The α1- and α2-isoforms of Na-K-ATPase play different roles in skeletal muscle contractility

No abstract is available for this paper.

• Publication year

  2001

• Venue

  American Journal of Physiology-regulatory Integrative and Comparative Physiology

• Publication date

  2001-09-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1152/AJPREGU.2001.281.3.R917
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar

• No claims are published for this paper.

• No concepts are published for this paper.

• Sperm Motility Is Dependent on a Unique Isoform of the Na,K-ATPase*

  2000cited by this paper
• Sarcomeric Ca2+ gradients during activation of frog skeletal muscle fibres imaged with confocal and two‐photon microscopy

  2000cited by this paper
• Stimulation of both aerobic glycolysis and Na+-K+-ATPase activity in skeletal muscle by epinephrine or amylin.

  1999cited by this paper
• Identification of a specific role for the Na,K-ATPase alpha 2 isoform as a regulator of calcium in the heart.

  1999influential reference
• Comparative Ultrastructure of Ca2+ Release Units in Skeletal and Cardiac Muscle

  1998cited by this paper
• The Na+,K+ pump and muscle excitability.

  1998cited by this paper
• Isozymes of the Na-K-ATPase: heterogeneity in structure, diversity in function.

  1998cited by this paper
• Model of Sarcomeric Ca2+ Movements, Including ATP Ca2+ Binding and Diffusion, during Activation of Frog Skeletal Muscle

  1998cited by this paper
• Evidence for Na+/Ca2+ exchange in intact single skeletal muscle fibers from the mouse.

  1998cited by this paper
• Na+ pump low and high ouabain affinity alpha subunit isoforms are differently distributed in cells.

  1997cited by this paper
• Properties of tri- and tetracarboxylate Ca2+ indicators in frog skeletal muscle fibers.

  1996cited by this paper
• Role of skeletal muscle sodium pumps in the adaptation to potassium deprivation.

  1996cited by this paper
• The amplitude and time course of the myoplasmic free [Ca2+] transient in fast-twitch fibers of mouse muscle

  1996cited by this paper
• The influence of beta subunit structure on the interaction of Na+/K(+)-ATPase complexes with Na+. A chimeric beta subunit reduces the Na+ dependence of phosphoenzyme formation from ATP.

  1995cited by this paper
• The Influence of Subunit Structure on the Interaction of Na/K-ATPase Complexes with Na.

  1995cited by this paper
• Myosin heavy chain composition in young and old rat skeletal muscle: effects of endurance exercise.

  1995cited by this paper
• The influence of beta subunit structure on the stability of Na+/K(+)-ATPase complexes and interaction with K+.

  1994cited by this paper
• Human and rodent muscle Na(+)-K(+)-ATPase in diabetes related to insulin, starvation, and training.

  1994cited by this paper
• Expression of the β‐subunit isoforms of the Na, K‐ATpase in rat embryo tissues, inner ear and choroid plexus

  1994cited by this paper
• A putative fourth Na+,K(+)-ATPase alpha-subunit gene is expressed in testis.

  1994cited by this paper
• Contractile economy and aerobic recovery metabolism in skeletal muscle adapted to creatine depletion.

  1994cited by this paper
• Na+,K(+)-ATPase.

  1994cited by this paper
• The Na,K-ATPase

  1992cited by this paper
• K(+)-induced inhibition of contractile force in rat skeletal muscle: role of active Na(+)-K+ transport.

  1991cited by this paper
• Molecular and cellular adaptation of muscle in response to exercise: perspectives of various models.

  1991cited by this paper
• Functional and metabolic consequences of skeletal muscle remodeling in hypothyroidism.

  1991cited by this paper
• The adhesion molecule on glia (AMOG) is a homologue of the beta subunit of the Na,K-ATPase

  1990cited by this paper
• The concentration of the Na,K-pump in skeletal and heart muscle in congestive heart failure.

  1990cited by this paper
• Identification of a putative isoform of the Na,K-ATPase beta subunit. Primary structure and tissue-specific expression.

  1989cited by this paper
• Identification of three isozyme proteins of the catalytic subunit of the Na,K-ATPase in rat brain.

