Manganese-induced Neurotoxicity: From C. elegans to Humans.

No abstract is available for this paper.

• Publication year

  2015

• Venue

  Toxicological Research

• Publication date

  2015-02-23

• Fields of study

  Biology, Medicine, Environmental Science

• Identifiers
  DOI 10.1039/C4TX00127CPMID 25893090PMCID PMC4399965
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• [Parkinson's disease].

  2022cited by this paper
• Protective role of sodium para-amino salicylic acid against manganese-induced hippocampal neurons damage.

  2014cited by this paper
• Sleep Disorders in Parkinson's Disease

  2014cited by this paper
• A Prospective Analysis of Airborne Metal Exposures and Risk of Parkinson Disease in the Nurses’ Health Study Cohort

  2014cited by this paper
• Is Parkinson's Disease a Vesicular Dopamine Storage Disorder? Evidence from a Study in Isolated Synaptic Vesicles of Human and Nonhuman Primate Striatum

  2014cited by this paper
• Pathology of inherited manganese transporter deficiency

  2014cited by this paper
• Dopamine‐induced α‐synuclein oligomers show self‐ and cross‐propagation properties

  2014cited by this paper
• Manganese-Induced Atypical Parkinsonism Is Associated with Altered Basal Ganglia Activity and Changes in Tissue Levels of Monoamines in the Rat

  2014cited by this paper
• Manganese disturbs metal and protein homeostasis in Caenorhabditis elegans.

  2014cited by this paper
• Interaction of Curcumin with Manganese May Compromise Metal and Neurotransmitter Homeostasis in the Hippocampus of Young Mice

  2014cited by this paper
• Genetic factors and manganese-induced neurotoxicity

  2014cited by this paper
• The effects of pdr1, djr1.1 and pink1 loss in manganese-induced toxicity and the role of α-synuclein in C. elegans.

  2014cited by this paper
• Manganese accumulation in bone following chronic exposure in rats: steady-state concentration and half-life in bone.

  2014cited by this paper
• Zn²⁺ dyshomeostasis caused by loss of ATP13A2/PARK9 leads to lysosomal dysfunction and alpha-synuclein accumulation.

  2014cited by this paper
• SLC30A10 Is a Cell Surface-Localized Manganese Efflux Transporter, and Parkinsonism-Causing Mutations Block Its Intracellular Trafficking and Efflux Activity

  2014cited by this paper
• Parkinson's disease-linked human PARK9/ATP13A2 maintains zinc homeostasis and promotes α-Synuclein externalization via exosomes.

  2014cited by this paper
• Manganese Neurotoxicity: a Focus on Glutamate Transporters

  2013cited by this paper
• Manganese transport via the transferrin mechanism.

  2013cited by this paper
• Increased whole blood manganese concentrations observed in children with iron deficiency anaemia.

  2013cited by this paper
• Analysis of vesicular monoamine transporter 2 polymorphisms in Parkinson’s disease

  2013cited by this paper
• Manganese induces mitochondrial dynamics impairment and apoptotic cell death: a study in human Gli36 cells.

  2013cited by this paper
• Manganese exposure induces α-synuclein aggregation in the frontal cortex of non-human primates.

  2013cited by this paper
• Manganese‐induced parkinsonism in methcathinone abusers: bio‐markers of exposure and follow‐up

  2013cited by this paper
• Mechanisms of lead and manganese neurotoxicity.

  2013cited by this paper
• Neurobehavioral Deficits and Parkinsonism in Occupations with Manganese Exposure: A Review of Methodological Issues in the Epidemiological Literature

  2013cited by this paper
• Manganese efflux in Parkinsonism: insights from newly characterized SLC30A10 mutations.

  2013cited by this paper
• Manganese and the brain.

  2013cited by this paper
• Decreased brain volumes in manganese-exposed welders.

  2013cited by this paper
• Role of astrocytes in manganese mediated neurotoxicity

  2013cited by this paper
• Metal-induced neurodegeneration in C. elegans

  2013cited by this paper
• Nonoccupational environmental exposure to manganese is linked to deficits in peripheral and central olfactory function.

  2013cited by this paper
• Two-year follow-up after chelating therapy in a patient with adult-onset parkinsonism and hypermanganesaemia due to SLC30A10 mutations

  2013cited by this paper
• Manganese-induced oxidative DNA damage in neuronal SH-SY5Y cells: attenuation of thymine base lesions by glutathione and N-acetylcysteine.

