Expression of thyroid-specific transcription factors TTF-1 and PAX-8 in human thyroid neoplasms.

No abstract is available for this paper.

• Publication year

  1994

• Venue

  Cancer Research

• Publication date

  1994-09-01

• Fields of study

  Biology, Medicine

• Identifiers
  PMID 8062273
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Proliferative activity of human thyroid tumors evaluated by proliferating cell nuclear antigen/cyclin immunohistochemical studies.

  1994cited by this paper
• Overexpression of p53 as a Possible Prognostic Factor in Human Thyroid Carcinoma

  1993cited by this paper
• High prevalence of mutations of the p53 gene in poorly differentiated human thyroid carcinomas.

  1993cited by this paper
• Genomic sequencing.

  1993cited by this paper
• Proliferative activity of human thyroid tumors evaluated by proliferating cell nuclear antigen/cyclin immunohistochemical studies

  1993cited by this paper
• Poorly Differentiated Thyroid Carcinomas with Primordial Cell Component: A Group of Aggressive Lesions Sharing Insular, Trabecular,and Solid Patterns

  1993cited by this paper
• POU domain transcription factors.

  1993cited by this paper
• Pax-8, a paired domain-containing protein, binds to a sequence overlapping the recognition site of a homeodomain and activates transcription from two thyroid-specific promoters

  1992cited by this paper
• Anterior pituitary development: short tales from dwarf mice.

  1992cited by this paper
• Multiple mechanisms of interference between transformation and differentiation in thyroid cells

  1992cited by this paper
• Expression of c-erbB-2 protein in papillary thyroid carcinomas.

  1992cited by this paper
• Cell-type-specific expression of the rat thyroperoxidase promoter indicates common mechanisms for thyroid-specific gene expression

  1992cited by this paper
• Overexpression of the c-MET/HGF receptor gene in human thyroid carcinomas.

  1992cited by this paper
• The homeobox in perspective.

  1992cited by this paper
• Ret oncogene activation in human thyroid neoplasms is restricted to the papillary cancer subtype.

  1992cited by this paper
• Control of Drosophila body pattern by the hunchback morphogen gradient.

  1992cited by this paper
• Insular carcinoma: a distinct thyroid carcinoma with associated iodine-131 localization.

  1991cited by this paper
• The molecular biology of the human anaplastic thyroid carcinoma cell.

  1991cited by this paper
• CCAAT-enhancer binding protein: a component of a differentiation switch.

  1991cited by this paper
• The transcription factor TTF-1 is expressed at the onset of thyroid and lung morphogenesis and in restricted regions of the foetal brain.

  1991cited by this paper
• Reversible inhibition of a thyroid-specific trans-acting factor by Ras.

  1991cited by this paper
• The myoD gene family: nodal point during specification of the muscle cell lineage.

  1991cited by this paper
• Human thyrotropin receptor gene: expression in thyroid tumors and correlation to markers of thyroid differentiation and dedifferentiation.

  1991cited by this paper
• gsp mutations in human thyroid tumours.

  1991cited by this paper
• Presence of mutations in all three ras genes in human thyroid tumors.

  1990cited by this paper
• Thyroid nuclear factor 1 (TTF‐1) contains a homeodomain and displays a novel DNA binding specificity.

  1990cited by this paper
• Insulin-like growth factor-I receptors in nonfunctioning thyroid nodules.

  1990cited by this paper
• Pax8, a murine paired box gene expressed in the developing excretory system and thyroid gland.

  1990cited by this paper
• High frequency of ras oncogene activation in all stages of human thyroid tumorigenesis.

  1989cited by this paper
• Thyrotropin regulation of thyroid peroxidase messenger ribonucleic acid levels in cultured rat thyroid cells: evidence for the involvement of a nontranscriptional mechanism.

  1989cited by this paper
• The gradient morphogen bicoid is a concentration-dependent transcriptional activator.

  1989cited by this paper
• Transcriptional regulation in mammalian cells by sequence-specific DNA binding proteins.

  1989cited by this paper
• Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction.

  1987cited by this paper
• Genomic sequencing.

  1984cited by this paper
• The aetiology of thyroid tumours.