  1989influential reference
• Ouabain-sensitive (Na+ + K+)-ATPase activity expressed in mouse L cells by transfection with DNA encoding the alpha-subunit of an avian sodium pump.

  1988influential reference
• [The family of human Na+,K+-ATPase genes. At least 5 genes and/or pseudogenes homologous to alpha-subunit].

  1987cited by this paper
• Diabetes Decreases Na+-K+ Pump Concentration in Skeletal Muscles, Heart Ventricular Muscle, and Peripheral Nerves of Rat

  1987cited by this paper
• The family of human Na+,K+‐ATPase genes No less than five genes and/or pseudogenes related to the α‐subunit

  1987cited by this paper
• Molecular cloning of three distinct forms of the Na+,K+-ATPase alpha-subunit from rat brain.

  1986cited by this paper
• Regulation of active Na+-K+ transport in skeletal muscle.

  1986cited by this paper
• All members of the MHC multigene family respond to thyroid hormone in a highly tissue-specific manner.

  1986cited by this paper
• Enzymatic properties of separated isozymes of the Na,K-ATPase. Substrate affinities, kinetic cooperativity, and ion transport stoichiometry.

  1985cited by this paper
• Invited review: Neural control of phenotypic expression in mammalian muscle fibers

  1985cited by this paper
• Multiplicity of cardiac glycoside receptors in the heart

  1985cited by this paper
• Amino-acid sequence of the catalytic subunit of the (Na+ + K+)ATPase deduced from a complementary DNA

  1985cited by this paper
• Loss of fast-twitch isomyosins in skeletal muscles of the diabetic rat.

  1984cited by this paper
• Myosin isoenzymes in fast‐twitch and slow‐twitch muscles of normal and dystrophic mice.

  1983cited by this paper
• Effect of thyroid status on ouabain binding to the human lymphocyte.

  1982cited by this paper
• Organ secificity of rat sodium- and potassium-activated adenosine triphosphatase.

  1979cited by this paper
• Two molecular forms of (Na+ + K+)-stimulated ATPase in brain. Separation, and difference in affinity for strophanthidin.

  1979cited by this paper
• Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4

  1970cited by this paper

• Na,K-ATPase mediated and cardiotonic induced signaling in health and disease

  2025cites this paper
• Integrating genomic selection and genome-wide association study to enhance growth performance in swamp buffalo.

  2025cites this paper
• Physiological and Molecular Analyses of Low-Salinity Stress Response in the Cuttlefish (Sepia pharaonis) Juveniles

  2022cites this paper
• Chronic Ouabain Prevents Radiation-Induced Reduction in the α2 Na,K-ATPase Function in the Rat Diaphragm Muscle

  2022cites this paper
• Catecholamine-dependent hyperpolarization of the junctional membrane via β2- adrenoreceptor / Gi-protein / α2-Na-K-ATPase pathway.

  2022cites this paper
• Sleep deprivation is associated with increased circulating levels of endogenous ouabain: Potential role in bipolar disorder.

  2022cites this paper
• Short-Term Mild Hypoxia Modulates Na,K-ATPase to Maintain Membrane Electrogenesis in Rat Skeletal Muscle

  2022cites this paper
• Physiological, biochemical and molecular responses of Sepia pharaonis juveniles to low salinity

  2021cites this paper
• Molecular and Functional Heterogeneity of Na,K-ATPase in the Skeletal Muscle

  2021cites this paper
• The role of AMPK in regulation of Na+,K+-ATPase in skeletal muscle: does the gauge always plug the sink?

  2021cites this paper
• Effect of differentiation, de novo innervation, and electrical pulse stimulation on mRNA and protein expression of Na+,K+-ATPase, FXYD1, and FXYD5 in cultured human skeletal muscle cells

  2021cites this paper
• The Na/K‐ATPase α1/Src interaction regulates metabolic reserve and Western diet intolerance

  2021cites this paper
• Chronic Ouabain Prevents Na,K-ATPase Dysfunction and Targets AMPK and IL-6 in Disused Rat Soleus Muscle

  2021cites this paper
• The Na+ and K+ transport system of sperm (ATP1A4) is essential for male fertility and an attractive target for male contraception

  2020cites this paper
• Ouabain Suppresses IL-6/STAT3 Signaling and Promotes Cytokine Secretion in Cultured Skeletal Muscle Cells

  2020cites this paper
• Biallelic loss of function variants in ATP1A2 cause hydrops fetalis, microcephaly, arthrogryposis and extensive cortical malformations.

