Associations between Adipokines in Arthritic Disease and Implications for Obesity

Iona J MᵃᶜDonald,Shan-Chi Liu,Chien-Chung Huang,Shu-Jui Kuo,Chun-Hao Tsai,Chih-Hsin Tang

Published 2019 in International Journal of Molecular Sciences

ABSTRACT

Secretion from adipose tissue of adipokines or adipocytokines, comprising of bioactive peptides or proteins, immune molecules and inflammatory mediators, exert critical roles in inflammatory arthritis and obesity. This review considers the evidence generated over the last decade regarding the effects of several adipokines including leptin, adiponectin, visfatin, resistin, chemerin and apelin, in cartilage and bone homeostasis in the pathogenesis of rheumatoid arthritis and osteoarthritis, which has important implications for obesity.

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