The aminoglycoside antibiotic dihydrostreptomycin rapidly enters mouse outer hair cells through the mechano 
‐electrical transducer channels

No abstract is available for this paper.

• Publication year

  2005

• Venue

  Journal of Physiology

• Publication date

  2005-09-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1113/jphysiol.2005.085951PMID 15994187PMCID PMC1474200
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Probing the pore of the auditory hair cell mechanotransducer channel in turtle

  2004influential reference
• TRPA1 is a candidate for the mechanosensitive transduction channel of vertebrate hair cells

  2004cited by this paper
• Mechanoelectrical transduction of adult outer hair cells studied in a gerbil hemicochlea

  2004cited by this paper
• Fast adaptation of mechanoelectrical transducer channels in mammalian cochlear hair cells

  2003influential reference
• Lighting up the Senses: FM1-43 Loading of Sensory Cells through Nonselective Ion Channels

  2003influential reference
• AMINOGLYCOSIDE ANTIBIOTICS

  2003influential reference
• Channel gating forces govern accuracy of mechano-electrical transduction in hair cells

  2003influential reference
• Block of the ryanodine receptor channel by neomycin is relieved at high holding potentials.

  2002cited by this paper
• Differences in mechano-transducer channel kinetics underlie tonotopic distribution of fast adaptation in auditory hair cells.

  2002influential reference
• Reduced climbing and increased slipping adaptation in cochlear hair cells of mice with Myo7a mutations

  2002cited by this paper
• FM1-43 Dye Behaves as a Permeant Blocker of the Hair-Cell Mechanotransducer Channel

  2001influential reference
• Aminoglycoside Antibiotics

  2000cited by this paper
• Gentamicin blocks ACh‐evoked K+ current in guinea‐pig outer hair cells by impairing Ca2+ entry at the cholinergic receptor

  2000influential reference
• Vestibular and cochlear toxicity of aminoglycosides--a review.

  2000cited by this paper
• Calcium permeation of the turtle hair cell mechanotransducer channel and its relation to the composition of endolymph

  1998cited by this paper
• Amiloride causes changes in the mechanical properties of hair cell bundles in the fish lateral line similar to those induced by dihydrostreptomycin

  1998cited by this paper
• Development of Sensory and Neural Structures in the Mammalian Cochlea

  1998cited by this paper
• Permeation and block of rat glur6 glutamate receptor channels by internal and external polyamines

  1997cited by this paper
• Myosin VIIA Is Required for Aminoglycoside Accumulation in Cochlear Hair Cells

  1997cited by this paper
• A quantitative comparison of mechanoelectrical transduction in vestibular and auditory hair cells of neonatal mice

  1997influential reference
• Physiology of Mammalian Cochlear Hair Cells

  1996influential reference
• Ototoxicity: Of Mice and Men

  1996cited by this paper
• Ion Channels in Excitable Membranes

  1996influential reference
• Fast steps in exocytosis and endocytosis studied by capacitance measurements in endocrine cells.

  1996cited by this paper
• Block of P/Q-type calcium channels by therapeutic concentrations of aminoglycoside antibiotics.

  1996cited by this paper
• Profoundly different calcium permeation and blockage determine the specific function of distinct cyclic nucleotide-gated channels.

  1995cited by this paper
• Permeation and block by internal and external divalent cations of the catfish cone photoreceptor cGMP-gated channel

  1995cited by this paper
• Direct measurements of Ca2+-activated K+ currents in inner hair cells of the guinea-pig cochlea using photolabile Ca2+ chelators

  1995cited by this paper
• Block of native Ca(2+)‐permeable AMPA receptors in rat brain by intracellular polyamines generates double rectification.

  1995cited by this paper
• Endocytosis of aminoglycoside antibiotics in sensory hair cells.

  1995cited by this paper
• Block by amiloride and its derivatives of mechano‐electrical transduction in outer hair cells of mouse cochlear cultures.

  1994influential reference
• A molecular and cellular hypothesis for aminoglycoside-induced deafness.

  1994cited by this paper
• Voltage-dependent block by neomycin of the ATP-induced whole cell current of guinea-pig outer hair cells.

  1993cited by this paper
• Regenerative proliferation in inner ear sensory epithelia from adult guinea pigs and humans.