  2020cites this paper
• Isoform-Specific Na,K-ATPase and Membrane Cholesterol Remodeling in the Motor Endplates in Distinct Mouse Models of Myodystrophy.

  2020cites this paper
• Resistance training upregulates skeletal muscle Na+, K+-ATPase content, with elevations in both α1 and α2, but not β isoforms

  2020cites this paper
• Abnormal Membrane Localization of α2 Isoform of Na,K-ATPase in m. soleus of Dysferlin-Deficient Mice

  2019cites this paper
• Cholesterol and the Safety Factor for Neuromuscular Transmission

  2019cites this paper
• Hormonal regulation of Na+-K+-ATPase from the evolutionary perspective.

  2019cites this paper
• Inactivity and exercise training differentially regulate the abundance of Na+, K+-ATPase in human skeletal muscle.

  2019cites this paper
• Effects of testosterone suppression, hind limb immobilization and recovery on [3H]ouabain binding site content and Na+, K+-ATPase isoforms in rat soleus muscle.

  2019cites this paper
• K+ and Rb+ Affinities of the Na,K-ATPase α1 and α2 Isozymes: An Application of ICP-MS for Quantification of Na+ Pump Kinetics in Myofibers

  2018cites this paper
• The pump, the exchanger, and the holy spirit: origins and 40-year evolution of ideas about the ouabain-Na+ pump endocrine system.

  2018cites this paper
• Muscle phenotype is related to motor unit behavior of the vastus lateralis during maximal isometric contractions

  2018cites this paper
• Isoform-specific role of Na/K-ATPase (cid:2) 1 in skeletal muscle

  2018cites this paper
• Isoform-specific role of Na/K-ATPase α1 in skeletal muscle.

  2018cites this paper
• Exercise Training, Immobilisation and Castration Effects on Skeletal Muscle Na+,K+-ATPase

  2018influential citation
• Src kinase is involved in comenic acid-triggered signaling pathways in sensory neurons

  2018cites this paper
• Sequence characterization of alpha 1 isoform (ATP1A1) of Na+/K+-ATPase gene and expression characteristics of its major isoforms across tissues of riverine buffaloes (Bubalus bubalis)

  2018cites this paper
• Natrium-Kalium-ATPase (atp1a1a.1) : ein essentieller Regulator des kardialen Rhythmus im Zebrafisch

  2018cites this paper
• Preconditioning and Postconditioning by Cardiac Glycosides in the Mouse Heart

  2017cites this paper
• Gestation changes sodium pump isoform expression, leading to changes in ouabain sensitivity, contractility, and intracellular calcium in rat uterus

  2017cites this paper
• Subcellular localization of Na/K-ATPase isoforms in ventricular myocytes.

  2017cites this paper
• Intense interval training in healthy older adults increases skeletal muscle [3H]ouabain‐binding site content and elevates Na+,K+‐ATPase α2 isoform abundance in Type II fibers

  2017cites this paper
• The Structure and Function of the Na,K-ATPase Isoforms in Health and Disease

  2017cites this paper
• The pump, the exchanger, and the holy spirit: origins and 40-year evolution of ideas about the ouabain-Na (cid:2) pump endocrine system

  2017cites this paper
• Distinct α2 Na,K-ATPase membrane pools are differently involved in early skeletal muscle remodeling during disuse

  2016cites this paper
• Effects of Age on Na+,K+-ATPase Expression in Human and Rodent Skeletal Muscle

  2016influential citation
• ATP1A2 Mutations in Migraine: Seeing through the Facets of an Ion Pump onto the Neurobiology of Disease

  2016cites this paper
• Specialized Functional Diversity and Interactions of the Na,K-ATPase

  2016cites this paper
• Cell specific differences in the protein abundances of GAPDH and Na(+),K(+)-ATPase in skeletal muscle from aged individuals.

