Ferrostatins Inhibit Oxidative Lipid Damage and Cell Death in Diverse Disease Models

Ferrostatin-1 (Fer-1) inhibits ferroptosis, a form of regulated, oxidative, nonapoptotic cell death. We found that Fer-1 inhibited cell death in cellular models of Huntington’s disease (HD), periventricular leukomalacia (PVL), and kidney dysfunction; Fer-1 inhibited lipid peroxidation, but not mitochondrial reactive oxygen species formation or lysosomal membrane permeability. We developed a mechanistic model to explain the activity of Fer-1, which guided the development of ferrostatins with improved properties. These studies suggest numerous therapeutic uses for ferrostatins, and that lipid peroxidation mediates diverse disease phenotypes.

• Publication year

  2014

• Venue

  Journal of the American Chemical Society

• Publication date

  2014-03-04

• Fields of study

  Medicine, Chemistry

• Identifiers
  DOI 10.1021/ja411006aPMID 24592866PMCID 3985476
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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