Ligand binding and the gelation of sickle cell hemoglobin.

No abstract is available for this paper.

• Publication year

  1979

• Venue

  Journal of Molecular Biology

• Publication date

  1979-03-01

• Fields of study

  Medicine, Chemistry

• Identifiers
  DOI 10.1016/0022-2836(79)90092-5PMID 439139
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Three-dimensional reconstruction of the 14-filament fibers of hemoglobin S.

  1979cited by this paper
• Mixed gelation theory. Kinetics, equilibrium and gel incorporation in sickle hemoglobin mixtures.

  1979cited by this paper
• Oxygen binding to sickle cell hemoglobin.

  1979cited by this paper
• Gelation of sickle cell hemoglobin in mixtures with normal adult and fetal hemoglobins.

  1979cited by this paper
• X-ray diffraction studies of fibers and crystals of deoxygenated sickle cell hemoglobin.

  1979cited by this paper
• Aggregation effects on oxygen binding of sickle cell hemoglobin.

  1978cited by this paper
• Three-dimensional reconstruction of the fibres of sickle cell haemoglobin

  1978cited by this paper
• Temperature dependence of nonideality in concentrated solutions of hemoglobin.

  1978cited by this paper
• Oxygen affinity as an index of hemoglobin S polymerization: a new micromethod.

  1978cited by this paper
• Sickle hemoglobin gelation. Reaction order and critical nucleus size.

  1978cited by this paper
• Gelation of sickle cell hemoglobin. IV. Phase transitions in hemoglobin S gels: separate measures of aggregation and solution--gel equilibrium.

  1978cited by this paper
• Thermodynamics of gelation of sickle cell deoxyhemoglobin.

  1977cited by this paper
• Effects of amino acids on gelation kinetics and solubility of sickle hemoglobin.

  1977cited by this paper
• Analysis of non-ideal behavior in concentrated hemoglobin solutions.

  1977cited by this paper
• Mechanism of inhibition of hemoglobin S polymerization by cyanate.

  1977cited by this paper
• Participation of hemoglobins A and F in polymerization of sickle hemoglobin.

  1977cited by this paper
• Effect of 2, 3-diphosphoglycerate on the solubility of deoxy-sickle hemoglobin.

  1977cited by this paper
• Non-ideality and the thermodynamics of sickle-cell hemoglobin gelation.

  1977cited by this paper
• Polymorphism of sickle cell hemoglobin fibers.

  1976cited by this paper
• Bacteriophage T4 polyheads: crystallographic and geometrical conventions.

  1976cited by this paper
• Editorial: Delay time of gelation: a possible determinant of clinical severity in sickle cell disease

  1976cited by this paper
• Effect of oxygen concentration on transverse water proton relaxation times in erythrocytes homozygous and heterozygous for hemoglobin S

  1976cited by this paper
• Linear dichroism of biological chromophores.

  1976cited by this paper
• Structure of horse carbonmonoxyhaemoglobin.

  1976cited by this paper
• Editorial: Delay time of gelation: a possible determinant of clinical severity in sickle cell disease.

  1976cited by this paper
• Comparison of sickle cell hemoglobin gelation kinetics measured by NMR and optical methods.

  1976cited by this paper
• Thermodynamic studies of polymerization of deoxygenated sickle cell hemoglobin.

  1976cited by this paper
• Supersaturation in sickle cell hemoglobin solutions.

  1976cited by this paper
• Determinants of red cell sickling. Effects of varying pH and of increasing intracellular hemoglobin concentration by osmotic shrinkage.

  1976cited by this paper
• Structure and mechanism of haemoglobin.

  1976cited by this paper
• Relations between oxygen saturation and aggregation of sickle-cell hemoglobin.

  1976cited by this paper
• Three-dimensional Fourier synthesis of human deoxyhemoglobin at 2-5 A resolution I. X-ray analysis.

  1976cited by this paper
• Three-dimensional fourier synthesis of human deoxyhaemoglobin at 2-5 A resolution: refinement of the atomic model.