  2016cites this paper
• Isoform-specific functions of Na,K-ATPase in skeletal muscle

  2016cites this paper
• Na, K-ATPase α4: An Isoform Dedicated to Sperm Function

  2016cites this paper
• Na,K-ATPase regulation in skeletal muscle.

  2016cites this paper
• Pivotal role of α2 Na+ pumps and their high affinity ouabain binding site in cardiovascular health and disease

  2016cites this paper
• CALL FOR PAPERS Cell Signaling: Proteins, Pathways and Mechanisms Phospholemman is not required for the acute stimulation of Na (cid:2) -K (cid:2) -ATPase (cid:3) 2 -activity during skeletal muscle fatigue

  2015cites this paper
• Single-fiber expression and fiber-specific adaptability to short-term intense exercise training of Na+-K+-ATPase α- and β-isoforms in human skeletal muscle.

  2015cites this paper
• Isoform-Specific Na,K-ATPase Alterations Precede Disuse-Induced Atrophy of Rat Soleus Muscle

  2015cites this paper
• Na,K-ATPase α2 activity in mammalian skeletal muscle T-tubules is acutely stimulated by extracellular K+

  2015influential citation
• Na+/K+-ATPase α-subunit (nkaα) Isoforms and Their mRNA Expression Levels, Overall Nkaα Protein Abundance, and Kinetic Properties of Nka in the Skeletal Muscle and Three Electric Organs of the Electric Eel, Electrophorus electricus

  2015cites this paper
• Na+/Ca2+ exchange and Na+/K+-ATPase in the heart

  2015cites this paper
• CALL FOR PAPERS Cell Signaling: Proteins, Pathways and Mechanisms Phospholemman is not required for the acute stimulation of Na (cid:2) -K (cid:2) -ATPase (cid:3) 2 -activity during skeletal muscle fatigue

  2015cites this paper
• Phospholemman is not required for the acute stimulation of Na⁺-K⁺-ATPase α₂-activity during skeletal muscle fatigue.

  2015cites this paper
• The Role of Na+/K+-ATPase during Chick Skeletal Myogenesis

  2015cites this paper
• Na+, K+-ATPase in single skeletal muscle fibres and the effects of ageing, training and inactivity

  2014cites this paper
• Cardiac Na/K-ATPase in ischemia-reperfusion injury and cardioprotection

  2014cites this paper
• Muscle ciliary neurotrophic factor receptor α promotes axonal regeneration and functional recovery following peripheral nerve lesion

  2013cites this paper
• Novel role of ouabain as a cystogenic factor in autosomal dominant polycystic kidney disease.

  2013cites this paper
• Chronic Actions of Nicotine on the Electrogenic Activity of Na+,K+-ATPase and the Contractile Characteristics of Rat Diaphragm

  2013cites this paper
• Quantification of Na+,K+ pumps and their transport rate in skeletal muscle: Functional significance

  2013cites this paper
• Increase in Body Na+/Water Ratio Is Associated With Cerebral Aneurysm Formation in Oophorectomized Rats

  2012cites this paper
• Physiological Role of the α 2 -Isoform of the Na, K-ATPase in the Regulation of Cardiovascular Function

  2012cites this paper
• Regulatory function of the Na,K-ATPase α2-isoform

  2012cites this paper
• Tissue-specific Role of the Na,K-ATPase α2 Isozyme in Skeletal Muscle*

  2012influential citation
• Unchanged [3H]ouabain binding site content but reduced Na+-K+ pump α2-protein abundance in skeletal muscle in older adults.

  2012cites this paper
• Exercise-induced regulation of muscular Na+-K+ pump, FXYD1, and NHE1 mRNA and protein expression: importance of training status, intensity, and muscle type.

