Biomolecular Targets of Oxyprenylated Phenylpropanoids and Polyketides.

No abstract is available for this paper.

• Publication year

  2019

• Venue

  Progress in the chemistry of organic natural products

• Publication date

  Unknown publication date

• Fields of study

  Biology, Medicine, Chemistry

• Identifiers
  DOI 10.1007/978-3-030-01099-7_2PMID 30924014
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Design, synthesis, and evaluation of new series of Imperatorin analogs with potential vasodilatory activity

  2019cited by this paper
• Risk of gastric cancer in association with Helicobacter pylori different virulence factors: A systematic review and meta-analysis.

  2018cited by this paper
• Natural oxyprenylated coumarins are modulators of melanogenesis.

  2018cited by this paper
• Secretase inhibitors for the treatment of Alzheimer's disease: Long road ahead.

  2018cited by this paper
• Hepatoprotection of auraptene from peels of citrus fruits against thioacetamide-induced hepatic fibrosis in mice by activating farnesoid X receptor.

  2018cited by this paper
• Interaction of 7-Alkoxycoumarins with the Aryl Hydrocarbon Receptor.

  2017cited by this paper
• Computational discovery and experimental verification of farnesoid X receptor agonist auraptene to protect against cholestatic liver injury

  2017cited by this paper
• Imperatorin suppresses proliferation and angiogenesis of human colon cancer cell by targeting HIF-1α via the mTOR/p70S6K/4E-BP1 and MAPK pathways.

  2017cited by this paper
• Imperatorin is Transported through Blood-Brain Barrier by Carrier-Mediated Transporters

  2017cited by this paper
• The Dietary Furocoumarin Imperatorin Increases Plasma GLP-1 Levels in Type 1-Like Diabetic Rats

  2017cited by this paper
• Imperatorin possesses notable anti-inflammatory activity in vitro and in vivo through inhibition of the NF-κB pathway

  2017cited by this paper
• Auraptene Induces Apoptosis via Myeloid Cell Leukemia 1‐Mediated Activation of Caspases in PC3 and DU145 Prostate Cancer Cells

  2017cited by this paper
• Auraptene Attenuates Malignant Properties of Esophageal Stem-Like Cancer Cells

  2017cited by this paper
• Antidepressive-like effect of imperatorin from Angelica dahurica in prenatally stressed offspring rats through 5-hydroxytryptamine system

  2017cited by this paper
• A review of the ethnopharmacology, phytochemistry and pharmacology of Notopterygium incisum.

  2017cited by this paper
• Isoimperatorin induces apoptosis of the SGC-7901 human gastric cancer cell line via the mitochondria-mediated pathway.

  2017cited by this paper
• Imperatorin protects H9c2 cardiomyoblasts cells from hypoxia/reoxygenation-induced injury through activation of ERK signaling pathway

  2017cited by this paper
• A re‐investigation of the phytochemical composition of the edible herb Amaranthus retroflexus L.

  2017cited by this paper
• Oxyprenylated Phenylpropanoids Bind to MT1 Melatonin Receptors and Inhibit Breast Cancer Cell Proliferation and Migration.

  2017cited by this paper
• Quantification of biologically active O‐prenylated and unprenylated phenylpropanoids in dill (Anethum graveolens), anise (Pimpinella anisum), and wild celery (Angelica archangelica)

  2017cited by this paper
• Umbelliprenin Mediates Its Apoptotic Effect by Hormesis: A Commentary

  2017cited by this paper
• The interaction of auraptene and other oxyprenylated phenylpropanoids with glucose transporter type 4.

  2017cited by this paper
• A Review of the Composition of the Essential Oils and Biological Activities of Angelica Species

  2017cited by this paper
• Imperatorin efficiently blocks TNF-α-mediated activation of ROS/PI3K/Akt/NF-κB pathway.

  2017cited by this paper
• Plumbagin, Juglone, and Boropinal as Novel TRPA1 Agonists.

  2016cited by this paper
• Preventive effects of imperatorin on perfluorohexanesulfonate-induced neuronal apoptosis via inhibition of intracellular calcium-mediated ERK pathway

  2016cited by this paper
• Anti-inflammatory terpenylated coumarins from the leaves of Zanthoxylum schinifolium with α-glucosidase inhibitory activity

  2016cited by this paper
• Comparison of different extraction methods and HPLC quantification of prenylated and unprenylated phenylpropanoids in raw Italian propolis.