  1993cited by this paper
• Dihydrostreptomycin modifies adaptation and blocks the mechano-electric transducer in chick cochlear hair cells.

  1993influential reference
• Gentamicin uptake by cochlear hair cells precedes hearing impairment during chronic treatment.

  1993cited by this paper
• LA GENTAMICINE ADMINISTREE A LONG TERME PENETRE DANS LES CELLULES CILIEES DE LA COCHLEE AVANT L'APPARITION D'UN TROUBLE DE L'AUDITION

  1993cited by this paper
• Ultrastructural evidence for hair cell regeneration in the mammalian inner ear.

  1993cited by this paper
• Mechano-electrical transducer currents in hair cells of the cultured neonatal mouse cochlea

  1992influential reference
• Mechanoelectrical transduction by hair cells.

  1992influential reference
• Mechanical response of frog saccular hair bundles to the aminoglycoside block of mechanoelectrical transduction.

  1992influential reference
• Cadmium block of squid calcium currents. Macroscopic data and a kinetic model

  1991cited by this paper
• Amiloride block of the mechanosensitive cation channel in Xenopus oocytes.

  1991influential reference
• The actions of calcium on the mechano‐electrical transducer current of turtle hair cells.

  1991influential reference
• Aminoglycoside blockade of Ca2+-activated K+ channel from rat brain synaptosomal membranes incorporated into planar bilayers

  1990cited by this paper
• Ultrastructural localization of gentamicin in the cochlea.

  1990cited by this paper
• Blockade of current through single calcium channels by trivalent lanthanide cations. Effect of ionic radius on the rates of ion entry and exit

  1990cited by this paper
• Blockage of the transduction channels of hair cells in the bullfrog's sacculus by aminoglycoside antibiotics.

  1989influential reference
• Activation and adaptation of transducer currents in turtle hair cells.

  1989influential reference
• Dynamic changes following combined treatment with gentamicin and ethacrynic acid with and without acoustic stimulation. Cellular uptake and functional correlates.

  1989cited by this paper
• Voltage dependence of adaptation and active bundle movement in bullfrog saccular hair cells.

  1989influential reference
• Mechanoelectrical transduction by hair cells.

  1988cited by this paper
• Compliance of the hair bundle associated with gating of mechanoelectrical transduction channels in the bullfrog's saccular hair cell.

  1988influential reference
• Cadmium block of squid calcium currents

  1988cited by this paper
• Adaptation of mechanoelectrical transduction in hair cells of the bullfrog's sacculus

  1987cited by this paper
• The responses of inner and outer hair cells in the basal turn of the guinea-pig cochlea and in the mouse cochlea grown in vitro.

  1986influential reference
• Molecular mechanisms of drug-induced hearing loss.

  1986cited by this paper
• Blockade of current through single calcium channels by Cd2+, Mg2+, and Ca2+. Voltage and concentration dependence of calcium entry into the pore

  1986influential reference
• Drug ototoxicity.

  1986cited by this paper
• Effects of noise and ototoxic drugs at the cellular level in the cochlea: a review.

  1986cited by this paper
• Mechano‐electrical transduction currents in isolated vestibular hair cells of the chick.

  1985influential reference
• Action of streptomycin and calcium on the apical membrane of hair cells of the frog isolated semicircular canal.

  1983cited by this paper
• Calcium antagonism and reversibility of gentamicin-induced loss of cochlear microphonics in the guinea pig.

  1982cited by this paper
• Effects of ototoxic antibiotics on sensory hair cell functioning.

  1982cited by this paper
• Pharmacokinetics of gentamicin in perilymph and endolymph of the rat as determined by radioimmunoassay.

  1981cited by this paper
• Dual action of ototoxic antibiotics on sensory hair cells

  1980cited by this paper
• Ionic basis of the receptor potential in a vertebrate hair cell

  1979cited by this paper
• Very low calcium content of cochlear endolymph, an extracellular fluid

  1978cited by this paper
• Sodium ions as blocking agents and charge carriers in the potassium channel of the squid giant axon

  1977cited by this paper
• Ionic Blockage of Sodium Channels in Nerve

  1973influential reference
• Experiments on ototoxic effects of antibiotics.

