Differential gene expression in response to methoxychlor and estradiol through ERalpha, ERbeta, and AR in reproductive tissues of female mice.

No abstract is available for this paper.

• Publication year

  2001

• Venue

  Toxicological Sciences

• Publication date

  2001-09-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1093/TOXSCI/63.1.47PMID 11509743
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Differential expression patterns of cathepsins B, H, K, L and S in the mouse ovary.

  2001cited by this paper
• Effect of Estradiol on Estrogen Receptor Expression in Rat Uterine Cell Types1

  2000cited by this paper
• The effect of raloxifene on the uterine weight response in immature mice exposed to 17beta-estradiol, 1,1,1-trichloro-2, 2-bis(p-chlorophenyl)ethane, and methoxychlor.

  2000cited by this paper
• Gene expression profiles of human endometrial cancer samples using a cDNA-expression array technique: assessment of an analysis method

  2000cited by this paper
• Paracrine Regulation of Epithelial Progesterone Receptor by Estradiol in the Mouse Female Reproductive Tract

  2000cited by this paper
• Activation of a uterine insulin-like growth factor I signaling pathway by clinical and environmental estrogens: requirement of estrogen receptor-alpha.

  2000cited by this paper
• Estrogen Receptor α Rapidly Activates the IGF-1 Receptor Pathway*

  2000cited by this paper
• Estradiol and pesticide methoxychlor do not exhibit additivity or synergism in the reproductive tract of adult ovariectomized mice.

  2000cited by this paper
• Estrogen receptor ( ER ) b , a modulator of ER a in the uterus

  2000cited by this paper
• Interaction of methoxychlor and related compounds with estrogen receptor alpha and beta, and androgen receptor: structure-activity studies.

  2000cited by this paper
• Ability of xeno- and phytoestrogens to modulate expression of estrogen-sensitive genes in rat uterus: estrogenicity profiles and uterotropic activity.

  2000cited by this paper
• Localization of oestrogen receptor alpha, oestrogen receptor beta and androgen receptors in the rat reproductive organs.

  2000cited by this paper
• Interaction of Methoxychlor and Related Compounds with Estrogen Receptor α and β, and Androgen Receptor: Structure-Activity Studies

  2000cited by this paper
• Estrogen receptor (ER) , a modulator of ER in the uterus

  2000cited by this paper
• Paracrine Regulation of Epithelial Progesterone Receptor by Estradiol in the Mouse Female Reproductive Tract1

  2000cited by this paper
• Printed in U.S.A. Copyright © 2000 by The Endocrine Society Activation of a Uterine Insulin-Like Growth Factor I Signaling Pathway by Clinical and Environmental

  2000cited by this paper
• Estrogenic effects of organochlorine pesticides on uterine leiomyoma cells in vitro.

  2000cited by this paper
• Estrogen directly respresses gonadotropin-releasing hormone (GnRH) gene expression in estrogen receptor-alpha (ERalpha)- and ERbeta-expressing GT1-7 GnRH neurons.

  1999cited by this paper
• Methoxychlor Stimulates Estrogen-Responsive Messenger Ribonucleic Acids in Mouse Uterus through a Non-Estrogen Receptor (Non-ER)α and Non-ERβ Mechanism.

  1999cited by this paper
• Differential Interaction of the Methoxychlor Metabolite 2,2-Bis-(p-Hydroxyphenyl)-1,1,1-Trichloroethane with Estrogen Receptors α and β1.

  1999cited by this paper
• Differential Expression of Estrogen Receptor-β and Estrogen Receptor-α in the Rat Ovary.

  1999cited by this paper
• Printed in U.S.A. Copyright © 1999 by The Endocrine Society Estrogen Directly Represses Gonadotropin-Releasing Hormone (GnRH) Gene Expression in Estrogen Receptor- � (ER�)- and ER�-Expressing

  1999cited by this paper
• Differential interaction of the methoxychlor metabolite 2,2-bis-(p-hydroxyphenyl)-1,1,1-trichloroethane with estrogen receptors alpha and beta.

  1999cited by this paper
• Differential expression of estrogen receptor-beta and estrogen receptor-alpha in the rat ovary.

  1999cited by this paper
• Methoxychlor stimulates estrogen-responsive messenger ribonucleic acids in mouse uterus through a non-estrogen receptor (non-ER) alpha and non-ER beta mechanism.

  1999cited by this paper
• Glutathione S-transferase in hormonal carcinogenesis.

  1998cited by this paper
• Hormone induction of progesterone receptor (PR) messenger ribonucleic acid and activation of PR promoter regions in ovarian granulosa cells: evidence for a role of cyclic adenosine 3',5'-monophosphate but not estradiol.

