p75NTR: A Molecule with Multiple Functions in Amyloid-Beta Metabolism and Neurotoxicity

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• Publication year

  2014

• Venue

  Unknown venue

• Publication date

  Unknown publication date

• Fields of study

  Biology, Medicine, Chemistry

• Identifiers
  DOI 10.1007/978-1-4614-5836-4_28
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar

• No claims are published for this paper.

• No concepts are published for this paper.

• TRAF6 and p62 inhibit amyloid β-induced neuronal death through p75 neurotrophin receptor.

  2012cited by this paper
• Involvement of Insulin-Like Growth Factor 1 Receptor Signaling in the Amyloid-β Peptide Oligomers-Induced p75 Neurotrophin Receptor Protein Expression in Mouse Hippocampus

  2012cited by this paper
• The p75 neurotrophin receptor localization in blood-CSF barrier: expression in choroid plexus epithelium

  2011cited by this paper
• The p75NTR extracellular domain

  2011cited by this paper
• Neuronal Growth Cone Retraction Relies on Proneurotrophin Receptor Signaling Through Rac

  2011cited by this paper
• Structural and mechanistic commonalities of amyloid-β and the prion protein

  2011cited by this paper
• The cholinergic system, nerve growth factor and the cytoskeleton.

  2011cited by this paper
• p75NTR Regulates Aβ Deposition by Increasing Aβ Production But Inhibiting Aβ Aggregation with Its Extracellular Domain

  2011cited by this paper
• Effects of proNGF on Neuronal Viability, Neurite Growth and Amyloid-beta Metabolism

  2010cited by this paper
• Role of p75NTR in NMDAR-mediated excitotoxic brain injury in neonatal mice.

  2010cited by this paper
• Signaling effect of amyloid-beta(42) on the processing of AbetaPP.

  2010cited by this paper
• Dissecting the involvement of tropomyosin-related kinase A and p75 neurotrophin receptor signaling in NGF deficit-induced neurodegeneration

  2010cited by this paper
• Chronic and Acute Models of Retinal Neurodegeneration TrkA Activity Are Neuroprotective whereas p75NTR Activity Is Neurotoxic through a Paracrine Mechanism*

  2010cited by this paper
• Amyloid-β Peptides Stimulate the Expression of the p75NTR Neurotrophin Receptor in SHSY5Y Human Neuroblastoma Cells and AD Transgenic Mice

  2010cited by this paper
• Somatic tetraploidy in specific chick retinal ganglion cells induced by nerve growth factor

  2009cited by this paper
• The Role of the p75 Neurotrophin Receptor in Cholinergic Dysfunction in Alzheimer's Disease

  2009cited by this paper
• p75 reduces β-amyloid-induced sympathetic innervation deficits in an Alzheimer's disease mouse model

  2009cited by this paper
• Sall2 is a novel p75NTR‐interacting protein that links NGF signalling to cell cycle progression and neurite outgrowth

  2009cited by this paper
• The p75 Neurotrophin Receptor Promotes Amyloid-β(1-42)-Induced Neuritic Dystrophy In Vitro and In Vivo

  2009cited by this paper
• Selective vulnerability in Alzheimer's disease: Amyloid precursor protein and p75NTR interaction

  2009cited by this paper
• Induction of Proneurotrophins and Activation of p75NTR-Mediated Apoptosis via Neurotrophin Receptor-Interacting Factor in Hippocampal Neurons after Seizures

  2008cited by this paper
• Animal models of Alzheimer's disease and frontotemporal dementia

  2008cited by this paper
• Small Molecule, Non-Peptide p75NTR Ligands Inhibit Aβ-Induced Neurodegeneration and Synaptic Impairment

  2008cited by this paper
• Neurotoxic and neurotrophic roles of proNGF and the receptor sortilin in the adult and ageing nervous system

  2008cited by this paper
• The beta-amyloid protein of Alzheimer's disease increases neuronal CRMP-2 phosphorylation by a Rho-GTP mechanism.

  2008cited by this paper
• β-Amyloid1–42 Induces Neuronal Death through the p75 Neurotrophin Receptor

  2008cited by this paper
• The function of p75NTR in glia.

  2008cited by this paper
• Human ProNGF: biological effects and binding profiles at TrkA, P75NTR and sortilin

  2008cited by this paper
• β-Site Amyloid Precursor Protein Cleaving Enzyme 1 Levels Become Elevated in Neurons around Amyloid Plaques: Implications for Alzheimer's Disease Pathogenesis

  2007cited by this paper
• The p75 neurotrophin receptor is essential for neuronal cell survival and improvement of functional recovery after spinal cord injury.