  1973cited by this paper
• Time Course of TEA+-Induced Anomalous Rectification in Squid Giant Axons

  1966influential reference

• Inhibition of GABARAP or GABARAPL1 prevents aminoglycoside- induced hearing loss

  2025cites this paper
• Cross-species validation of a human age-related hearing loss candidate KLHDC7B as essential for mammalian hearing

  2025cites this paper
• Protective effects of MET channels on aminoglycosides- and cisplatin-induced ototoxicity

  2025influential citation
• Cohesin protein Smc3 influences kinocilial structure and function

  2025cites this paper
• Aminoglycoside induces RIPOR2 translocation and phosphatidylserine externalization via distinct mechanisms

  2025cites this paper
• Natural product inspired antibiotics approved for human use - 1943 to 2025.

  2025cites this paper
• Transcriptomic change in human utricles after aminoglycoside-induced hair cell ablation: Dynamic alterations to hair cell and supporting cell genes.

  2025cites this paper
• The mechanisms of frequency tuning in gecko auditory hair cells.

  2025cites this paper
• Identification of druggable binding sites and small molecules as modulators of TMC1

  2025influential citation
• Inner ear uptake of fluorescent gentamicin in neonatal mice: an experimental animal study

  2025cites this paper
• Identification of Druggable Binding Sites and Small Molecules as Modulators of TMC1

  2024influential citation
• Role of Oxidative Stress in Sensorineural Hearing Loss

  2024cites this paper
• Murine cochlear damage models in the context of hair cell regeneration research.

  2024cites this paper
• Suppression of the TGF-β signaling exacerbates degeneration of auditory neurons in kanamycin-induced ototoxicity in mice

  2024cites this paper
• Role of Memantine in Limiting Cochleotoxicity in Rats

  2024cites this paper
• The Piezo channel is a mechano-sensitive complex component in the mammalian inner ear hair cell

  2024cites this paper
• Potential role of modulating autophagy levels in sensorineural hearing loss.

  2024cites this paper
• Calcium channel inhibitor and extracellular calcium improve aminoglycoside-induced hair cell loss in zebrafish

  2024influential citation
• The role of cilia in the development, survival, and regeneration of hair cells

  2024cites this paper
• Role of Kir4.1 Channels in Aminoglycoside-Induced Ototoxicity of Hair Cells

  2023cites this paper
• Charge and lipophilicity are required for effective block of the hair-cell mechano-electrical transducer channel by FM1-43 and its derivatives

  2023cites this paper
• Use of Skull Vibration-Induced Nystagmus in the Follow-up of Patients With Ménière Disease Treated With Intratympanic Gentamicin

  2023cites this paper
• Aminoglycosides-Related Ototoxicity: Mechanisms, Risk Factors, and Prevention in Pediatric Patients

  2023cites this paper
• Otoprotection against aminoglycoside- and cisplatin-induced ototoxicity focusing on the upstream drug uptake pathway

  2023cites this paper
• The Piezo channel is central to the mechano-sensitive channel complex in the mammalian inner ear.

  2023cites this paper
• Macrophage Depletion Protects Against Cisplatin-Induced Ototoxicity and Nephrotoxicity

  2023cites this paper
• Otoprotective Effects of Fucoidan Reduce Cisplatin-Induced Ototoxicity in Mouse Cochlear UB/OC-2 Cells

  2023cites this paper
• Blood–Labyrinth Barrier in Health and Diseases: Effect of Hormetic Nutrients

  2023cites this paper
• Mechanisms and Impact of Aminoglycoside-Induced Vestibular Deficits.

  2023cites this paper
• Salicylate attenuates gentamicin-induced ototoxicity and facilitates the recovery in the basilar papilla of the lizard Podarcis siculus.

  2022cites this paper
• Hair cell toxicology: With the help of a little fish

  2022cites this paper
• The conductance and organization of the TMC1-containing mechanotransducer channel complex in auditory hair cells

  2022cites this paper
• Functional Characterization of TRPV-Like Ion Channels Involved in Nematocyst Discharge from the Sea Anemone Diadumene lineata

  2022cites this paper
• Local Delivery of Therapeutics to the Cochlea Using Nanoparticles and Other Biomaterials

  2022cites this paper
• An in vivo Biomarker to Characterize Ototoxic Compounds and Novel Protective Therapeutics

  2022cites this paper
• Aminoglycoside treatment alters hearing-related genes and depicts behavioral defects in Drosophila.