  1998cited by this paper
• Estrogenic regulation of clusterin mRNA in normal and malignant endometrial tissue

  1998cited by this paper
• Inhibition of glutathione S-transferase activity by the quinoid metabolites of equine estrogens.

  1998cited by this paper
• Tissue Distribution and Quantitative Analysis of Estrogen Receptor-α (ERα) and Estrogen Receptor-β (ERβ) Messenger Ribonucleic Acid in the Wild-Type and ERα-Knockout Mouse.

  1997cited by this paper
• The effects of perinatal/juvenile methoxychlor exposure on adult rat nervous, immune, and reproductive system function.

  1997cited by this paper
• The mouse intraovarian insulin-like growth factor I system: departures from the rat paradigm.

  1997cited by this paper
• Comparison of the ligand binding specificity and transcript tissue distribution of estrogen receptors alpha and beta.

  1997cited by this paper
• Tissue distribution and quantitative analysis of estrogen receptor-alpha (ERalpha) and estrogen receptor-beta (ERbeta) messenger ribonucleic acid in the wild-type and ERalpha-knockout mouse.

  1997cited by this paper
• Effect of methoxychlor on implantation and embryo development in the mouse.

  1997cited by this paper
• Estradiol or methoxychlor stimulates estrogen receptor (ER) expression in uteri.

  1996cited by this paper
• Assessing environmental chemicals for estrogenicity using a combination of in vitro and in vivo assays.

  1996influential reference
• Methoxychlor mimics the action of 17 beta-estradiol on induction of uterine epidermal growth factor receptors in immature female rats.

  1996cited by this paper
• Glutathione peroxidase activity in endometrium: effects of sex hormones and cancer.

  1996cited by this paper
• Glutathione-S-transferase in rat ovary: its changes during estrous cycle and increase in its activity by estradiol-17 beta.

  1996cited by this paper
• Influence of organochlorine pesticides on development of mouse embryos in vitro.

  1996cited by this paper
• Neonatal exposures to technical methoxychlor alters ovaries in adult mice.

  1995cited by this paper
• Expression of apolipoprotein J in the uterus is associated with tissue remodeling.

  1995cited by this paper
• Response of adult murine uterine epithelium to 50% methoxychlor.

  1994cited by this paper
• Follicular oestrogen synthesis: the 'two-cell, two-gonadotrophin' model revisited.

  1994cited by this paper
• Mechanisms of the stimulation of rat uterine peroxidase activity by methoxychlor.

  1994cited by this paper
• Purified methoxychlor stimulates the reproductive tract in immature female mice.

  1993cited by this paper
• Role of the free radical-scavenger system in aromatase activity of the human ovary.

  1993cited by this paper
• Expression of insulin-like growth factor-I (IGF-I) and its receptor in the peri-implantation mouse uterus, and cell-specific regulation of IGF-I gene expression by estradiol and progesterone.

  1992cited by this paper
• Effects of the antiandrogen hydroxyflutamide on progesterone secretion by preovulatory rat follicles in vivo and in vitro.

  1991cited by this paper
• Ultrastructure of vagina and uterus in young mice after methoxychlor exposure.

  1991influential reference
• Insulin-like growth factor-I gene expression during development and estrous cycle in the rat uterus.

  1991influential reference
• Uterine insulin-like growth factor-I receptors: regulation by estrogen and variation throughout the estrous cycle.

  1989cited by this paper
• Antifertility effect of methoxychlor in female rats: dose- and time-dependent blockade of pregnancy.

  1989cited by this paper
• A dose-response analysis of methoxychlor-induced alterations of reproductive development and function in the rat.

  1989cited by this paper
• Differential effects of estrogen and growth hormone on uterine and hepatic insulin-like growth factor I gene expression in the ovariectomized hypophysectomized rat.

  1988cited by this paper
• Methoxychlor induces estrogen-like alterations of behavior and the reproductive tract in the female rat and hamster: effects on sex behavior, running wheel activity, and uterine morphology.

  1988cited by this paper
• Animal models for study of polycystic ovaries and ovarian atresia.

  1987cited by this paper
• Metabolic activation of pesticides with proestrogenic activity.

  1987cited by this paper
• Estrogen induces insulin-like growth factor-I expression in the rat uterus.

  1987cited by this paper
• The influence of 17 beta-estradiol on patterns of cell division in the uterus.

