STUDIES ON THE VIRULENCE OF TUBERCLE BACILLI ISOLATION AND BIOLOGICAL PROPERTIES OF A CONSTITUENT OF VIRULENT ORGANISMS

No abstract is available for this paper.

• Publication year

  1950

• Venue

  Journal of Experimental Medicine

• Publication date

  1950-02-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1084/JEM.91.2.197
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar

• No claims are published for this paper.

• No concepts are published for this paper.

• No references are available for this paper.

• Dynamic Architecture of Mycobacterial Outer Membranes Revealed by All-Atom Simulations

  2026cites this paper
• Linkage-Editing of 6,6'-Diacyl Neotrehalose and Evaluation of Mincle Activation Ability.

  2025cites this paper
• Detergent-induced quantitatively limited formation of diacyl phosphatidylinositol dimannoside in Mycobacterium smegmatis

  2024cites this paper
• Lack of methoxy-mycolates characterizes the geographically restricted lineage 7 of Mycobacterium tuberculosis complex

  2023cites this paper
• Polysaccharides and glycolipids of Mycobacterium tuberculosis and their induced immune responses

  2023cites this paper
• Nocardia seriolae cell wall lipids: An effective protective mechanism in resistance and virulence.

  2023cites this paper
• Lipids of Clinically Significant Mycobacteria

  2020cites this paper
• Identification of antigens presented by MHC for vaccines against tuberculosis

  2020cites this paper
• Differential Host Pro-Inflammatory Response to Mycobacterial Cell Wall Lipids Regulated by the Mce1 Operon

  2020cites this paper
• MSU Crystals Enhance TDB-Mediated Inflammatory Macrophage IL-1β Secretion

  2019cites this paper
• Novel D-LAK peptides combinations against mycobacteria : bioefficacy and mechanistic studies

  2019cites this paper
• Study of the conformational behaviour of trehalose mycolates by FT-IR spectroscopy.

  2019cites this paper
• Mycobacterial trehalose 6,6'-dimycolate induced vascular occlusion is accompanied by subendothelial inflammation.

  2019cites this paper
• Aggregation of Nontuberculous Mycobacteria Is Regulated by Carbon-Nitrogen Balance

  2019cites this paper
• MmpL Proteins in Physiology and Pathogenesis of M. tuberculosis

  2019cites this paper
• Underestimated Manipulative Roles of Mycobacterium tuberculosis Cell Envelope Glycolipids During Infection

  2019cites this paper
• Mycobacterial Trehalose 6,6'-Dimycolate Induced M1-Type Inflammation.

  2019cites this paper
• Trehalose Dimycolate (Cord Factor) as a Contributing Factor to Tuberculosis Pathogenesis

  2019cites this paper
• Selective delipidation of Mycobacterium bovis BCG enables direct pulmonary vaccination and enhances protection against Mycobacterium tuberculosis

  2019cites this paper
• Characterizing phenotypes of Mycobacterium tuberculosis and exploring anti-mycobacterial compounds through high content screening

  2019cites this paper
• Characterization of the Cellular Immune Defect in Chronic Bovine Paratuberculosis.

  2018cites this paper
• Identification and Biological Activity of Synthetic Macrophage Inducible C-Type Lectin Ligands

  2018cites this paper
• Rapid detection of Mycobacterium tuberculosis in sputum with a solvatochromic trehalose probe

  2018cites this paper
• Mechanism of neuroprotection by trehalose: controversy surrounding autophagy induction

  2018cites this paper
• Mycobacterium tuberculosis cording in alveolar macrophages of patients with pulmonary tuberculosis is likely associated with increased mycobacterial virulence.

  2018cites this paper
• Rational design of adjuvants targeting the C-type lectin Mincle

  2017cites this paper
• The Mincle ligand trehalose dibehenate differentially modulates M1‐like and M2‐like macrophage phenotype and function via Syk signaling

  2017cites this paper
• Sensing Lipids with Mincle: Structure and Function

  2017cites this paper
• Trehalose Polyphleates, External Cell Wall Lipids in Mycobacterium abscessus, Are Associated with the Formation of Clumps with Cording Morphology, Which Have Been Associated with Virulence

  2017influential citation
• Bacterial immunostat: Mycobacterium tuberculosis lipids and their role in the host immune response.

