms.

  2018cited by this paper
• Inhibition of Vascular Calcification: A New Antiatherogenic Mechanism of Topo II (DNA Topoisomerase II) Inhibitors

  2018cited by this paper
• Differential Gene Expression in Macrophages From Human Atherosclerotic Plaques Shows Convergence on Pathways Implicated by Genome-Wide Association Study Risk Variants

  2018cited by this paper
• Myeloid HMG-CoA (3-Hydroxy-3-Methylglutaryl-Coenzyme A) Reductase Determines Atherosclerosis by Modulating Migration of Macrophages

  2018cited by this paper
• Endothelial Cell–Derived Von Willebrand Factor, But Not Platelet-Derived, Promotes Atherosclerosis in Apolipoprotein E–Deficient Mice

  2018cited by this paper
• SM22&agr; (Smooth Muscle Protein 22-&agr;) Promoter-Driven IGF1R (Insulin-Like Growth Factor 1 Receptor) Deficiency Promotes Atherosclerosis

  2018cited by this paper
• Genome-Wide Association and Functional Studies Identify SCML4 and THSD7A as Novel Susceptibility Genes for Coronary Artery Disease

  2018cited by this paper
• Vascular Semaphorin 7A Upregulation by Disturbed Flow Promotes Atherosclerosis Through Endothelial &bgr;1 Integrin

  2018cited by this paper
• &Dgr;-5 Fatty Acid Desaturase FADS1 Impacts Metabolic Disease by Balancing Proinflammatory and Proresolving Lipid Mediators

  2018cited by this paper
• Inflammasome Activation Aggravates Cutaneous Xanthomatosis and Atherosclerosis in ACAT1 (Acyl-CoA Cholesterol Acyltransferase 1) Deficiency in Bone Marrow

  2018cited by this paper
• From High-Density Lipoprotein Cholesterol to Measurements of Function: Prospects for the Development of Tests for High-Density Lipoprotein Functionality in Cardiovascular Disease.

  2018cited by this paper
• AAV8-mediated overexpression of mPCSK9 in liver differs between male and female mice.

  2018cited by this paper
• Lp(a) (Lipoprotein(a)) Levels Predict Progression of Carotid Atherosclerosis in Subjects With Atherosclerotic Cardiovascular Disease on Intensive Lipid Therapy: An Analysis of the AIM-HIGH (Atherothrombosis Intervention in Metabolic Syndrome With Low HDL/High Triglycerides Impact on Global Health Ou

  2018cited by this paper
• HDL (High-Density Lipoprotein) Metrics and Atherosclerotic Risk in Women: Do Menopause Characteristics Matter? MESA

  2018cited by this paper
• Inhibition of Local Macrophage Growth Ameliorates Focal Inflammation and Suppresses Atherosclerosis

  2018cited by this paper
• Somatic Editing of Ldlr With Adeno-Associated Viral-CRISPR Is an Efficient Tool for Atherosclerosis Research

  2018cited by this paper
• Transcription Factor Zhx2 Deficiency Reduces Atherosclerosis and Promotes Macrophage Apoptosis in Mice

  2018cited by this paper
• FOXO3a (Forkhead Transcription Factor O Subfamily Member 3a) Links Vascular Smooth Muscle Cell Apoptosis, Matrix Breakdown, Atherosclerosis, and Vascular Remodeling Through a Novel Pathway Involving MMP13 (Matrix Metalloproteinase 13)

  2018cited by this paper
• Thoracic Aorta Calcification and Noncardiovascular Disease–Related Mortality: The Multi-Ethnic Study of Atherosclerosis

  2018cited by this paper
• Leukocyte Overexpression of Intracellular NAMPT Attenuates Atherosclerosis by Regulating PPAR&ggr;-Dependent Monocyte Differentiation and Function

  2017cited by this paper
• Role of KCa3.1 Channels in Macrophage Polarization and Its Relevance in Atherosclerotic Plaque Instability

  2017cited by this paper
• Linking Hemorrhage, Angiogenesis, Macrophages, and Iron Metabolism in Atherosclerotic Vascular Diseases

  2017cited by this paper
• Recommendation on Design , Execution , and Reporting of Animal Atherosclerosis Studies

  2017cited by this paper
• NLRP3 Inflammasome Inhibition by MCC950 Reduces Atherosclerotic Lesion Development in Apolipoprotein E–Deficient Mice—Brief Report

  2017cited by this paper
• DBA/2J Haplotype on Distal Chromosome 2 Reduces Mertk Expression, Restricts Efferocytosis, and Increases Susceptibility to Atherosclerosis

  2017cited by this paper
• Recommendation on Design, Execution, and Reporting of Animal Atherosclerosis Studies: A Scientific Statement From the American Heart Association.

  2017cited by this paper
• Activation of Adiponectin Receptor Regulates Proprotein Convertase Subtilisin/Kexin Type 9 Expression and Inhibits Lesions in ApoE-Deficient Mice

  2017cited by this paper
• Apolipoprotein A-I Mimetic Peptides: Discordance Between In Vitro and In Vivo Properties—Brief Report

  2017cited by this paper
• ATVB Distinguished Scientist Award: How Costimulatory and Coinhibitory Pathways Shape Atherosclerosis

  2017cited by this paper
• Deficiency of LRP1 in Mature Adipocytes Promotes Diet-Induced Inflammation and Atherosclerosis—Brief Report

  2017cited by this paper
• Simvastatin treatment aggravates the glucocorticoid insufficiency associated with hypocholesterolemia in mice.