  1979cited by this paper
• Changing Clinical, Pathologic, Therapeutic, and Survival Patterns in Differentiated Thyroid Carcinoma

  1976cited by this paper
• The Thyroid: A Fundamental and Clinical Text

  1971cited by this paper

• Unusual Metastasis from Follicular Thyroid Carcinoma: A Case Report and Literature Review

  2025cites this paper
• “Immunocytochemistry in Cytology: Myth or Reality”: Unraveling the Myth – Immunocytochemistry Applications in Thyroid Lesions

  2024cites this paper
• SATB2 is an Emergent Biomarker of Anaplastic Thyroid Carcinoma: A Series with Comprehensive Biomarker and Molecular Studies

  2024cites this paper
• Development and primary characterization of a human thyroid organoid in vitro model for thyroid metabolism investigation.

  2024cites this paper
• A comparative analysis of treatment efficacy in intermediate-risk thyroid cancer

  2023cites this paper
• Modulation of EZH2 Activity Induces an Antitumoral Effect and Cell Redifferentiation in Anaplastic Thyroid Cancer

  2023cites this paper
• Deiodinases in thyroid tumorigenesis

  2023cites this paper
• The Unique Importance of Differentiation and Function in Endocrine Neoplasia

  2023cites this paper
• Pax‐8: Molecular biology, pathophysiology, and potential pathogenesis

  2023cites this paper
• Mandibular metastasis of follicular thyroid carcinoma: A case report along with the concise review of literature

  2022cites this paper
• Carcinoma of Unknown Primary Origin: Application of Immunohistochemistry With Emphasis to Different Cytokeratin 7 and 20 Staining Patterns

  2022cites this paper
• NK2 homeobox gene cluster: Functions and roles in human diseases

  2022cites this paper
• Transcription factor PAX4 facilitates gastric cancer progression through interacting with miR-27b-3p/Grb2 axis

  2021cites this paper
• PAX8, an Emerging Player in Ovarian Cancer.

  2021cites this paper
• Molecular mechanisms of radioactive iodine refractoriness in differentiated thyroid cancer: Impaired sodium iodide symporter (NIS) expression owing to altered signaling pathway activity and intracellular localization of NIS

  2021cites this paper
• Advances in Functional Imaging of Differentiated Thyroid Cancer

  2021cites this paper
• Survival analyses and immunohistochemical study of primary signet ring cell carcinoma of the lung adenocarcinoma

  2020cites this paper
• Analysis of PAX8 immunohistochemistry in lung cancers: a meta-analysis

  2020cites this paper
• Identifying Cattle Breed-Specific Partner Choice of Transcription Factors during the African Trypanosomiasis Disease Progression Using Bioinformatics Analysis

  2020cites this paper
• A Positive Feedback Loop Between DICER1 and Differentiation Transcription Factors Is Important for Thyroid Tumorigenesis

  2020cites this paper
• A Novel Tyrosine Kinase Inhibitor Can Augment Radioactive Iodine Uptake Through Endogenous Sodium/Iodide Symporter Expression in Anaplastic Thyroid Cancer

  2020cites this paper
• Immunotherapy for advanced thyroid cancers — rationale, current advances and future strategies

  2020cites this paper
• Canine Thyroid Cancer: Molecular Characterization and Cell Line Growth in Nude Mice

  2020cites this paper
• miR-19a Is Involved In Progression And Malignancy Of Anaplastic Thyroid Cancer Cells

  2019cites this paper
• EGL-38/Pax coordinates development in the Caenhorhabditis elegans egg-laying system through EGF pathway dependent and independent functions.

  2019cites this paper
• Effects of perinatal di (2-ethylhexyl) phthalate exposure on thyroid function in rat offspring.

  2019cites this paper
• FOXE1 regulates migration and invasion in thyroid cancer cells and targets ZEB1

  2019cites this paper
• miR-19a Is Involved In Progression And Malignancy Of Anaplastic Thyroid Cancer Cells

  2019cites this paper
• Napsin A Expression in Subtypes of Thyroid Tumors: Comparison with Lung Adenocarcinomas

  2019cites this paper
• Rolle von transmembranen Ektoenzymen wie Aminopeptidase N und Autotaxin beim Schilddrüsenkarzinom bezüglich ihres Einflusses auf Dedifferenzierung, Invasivität und Transformation

  2018cites this paper
• Immunohistochemical Biomarkers of Gastrointestinal, Pancreatic, Pulmonary, and Thymic Neuroendocrine Neoplasms

  2018cites this paper
• MiR-19a Overexpression in FTC-133 Cell Line Induces a More De-Differentiated and Aggressive Phenotype

  2018influential citation
• PAX8 Expression in Thyroid Tumors: Comparison with PAX2, TTF-1, and Thyroglobulin

  2017influential citation
• Utilization of ancillary studies in the cytologic diagnosis of respiratory lesions: The papanicolaou society of cytopathology consensus recommendations for respiratory cytology

  2016cites this paper
• Mammary analog secretory carcinoma of the thyroid gland: A primary thyroid adenocarcinoma harboring ETV6–NTRK3 fusion

  2016cites this paper
• Immunohistochemical Detection of Pax8 and Napsin A in Canine Thyroid Tumours: Comparison with Thyroglobulin, Calcitonin and Thyroid Transcription Factor 1.