  1984cited by this paper
• The Influence of 17β-Estradiol on Patterns of Cell Division in the Uterus

  1984cited by this paper
• Influence of estrogen on glutathione levels and glutathione-metabolizing enzymes in uteri and R3230AC mammary tumors of rats.

  1980cited by this paper
• Studies on the in vivo and in vitro estrogenic activities of methoxychlor and its metabolites. Role of hepatic mono-oxygenase in methoxychlor activation.

  1978cited by this paper
• Surface modifications evoked by estradiol and diethylstilbestrol in isolated endometrial cells: evidence from lectin probes and extracellular release of lysosomal protease.

  1975cited by this paper

• Associations Between Follicular Fluid Biomarkers and IVF/ICSI Outcomes in Normo-Ovulatory Women—A Systematic Review

  2025cites this paper
• Adverse Effects of Pesticides on the Ovary: Evidence from Epidemiological and Toxicological Studies

  2025cites this paper
• Exposure to air pollution and ovarian reserve parameters

  2024cites this paper
• Reproductive toxicity of combined effects of endocrine disruptors on human reproduction

  2023influential citation
• Application of an in Vitro Assay to Identify Chemicals That Increase Estradiol and Progesterone Synthesis and Are Potential Breast Cancer Risk Factors

  2021cites this paper
• Endocrine Disruptors Driven Female Reproductive Ailments

  2021cites this paper
• Organochlorine pesticides: Agrochemicals with potent endocrine-disrupting properties in fish.

  2020cites this paper
• Reproductive Toxicity Biomarkers

  2019cites this paper
• Androgenic/antiandrogenic activities of PAEs determined by a novel AR-mediated reporter gene assay based on LLC-MK2 cells.

  2019cites this paper
• Technical-grade chlordane compromises rat Sertoli cells proliferation, viability and metabolic activity.

  2019cites this paper
• Enantioselective Elimination and Gonadal Disruption of Lambda-Cyhalothrin on Lizards ( Eremias argus).

  2019cites this paper
• Potassium chloride released from contracting skeletal muscle may stimulate development of its hypertrophy

  2019cites this paper
• Water and soil pollution as determinant of water and food quality/contamination and its impact on male fertility

  2019cites this paper
• Genetic Mouse Models for Female Reproductive Toxicology Studies

  2018cites this paper
• Antigonadal and endocrine-disrupting activities of lambda cyhalothrin in female rats and its attenuation by taurine

  2018cites this paper
• A Novel Action of Endocrine-Disrupting Chemicals on Wildlife; DDT and Its Derivatives Have Remained in the Environment

  2018cites this paper
• FUNCTION OFSEXUAL GLANDS AND MECHANISM OF DIFFERENTIATION SEX

  2017cites this paper
• Traditional Approaches to Molecular Genetic Analysis.

  2017cites this paper
• A hindsight reflection on the clinical studies of poly(l-glutamic acid)-paclitaxel.

  2017cites this paper
• Clusterin in the Brain

  2017cites this paper
• Human exposure to endocrine disrupting chemicals: effects on the male and female reproductive systems.

  2017cites this paper
• Why (multi)targeting of cyclin-dependent kinases is a promising therapeutic option for hormone-positive breast cancer and beyond.

  2016cites this paper
• Running title: Endocrine Disruptors Affect Ovarian Function Summary: This is a mini-review of the effects of selected endocrine disruptors on the adult mammalian ovary.

  2015cites this paper
• Effects of Endocrine-Disrupting Chemicals on the Ovary1

  2015cites this paper
• The association between follicular fluid levels of cathepsin B, relaxin or AMH with clinical pregnancy rates in infertile patients.

  2015cites this paper
• Effect of myomectomy on endometrial glutathione peroxidase 3 (GPx3) and glycodelin mRNA expression at the time of the implantation window.

  2014cites this paper
• Environmental Chemicals Targeting Estrogen Signaling Pathways

  2014cites this paper
• A novel ERα-mediated reporter gene assay for screening estrogenic/antiestrogenic chemicals based on LLC-MK2 cells

  2014cites this paper
• Organoklorovi insekticidi - mehanizmi toksičnog djelovanja Organochlorinated insecticides - mechanisms of toxic action

  2014cites this paper
• Exposure of single-walled carbon nanotubes impairs the functions of primarily cultured murine peritoneal macrophages

  2013cites this paper
• GABA y receptores GABA B en el eje reproductivo: su relación con GnRH y kisspeptinas

  2013cites this paper
• The AF-1 activation function of estrogen receptor α is necessary and sufficient for uterine epithelial cell proliferation in vivo.