  2016cited by this paper
• Auraptene and Other Prenyloxyphenylpropanoids Suppress Microglial Activation and Dopaminergic Neuronal Cell Death in a Lipopolysaccharide-Induced Model of Parkinson’s Disease

  2016cited by this paper
• Essential oil composition and biological aspects of Aconitum heterophyllum

  2016cited by this paper
• Inhibition of melatonin metabolism in humans induced by chemical components from herbs and effective prediction of this risk using a computational model

  2016cited by this paper
• Imperatorin–pharmacological meaning and analytical clues: profound investigation

  2016cited by this paper
• Simvastatin in combination with bergamottin potentiates TNF-induced apoptosis through modulation of NF-κB signalling pathway in human chronic myelogenous leukaemia

  2016cited by this paper
• Native Australian plant extracts differentially induce Collagen I and Collagen III in vitro and could be important targets for the development of new wound healing therapies.

  2016cited by this paper
• Molecular mechanisms for tumour resistance to chemotherapy

  2016cited by this paper
• Auraptene induces oligodendrocyte lineage precursor cells in a cuprizone-induced animal model of demyelination.

  2016cited by this paper
• Two novel cinnamic acid derivatives from honey and propolis

  2016cited by this paper
• Imperatorin exerts antiallergic effects in Th2-mediated allergic asthma via induction of IL-10-producing regulatory T cells by modulating the function of dendritic cells.

  2016cited by this paper
• Imperatorin exhibits anticancer activities in human colon cancer cells via the caspase cascade.

  2016cited by this paper
• Bergamottin isolated from Citrus bergamia exerts in vitro and in vivo antitumor activity in lung adenocarcinoma through the induction of apoptosis, cell cycle arrest, mitochondrial membrane potential loss and inhibition of cell migration and invasion.

  2016cited by this paper
• Improvement of Transmembrane Transport Mechanism Study of Imperatorin on P-Glycoprotein-Mediated Drug Transport

  2016cited by this paper
• Inhibitory effect of imperatorin on insulin-like growth factor-1-induced sebum production in human sebocytes cultured in vitro.

  2016cited by this paper
• Madagascine Induces Vasodilatation via Activation of AMPK

  2016cited by this paper
• Chemistry and health effects of furanocoumarins in grapefruit

  2016cited by this paper
• Immune-associated proteins with potential in vivo anti-tumor activities are upregulated in lung cancer cells treated with umbelliprenin: A proteomic approach.

  2016cited by this paper
• Mechanism-based inactivation of cytochrome P450 2B6 by isoimperatorin.

  2015cited by this paper
• Suppression of mitochondrial respiration with auraptene inhibits the progression of renal cell carcinoma: involvement of HIF-1α degradation

  2015cited by this paper
• Inhibitory effects of imperatorin on voltage-gated K^+ channels and ATP-sensitive K^+ channels

  2015cited by this paper
• Imperatorin acts as a cisplatin sensitizer via downregulating Mcl-1 expression in HCC chemotherapy

  2015cited by this paper
• Reversal of P-glycoprotein-mediated multidrug resistance in MCF-7/Adr cancer cells by sesquiterpene coumarins.

  2015cited by this paper
• Imperatorin Suppresses Degranulation and Eicosanoid Generation in Activated Bone Marrow-Derived Mast Cells

  2015cited by this paper
• Auraptene Acts as an Anti-Inflammatory Agent in the Mouse Brain

  2015cited by this paper
• New coumarins from the roots of Angelica dahurica var. formosana cv. Chuanbaizhi and their inhibition on NO production in LPS-activated RAW264.7 cells.

  2015cited by this paper
• Auraptene, a Major Compound of Supercritical Fluid Extract of Phalsak (Citrus Hassaku Hort ex Tanaka), Induces Apoptosis through the Suppression of mTOR Pathways in Human Gastric Cancer SNU-1 Cells

  2015cited by this paper
• Effect of Imperatorin on the Spontaneous Motor Activity of Rat Isolated Jejunum Strips

  2015cited by this paper
• Imperatorin Is a Mechanism-Based Inactivator of CYP2B6

  2015cited by this paper
• A newly synthesized compound, 4′‐geranyloxyferulic acid–N(omega)‐nitro‐l‐arginine methyl ester suppresses inflammation‐associated colorectal carcinogenesis in male mice

  2014cited by this paper
• Prenylation of Aromatic Secondary Metabolites: A New Frontier for Development of Novel Drugs

  2014cited by this paper
• Effects of imperatorin on scopolamine-induced cognitive impairment and oxidative stress in mice

  2014cited by this paper
• The effect of quercetin and imperatorin on programmed cell death induction in T98G cells in vitro

  2014cited by this paper
• Antioxidant effect of imperatorin from Angelica dahurica in hypertension via inhibiting NADPH oxidase activation and MAPK pathway.