  2007cited by this paper
• NGF-cholinergic dependency in brain aging, MCI and Alzheimer's disease.

  2007cited by this paper
• Intracellular sortilin expression pattern regulates proNGF-induced naturally occurring cell death during development

  2007cited by this paper
• Roles for the pro-neurotrophin receptor sortilin in neuronal development, aging and brain injury

  2007cited by this paper
• ProNGF, Sortilin, and Age‐related Neurodegeneration

  2007cited by this paper
• Pro-NGF secreted by astrocytes promotes motor neuron cell death.

  2007cited by this paper
• Pro-NGF from Alzheimer's disease and normal human brain displays distinctive abilities to induce processing and nuclear translocation of intracellular domain of p75NTR and apoptosis.

  2006cited by this paper
• An aging pathway controls the TrkA to p75NTR receptor switch and amyloid β‐peptide generation

  2006cited by this paper
• Down regulation of trk but not p75NTR gene expression in single cholinergic basal forebrain neurons mark the progression of Alzheimer's disease

  2006cited by this paper
• Does the p75 neurotrophin receptor mediate Aβ‐induced toxicity in Alzheimer's disease?

  2006cited by this paper
• Pro-NGF isolated from the human brain affected by Alzheimer's disease induces neuronal apoptosis mediated by p75NTR.

  2005cited by this paper
• Low concentrations of aggregated β-amyloid induce neurite formation via the neurotrophin receptor p75

  2005cited by this paper
• A TrkA-to-p75NTR molecular switch activates amyloid beta-peptide generation during aging.

  2005cited by this paper
• The expression of p75 neurotrophin receptor protects against the neurotoxicity of soluble oligomers of beta-amyloid.

  2005cited by this paper
• Increased proNGF Levels in Subjects with Mild Cognitive Impairment and Mild Alzheimer Disease

  2004cited by this paper
• ProNGF: a neurotrophic or an apoptotic molecule?

  2004cited by this paper
• Multi‐tasking by the p75 neurotrophin receptor: sortilin things out?

  2004cited by this paper
• Deficient p75 low-affinity neurotrophin receptor expression exacerbates experimental allergic encephalomyelitis in C57/BL6 mice.

  2004cited by this paper
• p75 neurotrophin receptor signaling in the nervous system.

  2004cited by this paper
• Sortilin is essential for proNGF-induced neuronal cell death

  2004cited by this paper
• LINGO-1 is a component of the Nogo-66 receptor/p75 signaling complex

  2004cited by this paper
• Evidence for a Critical Role of the Tumor Necrosis Factor α Convertase (TACE) in Ectodomain Shedding of the p75 Neurotrophin Receptor (p75NTR)*

  2004cited by this paper
• Trk receptors: roles in neuronal signal transduction.

  2003cited by this paper
• Apoptosis Induced by p75NTR Overexpression Requires Jun Kinase-Dependent Phosphorylation of Bad

  2003cited by this paper
• ProNGF induces p75-mediated death of oligodendrocytes following spinal cord injury.

  2002cited by this paper
• p75 interacts with the Nogo receptor as a co-receptor for Nogo, MAG and OMgp

  2002cited by this paper
• Oligodendrocyte-myelin glycoprotein is a Nogo receptor ligand that inhibits neurite outgrowth

  2002cited by this paper
• Neurotrophin signaling through the p75 neurotrophin receptor.

  2002cited by this paper
• The p75 receptor transduces the signal from myelin-associated glycoprotein to Rho

  2002cited by this paper
• Complete Deletion of the Neurotrophin Receptor p75NTRLeads to Long-Lasting Increases in the Number of Basal Forebrain Cholinergic Neurons

  2002cited by this paper
• Neurotrophins: to cleave or not to cleave.

  2002cited by this paper
• A p75NTR and Nogo receptor complex mediates repulsive signaling by myelin-associated glycoprotein

  2002cited by this paper
• Mechanisms of p75-mediated Death of Hippocampal Neurons

  2002cited by this paper
• The neurotrophin receptor p75NTR: novel functions and implications for diseases of the nervous system

  2002cited by this paper
• Gene Expression Profiles of Cholinergic Nucleus Basalis Neurons in Alzheimer's Disease

  2002cited by this paper
• Increased p75(NTR) expression in hippocampal neurons containing hyperphosphorylated tau in Alzheimer patients.

  2002cited by this paper
• The precursor pro-nerve growth factor is the predominant form of nerve growth factor in brain and is increased in Alzheimer's disease.

