Toll-like Receptor (TLR) and Nucleotide-Binding Oligomerization Domain (NOD) Signaling during Vibrio Cholerae Infection

Cholera remains a significant health problem in developing countries due to its ability to spread rapidly and kills a high proportion of those affected. The disease is produced by Vibrio cholerae that colonizes in the human intestine and causes inflammatory diarrheal diseases. The reactogenicity of vaccine strain causes a serious problem in clinical settings. Besides the study of organisms V. cholerae, a thorough understanding of the host response following V. cholerae infection is indispensable to combat the disease from newly emerging threats. Elucidation of molecular mechanisms of V. cholerae induced inflammatory response through Toll-like receptor (TLR) and nucleotide-binding oligomerization domain (NOD) will eventually help to design proper vaccine or drugs for appropriate targets.

• Publication year

  2015

• Venue

  MOJ Immunology

• Publication date

  2015-01-15

• Fields of study

  Biology, Medicine, Environmental Science

• Identifiers
  DOI 10.15406/MOJI.2015.02.00033
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar

• No claims are published for this paper.

• No concepts are published for this paper.

• Toll/interleukin-1 receptor (TIR) domain-mediated cellular signaling pathways

  2015cited by this paper
• The 3 major types of innate and adaptive cell-mediated effector immunity.

  2015cited by this paper
• Transmembrane oligomeric form of Vibrio cholerae cytolysin triggers TLR2/TLR6-dependent proinflammatory responses in monocytes and macrophages.

  2015cited by this paper
• Comparative Proteomic Analysis Reveals Activation of Mucosal Innate Immune Signaling Pathways during Cholera

  2015cited by this paper
• Collaborative Action of Toll-Like and Nod-Like Receptors as Modulators of the Inflammatory Response to Pathogenic Bacteria

  2014cited by this paper
• Antimicrobial drugs for treating cholera (Review)

  2014cited by this paper
• Vibrio cholerae-Induced Inflammation in the Neonatal Mouse Cholera Model

  2014cited by this paper
• NOD1 and NOD2: signaling, host defense, and inflammatory disease.

  2014cited by this paper
• Newly described pattern recognition receptors team up against intracellular pathogens

  2013cited by this paper
• Synergistic Effect of Various Virulence Factors Leading to High Toxicity of Environmental V. cholerae Non-O1/ Non-O139 Isolates Lacking ctx Gene : Comparative Study with Clinical Strains

  2013cited by this paper
• The history of Toll-like receptors — redefining innate immunity

  2013cited by this paper
• Vibrio cholerae Porin OmpU Induces Pro-Inflammatory Responses, but Down-Regulates LPS-Mediated Effects in RAW 264.7, THP-1 and Human PBMCs

  2013cited by this paper
• Lipopolysaccharide Modifications of a Cholera Vaccine Candidate Based on Outer Membrane Vesicles Reduce Endotoxicity and Reveal the Major Protective Antigen

  2013influential reference
• Interleukin‐8 gene regulation in epithelial cells by Vibrio cholerae: role of multiple promoter elements, adherence and motility of bacteria and host MAPKs

  2012cited by this paper
• Human epithelial cells stimulated with Vibrio cholerae produce thymic stromal lymphopoietin and promote dendritic cell-mediated inflammatory Th2 response.

  2012cited by this paper
• Vibrio cholerae O395 Outer Membrane Vesicles Modulate Intestinal Epithelial Cells in a NOD1 Protein-dependent Manner and Induce Dendritic Cell-mediated Th2/Th17 Cell Responses*

  2012influential reference
• Elucidation of a novel Vibrio cholerae lipid A secondary hydroxy-acyltransferase and its role in innate immune recognition

  2011cited by this paper
• Toll-like receptors and their crosstalk with other innate receptors in infection and immunity.

  2011cited by this paper
• Cholera: a great global concern.

  2011cited by this paper
• Vibrio cholerae O1 Infection Induces Proinflammatory CD4+ T-Cell Responses in Blood and Intestinal Mucosa of Infected Humans

  2011cited by this paper
• The two faces of ToxR: activator of ompU, co‐regulator of toxT in Vibrio cholerae

  2011influential reference
• Hemolysin Induces Toll-like Receptor (TLR)-independent Apoptosis and Multiple TLR-associated Parallel Activation of Macrophages

  2011cited by this paper
• The complexity of ToxT-dependent transcription in Vibrio cholerae

  2011cited by this paper
• Nod‐like receptors in intestinal homeostasis, inflammation, and cancer

  2011cited by this paper
• Antimicrobials & cholera: are we stranded?

  2011cited by this paper
• TLR-based immune adjuvants.

