Both Cell Fusion and Transdifferentiation Account for the Transformation of Human Peripheral Blood CD34-Positive Cells Into Cardiomyocytes In Vivo

No abstract is available for this paper.

• Publication year

  2004

• Venue

  Circulation

• Publication date

  2004-12-21

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1161/01.CIR.0000150796.18473.8EPMID 15596566
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Haematopoietic stem cells adopt mature haematopoietic fates in ischaemic myocardium

  2004cited by this paper
• Haematopoietic stem cells do not transdifferentiate into cardiac myocytes in myocardial infarcts

  2004cited by this paper
• Fusion of bone-marrow-derived cells with Purkinje neurons, cardiomyocytes and hepatocytes

  2003cited by this paper
• Transendocardial, Autologous Bone Marrow Cell Transplantation for Severe, Chronic Ischemic Heart Failure

  2003cited by this paper
• Transplanted bone marrow regenerates liver by cell fusion

  2003cited by this paper
• Infarct Remodeling After Intracoronary Progenitor Cell Treatment in Patients With Acute Myocardial Infarction (TOPCARE-AMI): Mechanistic Insights From Serial Contrast-Enhanced Magnetic Resonance Imaging

  2003cited by this paper
• Transdifferentiation of Blood-Derived Human Adult Endothelial Progenitor Cells Into Functionally Active Cardiomyocytes

  2003cited by this paper
• Transdifferentiation of Human Peripheral Blood CD34+-Enriched Cell Population Into Cardiomyocytes, Endothelial Cells, and Smooth Muscle Cells In Vivo

  2003cited by this paper
• Adult cardiac stem cells are multipotent and support myocardial regeneration.

  2003cited by this paper
• Stem cell repair of infarcted myocardium: an overview for clinicians.

  2003cited by this paper
• Human cord blood-derived cells can differentiate into hepatocytes in the mouse liver with no evidence of cellular fusion.

  2003cited by this paper
• Cardiac progenitor cells from adult myocardium: Homing, differentiation, and fusion after infarction

  2003cited by this paper
• In vivo derivation of glucose-competent pancreatic endocrine cells from bone marrow without evidence of cell fusion.

  2003cited by this paper
• Cell fusion is the principal source of bone-marrow-derived hepatocytes

  2003cited by this paper
• Changing potency by spontaneous fusion

  2002cited by this paper
• Hepatocytes and epithelial cells of donor origin in recipients of peripheral-blood stem cells.

  2002cited by this paper
• Bone marrow cells adopt the phenotype of other cells by spontaneous cell fusion

  2002cited by this paper
• Stem cells for myocardial regeneration.

  2002cited by this paper
• Multi-organ, multi-lineage engraftment by a single bone marrow-derived stem cell.

  2001cited by this paper
• Increased carnitine palmitoyltransferase in cardiac myocytes is mediated by insulin growth factor I.

  1996cited by this paper
• Analysis of the effects of tumor necrosis factor inhibitors on human hematopoiesis

  1993cited by this paper
• Changing potency by spontaneous fusion

  year unknowncited by this paper

• Stem Cell Therapies in Canine Cardiology: Comparative Efficacy, Emerging Trends, and Clinical Integration

  2025cites this paper
• “Advancing cardiac patch viability and functionality: innovations in scaffold design and cellular optimization”

  2025cites this paper
• Stimuli-responsive hydrogels: smart state of-the-art platforms for cardiac tissue engineering

  2023cites this paper
• Deciphering the Cardiovascular Potential of Human CD34+ Stem Cells

  2023cites this paper
• M-CSF-stimulated myeloid cells can convert into epithelial cells to participate in re-epithelialization and hair follicle regeneration during dermal wound healing

  2022cites this paper
• Liver Regeneration by Hematopoietic Stem Cells: Have We Reached the End of the Road?

  2022cites this paper
• M-CSF-stimulated myeloid cells can convert into epithelial cells to participate in re-epithelialization and hair follicle regeneration during skin wound healing

  2021cites this paper
• SnRNA sequencing defines signaling by RBC-derived extracellular vesicles in the murine heart

  2021cites this paper
• Preparation of Cell-Seeded Heart Patch In Vitro; Co-Culture of Adipose-Derived Mesenchymal Stem Cell and Cardiomyocytes in Amnion Bilayer Patch

  2021cites this paper
• Problems of clinical trials of cell therapy effectiveness today

  2021cites this paper
• Key Success Factors for Regenerative Medicine in Acquired Heart Diseases

  2020cites this paper
• Promise of Autologous CD34+ Stem/Progenitor Cell Therapy for Treatment of Cardiovascular Disease.