  2017cites this paper
• Virulence, biochemistry, morphology and host-interacting properties of detergent-free cultured mycobacteria: An update.

  2016cites this paper
• Association of pellicle growth morphological characteristics and clinical presentation of Mycobacterium tuberculosis isolates.

  2016cites this paper
• Cord factor as an invisibility cloak? A hypothesis for asymptomatic TB persistence.

  2016cites this paper
• Tuberculosis in cattle (M. caprae) in the years 2009-2014

  2016cites this paper
• Trehalose 6,6-Dimycolate from Mycobacterium tuberculosis Induces Hypercoagulation.

  2016cites this paper
• An Insight into the Cell Wall of Mycobacterium Tuberculosis

  2015cites this paper
• Fonction et régulation des gènes de biosynthèse des acides mycoliques chez les mycobactéries

  2015cites this paper
• Mycobacterium-Host Cell Relationships in Granulomatous Lesions in a Mouse Model of Latent Tuberculous Infection

  2015cites this paper
• Tuberculosis among patients Infected with Human Immunodeficiency Virus

  2015cites this paper
• The Uptake of Trehalose Glycolipids by Macrophages Is Independent of Mincle

  2015cites this paper
• Contribution of MINCLE–SYK Signaling to Activation of Primary Human APCs by Mycobacterial Cord Factor and the Novel Adjuvant TDB

  2015cites this paper
• Microbiology of Tubercle Bacilli1

  2015cites this paper
• Trehalose diesters, lipoteichoic acids and α-GalCer: using chemistry to understand immunology.

  2014cites this paper
• Strategies for desymmetrising trehalose to synthesise trehalose glycolipids.

  2014cites this paper
• Vizantin Inhibits Endotoxin-Mediated Immune Responses via the TLR 4/MD-2 Complex

  2014cites this paper
• Pathogenesis of post primary tuberculosis: immunity and hypersensitivity in the development of cavities.

  2014cites this paper
• Tuberculosis: Molecular Basis of Pathogenesis

  2014cites this paper
• The mycobacterial cell envelope-lipids.

  2014cites this paper
• Mycolic acids: structures, biosynthesis, and beyond.

  2014cites this paper
• Role of the PknA and PknB kinases in Mycobacterium tuberculosis

  2014cites this paper
• The cell envelope glycoconjugates of Mycobacterium tuberculosis

  2014cites this paper
• Evidence for a unique species-specific hypersensitive epitope in Mycobacterium tuberculosis derived cord factor.

  2013cites this paper
• Trehalose 6,6'-dimycolate--a coat to regulate tuberculosis immunopathogenesis.

  2013cites this paper
• Development of a benzophenone and alkyne functionalised trehalose probe to study trehalose dimycolate binding proteins.

  2013cites this paper
• Tuberculosis as a Persistent Malady

  2013cites this paper
• Host-pathogen interactions during Mycobacterium tuberculosis infections.

  2013cites this paper
• Pathogenesis of Mycobacterium tuberculosis and its Interaction with the Host Organism

  2013cites this paper
• Mincle is not essential for controlling Mycobacterium tuberculosis infection.

  2013cites this paper
• C-type lectin MCL is an FcRγ-coupled receptor that mediates the adjuvanticity of mycobacterial cord factor.

  2013cites this paper
• Cord factors from atypical mycobacteria (Mycobacterium alvei, Mycobacterium brumae) stimulate the secretion of some pro-inflammatory cytokines of relevance in tuberculosis.

  2012cites this paper
• Dendritic Responses favoring Development of Experimental

  2012cites this paper
• Nocardia brasiliensis Cell Wall Lipids Modulate Macrophage and Dendritic Responses That Favor Development of Experimental Actinomycetoma in BALB/c Mice

  2012influential citation
• The Cord Factor: Structure, Biosynthesis and Application in Drug Research – Achilles Heel of Mycobacterium tuberculosis?

  2012cites this paper
• Trehalose glycolipids--synthesis and biological activities.

  2012cites this paper
• Broadening Our View About the Role of Mycobacterium tuberculosis Cell Envelope Components During Infection: A Battle for Survival

  2012cites this paper
• Mycobacterial TDM: A Coat to Modulate Post Primary Pathogenesis?