  2013cited by this paper
• The Role of Autophagy Dysregulation in Manganese-Induced Dopaminergic Neurodegeneration

  2013cited by this paper
• Consequences of manganese administration for striatal dopamine and motor behavior in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-exposed C57BL/6 mice

  2013cited by this paper
• Evaluation of neurobehavioral and neuroinflammatory end-points in the post-exposure period in rats sub-acutely exposed to manganese.

  2013cited by this paper
• Blood Manganese Concentration is Elevated in Infants with Iron Deficiency

  2013cited by this paper
• Manganese-exposed developing rats display motor deficits and striatal oxidative stress that are reversed by Trolox

  2013cited by this paper
• Early life versus lifelong oral manganese exposure differently impairs skilled forelimb performance in adult rats.

  2013cited by this paper
• Microarray genomic profile of mitochondrial and oxidant response in manganese chloride treated PC12 cells.

  2012cited by this paper
• The iron transporter ferroportin can also function as a manganese exporter.

  2012cited by this paper
• Syndrome of hepatic cirrhosis, dystonia, polycythemia, and hypermanganesemia caused by mutations in SLC30A10, a manganese transporter in man.

  2012cited by this paper
• Effect of intranasal manganese administration on neurotransmission and spatial learning in rats.

  2012cited by this paper
• Manganese-induced toxicity in normal and human B lymphocyte cell lines containing a homozygous mutation in parkin.

  2012cited by this paper
• Genetic risk for Parkinson's disease correlates with alterations in neuronal manganese sensitivity between two human subjects.

  2012cited by this paper
• Physiologic implications of metal-ion transport by ZIP14 and ZIP8

  2012cited by this paper
• Increased risk of parkinsonism associated with welding exposure.

  2012cited by this paper
• Toxicological Profile for Manganese

  2012cited by this paper
• Mutations in SLC30A10 cause parkinsonism and dystonia with hypermanganesemia, polycythemia, and chronic liver disease.

  2012cited by this paper
• In Vivo Manganese Exposure Modulates Erk, Akt and Darpp-32 in the Striatum of Developing Rats, and Impairs Their Motor Function

  2012cited by this paper
• Dystonia with Brain Manganese Accumulation Resulting From SLC30A10 Mutations: A New Treatable Disorder

  2012cited by this paper
• Parkinson's disease and other neurodegenerative disorders among welders: A Danish cohort study

  2012cited by this paper
• The extrinsic and intrinsic apoptotic pathways are involved in manganese toxicity in rat astrocytoma C6 cells.

  2011cited by this paper
• Manganese-Induced Parkinsonism due to Ephedrone Abuse

  2011cited by this paper
• Prospective study on neurotoxic effects in manganese-exposed bridge construction welders.

  2011cited by this paper
• Blood manganese levels in patients with hepatic encephalopathy.

  2011cited by this paper
• Associations of iron metabolism genes with blood manganese levels: a population-based study with validation data from animal models

  2011cited by this paper
• Iron deficiency increases blood manganese level in the Korean general population according to KNHANES 2008.

  2011cited by this paper
• Role of manganese in neurodegenerative diseases.

  2011cited by this paper
• α-Synuclein overexpression enhances manganese-induced neurotoxicity through the NF-κB-mediated pathway

  2011cited by this paper
• DMT1 polymorphism and risk of Parkinson's disease.

  2011cited by this paper
• Changes in dietary iron exacerbate regional brain manganese accumulation as determined by magnetic resonance imaging.

  2011cited by this paper
• Nrf2/HO‐1 pathway activation by manganese is associated with reactive oxygen species and ubiquitin–proteasome pathway, not MAPKs signaling

  2011cited by this paper
• Preweaning Mn exposure leads to prolonged astrocyte activation and lasting effects on the dopaminergic system in adult male rats

  2011cited by this paper
• Intellectual Impairment in School-Age Children Exposed to Manganese from Drinking Water

  2010cited by this paper
• A possible neuroprotective action of a vinylic telluride against Mn-induced neurotoxicity.

  2010cited by this paper
• Treatment strategies for Parkinson’s disease

  2010cited by this paper
• Ferroportin is a manganese‐responsive protein that decreases manganese cytotoxicity and accumulation

  2010cited by this paper
• Impaired in vivo dopamine release in parkin knockout mice.