  2016cites this paper
• Cervical lymph node metastases from remote primary tumor sites

  2016cites this paper
• Integrated microRNA, gene expression and transcription factors signature in papillary thyroid cancer with lymph node metastasis

  2016cites this paper
• Expression of PAX8 Target Genes in Papillary Thyroid Carcinoma

  2016cites this paper
• Expression of Tenascin C, EGFR, E-Cadherin, and TTF-1 in Medullary Thyroid Carcinoma and the Correlation with RET Mutation Status

  2016cites this paper
• Unusual Papillary Thyroid Cancer Metastases to Kidney and Pharynx: A Case Report

  2016cites this paper
• A Concise Atlas of Thyroid Cancer Next-Generation Sequencing Panel ThyroSeq v.2

  2016cites this paper
• Practical Applications in Immunohistochemistry: Carcinomas of Unknown Primary Site.

  2016cites this paper
• Gene expression of thyroid-specific transcription factors may help diagnose thyroid lesions but are not determinants of tumor progression

  2016influential citation
• Semiquantitative immunohistochemical marker staining and localization in canine thyroid carcinoma and normal thyroid gland.

  2016cites this paper
• A presenting with obstructive jaundice in pulmonary adenocarcinoma: a case report.

  2015cites this paper
• Thyroid, Parathyroid and Adrenal Glands

  2015cites this paper
• Modeling Anaplastic Thyroid Carcinoma in the Mouse

  2015cites this paper
• [Thyroid pathology. Case No. 6. Thyroid undifferentiated carcinoma (anaplasic) developed on a papillary carcinoma].

  2015cites this paper
• Diagnostic significance of PAX8 in thyroid squamous cell carcinoma.

  2015cites this paper
• Neuropilin-2 Is a Newly Identified Target of PAX8 in Thyroid Cells

  2015cites this paper
• Diagnostic significance of PAX 8 in thyroid squamous cell carcinoma

  2015cites this paper
• Application of immunohistochemistry in thyroid pathology.

  2015cites this paper
• Transcriptional control of PAX4-regulated miR-144/451 modulates metastasis by suppressing ADAMs expression

  2014cites this paper
• Genetic diversity analysis of the thyroglobulin gene promoter in buffalo and other bovines

  2014cites this paper
• Comprehensive genotyping and clinical characterisation reveal 27 novel NKX2-1 mutations and expand the phenotypic spectrum

  2014cites this paper
• B-RafV600E inhibits sodium iodide symporter expression via regulation of DNA methyltransferase 1

  2014cites this paper
• Adrenocortical Carcinoma: A Comprehensive Immunohistochemical Study of 40 Cases

  2014cites this paper
• Pax8 modulates the expression of Wnt4 that is necessary for the maintenance of the epithelial phenotype of thyroid cells

  2014cites this paper
• Update on Anaplastic Thyroid Carcinoma: Morphological, Molecular, and Genetic Features of the Most Aggressive Thyroid Cancer

  2014cites this paper
• Associations between rs965513/rs944289 and papillary thyroid carcinoma risk: a meta-analysis

  2014cites this paper
• Comprehensive discovery of DNA motifs in 349 human cells and tissues reveals new features of motifs

  2014influential citation
• Are the SNPs of NKX2-1 associated with papillary thyroid carcinoma in the Han population of Northern China?

  2014cites this paper
• Relevance of targeting RET/PTC junction oncogene and Wnt/β-catenin pathway in the treatment of papillary thyroid carcinoma: skill of 8-year work

  2014cites this paper
• Synergistic Signaling of KRAS and Thyroid Hormone Receptor β Mutants Promotes Undifferentiated Thyroid Cancer through MYC Up-Regulation12

  2014cites this paper
• Napsin A Expression in Anaplastic, Poorly Differentiated, and Micropapillary Pattern Thyroid Carcinomas

  2013cites this paper
• Comparative immunohistochemical analysis of pulmonary and thymic neuroendocrine carcinomas using PAX8 and TTF-1

  2013cites this paper
• Role of thyroid transcription factor-1 and P63 immunocytochemistry in cytologic typing of non-small cell lung carcinomas.