  2020cites this paper
• CD34 cells in somatic, regenerative and cancer stem cells: Developmental biology, cell therapy, and omics big data perspective

  2019cites this paper
• Cutaneous extramedullary haematopoiesis: Implications in human disease and treatment

  2019cites this paper
• Red blood cell-derived extracellular vesicles mediate intercellular communication in ischemic heart failure

  2019cites this paper
• Engineering Functional Cardiac Tissues for Regenerative Medicine Applications

  2019cites this paper
• Engineering megakaryocytic microparticles for nucleic acid delivery and their biological effects to hematopoietic stem/progenitor cells

  2019cites this paper
• 5.21 Stem Cell Therapy to Treat Heart Failure q

  2019cites this paper
• Innovations in Human Stem Cell Research: A Holy Grail for Regenerative Medicine

  2019cites this paper
• Stem Cell Therapy in Heart Diseases – Cell Types, Mechanisms and Improvement Strategies

  2018cites this paper
• Clinical Studies of Cell Therapy in Cardiovascular Medicine: Recent Developments and Future Directions

  2018cites this paper
• A Mixture of Mesenchymal Stem Cells from Perinatal Sources Supports Consistent Ex-vivo

  2018cites this paper
• Concise Review: Evidence for CD34 as a Common Marker for Diverse Progenitors

  2018cites this paper
• Enhancement Strategies for Cardiac Regenerative Cell Therapy: Focus on Adult Stem Cells.

  2018cites this paper
• Strategies of regenerative medicine

  2018cites this paper
• Stem cells and heart disease - Brake or accelerator?

  2017cites this paper
• Cell Reprogramming: Mirage or Reality?

  2017cites this paper
• Systemic Transplantation of Bone Marrow Mononuclear Cells Promotes Axonal Regeneration and Analgesia in a Model of Wallerian Degeneration

  2017cites this paper
• How do megakaryocytic microparticles target and deliver cargo to alter the fate of hematopoietic stem cells?

  2017cites this paper
• Biology and Function of Stem Cells

  2016cites this paper
• Viral-mediated fusion of mesenchymal stem cells with cells of the infarcted heart hinders healing via decreased vascularization and immune modulation

  2016cites this paper
• Empowering Adult Stem Cells for Myocardial Regeneration V2.0: Success in Small Steps.

  2016cites this paper
• Cellular Therapy for Heart Failure

  2016cites this paper
• CD34+ Liver Cancer Stem Cells Were Formed by Fusion of Hepatobiliary Stem/Progenitor Cells with Hematopoietic Precursor-Derived Myeloid Intermediates

  2015cites this paper
• Use of a Collagen I Matrix to Enhance the Potential of Circulating Angiogenic Cells (CACs) for Therapy

  2015cites this paper
• Exploring the regulation of megakaryocytic differentiation and platelet production by mechanical forces and cell-derived microparticles

  2015cites this paper
• Rapid fusion between mesenchymal stem cells and cardiomyocytes yields electrically active, non-contractile hybrid cells

  2015cites this paper
• Signaling molecules, transcription growth factors and other regulators revealed from in-vivo and in-vitro models for the regulation of cardiac development.

  2015cites this paper
• On the existence of cardiomesenchymal stem cells.

  2015cites this paper
• Cell memory-based therapy

  2015cites this paper
• Tracking Fusion of Human Mesenchymal Stem Cells After Transplantation to the Heart

  2015cites this paper
• Guideline for stable coronary artery disease.

  2014cites this paper
• Concise Review: Evidence for CD34 as a Common Marker for Diverse Progenitors

  2014cites this paper
• Potentiating the naturally occurring process for repair of damaged heart.

  2014cites this paper
• Cell therapy for cardiac repair – bench to bedside and back

  2014cites this paper
• Current Status and Perspectives in Stem Cell Therapy for Heart.

  2014cites this paper
• Regenerative strategies for preserving and restoring cardiac function.

  2013cites this paper
• Application of Stem Cells in Ischemic Heart Disease

  2013cites this paper
• Mesenchymal Stem Cell-Cardiomyocyte Interactions under Defined Contact Modes on Laser-Patterned Biochips

  2013cites this paper
• Revisiting cardiovascular regeneration with bone marrow‐derived angiogenic and vasculogenic cells

  2013cites this paper
• Studies of granulocyte colony-stimulating factor ( GCSF ) in renal stem cells regeneration

  2013cites this paper
• Wharton's jelly or bone marrow mesenchymal stromal cells improve cardiac function following myocardial infarction for more than 32 weeks in a rat model: a preliminary report.

  2013cites this paper
• A Melanoma Brain Metastasis with a Donor-Patient Hybrid Genome following Bone Marrow Transplantation: First Evidence for Fusion in Human Cancer

  2013cites this paper
• Cell Therapy for Heart Failure: A Comprehensive Overview of Experimental and Clinical Studies, Current Challenges, and Future Directions

  2013cites this paper
• Stem cell therapy is a promising tool for refractory angina: a meta-analysis of randomized controlled trials.

  2013cites this paper
• Stem Cell and G ranulocyte C olony - stimulating F actor (GCSF)

  2013cites this paper
• Cardiovascular repair with bone marrow-derived cells

  2013cites this paper
• Current concepts and advances in the application of tissue engineering in otorhinolaryngology and head and neck surgery.