  2010cited by this paper
• Manganese and Parkinson’s Disease: A Critical Review and New Findings

  2010cited by this paper
• An analysis of the effects of Mn2+ on oxidative phosphorylation in liver, brain, and heart mitochondria using state 3 oxidation rate assays.

  2010cited by this paper
• Extracellular Dopamine Potentiates Mn-Induced Oxidative Stress, Lifespan Reduction, and Dopaminergic Neurodegeneration in a BLI-3–Dependent Manner in Caenorhabditis elegans

  2010cited by this paper
• SMF-1, SMF-2 and SMF-3 DMT1 Orthologues Regulate and Are Regulated Differentially by Manganese Levels in C. elegans

  2009cited by this paper
• Iron-enhanced paraquat-mediated dopaminergic cell death due to increased oxidative stress as a consequence of microglial activation.

  2009cited by this paper
• Age-dependent susceptibility to manganese-induced neurological dysfunction.

  2009cited by this paper
• Subacute intratracheal exposure of rats to manganese nanoparticles: Behavioral, electrophysiological, and general toxicological effects

  2009cited by this paper
• A Chronic Iron-Deficient/High-Manganese Diet in Rodents Results in Increased Brain Oxidative Stress and Behavioral Deficits in the Morris Water Maze

  2009cited by this paper
• The Divalent Metal Transporter Homologues SMF-1/2 Mediate Dopamine Neuron Sensitivity in Caenorhabditis elegans Models of Manganism and Parkinson Disease*

  2009cited by this paper
• From Manganism to Manganese-Induced Parkinsonism: A Conceptual Model Based on the Evolution of Exposure

  2009cited by this paper
• Ethanol preference in C. elegans

  2009cited by this paper
• Uptake of Materials from the Nasal Cavity into the Blood and Brain

  2009cited by this paper
• Cognitive impairment in an adult Mexican population non-occupationally exposed to manganese.

  2009cited by this paper
• Mitochondrial-dependent manganese neurotoxicity in rat primary astrocyte cultures.

  2008cited by this paper
• Inhalation of divalent and trivalent manganese mixture induces a Parkinson's disease model: immunocytochemical and behavioral evidences.

  2008cited by this paper
• Slc39a14 Gene Encodes ZIP14, A Metal/Bicarbonate Symporter: Similarities to the ZIP8 Transporter

  2008cited by this paper
• Abnormal motor function and the expression of striatal dopamine D2 receptors in manganese-treated mice.

  2008cited by this paper
• Effects of acute administration of the hydroalcoholic extract of mate tea leaves (Ilex paraguariensis) in animal models of learning and memory.

  2008cited by this paper
• Divalent metal transporter 1 (DMT1) contributes to neurodegeneration in animal models of Parkinson's disease

  2008cited by this paper
• Postnatal manganese exposure alters dopamine transporter function in adult rats: Potential impact on nonassociative and associative processes.

  2008cited by this paper
• Structure, mechanism and regulation of pyruvate carboxylase.

  2008cited by this paper
• Effect of Chronic Low Level Manganese Exposure on Postural Balance: A Pilot Study of Residents in Southern Ohio

  2008cited by this paper
• Manganese accumulates in iron-deficient rat brain regions in a heterogeneous fashion and is associated with neurochemical alterations

  2007cited by this paper
• Molecular genetic studies of DMT1 on 12q in French‐Canadian restless legs syndrome patients and families

  2007cited by this paper
• Reduced mitochondrial SOD displays mortality characteristics reminiscent of natural aging.

  2007cited by this paper
• Iron and Paraquat as Synergistic Environmental Risk Factors in Sporadic Parkinson's Disease Accelerate Age-Related Neurodegeneration

  2007cited by this paper
• A study of the relationships between Parkinson's disease and markers of traffic-derived and environmental manganese air pollution in two Canadian cities.

  2007cited by this paper
• Direct effects of manganese compounds on dopamine and its metabolite Dopac: an in vitro study.

  2007cited by this paper
• Brain manganese accumulation is inversely related to gamma-amino butyric acid uptake in male and female rats.

  2007cited by this paper
• p44/42 MAP kinase and c-Jun N-terminal kinase contribute to the up-regulation of caspase-3 in manganese-induced apoptosis in PC12 cells.

