Species Differences in the Distribution of Drug-Metabolizing Enzymes in the Pancreas

No abstract is available for this paper.

• Publication year

  2002

• Venue

  Toxicologic pathology (Print)

• Publication date

  2002-02-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1080/019262302753559588PMID 11950168
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Pharmacogenetics of the cytochromes P450.

  2004cited by this paper
• Increased Expression of Glutathione S-Transferase-&pgr; in the Islets of Patients with Primary Chronic Pancreatitis But Not Secondary Chronic Pancreatitis

  2001cited by this paper
• Guide to Cytochromes P450 : structure and function

  2001cited by this paper
• Circadian variation in O6‐alkylguanine‐DNA alkyltransferase activity in circulating blood mononuclear cells of healthy human subjects

  2001cited by this paper
• Insulin is a dominant suppressor of sterol 12 alpha-hydroxylase P450 (CYP8B) expression in rat liver: possible role of insulin in circadian rhythm of CYP8B.

  2000cited by this paper
• Circadian variation of the urinary 6β-hydroxycortisol to cortisol ratio that would reflect hepatic CYP3A activity

  2000cited by this paper
• Expression of Glutathione S‐Transfer α, P1–1 and T1–1 in the Human Gastrointestinal Tract

  2000cited by this paper
• Polymorphisms of xenobiotic-metabolizing enzymes and susceptibility to cancer.

  1999influential reference
• Immunohistochemical study of cytochrome P450 2C and 3A in human non-neoplastic and neoplastic tissues

  1999cited by this paper
• Human cytochromes P450

  1999cited by this paper
• Up‐Regulation of Cytochrome P450 1A2, 2C9, and 2E1 in Chronic Pancreatitis

  1998cited by this paper
• Cytochromes P450 and species differences in xenobiotic metabolism and activation of carcinogen.

  1998influential reference
• Comparisons of catalytic selectivity of cytochrome P450 subfamily enzymes from different species.

  1997cited by this paper
• Frequencies of the defective CYP2C19 alleles responsible for the mephenytoin poor metabolizer phenotype in various Oriental, Caucasian, Saudi Arabian and American black populations.

  1997cited by this paper
• Cytochromes P450: structure, function and mechanism.

  1996cited by this paper
• Human glutathione S-transferases.

  1994cited by this paper
• Role of human cytochromes P450 in the metabolic activation of chemical carcinogens and toxins.

  1994cited by this paper
• A reexamination of the low prevalence of carcinogens in an early carcinogen screen.

  1994cited by this paper
• P450 in the rat and man: methods of investigation, substrate specificities and relevance to cancer.

  1994cited by this paper
• Expression of glutathione S-transferases in normal and malignant pancreas: an immunohistochemical study.

  1994cited by this paper
• A new technique for simultaneous demonstration of 4 tumor-associated antigens in pancreatic cancer cells.

  1994cited by this paper
• Cytochrome P450

  1993cited by this paper
• Induction of drug‐metabolizing enzymes in human pancreatic cancer and chronic pancreatitis

  1993cited by this paper
• The influence of chemical structure on the extent and sites of carcinogenesis for 522 rodent carcinogens and 55 different human carcinogen exposures.

  1993cited by this paper
• Predictive Strategies for Selecting 379 NCI/NTP Chemicals Evaluated for Carcinogenic Potential: Scientific and Public Health Impact

  1993cited by this paper
• Life-span and cancer: the induction time of tumors in diverse animal species treated with nitrosodiethylamine.

  1993cited by this paper
• Predictive strategies for selecting 379 NCI/NTP chemicals evaluated for carcinogenic potential: scientific and public health impact.

  1993cited by this paper
• Hydroxylation of warfarin by human cDNA-expressed cytochrome P-450: a role for P-4502C9 in the etiology of (S)-warfarin-drug interactions.

  1992cited by this paper
• Cytochrome P-450 3A4 (nifedipine oxidase) is responsible for the C-oxidative metabolism of 1-nitropyrene in human liver microsomal samples.

  1992cited by this paper
• An analysis of the 1987 list of IARC-identified human carcinogens and the correlated animal studies.

  1992cited by this paper
• The human hepatic cytochromes P450 involved in drug metabolism.

  1992cited by this paper
• Immunohistologic localization of alpha, Mu, and Pi class glutathione S‐transferases in human tissues

  1991cited by this paper
• Target organs in chronic bioassays of 533 chemical carcinogens.