  2017cited by this paper
• Coronary Artery Plaque Imaging

  2017cited by this paper
• Scavenger Receptor CD36 Directs Nonclassical Monocyte Patrolling Along the Endothelium During Early Atherogenesis

  2017cited by this paper
• Tracking Adventitial Fibroblast Contribution to Disease: A Review of Current Methods to Identify Resident Fibroblasts.

  2017cited by this paper
• 2016 Russell Ross Memorial Lecture in Vascular Biology: Molecular–Cellular Mechanisms in the Progression of Atherosclerosis

  2017cited by this paper
• Protective Aptitude of Annexin A1 in Arterial Neointima Formation in Atherosclerosis-Prone Mice—Brief Report

  2017cited by this paper
• Macrophage-mediated mechanisms in atherosclerosis: still tangled.

  2017cited by this paper
• Prevention of Diet-Induced Metabolic Dysregulation, Inflammation, and Atherosclerosis in Ldlr−/− Mice by Treatment With the ATP-Citrate Lyase Inhibitor Bempedoic Acid

  2017cited by this paper
• Increased Hepatic Expression of Endothelial Lipase Inhibits Cholesterol Diet–Induced Hypercholesterolemia and Atherosclerosis in Transgenic Rabbits

  2017cited by this paper
• Oligogalacturonic Acid Inhibits Vascular Calcification by Two Mechanisms: Inhibition of Vascular Smooth Muscle Cell Osteogenic Conversion and Interaction With Collagen

  2017cited by this paper
• Polyglucose nanoparticles with renal elimination and macrophage avidity facilitate PET imaging in ischaemic heart disease

  2017cited by this paper
• Relationship of Autoantibodies to MDA-LDL and ApoB-Immune Complexes to Sex, Ethnicity, Subclinical Atherosclerosis, and Cardiovascular Events

  2017cited by this paper
• Association Between Carotid Atherosclerotic Plaque Calcification and Intraplaque Hemorrhage: A Magnetic Resonance Imaging Study

  2017cited by this paper
• Mitochondrial Respiration Is Reduced in Atherosclerosis, Promoting Necrotic Core Formation and Reducing Relative Fibrous Cap Thickness

  2017cited by this paper
• Pathology of Human Coronary and Carotid Artery Atherosclerosis and Vascular Calcification in Diabetes Mellitus.

  2017cited by this paper
• Arterial Calcification in Diabetes Mellitus: Preclinical Models and Translational Implications.

  2017cited by this paper
• Endosialin Promotes Atherosclerosis Through Phenotypic Remodeling of Vascular Smooth Muscle Cells

  2017cited by this paper
• Rac2 Modulates Atherosclerotic Calcification by Regulating Macrophage Interleukin-1&bgr; Production

  2017cited by this paper
• Rosuvastatin Reduces Aortic Sinus and Coronary Artery Atherosclerosis in SR-B1 (Scavenger Receptor Class B Type 1)/ApoE (Apolipoprotein E) Double Knockout Mice Independently of Plasma Cholesterol Lowering

  2017cited by this paper
• Tracking Monocyte Recruitment and Macrophage Accumulation in Atherosclerotic Plaque Progression Using a Novel hCD68GFP/ApoE−/− Reporter Mouse—Brief Report

  2017cited by this paper

• Adult thymectomy is associated with increased mortality risk from cancer but not cardiovascular disease

  2025cites this paper
• A bibliometric and visualization analysis of global trends and frontiers on macrophages in abdominal aortic aneurysms research

  2024cites this paper
• Survey of Approaches for Investigation of Atherosclerosis In Vivo.

  2022cites this paper
• A mini-review on quantification of atherosclerosis in hypercholesterolemic mice

  2022cites this paper
• Fludrocortisone Induces Aortic Pathologies in Mice

  2022cites this paper
• Prediction model for different progressions of Atherosclerosis in ApoE-/- mice based on lipidomics.

  2022cites this paper
• Atherosclerosis

  2021cites this paper
• E17241 as a Novel ABCA1 (ATP-Binding Cassette Transporter A1) Upregulator Ameliorates Atherosclerosis in Mice

  2021cites this paper
• Effectiveness of Consumption of a Combination of Citrus Fruit Flavonoids and Olive Leaf Polyphenols to Reduce Oxidation of Low-Density Lipoprotein in Treatment-Naïve Cardiovascular Risk Subjects: A Randomized Double-Blind Controlled Study

  2021cites this paper
• Automatic Quantification of Atherosclerosis in Contrast-Enhanced MicroCT Scans of Mouse Aortas Ex Vivo

  2021cites this paper
• Impact of calcific aortic valve disease on valve mechanics

  2021cites this paper
• Research methods for animal models of atherosclerosis

  2021cites this paper
• Molecular Interactions Between Vascular Smooth Muscle Cells and Macrophages in Atherosclerosis

  2021cites this paper
• Diagnostic and Prognostic Significance of serum miR-18a-5p in Patients with Atherosclerosis

  2021cites this paper
• Oscillatory fluid-induced mechanobiology in heart valves with parallels to the vasculature

  2020cites this paper
• Differential Characterization of Human Umbilical Artery and Umbilical Vein Endothelial Cells under Same Culture Conditions In Vitro

  2020cites this paper
• Recent Advances in Vascular Imaging.

  2020cites this paper
• Macrophage Biology in Cardiovascular Diseases.

  2020cites this paper
• Vascular Endothelial Cells and Innate Immunity.

  2020cites this paper
• Replacing Saturated Fat With Unsaturated Fat in Western Diet Reduces Foamy Monocytes and Atherosclerosis in Male Ldlr-/- Mice.

  2019cites this paper
• Lp(a) [Lipoprotein(a)]-Related Risk of Heart Failure Is Evident in Whites but Not in Other Racial/Ethnic Groups: The Multi-Ethnic Study of Atherosclerosis

  2018cites this paper