  2013cites this paper
• Novel Therapeutic Targets and Strategies against Myocardial Diseases

  2012cites this paper
• Allogeneic amniotic membrane-derived mesenchymal stromal cell transplantation in a porcine model of chronic myocardial ischemia

  2012cites this paper
• Activation of Toll-like receptor 3 amplifies mesenchymal stem cell trophic factors and enhances therapeutic potency.

  2012cites this paper
• Functional Multipotency of Stem Cells: What Do We Need from Them in the Heart?

  2012cites this paper
• The role of bone marrow derived cells in cardiac repair

  2012cites this paper
• Stem cell mediated cardiovascular repair.

  2012cites this paper
• THE SYSTEMIC STEM CELL RESPONSE TO CARDIAC PRESSURE OVERLOAD

  2012cites this paper
• Directed Fusion of Mesenchymal Stem Cells with Cardiomyocytes via VSV-G Facilitates Stem Cell Programming

  2012cites this paper
• A bird's‐eye view of cell therapy and tissue engineering for cardiac regeneration

  2012cites this paper
• potencycell trophic factors and enhances therapeutic Activation of Toll-like receptor 3 amplifies mesenchymal

  2012cites this paper
• Development of Serum‐Free Quality and Quantity Control Culture of Colony‐Forming Endothelial Progenitor Cell for Vasculogenesis

  2012cites this paper
• Adipose-Derived Stem Cells Seeded on Acellular Dermal Matrix Grafts Enhance Wound Healing in a Murine Model of a Full-Thickness Defect

  2012cites this paper
• Mesenchymal Stem Cell Transplantation Improves Regional Cardiac Remodeling Following Ovine Infarction

  2012cites this paper
• Stem Cell Therapy to Treat Heart Failure

  2011cites this paper
• Autologous Stem Cells for Cardiac Repair: New Insights on Clinical Trial Safety and Best Cell Source

  2011cites this paper
• CD34+ autologous human stem cells in treating refractory angina.

  2011cites this paper
• Human cord blood CD34+ progenitor cells acquire functional cardiac properties through a cell fusion process.

  2011cites this paper
• Bone marrow-derived stem cell therapy in acute myocardial infarction : an experimental porcine model

  2011cites this paper
• Getting to the heart of myocardial stem cells and cell therapy.

  2011cites this paper
• CD34+/M-cadherin+ Bone Marrow Progenitor Cells Promote Arteriogenesis in Ischemic Hindlimbs of ApoE−/− Mice

  2011cites this paper
• processcardiac properties through a cell fusion

  2011cites this paper
• Stem-cell-capturing collagen scaffold promotes cardiac tissue regeneration.

  2011cites this paper
• Empowering adult stem cells for myocardial regeneration.

  2011cites this paper
• CD34-positive stem cells: in the treatment of heart and vascular disease in human beings.

  2011cites this paper
• Safety and Efficacy of Intramyocardial Implantation of Peripheral Blood Stem Cell for Cardiomyopathy

  2011cites this paper
• Cell fusion and stem cells

  2011cites this paper
• Management of Liver Failure: From Transplantation to Cell-Based Therapy.

  2011cites this paper
• Bone Marrow Cell Injection for Chronic Myocardial Ischemia: The Past and the Future

  2011cites this paper
• Gene Therapy for Cardiovascular Disorders

  2011cites this paper
• COMPARE-AMI Trial: Comparison of Intracoronary Injection of CD133+ Bone Marrow Stem Cells to Placebo in Patients After Acute Myocardial Infarction and Left Ventricular Dysfunction: Study Rationale and Design

  2010cites this paper
• Role of Stem Cells in Regeneration of Myocardium in Experimentally Induced Myocardial Infarction

  2010cites this paper
• Human CD34 (cid:1) Cells in Experimental Myocardial Infarction Long-Term Survival, Sustained Functional Improvement, and Mechanism of Action

  2010cites this paper
• Dynamics of Progenitor Cells and Ventricular Assist Device Intervention

  2010cites this paper
• Original Article Role of Stem Cells in Regeneration of Myocardium in Experimentall y Induced Myocardial Infarction

  2010cites this paper
• Both cultured and freshly isolated adipose tissue-derived stem cells enhance cardiac function after acute myocardial infarction.

  2010cites this paper
• Direct myocardial implantation of human fetal stem cells in heart failure patients: long-term results.

  2010cites this paper
• Adult Stem Cell-Based Therapy for the Heart

  2010cites this paper
• Human CD 34 Cells in Experimental Myocardial Infarction Long-Term Survival , Sustained Functional Improvement , and Mechanism of Action

  2010cites this paper
• Hepatic stem cells.

  2010cites this paper
• STEM CELL TRANSPLANTATION: A FUTURE FOR DIABETIC PATIENT

  2010cites this paper
• Human adipose-derived stem cells: Potential clinical applications in surgery

  2010cites this paper
• Tissue engineering by self-assembly and bio-printing of living cells

  2010cites this paper