  2011cited by this paper
• Cholera in the 21st century

  2011cited by this paper
• Association of cholera toxin with Vibrio cholerae outer membrane vesicles which are internalized by human intestinal epithelial cells

  2011cited by this paper
• NOD-Like Receptor Activation by Outer Membrane Vesicles from Vibrio cholerae Non-O1 Non-O139 Strains Is Modulated by the Quorum-Sensing Regulator HapR

  2011cited by this paper
• LPLUNC1 modulates innate immune responses to Vibrio cholerae.

  2011influential reference
• The utility of human challenge studies in vaccine development: lessons learned from cholera.

  2011cited by this paper
• Pathogenic Vibrio Activate NLRP3 Inflammasome via Cytotoxins and TLR/Nucleotide-Binding Oligomerization Domain-Mediated NF-κB Signaling

  2010cited by this paper
• Cholera Toxin Impairs the Differentiation of Monocytes into Dendritic Cells, Inducing Professional Antigen-Presenting Myeloid Cells

  2010cited by this paper
• Virulence and Immunomodulatory Roles of Bacterial Outer Membrane Vesicles

  2010cited by this paper
• Biological functions and biogenesis of secreted bacterial outer membrane vesicles.

  2010cited by this paper
• Vibrio cholerae Proteome-Wide Screen for Immunostimulatory Proteins Identifies Phosphatidylserine Decarboxylase as a Novel Toll-Like Receptor 4 Agonist

  2009cited by this paper
• Cholera Caused by Vibrio cholerae O1 Induces T-Cell Responses in the Circulation

  2009cited by this paper
• Activation of proinflammatory response in human intestinal epithelial cells following Vibrio cholerae infection through PI3K/Akt pathway.

  2009cited by this paper
• Involvement of intracellular signaling cascades in inflammatory responses in human intestinal epithelial cells following Vibrio cholerae infection.

  2009cited by this paper
• NOD-like receptors: role in innate immunity and inflammatory disease.

  2009cited by this paper
• Three-Dimensional Structure of Different Functional Forms of the Vibrio cholerae Hemolysin Oligomer: a Cryo-Electron Microscopic Study

  2009cited by this paper
• Cholera toxin-specific memory B cell responses are induced in patients with dehydrating diarrhea caused by Vibrio cholerae O1.

  2008cited by this paper
• IL-1beta expression in Int407 is induced by flagellin of Vibrio cholerae through TLR5 mediated pathway.

  2008cited by this paper
• The Vibrio cholerae cytolysin promotes activation of mast cell (T helper 2) cytokine production

  2008cited by this paper
• Vibrio cholerae Flagellins Induce Toll-Like Receptor 5-Mediated Interleukin-8 Production through Mitogen-Activated Protein Kinase and NF-κB Activation

  2008cited by this paper
• Characterization of Vibrio cholerae Outer Membrane Vesicles as a Candidate Vaccine for Cholera

  2008cited by this paper
• Human intestinal epithelial cell cytokine mRNA responses mediated by NF-kappaB are modulated by the motility and adhesion process of Vibrio cholerae.

  2007cited by this paper
• TLR-mediated stimulation of APC: Distinct cytokine responses of B cells and dendritic cells

  2007cited by this paper
• Transcriptional upregulation of inflammatory cytokines in human intestinal epithelial cells following Vibrio cholerae infection

  2007cited by this paper
• Regulation of virulence in Vibrio cholerae: the ToxR regulon.

  2007cited by this paper
• T Cell Activation by TLRs: A Role for TLRs in the Adaptive Immune Response

  2007cited by this paper
• MARTX, Multifunctional Autoprocessing Repeats-in-Toxin Toxins

  2007cited by this paper
• Single-dose azithromycin for the treatment of cholera in adults.

  2006cited by this paper
• Antibodies Enhance Interaction of Vibrio cholerae with Intestinal M-Like Cells

  2006cited by this paper
• TLR1- and TLR6-independent Recognition of Bacterial Lipopeptides*

  2006cited by this paper
• Toll-like receptors and innate immunity

  2006cited by this paper
• Going against the grain: chemotaxis and infection in Vibrio cholerae

  2005cited by this paper
• Differential Induction of the Toll-Like Receptor 4-MyD88-Dependent and -Independent Signaling Pathways by Endotoxins

  2005cited by this paper
• Virus Infection Switches TLR-3-Positive Human Neurons To Become Strong Producers of Beta Interferon

  2005cited by this paper
• Role of Toll-Like Receptor 4 in the Proinflammatory Response to Vibrio cholerae O1 El Tor Strains Deficient in Production of Cholera Toxin and Accessory Toxins

  2005cited by this paper
• Crystal structure of the Vibrio cholerae cytolysin (VCC) pro-toxin and its assembly into a heptameric transmembrane pore.

  2005cited by this paper
• LPS, TLR4 and infectious disease diversity

  2005cited by this paper
• Toll-like receptors in innate immunity.

  2004cited by this paper
• Association of adherence and motility in interleukin 8 induction in human intestinal epithelial cells by Vibrio cholerae.