  2006cited by this paper
• Homeostatic and toxic mechanisms regulating manganese uptake, retention, and elimination.

  2006cited by this paper

• C. elegans as a powerful model for neurotoxicity assessment.

  2025cites this paper
• Withania somnifera root extract reduces susceptibility of the model worm Caenorhabditis elegans to different types of stressors

  2025cites this paper
• EPR spectroscopy reveals antioxidant manganese defenses in the Lyme disease pathogen Borrelia burgdorferi

  2025cites this paper
• Versatility of Caenorhabditis elegans as a Model Organism for Evaluating Foodborne Neurotoxins and Food Bioactive Compounds in Nutritional Neuroscience

  2025cites this paper
• ZA-II-05, a novel NMDA-receptor antagonist reverses vanadium-induced neurotoxicity in Caenorhabditis elegans (C. elegans)

  2024cites this paper
• Dopamine controls the Sensitivity to Manganese induced Dopaminergic neurotoxicity in Caenorhabditis elegans

  2024cites this paper
• ATP13A2 (PARK9) and basal ganglia function

  2024cites this paper
• Comparison on distribution and sources of typical major and toxic trace elements in various glacial watersheds of the northeast Tibetan Plateau.

  2023cites this paper
• Characterization of Manganese-Induced Neurodegenration in C. elegans Treated with Winterberry Leaf Extract

  2023cites this paper
• Evaluation of a battery of biotests to improve waste ecotoxicity assessment (HP 14), using incineration bottom ash as a case study.

  2023cites this paper
• Neurotoxicology of metals and metallic nanoparticles in Caenorhabditis elegans.

  2023cites this paper
• Lipidomic and Metallomic Alteration of Caenorhabditis elegans after Acute and Chronic Manganese, Iron, and Zinc Exposure with a Link to Neurodegenerative Disorders.

  2023cites this paper
• Manganese-driven CoQ deficiency

  2022cites this paper
• Multi-Elemental Analysis of Human Optic Chiasm—A New Perspective to Reveal the Pathomechanism of Nerve Fibers’ Degeneration

  2022cites this paper
• Cs sorption of Mn-Fe based Prussian blue analogs with periodic precipitation banding in agarose gel.

  2022cites this paper
• Are free-living nematodes effective environmental quality indicators? Insights from Bohai Bay, China

  2021cites this paper
• Manganese exposure during early larval stages of C. elegans causes learning disability in the adult stage.

  2021cites this paper
• Distribution of Pb and Se in mouse brain following subchronic Pb exposure by using synchrotron X-ray fluorescence.

  2021cites this paper
• Liver Function of Male Rats Exposed to Manganese at Different Time Points

  2020cites this paper
• Acute toxicity of manganese and its role in regulating testicular enzyme activity of male rats at different time points

  2020cites this paper
• Role of biometals in pathogenesis treatment of Parkinson's disease (overview)

  2020cites this paper
• Estimating daily intakes of manganese due to breast milk, infant formulas, or young child nutritional beverages in the United States and France: Comparison to sufficiency and toxicity thresholds

  2020cites this paper
• Heavy Metals Exposure and Alzheimer’s Disease and Related Dementias

  2020cites this paper
• Activation of protein kinase R in the manganese-induced apoptosis of PC12 cells.

  2020cites this paper
• The impact of manganese on neurotransmitter systems.

  2020cites this paper
• NEUROTOXICOLOGY OF NANOMATERIALS.

  2020cites this paper
• Brain manganese and the balance between essential roles and neurotoxicity

  2020cites this paper
• Caenorhabditis elegans-on-a-chip: microfluidic platforms for high-resolution imaging and phenotyping

  2020cites this paper
• In situ XRF analysis of Cs adsorption by the precipitation bands of Prussian blue analogues formed in agarose gels

  2019cites this paper
• Caenorhabditis elegans and its applicability to studies on restless legs syndrome.

  2019cites this paper
• High-throughput assessment of toxic effects of metal mixtures of cadmium(Cd), lead(Pb), and manganese(Mn) in nematode Caenorhabditis elegans.

  2019cites this paper
• Manganese neurotoxicity: nano-oxide compensates for ion-damage in mammals.

