Induction of apoptosis by human Nbk/Bik, a BH3-containing protein that interacts with E1B 19K

No abstract is available for this paper.

• Publication year

  1996

• Venue

  Molecular and Cellular Biology

• Publication date

  1996-10-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1128/MCB.16.10.5857PMID 8816500PMCID PMC231587
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Life, death, and the pursuit of apoptosis.

  1996cited by this paper
• The E1B 19K protein blocks apoptosis by interacting with and inhibiting the p53-inducible and death-promoting Bax protein.

  1996cited by this paper
• Cloning of a bcl-2 homologue by interaction with adenovirus E1B 19K

  1995cited by this paper
• Cloning of a bcl-2 homologue by interaction with adenovirus E1B 19K

  1995cited by this paper
• A conserved domain in Bak, distinct from BH1 and BH2, mediates cell death and protein binding functions.

  1995influential reference
• Activated H-ras rescues E1A-induced apoptosis and cooperates with E1A to overcome p53-dependent growth arrest

  1995cited by this paper
• Essential role for p53-mediated transcription in E1A-induced apoptosis.

  1995cited by this paper
• Modulation of p53-mediated transcriptional repression and apoptosis by the adenovirus E1B 19K protein

  1995cited by this paper
• Regulation of p53-dependent apoptosis by E1A and E1B.

  1995cited by this paper
• Bik, a novel death-inducing protein shares a distinct sequence motif with Bcl-2 family proteins and interacts with viral and cellular survival-promoting proteins.

  1995cited by this paper
• Function of the adenovirus E1B oncogene in infected and transformed cells

  1994cited by this paper
• BH1 and BH2 domains of Bcl-2 are required for inhibition of apoptosis and heterodimerization with Bax

  1994cited by this paper
• Bcl-2 blocks p53-dependent apoptosis

  1994cited by this paper
• Functional complementation of the adenovirus E1B 19-kilodalton protein with Bcl-2 in the inhibition of apoptosis in infected cells

  1994cited by this paper
• Functional similarity between adenovirus e1b 19k gene and bcl2 oncogene - mutant complementation and suppression of cell-death induced by DNA-damaging agents.

  1993cited by this paper
• Isolation of the Rb-related p130 through its interaction with CDK2 and cyclins.

  1993influential reference
• Bcl-2 heterodimerizes in vivo with a conserved homolog, Bax, that accelerates programmed cell death.

  1993cited by this paper
• Wild-type p53 mediates apoptosis by E1A, which is inhibited by E1B.

  1993cited by this paper
• The adenovirus E1A proteins induce apoptosis, which is inhibited by the E1B 19-kDa and Bcl-2 proteins.

  1992cited by this paper
• The 19-kilodalton adenovirus E1B transforming protein inhibits programmed cell death and prevents cytolysis by tumor necrosis factor alpha

  1992cited by this paper
• Identification of programmed cell death in situ via specific labeling of nuclear DNA fragmentation

  1992cited by this paper
• The E1B 19,000-molecular-weight protein of group C adenoviruses prevents tumor necrosis factor cytolysis of human cells but not of mouse cells

  1991cited by this paper
• Adenovirus E1B 19-kilodalton protein overcomes the cytotoxicity of E1A proteins

  1991cited by this paper
• The E1b oncogene of adenovirus confers cellular resistance to cytotoxicity of tumor necrosis factor and monoclonal anti-Fas antibody.

  1991cited by this paper
• Basic local alignment search tool.

  1990cited by this paper
• Role of adenovirus E1B proteins in transformation: altered organization of intermediate filaments in transformed cells that express the 19-kilodalton protein

  1990cited by this paper
• Specific disruption of intermediate filaments and the nuclear lamina by the 19-kDa product of the adenovirus E1B oncogene.

  1989cited by this paper
• Nuclear envelope localization of an adenovirus tumor antigen maintains the integrity of cellular DNA

  1984cited by this paper

• A comparative review of adenovirus A12 and C5 oncogenes.

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• Cellular communication during apoptosis

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• Reduced Bik expression drives low-grade airway inflammation and increased risk for COPD in females

  2024cites this paper
• Bik promotes proteasomal degradation to control low-grade inflammation

  2023cites this paper
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• Liposomes in the Targeted Gene Therapy of Cancer: A Critical Review.

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• Structural insights of macromolecules involved in bacteria-induced apoptosis in the pathogenesis of human diseases.

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• The Bcl-2 Family: Ancient Origins, Conserved Structures, and Divergent Mechanisms

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  2018cites this paper
• Apoptosis and Cancer

  2017cites this paper
• Autophagy regulatory molecule, TMEM74, interacts with BIK and inhibits BIK-induced apoptosis.

  2017cites this paper
• A novel oncolytic adenovirus based on simian adenovirus serotype 24

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• Direct Activation of Bax Protein for Cancer Therapy

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• Osteopontin-stimulated apoptosis in cardiac myocytes involves oxidative stress and mitochondrial death pathway: role of a pro-apoptotic protein BIK

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• c-Jun-Mediated Transcription Protein Activates c-Jun N-Terminal Kinase and Adenovirus E1B 19,000-Molecular-Weight

  2014cites this paper
• PROTEASOME INHIBITION ENHANCES THE EFFECT OF BIKDD GENE THERAPY

  2014cites this paper
• PROTEASOME INHIBITION ENHANCES THE EFFECT OF BIKDD GENE THERAPY

  2014cites this paper
• Participación de la proteína BIK en los procesos apoptóticos

  2014cites this paper
• Comparaison des propriétés antiapoptotiques de quatre protéines du virus de la vaccine en isolement et au cours de l’infection virale.