  2013cites this paper
• Metastatic common bile duct cancer from pulmonary adenocarcinoma presenting as obstructive jaundice.

  2013cites this paper
• target as a functional transcriptional LMO 3 lung adenocarcinoma identifies in NKX 2-1 Integrated cistromic and expression analysis of amplified Material Supplemental

  2013cites this paper
• Integrated cistromic and expression analysis of amplified NKX2-1 in lung adenocarcinoma identifies LMO3 as a functional transcriptional target.

  2013cites this paper
• Hypothyroxinemia Induced by Mild Iodine Deficiency Deregulats Thyroid Proteins during Gestation and Lactation in Dams

  2013cites this paper
• Value of Thyroid Transcription Factor-1 Immunostaining in Tumor Diagnosis: A Review and Update

  2012cites this paper
• Expression of thyroid-specific transcription factors in thyroid carcinoma, contralateral thyroid lobe and healthy thyroid gland in dogs.

  2012cites this paper
• Cyclic AMP–Response Element Modulator Inhibits the Promoter Activity of the Sodium Iodide Symporter Gene in Thyroid Cancer Cells

  2012influential citation
• Napsin A, a new marker for lung adenocarcinoma, is complementary and more sensitive and specific than thyroid transcription factor 1 in the differential diagnosis of primary pulmonary carcinoma: evaluation of 1674 cases by tissue microarray.

  2012cites this paper
• Elucidation of the sugar recognition ability of the lectin domain of UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase 3 by using unnatural glycopeptide substrates.

  2012cites this paper
• Antitumor Effects of Proteasome Inhibition in Anaplastic Thyroid Carcinoma

  2012cites this paper
• The sodium iodide symporter (NIS): regulation and approaches to targeting for cancer therapeutics.

  2012cites this paper
• Diagnostic utility of PAX8, TTF-1 and napsin A for discriminating metastatic carcinoma from primary adenocarcinoma of the lung

  2012cites this paper
• Multifaceted suppression of aggressive behavior of thyroid carcinoma by all-trans retinoic acid induced re-differentiation.

  2011influential citation
• Pax8: A marker for carcinoma of Müllerian origin in serous effusions

  2011cites this paper
• Thyroid and Parathyroid Gland

  2011cites this paper
• TAZ/WWTR1 is overexpressed in papillary thyroid carcinoma.

  2011cites this paper
• Thyroid-Specific Transcription Factors and Their Roles in Thyroid Cancer

  2011cites this paper
• Etude du profil d'expression génique de pathologies tumorales thyroïdiennes se développant dans différents modèles de souris transgéniques

  2011cites this paper
• Diagnostic Use of PAX8, CAIX, TTF-1, and TGB in Metastatic Renal Cell Carcinoma of the Thyroid

  2011cites this paper
• Pax8 Expression in Thymic Epithelial Neoplasms: An Immunohistochemical Analysis

  2011cites this paper
• Combining transfer of TTF-1 and Pax-8 gene: a potential strategy to promote radioiodine therapy of thyroid carcinoma

  2011influential citation
• [TTF-1: neither angel nor demon].

  2011cites this paper
• In thyroid cancer cell lines expression of periostin gene is controlled by p73 and is not related to epigenetic marks of active transcription

  2011cites this paper
• Enhancer of zeste homolog 2 overexpression has a role in the development of anaplastic thyroid carcinomas.

  2011cites this paper
• PAX8 immunostaining of anaplastic thyroid carcinoma: a reliable means of discerning thyroid origin for undifferentiated tumors of the head and neck.

  2011cites this paper
• Wnt/β-Catenin Signaling Pathway Is a Direct Enhancer of Thyroid Transcription Factor-1 in Human Papillary Thyroid Carcinoma Cells

  2011cites this paper
• Nonconventional papillary thyroid carcinomas with pleomorphic tumor giant cells: a diagnostic pitfall with anaplastic carcinoma

  2010cites this paper
• Emerging Roles for PAX Transcription Factors in Cancer

  2010cites this paper
• The Use of Immunohistochemistry in the Diagnosis of Metastatic Clear Cell Renal Cell Carcinoma: A Review of PAX-8, PAX-2, hKIM-1, RCCma, and CD10

  2010cites this paper
• Carcinogenesis and therapeutic strategies in thyroid cancer.

  2010cites this paper
• Expression of Thyroid Transcription Factor-1 in Colorectal Carcinoma

  2010cites this paper
• Unifokale hyperfunktionelle Karzinome der Schilddrüse

  2010cites this paper