  2012cites this paper
• Exposure to a Cutinase-like Serine Esterase Triggers Rapid Lysis of Multiple Mycobacterial Species*

  2012cites this paper
• A proteomic view of mycobacteria

  2011cites this paper
• Mycobacterium tuberculosis Complex, Mycobacterium leprae, and Other Slow‐Growing Mycobacteria

  2010cites this paper
• Morphologische Untersuchungen über das Wachstum von Tuberkelbakterien auf Mikrokulturen

  2010cites this paper
• The effect of self-generated hypoxia on the expression of target genes coding for electron transport related products in mycobacterium tuberculosis.

  2010cites this paper
• Structural studies of cord factors from Mycobacterium simiae related to the capacity for tumour necrosis factor alpha (α-TNF) induction.

  2010cites this paper
• The Impact of Mouse Passaging of Mycobacterium tuberculosis Strains prior to Virulence Testing in the Mouse and Guinea Pig Aerosol Models

  2010cites this paper
• Vaccination experiments on animals with hexane-treated cultures of pathogenic tubercle bacilli.

  2009cites this paper
• GROWTH OF MYCOBACTERIUM TUBERCULOSIS DETERMINED BY DIRECT AGAR MICROSCOPY

  2009cites this paper
• Animal models of tuberculosis for vaccine development.

  2009cites this paper
• Glycosylated components of the mycobacterial cell wall: Structure and function

  2009cites this paper
• Trehalose 6,6'-dimycolate on the surface of Mycobacterium tuberculosis modulates surface marker expression for antigen presentation and costimulation in murine macrophages.

  2009cites this paper
• Immune Modulation by the Mycobacterium tuberculosis mce1 operon

  2009cites this paper
• Direct recognition of the mycobacterial glycolipid, trehalose dimycolate, by C-type lectin Mincle

  2009cites this paper
• Mincle is a long sought receptor for mycobacterial cord factor

  2009cites this paper
• TB research at UT-Houston--a review of cord factor: new approaches to drugs, vaccines and the pathogenesis of tuberculosis.

  2009cites this paper
• The Mycobacterium tuberculosis virulence factor trehalose dimycolate imparts desiccation resistance to model mycobacterial membranes.

  2008cites this paper
• Bacterial Components Concerned in the Early Phase of Infection

  2008cites this paper
• Succinic Dehydrogenase Activity in Tuberculous Animals

  2008cites this paper
• Structure-function relationships of mycolic acids in tuberculosis

  2008cites this paper
• Chemical Structure and Biological Activity of Mycolic Acids

  2008cites this paper
• Foamy Macrophages from Tuberculous Patients' Granulomas Constitute a Nutrient-Rich Reservoir for M. tuberculosis Persistence

  2008cites this paper
• Mycolic acid as antigen or analyte in tuberculosis

  2007cites this paper
• Molecular and supra-molecular structure related differences in toxicity and granulomatogenic activity of mycobacterial cord factor in mice.

  2007cites this paper
• Of mice, men, and elephants: Mycobacterium tuberculosis cell envelope lipids and pathogenesis.

  2006cites this paper
• The role of trehalose dimycolate (cord factor) on morphology of virulent M. tuberculosis in vitro.

  2006cites this paper
• Mycobacterial sulfolipid shows a virulence by inhibiting cord factor induced granuloma formation and TNF-alpha release.

  2006cites this paper
• Trehalose 6,6'-dimycolate and lipid in the pathogenesis of caseating granulomas of tuberculosis in mice.

  2006influential citation
• Multiple roles of cord factor in the pathogenesis of primary, secondary, and cavitary tuberculosis, including a revised description of the pathology of secondary disease.

  2006cites this paper
• Das elektronenoptische Bild ultradünner Schnitte von Tuberkelbacillen

  2005cites this paper
• Mycobacterium tuberculosis controls host innate immune activation through cyclopropane modification of a glycolipid effector molecule

  2005cites this paper
• Detection of anti-cord factor antibodies in intestinal tuberculosis for its differential diagnosis from Crohn's disease and ulcerative colitis

  2005cites this paper
• Erstisolierung von Tb.-Bacillen aus pathologischem Material auf festem Dubos-Nährboden

  2005cites this paper
• Mycobacterium tuberculosis cell envelope lipids and the host immune response

  2004cites this paper