  1991cited by this paper
• Tolbutamide and phenytoin hydroxylations by cDNA-expressed human liver cytochrome P4502C9.

  1991cited by this paper
• A tobacco smoke-derived nitrosamine, 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone, is activated by multiple human cytochrome P450s including the polymorphic human cytochrome P4502D6.

  1991cited by this paper
• Species differences in metabolism and pharmacokinetics: are we close to an understanding?

  1991cited by this paper
• Theta, a new class of glutathione transferases purified from rat and man.

  1991cited by this paper
• The metabolism of 1-nitropyrene by human cytochromes P450.

  1990cited by this paper
• Species variation in the response of the cytochrome P-450-dependent monooxygenase system to inducers and inhibitors.

  1990cited by this paper
• Evolution of the P450 gene superfamily: animal-plant 'warfare', molecular drive and human genetic differences in drug oxidation.

  1990cited by this paper
• Tolbutamide and mephenytoin hydroxylation by human cytochrome P450s in the CYP2C subfamily.

  1990cited by this paper
• Too many rodent carcinogens: mitogenesis increases mutagenesis.

  1990cited by this paper
• Five of 12 forms of vaccinia virus-expressed human hepatic cytochrome P450 metabolically activate aflatoxin B1.

  1990cited by this paper
• The glutathione S-transferases: an update.

  1989cited by this paper
• Expression of a human liver cytochrome P-450 protein with tolbutamide hydroxylase activity in Saccharomyces cerevisiae.

  1989cited by this paper
• Experimental pancreatic cancer.

  1989cited by this paper
• Human liver microsomal cytochrome P-450 enzymes involved in the bioactivation of procarcinogens detected by umu gene response in Salmonella typhimurium TA 1535/pSK1002.

  1989cited by this paper
• Special article the glutathione S‐transferases: An update

  1989cited by this paper
• Protective role of glutathione and glutathione transferases in mutagenesis and carcinogenesis.

  1988cited by this paper
• The immunocytochemical localisation and distribution of cytochrome P-450 in normal human hepatic and extrahepatic tissues with a monoclonal antibody to human cytochrome P-450.

  1988cited by this paper
• The predictivity of animal bioassays and short-term genotoxicity tests for carcinogenicity and non-carcinogenicity to humans.

  1987cited by this paper
• Mutagenic activation of carcinogenic N-nitrosopropylamines by rat liver: evidence for a cytochrome P-450 dependent reaction.

  1985cited by this paper
• Identification of three classes of cytosolic glutathione transferase common to several mammalian species: correlation between structural data and enzymatic properties.

  1985cited by this paper
• Carcinogenesis bioassay data: correlation by species and sex.

  1984cited by this paper
• Carcinogenesis bioassay data: correlation by species and sex.

  1984cited by this paper
• Experimental carcinogenesis in the pancreas.

  1984cited by this paper
• Experimental pancreatic carcinogenesis

  1982cited by this paper
• Metabolism of the pancreatic carcinogen N-nitroso-2,6-dimethylmorpholine by hamster liver and component cells of pancreas.

  1982cited by this paper
• The role of glutathione and glutathione S-transferases in the metabolism of chemical carcinogens and other electrophilic agents.

  1979cited by this paper
• The glutathione S-transferases: a group of multifunctional detoxification proteins.

  1978cited by this paper
• An enzyme from rat liver catalysing conjugations with glutathione.

  1961cited by this paper

• Glutathione transferases in cats and dogs: diversity, structure, and function

  2025cites this paper
• Identification of Ppy‐lineage cells as a novel origin of pancreatic ductal adenocarcinoma

  2024cites this paper
• Bioaccumulation and in vivo fate of toxic benzylalkyldimethylammonium chloride in rats via the radiotracer analysis.

  2023cites this paper
• Pancreas and Adverse Drug Reactions: A Literature Review

  2022cites this paper
• The role of some xenobiotic biotransformation genes snp in the development of acute pancreatitis

  2020cites this paper
• Chapter 35 – Endocrine Pancreas

  2018cites this paper
• Pancreatic Adenocarcinoma, Multiple Insular-Ductualr Alterations and Malignant PPoma in a Patient Treated With Glp-1 Analogs

  2017cites this paper
• Diabetes in Children and the Role of Micronutrients

  2017cites this paper
• Preclinical Safety Assessment of Drug Candidate‐Induced Pancreatic Toxicity

  2016cites this paper
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  2014cites this paper
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  2014cites this paper
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  2013cites this paper
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  2011cites this paper
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  2007cites this paper
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