  2014cited by this paper
• Synthesis and biological activities of 2,6-dihydroxy-4-isopentenyloxychalcone as an antimicrobial and anti-inflammatory compound.

  2014cited by this paper
• Oplopanax elatus (Nakai) Nakai: chemistry, traditional use and pharmacology.

  2014cited by this paper
• Furanocoumarins Are a Novel Class of Modulators for the Transient Receptor Potential Vanilloid Type 1 (TRPV1) Channel*

  2014cited by this paper
• Biological properties and molecular targets of umbelliprenin – a mini-review

  2014cited by this paper
• Nelumal A, the Active Principle of Ligularia nelumbifolia, is a Novel Aromatase Inhibitor

  2014cited by this paper
• Umbelliprenin induced production of IFN-γ and TNF-α, and reduced IL-10, IL-4, Foxp3 and TGF-β in a mouse model of lung cancer

  2014cited by this paper
• Imperatorin induces Mcl-1 degradation to cooperatively trigger Bax translocation and Bak activation to suppress drug-resistant human hepatoma.

  2014cited by this paper
• Bergamottin, a natural furanocoumarin obtained from grapefruit juice induces chemosensitization and apoptosis through the inhibition of STAT3 signaling pathway in tumor cells.

  2014cited by this paper
• Phytochemistry and pharmacognosy of naturally occurring prenyloxyanthraquinones.

  2013cited by this paper
• Anti-Inflammatory and Wound Healing Potential of Citrus Auraptene

  2013cited by this paper
• Effects of imperatorin, the active component from Radix Angelicae (Baizhi), on the blood pressure and oxidative stress in 2K,1C hypertensive rats.

  2013cited by this paper
• Auraptene suppresses inflammatory responses in activated RAW264 macrophages by inhibiting p38 mitogen-activated protein kinase activation.

  2013cited by this paper
• Conjugation of l-NAME to prenyloxycinnamic acids improves its inhibitory effects on nitric oxide production.

  2013cited by this paper
• Synthesis of Imperatorin Analogs and Their Evaluation as Acetylcholinesterase and Butyrylcholinesterase Inhibitors

  2013cited by this paper
• Collinin reduces Porphyromonas gingivalis growth and collagenase activity and inhibits the lipopolysaccharide-induced macrophage inflammatory response and osteoclast differentiation and function.

  2013cited by this paper
• Apoptosis and DNA intercalating activities of novel emodin derivatives

  2013cited by this paper
• Auraptene and its Effects on the Re‐emergence of Colon Cancer Stem Cells

  2013cited by this paper
• Imperatorin sensitizes anoikis and inhibits anchorage-independent growth of lung cancer cells

  2013cited by this paper
• The protective activity of imperatorin in cultured neural cells exposed to hypoxia re-oxygenation injury via anti-apoptosis.

  2013cited by this paper
• Suppression of voltage-gated Na(+) channels and neuronal excitability by imperatorin.

  2013cited by this paper
• Development and application of high-performance liquid chromatography for the study of two new oxyprenylated anthraquinones produced by Rhamnus species.

  2012cited by this paper
• Inducible nitric oxide synthase and cyclooxygenase-2 participate in anti-inflammatory activity of imperatorin from Glehnia littoralis.

  2012cited by this paper
• Imperatorin prevents cardiac hypertrophy and the transition to heart failure via NO-dependent mechanisms in mice.

  2012cited by this paper
• Biotransformation products of phellopterin by rat liver microsomes and the inhibition on NO production in LPS-activated RAW264.7 cells

  2012cited by this paper
• Bergamottin is a competitive inhibitor of CYP1A1 and is antimutagenic in the Ames test.

  2012cited by this paper
• Nelumal A, the active principle from Ligularia nelumbifolia, is a novel farnesoid X receptor agonist.