  2022cites this paper
• Changes of serum levels of Caspase-3 after trauma and ototoxic damage of the cochlea in rabbits: An in vivo study

  2022cites this paper
• Putative COVID-19 therapies imatinib, lopinavir, ritonavir, and ivermectin cause hair cell damage: A targeted screen in the zebrafish lateral line

  2022cites this paper
• RIPOR2-mediated autophagy dysfunction is critical for aminoglycoside-induced hearing loss.

  2022cites this paper
• Mechanical gating of the auditory transduction channel TMC1 involves the fourth and sixth transmembrane helices

  2022cites this paper
• Mitochondrial form and function in hair cells

  2022cites this paper
• Role of Oxidative Stress and Antioxidants in Acquired Inner Ear Disorders

  2022cites this paper
• Hearing loss drug discovery and medicinal chemistry: Current status, challenges, and opportunities.

  2022cites this paper
• Identifying targets to prevent aminoglycoside ototoxicity.

  2022cites this paper
• In vivo real-time imaging reveals megalin as the aminoglycoside gentamicin transporter into cochlea whose inhibition is otoprotective

  2022cites this paper
• Analysis of potential protective effects of caffeic acid phenethyl ester against gentamicin ototoxicity: An experimental study

  2022cites this paper
• Signal transmission in mature mammalian vestibular hair cells

  2022cites this paper
• Electrophysiological Recordings of Voltage-Dependent and Mechanosensitive Currents in Sensory Hair Cells of the Auditory and Vestibular Organs of the Mouse

  2022cites this paper
• Nonselective TRPC channel inhibition and suppression of aminoglycoside-induced premature termination codon readthrough by the small molecule AC1903

  2022cites this paper
• The global hearing therapeutic pipeline: 2021.

  2021cites this paper
• Mechanisms of Ototoxicity and Otoprotection.

  2021cites this paper
• Neuroplastin genetically interacts with Cadherin 23 and the encoded isoform Np55 is sufficient for cochlear hair cell function and hearing

  2021cites this paper
• Ototoxicity and Drug Transport in the Cochlea

  2021cites this paper
• Experimental animal models of drug-induced sensorineural hearing loss: a narrative review

  2021cites this paper
• Mechanisms of Aminoglycoside- and Cisplatin-Induced Ototoxicity

  2021cites this paper
• Cisplatin Chemotherapy and Cochlear Damage: Otoprotective and Chemosensitization Properties of Polyphenols

  2021cites this paper
• Gentamicin-induced hearing loss: A retrospective study using the Food and Drug Administration Adverse Event Reporting System and a toxicological study using drug−gene network analysis

  2021cites this paper
• Suppression of delayed rectifier K+ channels by gentamicin induces membrane hyperexcitability through JNK and PKA signaling pathways in vestibular ganglion neurons.

  2021cites this paper
• Detecting Novel Ototoxins and Potentiation of Ototoxicity by Disease Settings

  2021cites this paper
• Intratympanic Lipopolysaccharide Elevates Systemic Fluorescent Gentamicin Uptake in the Cochlea

  2021cites this paper
• Mitochondrial Dysfunction and Sirtuins: Important Targets in Hearing Loss

  2021cites this paper
• Hearing Loss: Environmental, Sensorineural, Drug Induced (Cisplatin, Antibiotics)

  2021cites this paper
• Mechanism and Prevention of Ototoxicity Induced by Aminoglycosides

  2021cites this paper
• Theophylline alleviates gentamicin-induced cytotoxicity to sensory hair cells by maintaining HDAC2 expression.

  2021cites this paper
• Identification of a series of hair-cell MET channel blockers that protect against aminoglycoside-induced ototoxicity

  2021cites this paper
• New Tmc1 Deafness Mutations Impact Mechanotransduction in Auditory Hair Cells

  2021cites this paper
• AJA2100006 887..900

  2021cites this paper
• Characterization of quinoxaline derivatives for protection against iatrogenically induced hearing loss

  2021cites this paper
• Hair Cell Protection from Ototoxic Drugs

  2021cites this paper
• MET currents and otoacoustic emissions from mice with a detached tectorial membrane indicate the extracellular matrix regulates Ca2+ near stereocilia

  2021cites this paper
• Suppression of aminoglycoside-induced premature termination codon readthrough by the TRP channel inhibitor AC1903

  2021cites this paper
• How Transmembrane Inner Ear (TMIE) plays role in the auditory system: A mystery to us

  2021cites this paper
• Ionic Conductances of Vestibular Afferent Neurons: Shaping Head Motion Signals From the Inner Ear

  2020cites this paper
• Dissociating antibacterial from ototoxic effects of gentamicin C-subtypes.

