Preclinical mouse models for BRCA1-associated breast cancer

A substantial part of all hereditary breast cancer cases is caused by BRCA1 germline mutations. In this review, we will discuss the insights into BRCA1 functions that we obtained from mouse models with conventional and conditional mutations in Brca1. The most advanced models closely resemble human BRCA1-related breast cancer and may therefore be useful for addressing clinically relevant questions.

• Publication year

  2009

• Venue

  British Journal of Cancer

• Publication date

  2009-09-29

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1038/sj.bjc.6605350PMID 19904273PMCID 2778535
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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