  2011cites this paper
• Contraction‐induced changes in skeletal muscle Na+,K+ pump mRNA expression – importance of exercise intensity and Ca2+‐mediated signalling

  2010cites this paper
• The Nicotinic Acetylcholine Receptor and the Na,K-ATPase α2 Isoform Interact to Regulate Membrane Electrogenesis in Skeletal Muscle*

  2010cites this paper
• Na+,K+-ATPase Na+ Affinity in Rat Skeletal Muscle Fiber Types

  2010cites this paper
• Expression and Distribution of Na, K-ATPase Isoforms in the Human Uterus

  2010cites this paper
• Effect of heparin treatment on the expression and activity of different ion-motive P-type ATPase isoforms from mouse extensor digitorum longus muscle during degeneration and regeneration after Bothrops jararacussu venom injection.

  2010cites this paper
• Potassium‐transporting proteins in skeletal muscle: cellular location and fibre‐type differences

  2010cites this paper
• Applications énergétiques : Na/K-ATPase et transmission neuromusculaire

  2009cites this paper
• Reduced volume and increased training intensity elevate muscle Na+-K+ pump alpha2-subunit expression as well as short- and long-term work capacity in humans.

  2009cites this paper
• Enhanced pressor response to increased CSF sodium concentration and to central ANG I in heterozygous alpha2 Na+ -K+ -ATPase knockout mice.

  2009cites this paper
• muscle: effects of high fat diet and exercise

  2009cites this paper
• The cardiac glycoside binding site on the Na,K-ATPase α2 isoform plays a role in the dynamic regulation of active transport in skeletal muscle

  2009cites this paper
• Na+-K+-ATPase in rat skeletal muscle: muscle fiber-specific differences in exercise-induced changes in ion affinity and maximal activity.

  2009cites this paper
• Altered expression and insulin-induced trafficking of Na+-K+-ATPase in rat skeletal muscle: effects of high-fat diet and exercise.

  2009cites this paper
• The alpha1 isoform of the Na+/K+ ATPase is up-regulated in dedifferentiated progenitor cells that mediate lens and retina regeneration in adult newts.

  2009cites this paper
• Exercise‐induced regulation of phospholemman (FXYD1) in rat skeletal muscle: implications for Na+/K+‐ATPase activity

  2008cites this paper
• Ca2+ clearance and contractility in vascular smooth muscle: evidence from gene-altered murine models.

  2008cites this paper
• Role of the ouabain-binding site of Na,K-ATPase in saline loading and DOCA-salt hypertension.

  2008cites this paper
• Glucose supplements increase human muscle in vitro Na+-K+-ATPase activity during prolonged exercise.

  2007cites this paper
• Endogenous and Exogenous Cardiac Glycosides and their Mechanisms of Action

  2007cites this paper
• Electrogenic Na+/Ca2+-exchange of nerve and muscle cells.

  2007cites this paper
• Deficiency in Na,K-ATPase α Isoform Genes Alters Spatial Learning, Motor Activity, and Anxiety in Mice

  2007cites this paper
• Endogenous and exogenous cardiac glycosides: their roles in hypertension, salt metabolism, and cell growth.

  2007cites this paper
• Differential distribution and regulation of mouse cardiac Na+/K+-ATPase alpha1 and alpha2 subunits in T-tubule and surface sarcolemmal membranes.

  2007cites this paper
• Physiological role of the α1- and α2-isoforms of the Na+-K+-ATPase and biological significance of their cardiac glycoside binding site

  2006cites this paper
• Separate Na,K-ATPase genes are required for otolith formation and semicircular canal development in zebrafish.

  2006cites this paper
• Fiber type-specific immunostaining of the Na+,K+-ATPase subunit isoforms in skeletal muscle: age-associated differential changes.

  2006cites this paper
• Role of the Na+,K+-ATPase α2 isoform in the positive inotropic effect of ouabain and marinobufagenin in the rat diaphragm

  2006cites this paper
• Alterations in Uterine and Placental Sodium Pump Abundance May Contribute to the Onset of Mouse Labor

  2005influential citation
• The NA/K-ATPase and its isozymes: what we have learned using the baculovirus expression system.

  2005cites this paper
• Decreased expression of both the α1- and α2-subunits of the Na-K-ATPase reduces maximal alveolar epithelial fluid clearance

  2005cites this paper
• Neuronal function and alpha3 isoform of the Na/K-ATPase.

  2005cites this paper
• Sodium pump α2 subunits control myogenic tone and blood pressure in mice

  2005cites this paper