  2020cites this paper
• Hair cell uptake of gentamicin in the developing mouse utricle

  2020influential citation
• Cytotoxic effect of aminoglycoside antibiotics on the mammalian cell lines

  2020cites this paper
• A Novel Active Peptide from Rapana venosa Protects Against Gentamicin-Induced Sensory Hair Cell Loss in Zebrafish

  2020cites this paper
• A Novel Active Peptide from Rapana venosa Protects Against Gentamicin-Induced Sensory Hair Cell Loss in Zebrafish

  2020cites this paper
• OTOTOXICITY AS A SIDE-EFFECT OF DRUGS: LITERATURE REVIEW

  2020cites this paper
• Citicoline Protects Auditory Hair Cells Against Neomycin-Induced Damage

  2020cites this paper
• Exosome-mediated protection of auditory hair cells from ototoxic insults.

  2020cites this paper
• Dextran Labeling and Uptake in Live and Functional Murine Cochlear Hair Cells.

  2020cites this paper
• Systemic Fluorescent Gentamicin Enters Neonatal Mouse Hair Cells Predominantly Through Sensory Mechanoelectrical Transduction Channels

  2020cites this paper
• Exosomes mediate sensory hair cell protection in the inner ear.

  2020cites this paper
• Berbamine Analogs Exhibit Differential Protective Effects From Aminoglycoside-Induced Hair Cell Death

  2020cites this paper
• Blebbistatin Inhibits Neomycin-Induced Apoptosis in Hair Cell-Like HEI-OC-1 Cells and in Cochlear Hair Cells

  2020cites this paper
• In vitro and in silico characterization of the inhibition of Kir4.1 channels by aminoglycoside antibiotics

  2020cites this paper
• Physiological Basis of Noise-Induced Hearing Loss in a Tympanal Ear

  2019cites this paper
• Toll-like Receptor 4 Signaling and Downstream Neutrophilic Inflammation Mediate Endotoxemia-Enhanced Blood-Labyrinth Barrier Trafficking.

  2019cites this paper
• Inflammation up-regulates cochlear expression of TRPV1 to potentiate drug-induced hearing loss

  2019influential citation
• Delivery of therapeutics to the inner ear: The challenge of the blood-labyrinth barrier

  2019cites this paper
• Tmc 1 point mutation affects Ca 2 + sensitivity and block by dihydrostreptomycin of the mechanoelectrical transducer current of mouse outer hair cells

  2019cites this paper
• Design, Synthesis, and Biological Evaluation of a New Series of Carvedilol Derivatives That Protect Sensory Hair Cells from Aminoglycoside-Induced Damage by Blocking the Mechanoelectrical Transducer Channel.

  2019cites this paper
• ORC-13661 protects sensory hair cells from aminoglycoside and cisplatin ototoxicity

  2019influential citation
• Transient Receptor Potential Cation Channel Subfamily Vanilloid 4 and 3 in the Inner Ear Protect Hearing in Mice

  2019cites this paper
• Lower ototoxicity and absence of hidden hearing loss point to gentamicin C1a and apramycin as promising antibiotics for clinical use

  2019cites this paper
• Drug-induced Stress Granule Formation Protects Sensory Hair Cells in Mouse Cochlear Explants During Ototoxicity

  2019cites this paper
• Mechanotransduction Activity Facilitates Hair Cell Toxicity Caused by the Heavy Metal Cadmium

  2019cites this paper
• Purinergic Signaling and Aminoglycoside Ototoxicity: The Opposing Roles of P1 (Adenosine) and P2 (ATP) Receptors on Cochlear Hair Cell Survival

  2019cites this paper
• Water Waves to Sound Waves: Using Zebrafish to Explore Hair Cell Biology

  2019cites this paper