  2004cited by this paper
• Toll-like receptor signalling

  2004cited by this paper
• The role of Toll-like receptors and Nod proteins in bacterial infection.

  2004cited by this paper
• Induction of Interleukin-8 in T84 Cells by Vibrio cholerae

  2004cited by this paper
• Transcriptional Responses of Intestinal Epithelial Cells to Infection with Vibrio cholerae

  2004cited by this paper
• Recognition of bacterial peptidoglycan by the innate immune system

  2003cited by this paper
• Development of Microbial-Human Enterocyte Interaction: Cholera Toxin

  2003cited by this paper
• Hijacking Rho GTPases by protein toxins and apoptosis: molecular strategies of pathogenic bacteria

  2003cited by this paper
• Activation and suppression of the proinflammatory immune response by Vibrio cholerae toxins.

  2003cited by this paper
• Nods, Nalps and Naip: intracellular regulators of bacterial‐induced inflammation

  2003cited by this paper
• The Contribution of Accessory Toxins of Vibrio cholerae O1 El Tor to the Proinflammatory Response in a Murine Pulmonary Cholera Model

  2002cited by this paper
• Comparison of single-dose azithromycin and 12-dose, 3-day erythromycin for childhood cholera: a randomised, double-blind trial.

  2002cited by this paper
• TLR4‐dependent recognition of lipopolysaccharide by epithelial cells requires sCD14

  2002cited by this paper
• Increased Levels of Inflammatory Mediators in Children and Adults Infected with Vibrio cholerae O1 and O139

  2002cited by this paper
• RICK/Rip2/CARDIAK mediates signalling for receptors of the innate and adaptive immune systems

  2002influential reference
• Increased nitrite and nitrate concentrations in sera and urine of patients with cholera or shigellosis

  2001cited by this paper
• Differential Interleukin-8 Response of Intestinal Epithelial Cell Line to Reactogenic and Nonreactogenic Candidate Vaccine Strains of Vibrio cholerae

  2001cited by this paper
• Bacterial lipopolysaccharides and innate immunity.

  2001influential reference
• Human TLR9 confers responsiveness to bacterial DNA via species-specific CpG motif recognition

  2001cited by this paper
• Characterization of the Role of the ToxR-Modulated Outer Membrane Porins OmpU and OmpT in Vibrio cholerae Virulence

  2001influential reference
• The innate immune response to bacterial flagellin is mediated by Toll-like receptor 5

  2001cited by this paper
• Structural basis for signal transduction by the Toll/interleukin-1 receptor domains

  2000cited by this paper
• Seasonal, nontoxigenic Vibrio cholerae O1 Ogawa infections in the Eastern Region of Saudi Arabia.

  2000cited by this paper
• Detection of faecal leucocytes & erythrocytes from stools of cholera patients suggesting an evidence of an inflammatory response in cholera.

  2000cited by this paper
• Preliminary Assessment of the Safety and Immunogenicity of a New CTXΦ-Negative, Hemagglutinin/Protease-Defective El Tor Strain as a Cholera Vaccine Candidate

  1999cited by this paper
• Morphological and cytoskeletal changes caused by non-membrane damaging cytotoxin of Vibrio cholerae on int 407 and HeLa cells.

  1999cited by this paper
• TcpP protein is a positive regulator of virulence gene expression in Vibrio cholerae.

  1998cited by this paper
• Adherence of Vibrio cholerae to cultured differentiated human intestinal cells: an in vitro colonization model

  1997cited by this paper
• The 18‐wheeler mutation reveals complex antibacterial gene regulation in Drosophila host defense

  1997cited by this paper
• Neisseria gonorrhoeae Epithelial Cell Interaction Leads to the Activation of the Transcription Factors Nuclear Factor κB and Activator Protein 1 and the Induction of Inflammatory Cytokines

  1997cited by this paper
• Copyright © 1998, American Society for Microbiology Differential Regulation of Multiple Flagellins in Vibrio cholerae

  1997cited by this paper
• The evolution of epidemic Vibrio cholerae strains.

  1997cited by this paper
• New evidence for an inflammatory component in diarrhea caused by selected new, live attenuated cholera vaccines and by El Tor and Q139 Vibrio cholerae

  1996cited by this paper
• Randomised controlled comparison of single-dose ciprofloxacin and doxycycline for cholera caused by Vibrio cholerae O1 or O139

  1996cited by this paper
• Erythromycin and trimethoprim-sulphamethoxazole in the treatment of cholera in children.

  1996cited by this paper
• Safety, immunogenicity, and efficacy of live attenuated Vibrio cholerae 0139 vaccine prototype

  1995cited by this paper
• Ultrastructural changes in the upper small intestinal mucosa in patients with cholera.

  1995cited by this paper

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  2020cites this paper