  2012cited by this paper
• Re-investigation of the Anthraquinone Pool of Rhamnus spp.: Madagascin from the Fruits of Rhamnus cathartica and R. intermedia

  2012cited by this paper
• Anthraquinone profiles, antioxidant and antimicrobial properties of Frangula rupestris (Scop.) Schur and Frangula alnus Mill. bark

  2012cited by this paper
• Neurotrophic Effect of Citrus Auraptene: Neuritogenic Activity in PC12 Cells

  2012cited by this paper
• Effects of Auraptene on IGF-1 Stimulated Cell Cycle Progression in the Human Breast Cancer Cell Line, MCF-7

  2012cited by this paper
• The plant coumarins auraptene and lacinartin as potential multifunctional therapeutic agents for treating periodontal disease

  2012cited by this paper
• Recent developments in the pharmacological properties of 4'-geranyloxyferulic acid, a colon cancer chemopreventive agent of natural origin.

  2012cited by this paper
• Imperatorin Attenuates LPS-Induced Inflammation by Suppressing NF-κB and MAPKs Activation in RAW 264.7 Macrophages

  2012cited by this paper
• Screening for oxyprenylated anthraquinones in Mediterranean Rhamnus species

  2012cited by this paper
• Byakangelicin induces cytochrome P450 3A4 expression via transactivation of pregnane X receptors in human hepatocytes

  2011cited by this paper
• A potential calcium antagonist and its antihypertensive effects.

  2011cited by this paper
• In vitro effects of natural prenyloxycinnamic acids on human cytochrome P450 isozyme activity and expression.

  2011cited by this paper
• Distinct Effects of Imperatorin on Allergic Rhinitis: Imperatorin Inhibits Caspase-1 Activity In Vivo and In Vitro

  2011cited by this paper
• Antibacterial and anti-inflammatory activities of 4-hydroxycordoin: potential therapeutic benefits.

  2011cited by this paper

• Habitat-driven ecological strategies shape Chinese pine functional traits and rhizosphere metabolites in Qinling Mountains, China

  2025cites this paper
• Comprehensive characterization of multi-omics landscapes between gut microbial metabolites and the druggable genome in sepsis

  2025cites this paper
• Multi-pronged approaches to the mechanism-based inactivation of aldose reductase by natural coumarins: molecular insights and experimental validation

  2025cites this paper
• Endophytic fungus Umbelopsis sp. TM01 as high-activity alternative to Tricholoma matsutake.

  2025cites this paper
• Enhancing the quality of fermented plant leaves: the role of metabolite signatures and associated fungi

  2024cites this paper
• Synthesis of liposomal nanoparticles to load 4-farnesyloxycoumarin and investigating its anti-cancer and anti-metastatic effects

  2024cites this paper
• Protection of Mitochondrial Potential and Activity by Oxyprenylated Phenylpropanoids

  2023cites this paper
• Novel insights into the biomolecular mechanism of action of 4'-geranyloxyferulic acid, a colon cancer chemopreventive agent.

  2023cites this paper
• An Integrated Molecular Networking and Docking Approach to Characterize the Metabolome of Helichrysum splendidum and Its Pharmaceutical Potentials

  2023cites this paper
• Dahuang zhechong pill ameliorates hepatic fibrosis by regulating gut microbiota and metabolites.

  2023cites this paper
• Metabonomic Characteristics of Myocardial Diastolic Dysfunction in Type 2 Diabetic Cardiomyopathy Patients

  2022cites this paper
• Estrogen Receptor 1 (ESR1) and the Wnt/β-Catenin Pathway Mediate the Effect of the Coumarin Derivative Umbelliferon on Bone Mineralization

  2022cites this paper
• The combined effect of protein hydrolysis and Lactobacillus plantarum fermentation on antioxidant activity and metabolomic profiles of quinoa beverage.

  2022cites this paper
• Oxyprenylated secondary metabolites: a survey of their innovative extraction methodologies

  2022cites this paper
• Semisynthesis of Selenoauraptene

  2021cites this paper
• Oxyprenylated Secondary Metabolites as Modulators of Lipid and Sugar Metabolism.

  2021cites this paper
• Auraptene and umbelliprenin: a review on their latest literature acquisitions

  2020cites this paper
• UPLC/MS-based untargeted metabolomics reveals the changes of metabolites profile of Salvia miltiorrhiza bunge during Sweating processing

  2020cites this paper
• UHPLC-UV/Vis Quantitative Analysis of Hydroxylated and O-prenylated Coumarins in Pomegranate Seed Extracts

  2019cites this paper