  2019cites this paper
• Association between long-term occupational manganese exposure and bone quality among retired workers

  2019cites this paper
• Ethanol via Regulation of NF-κB/p53 Signaling Pathway Increases Manganese-Induced Inflammation and Apoptosis in Hypothalamus of Rats

  2018cites this paper
• Effect of manganese on neural endocrine hormones in serum of welders and smelters.

  2018cites this paper
• Correction for “ SLC 39 A 14 deficiency alters manganese homeostasis and excretion resulting in brain manganese accumulation and motor deficits in mice

  2018cites this paper
• C. elegans as a model in developmental neurotoxicology

  2018cites this paper
• Highly selective apo-arginase based method for sensitive enzymatic assay of manganese (II) and cobalt (II) ions.

  2018cites this paper
• SLC39A14 deficiency alters manganese homeostasis and excretion resulting in brain manganese accumulation and motor deficits in mice

  2018cites this paper
• The Impact of Environmental Mn Exposure on Insect Biology

  2018cites this paper
• Manganese-Enhanced Magnetic Resonance Imaging: Overview and Central Nervous System Applications With a Focus on Neurodegeneration

  2018cites this paper
• Heavy Metal Mixture Exposure and Effects in Developing Nations: An Update

  2018cites this paper
• Trace element levels are associated with neuroinflammatory markers in children with autistic spectrum disorder.

  2018cites this paper
• Occupational manganese exposure, reproductive hormones, and semen quality in male workers: A cross-sectional study

  2018cites this paper
• From the Cover: Manganese and Rotenone-Induced Oxidative Stress Signatures Differ in iPSC-Derived Human Dopamine Neurons

  2017cites this paper
• Transgenic Mice Overexpressing the Divalent Metal Transporter 1 Exhibit Iron Accumulation and Enhanced Parkin Expression in the Brain

  2017cites this paper
• Generation of Mouse Haploid Somatic Cells by Small Molecules for Genome-wide Genetic Screening.

  2017cites this paper
• Downregulation of Mfn2 participates in manganese‐induced neuronal apoptosis in rat striatum and PC12 cells

  2017cites this paper
• Assessing human metal accumulations in an urban superfund site.

  2017cites this paper
• Subchronic, Low-Level Intraperitoneal Injections of Manganese (IV) Oxide and Manganese (II) Chloride Affect Rat Brain Neurochemistry

  2017cites this paper
• Severity scoring of manganese health effects for categorical regression

  2017cites this paper
• Are multitasking abilities impaired in welders exposed to manganese? Translating cognitive neuroscience to neurotoxicology

  2017cites this paper
• Drosophila divalent metal ion transporter Malvolio is required in dopaminergic neurons for feeding decisions

  2017cites this paper
• FOXO3 promoted mitophagy via nuclear retention induced by manganese chloride in SH-SY5Y cells.

  2017cites this paper
• Hepatic metal ion transporter ZIP8 regulates manganese homeostasis and manganese-dependent enzyme activity

  2017cites this paper
• Manganese Control of Glutamate Transporters' Gene Expression.

  2017cites this paper
• Hair Microelement Profile as a Prognostic Tool in Parkinson’s Disease

  2016cites this paper
• Editor's Highlight: Comparative Toxicity of Organophosphate Flame Retardants and Polybrominated Diphenyl Ethers to Caenorhabditis elegans.

  2016cites this paper
• Manganese dependent neurodegeneration of Dopaminergic neuron in a Caenorhabditis elegans UA44 genetic model for Parkinson’s Disease

  2016cites this paper
• Insights Into Effects of Ellagic Acid on the Nervous System: A Mini Review.

  2016cites this paper
• Exposure, epidemiology, and mechanism of the environmental toxicant manganese

  2016influential citation
• Insights into zinc and cadmium biology in the nematode Caenorhabditis elegans.

  2016cites this paper
• Metal and Microelement Biomarkers of Neurodegeneration in Early Life Permethrin-Treated Rats

  2016cites this paper
• Metals and Neurodegeneration

  2016cites this paper
• Epigenetics Involvement In Parkinson's Disease And Manganese-Induced Neurotoxicity

  2015cites this paper
• SLC30A10: A novel manganese transporter

  2015cites this paper
• IMPACT OF LIMING ON MICRONUTRIENTS STATUS IN MAIZE GRAIN

  2015cites this paper
• Metals and Neurodegeneration [version 1; peer review: 3 approved]

  year unknowncites this paper
• World Journal of Stem Cells

  year unknowncites this paper