  2013cites this paper
• Novel Direct Targets and Functional Roles for MicroRNA-21 in Granulosa Cells and Human Uterine Leiomyomas

  2013cites this paper
• Ovarian Actions of Estrogen Receptor-β: An Update

  2012cites this paper
• Methoxychlor inhibits growth and induces atresia through the aryl hydrocarbon receptor pathway in mouse ovarian antral follicles.

  2012cites this paper
• Impact of environmental exposures on ovarian function and role of xenobiotic metabolism during ovotoxicity.

  2012cites this paper
• Estrogenic effects of ginsenoside Rg1 in endometrial cells in vitro were not observed in immature CD-1 mice or ovariectomized mice model

  2012cites this paper
• Estrogen receptor alpha overexpressing mouse antral follicles are sensitive to atresia induced by methoxychlor and its metabolites.

  2012cites this paper
• Modulación por la poli (ADP-Ribosa) polimerasa-1 de la expresión genética durante la carcinogénesis epidérmica

  2011cites this paper
• The methoxychlor metabolite, HPTE, inhibits rat luteal cell progesterone production.

  2011cites this paper
• Stimulation of mechano-growth factor expression by second messengers.

  2011cites this paper
• Comparison of the removal efficiency of endocrine disrupting compounds between two lab-scale treatment processes

  2011cites this paper
• Anterior prostate epithelial AR inactivation modifies estrogen receptor expression and increases estrogen sensitivity.

  2011cites this paper
• Efectos de los pesticidas organoclorados sobre la neurotransmisión glutamatérgica en cultivos primarios neuronales. Interacciones con el sistema neuroendocrino.

  2011cites this paper
• Genomics in Characterizing Endocrine Toxicity

  2011cites this paper
• Increased sensitivity of estrogen receptor alpha overexpressing antral follicles to methoxychlor and its metabolites.

  2011influential citation
• Stimulation of mechano-growth factor expression by myofibrillar proteins in murine myoblasts and myotubes

  2011cites this paper
• Evaluation of Subacute Toxicity Induced by Methoxychlor: The protective Effect of Ascorbic acid

  2011cites this paper
• Endocrine-disrupting chemicals in ovarian function: effects on steroidogenesis, metabolism and nuclear receptor signaling.

  2011cites this paper
• Methoxychlor affects multiple hormone signaling pathways in the largemouth bass (Micropterus salmoides) liver.

  2011cites this paper
• Predicting developmental toxicity through toxicogenomics.

  2010cites this paper
• A phase II study of paclitaxel poliglumex in combination with transdermal estradiol for the treatment of metastatic castration-resistant prostate cancer after docetaxel chemotherapy

  2010cites this paper
• The importance of ER b signalling in the ovary

  2010cites this paper
• The importance of ERb signalling in the ovary

  2010cites this paper
• Effects of beta-cypermethrin on male rat reproductive system.

  2010cites this paper
• Chapter 18 – Pesticides as Endocrine-Disrupting Chemicalsa

  2010cites this paper
• Toxicology of DDT and Some Analogues

  2010cites this paper
• The aryl hydrocarbon receptor nuclear translocator-interacting protein 2 suppresses the estrogen receptor signaling via an Arnt-dependent mechanism.

  2010cites this paper
• Pregnancy and fetal correlations of cypermethrin in mice (Mus musculus)

  2010cites this paper
• Effect of the herbicide pendimethalin on rat uterine weight and gene expression and in silico receptor binding analysis.

  2010cites this paper
• Estrogenic Activity of Bisphenol A and 2,2-bis(p-Hydroxyphenyl)-1,1,1-trichloroethane (HPTE) Demonstrated in Mouse Uterine Gene Profiles

  2010cites this paper
• Effects of genistein and estrogen receptor subtype-specific agonists in ArKO mice following different administration routes.

  2010cites this paper
• The importance of ERbeta signalling in the ovary.

  2010cites this paper
• Methoxychlor‐induced alteration in the levels of HSP70 and clusterin is accompanied with oxidative stress in adult rat testis

  2009cites this paper
• PARP-1 is involved in autophagy induced by DNA damage

  2009cites this paper
• Androgen Receptor is Expressed in Murine Choroid Plexus and Downregulated by 5α-Dihydrotestosterone in Male and Female Mice

  2009cites this paper
• Metabolomics Approach to Risk Assessment: Methoxyclor Exposure in Rats

  2009cites this paper
• 17beta-Estradiol inhibits chondrogenesis in the skull development of zebrafish embryos.

  2009cites this paper
• Fetal and neonatal exposure to the endocrine disruptor methoxychlor causes epigenetic alterations in adult ovarian genes.