  2001cited by this paper
• Endogenous Brain-Derived Neurotrophic Factor and Neurotrophin-3 Antagonistically Regulate Survival of Axotomized Corticospinal Neurons In Vivo

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• Identification of a receptor mediating Nogo-66 inhibition of axonal regeneration

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• Age-Dependent Changes in Brain, CSF, and Plasma Amyloid β Protein in the Tg2576 Transgenic Mouse Model of Alzheimer's Disease

  2001cited by this paper
• Alzheimer's disease: genes, proteins, and therapy.

  2001cited by this paper
• A potential role for the p75 low-affinity neurotrophin receptor in spinal motor neuron degeneration in murine and human amyotrophic lateral sclerosis.

  2001cited by this paper
• Neurotrophins Induce Death of Hippocampal Neurons via the p75 Receptor

  2000cited by this paper
• P75 neurotrophin receptor in the nucleus basalis of meynert in relation to age, sex, and Alzheimer's disease.

  2000cited by this paper
• Enhanced Neurotrophin-Induced Axon Growth in Myelinated Portions of the CNS in Mice Lacking the p75 Neurotrophin Receptor

  1999cited by this paper
• Correction The Journal of Cell Biology

  1999cited by this paper
• Neurotrophin binding to the p75 receptor modulates Rho activity and axonal outgrowth.

  1999cited by this paper
• Nerve growth factor (NGF) induces motoneuron apoptosis in rat embryonic spinal cord in vitro

  1999cited by this paper
• Improved survival of injured sciatic nerve Schwann cells in mice lacking the p75 receptor.

  1999cited by this paper
• Ceramide Signaling Downstream of the p75 Neurotrophin Receptor Mediates the Effects of Nerve Growth Factor on Outgrowth of Cultured Hippocampal Neurons

  1999cited by this paper
• TrkB signalling inhibits p75-mediated apoptosis induced by nerve growth factor in embryonic proprioceptive neurons.

  1998cited by this paper
• Selective in vivo fluorescence labelling of cholinergic neurons containing p75(NTR) in the rat basal forebrain.

  1998cited by this paper
• Competitive Signaling Between TrkA and p75 Nerve Growth Factor Receptors Determines Cell Survival

  1998cited by this paper
• The p75 Neurotrophin Receptor Mediates Neuronal Apoptosis and Is Essential for Naturally Occurring Sympathetic Neuron Death

  1998cited by this paper
• Effects of facial nerve injury on mouse motoneurons lacking the p75 low-affinity neurotrophin receptor.

  1998cited by this paper
• Plastic Neuronal Remodeling Is Impaired in Patients with Alzheimer’s Disease Carrying Apolipoprotein ε4 Allele

  1997cited by this paper
• Binding of beta-amyloid to the p75 neurotrophin receptor induces apoptosis. A possible mechanism for Alzheimer's disease.

  1997cited by this paper
• Molecular, structural, and biological characteristics of the tumor necrosis factor ligand superfamily

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• Central glial and neuronal populations display differential sensitivity to ceramide‐dependent cell death

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• Human Tumor Necrosis Factor Receptor p75/80 (CD120b) Gene Structure and Promoter Characterization*

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• Survival of Cholinergic Forebrain Neurons in Developing p75NGFR-Deficient Mice

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• Reducing p75 nerve growth factor receptor levels using antisense oligonucleotides prevents the loss of axotomized sensory neurons in the dorsal root ganglia of newborn rats

  1996cited by this paper
• Selective Activation of NF-κB by Nerve Growth Factor Through the Neurotrophin Receptor p75

  1996cited by this paper
• Induction of p21ras in Alzheimer pathology.

  1995cited by this paper
• Increased expression and subcellular translocation of the mitogen activated protein kinase kinase and mitogen-activated protein kinase in Alzheimer's disease.

  1995cited by this paper
• The p75 nerve growth factor receptor mediates survival or death depending on the stage of sensory neuron development.

  1994cited by this paper
• Cortical neurons express nerve growth factor receptors in advanced age and Alzheimer disease.

  1992cited by this paper
• Brain-derived neurotrophic factor prevents the death of motoneurons in newborn rats after nerve section

  1992cited by this paper
• Low affinity nerve growth factor receptor binding in normal and Alzheimer's disease basal forebrain.

  1991cited by this paper
• Localization and development of nerve growth factor-sensitive rat basal forebrain neurons and their afferent projections to hippocampus and neocortex

  1989cited by this paper
• Nerve growth factor receptor mRNA distribution in human brain: normal levels in basal forebrain in Alzheimer's disease.

  1989cited by this paper

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