  2014cites this paper
• Caspase-activation complex ARCosome : its regulation and signalling for cell death

  2014cites this paper
• Papel de la vía endocítica en la infección del virus de la peste porcina africana

  2014cites this paper
• The increase in BIK expression following ERK1/2 pathway inhibition is a consequence of G₁ cell-cycle arrest and not a direct effect on BIK protein stability.

  2014cites this paper
• Alteraciones moleculares implicadas en la fisiopatogenia del cáncer y su utilidad para la investigación en medicina.

  2014cites this paper
• Towards the virtual screening of BIK inhibitors with the homology-modeled protein structure

  2013cites this paper
• Viral product trafficking to mitochondria, mechanisms and roles in pathogenesis.

  2012influential citation
• Peptide screening to knockdown Bcl-2's anti-apoptotic activity: implications in cancer treatment.

  2012cites this paper
• Advances in Liposome-Based Targeted Gene Therapy of Cancer

  2012cites this paper
• Neither loss of Bik alone, nor combined loss of Bik and Noxa, accelerate murine lymphoma development or render lymphoma cells resistant to DNA damaging drugs

  2012cites this paper
• Star-PAP control of BIK expression and apoptosis is regulated by nuclear PIPKIα and PKCδ signaling.

  2012cites this paper
• Regulation of the BH3-only protein PUMA by growth factor signalling.

  2011cites this paper
• BAX unleashed: the biochemical transformation of an inactive cytosolic monomer into a toxic mitochondrial pore.

  2011cites this paper
• The E1B19K Oncoprotein Complexes with Beclin 1 to Regulate Autophagy in Adenovirus-Infected Cells

  2011cites this paper
• The essential role of evasion from cell death in cancer.

  2011cites this paper
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  2011cites this paper
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  2011cites this paper
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  2010cites this paper
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  2010cites this paper
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  2010cites this paper
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  2010cites this paper
• Defining the Role of CtBP2 in p53-Independent Tumor Suppressor Function of ARF: A Dissertation

  2009cites this paper
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  2009cites this paper
• DISCRETE SUBSET OF BH3-ONLY PROTEINS TO INHIBIT APOPTOSIS 2

  2009cites this paper
• No association between the Bcl2-interacting killer (BIK) gene and schizophrenia.

  2009cites this paper
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• The Fowlpox Virus BCL-2 Homologue, FPV039, Interacts with Activated Bax and a Discrete Subset of BH3-Only Proteins To Inhibit Apoptosis

  2009influential citation
• Regulation of Bcl-2 family proteins by posttranslational modifications.

  2008cites this paper
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  2008cites this paper
• BIK, the founding member of the BH3-only family proteins: mechanisms of cell death and role in cancer and pathogenic processes

  2008cites this paper
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  2008cites this paper
• BH3-only proteins in apoptosis and beyond: an overview

  2008cites this paper
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  2008influential citation
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  2008cites this paper
• Die Rolle der Proteinkinase C im Apoptoseprogramm der Erythrozyten nach Glukosedepletion

  2007cites this paper
• Anti‐apoptotic genes Aven and E1B‐19K enhance performance of BHK cells engineered to express recombinant factor VIII in batch and low perfusion cell culture

  2007influential citation
• Development of Therapeutic Genes for Breast Cancer Treatment

  2007cites this paper
• Targeted expression of BikDD eradicates pancreatic tumors in noninvasive imaging models.

  2007cites this paper
• Mcl-1 determines the Bax dependency of Nbk / Bik-induced apoptosis

  2007cites this paper
• Enhanced cell culture performance using inducible anti‐apoptotic genes E1B‐19K and Aven in the production of a monoclonal antibody with Chinese hamster ovary cells

  2007influential citation
• Mcl-1 determines the Bax dependency of Nbk/Bik-induced apoptosis

  2007cites this paper
• Fowlpox Virus Encodes a Bcl-2 Homologue That Protects Cells from Apoptotic Death through Interaction with the Proapoptotic Protein Bak

  2007cites this paper
• NBK/BIK antagonizes MCL-1 and BCL-XL and activates BAK-mediated apoptosis in response to protein synthesis inhibition.

  2007cites this paper
• Molecular characterization of virus-host interactions

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• DNA-damage response network at the crossroads of cell-cycle checkpoints, cellular senescence and apoptosis

  2007cites this paper
• Mutant Bik gene transferred by cationic liposome inhibits peritoneal disseminated murine colon cancer

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  2006cites this paper
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• The control of endoplasmic reticulum-initiated apoptosis by the BCL-2 family of proteins.

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• Antagonistes de Bcl-2, thérapies anticancéreuses alternatives

  2005cites this paper
• The proteasome inhibitor bortezomib sensitizes cells to killing by death receptor ligand TRAIL via BH3-only proteins Bik and Bim

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• Caspase-independent induction of apoptosis in human melanoma cells by the proapoptotic Bcl-2-related protein Nbk / Bik

  2005cites this paper
• BH3-only BIK Regulates BAX,BAK-dependent Release of Ca2+ from Endoplasmic Reticulum Stores and Mitochondrial Apoptosis during Stress-induced Cell Death*

  2005cites this paper
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