  2009cites this paper
• Computational and functional analysis of growth hormone (GH)-regulated genes identifies the transcriptional repressor B-cell lymphoma 6 (Bc16) as a participant in GH-regulated transcription.

  2009cites this paper
• Variation in the Ovarian Reserve Is Linked to Alterations in Intrafollicular Estradiol Production and Ovarian Biomarkers of Follicular Differentiation and Oocyte Quality in Cattle1

  2009cites this paper
• Reproductive toxicology of endocrine disruptors : effects of cadmium, phthalates and phytoestrogens on testicular steroidogenesis

  2008cites this paper
• The methoxychlor metabolite, HPTE, directly inhibits the catalytic activity of cholesterol side-chain cleavage (P450scc) in cultured rat ovarian cells.

  2008cites this paper
• The use of metabolising systems for in vitro testing of endocrine disruptors.

  2008cites this paper
• In vivo and in vitro effects of the organochlorine pesticides DDT, TCPM, methoxychlor, and lindane on the female reproductive tract of mammals: a review.

  2008cites this paper
• DETAILED REVIEW PAPER ON THE USE OF METABOLISING SYSTEMS FOR IN VITRO TESTING OF ENDOCRINE DISRUPTORS Environment Directorate ORGANISATION FOR ECONOMIC CO-OPERATION AND DEVELOPMENT

  2008cites this paper
• ERbeta in breast cancer--onlooker, passive player, or active protector?

  2008cites this paper
• CARM1 promotes adipocyte differentiation by coactivating PPARγ

  2008cites this paper
• Effects of estrogen on gene expression profiles in mouse hypothalamus and white adipose tissue: target genes include glutathione peroxidase 3 and cell death-inducing DNA fragmentation factor, alpha-subunit-like effector A.

  2008cites this paper
• Evaluation of androgen receptor transcriptional activities of some pesticides in vitro.

  2008cites this paper
• Differential Regulation of Clusterin and Its Isoforms by Androgens in Prostate Cells*

  2007cites this paper
• Estrogen-induced upregulation of AR expression and enhancement of AR nuclear translocation in mouse fallopian tubes in vivo.

  2007cites this paper
• Uterine temporal response to acute exposure to 17alpha-ethinyl estradiol in the immature rat.

  2007cites this paper
• Paclitaxel poliglumex (PPX, CT-2103): macromolecular medicine for advanced non-small-cell lung cancer

  2007cites this paper
• Identification of differentially expressed genes using annealing control primer-based GeneFishing in human squamous cell cervical carcinoma.

  2007cites this paper
• In vitro and in vivo metabolism of paclitaxel poliglumex: identification of metabolites and active proteases

  2007cites this paper
• Effects of the common pesticide methoxychlor on ovarian steroidogenesis

  2007cites this paper
• Methoxychlor induces atresia of antral follicles in ERalpha-overexpressing mice.

  2006cites this paper
• Estrogen-induced upregulation of AR expression and enhancement of AR nuclear translocation in mouse fallopian tubes in vivo

  2006cites this paper
• Methoxychlor induces atresia of antral follicles in ERα-overexpressing mice

  2006cites this paper
• Methoxychlor metabolites may cause ovarian toxicity through estrogen-regulated pathways.

  2006influential citation
• Role of cathepsins in ovarian follicle growth and maturation.

  2006cites this paper
• Androgen receptor activities of p,p'-DDE, fenvalerate and phoxim detected by androgen receptor reporter gene assay.

  2006cites this paper
• Differential expression patterns of Wnt and beta-catenin/TCF target genes in the uterus of immature female rats exposed to 17alpha-ethynyl estradiol.

  2006cites this paper
• Effect of methoxychlor and estradiol on cytochrome p450 enzymes in the mouse ovarian surface epithelium.

  2006cites this paper
• Estrogenic effect of soy isoflavones on mammary gland morphogenesis and gene expression profile.

  2006cites this paper
• Differential Expression Patterns of Wnt and β-Catenin/TCF Target Genes in the Uterus of Immature Female Rats Exposed to 17α-Ethynyl Estradiol

  2006cites this paper
• Gene expression profile exploration of a large dataset on chronic fatigue syndrome.

  2006cites this paper
• PIONEER: a phase III randomized trial of paclitaxel poliglumex versus paclitaxel in chemotherapy-naive women with advanced-stage non-small-cell lung cancer and performance status of 2.

  2006cites this paper
• Multiple hormonal activities of UV filters and comparison of in vivo and in vitro estrogenic activity of ethyl-4-aminobenzoate in fish.

  2006cites this paper