  1975cited by this paper
• Calorimetric and optical characterization of sickle cell hemoglobin gelation.

  1975cited by this paper
• Cooperative interactions of hemoglobin.

  1975cited by this paper
• The Concentration Dependence of the Oxygen Affinity of Haemoglobin S

  1975cited by this paper
• Gelation of sickle hemoglobin. III. Nitrosyl hemoglobin.

  1975cited by this paper
• Crystal structure of sickle-cell deoxyhemoglobin at 5 A resolution.

  1975cited by this paper
• Structures of deoxy and carbonmonoxy haemoglobin Kansas in the deoxy quaternary conformation.

  1975cited by this paper
• Analysis of cooperativity in hemoglobin. Valency hybrids, oxidation, and methemoglobin replacement reactions.

  1975cited by this paper
• Structure and function of haemoglobin.

  1975cited by this paper
• Allosteric interpretation of haemoglobin properties

  1975cited by this paper
• Continuous determination of the oxygen dissociation curve for whole blood.

  1975cited by this paper
• Optical spectra and electronic structure of flavine mononucleotide in flavodoxin crystals.

  1975cited by this paper
• Thermodynamic analysis of the chemical inhibition of sickle-cell hemoglobin gelation.

  1975cited by this paper
• Kinetics and mechanism of deoxyhemoglobin S gelation: a new approach to understanding sickle cell disease.

  1974cited by this paper
• Optically Detected Conformational Changes in Haemoglobin Single Crystals

  1974cited by this paper
• A thermodynamic model for gelation of sickle-cell hemoglobin.

  1974cited by this paper
• The rates of polymerization and depolymerization of sickle cell hemoglobin.

  1974cited by this paper
• Effect of alkylureas on the polymerization of hemoglobin S.

  1974cited by this paper
• Structure of hemoglobin S fibers: optical determination of the molecular orientation in sickled erythrocytes.

  1973cited by this paper
• Use of a Stable Polarization Modulator in a Scanning Spectrophotometer and Ellipsometer

  1973cited by this paper
• Concerted formation of the gel of hemoglobin S.

  1973cited by this paper
• An enzymic reduction system for metmyoglobin and methemoglobin, and its application to functional studies of oxygen carriers.

  1973cited by this paper
• Structure of sickled erythrocytes and of sickle-cell hemoglobin fibers.

  1973cited by this paper
• Effects of pH, 2,3-diphosphoglycerate and salts on gelation of sickle cell deoxyhemoglobin.

  1973cited by this paper
• Erythrocyte Hb-S concentration. An important factor in the low oxygen affinity of blood in sickle cell anemia.

  1973cited by this paper
• Analyses of oxygen equilibria of native and chemically modified human adult hemoglobins on the basis of Adair's stepwise oxygenation theory and the allosteric model of Monod, Wyman, and Changeux.

  1973cited by this paper
• Analysis of oxygen equilibrium of hemoglobin and control mechanism of organic phosphates.

  1973cited by this paper
• POLARIZED SINGLE CRYSTAL ABSORPTION SPECTRA OF CARBOXY‐ AND OXYHEMOGLOBIN

  1973cited by this paper
• A mathematical model for structure-function relations in hemoglobin.

  1972cited by this paper
• X-ray Diffraction Study of Binding of 2,3-Diphosphoglycerate to Human Deoxyhaemoglobin

  1972cited by this paper
• Intermolecular Organization of Deoxygenated Sickle Haemoglobin determined by X-ray Diffraction

  1972cited by this paper
• Ligand-induced conformational dependence of hemoglobin in sickling interactios.

  1971cited by this paper
• Effect of isozanthopterin on the activity of transforming DNA in Bacillus subtilis.

  1971cited by this paper
• Hemoglobin Interaction: Modification of Solid Phase Composition in the Sickling Phenomenon

  1970cited by this paper
• Stereochemistry of Cooperative Effects in Haemoglobin: Haem–Haem Interaction and the Problem of Allostery

  1970cited by this paper
• Polarized single-crystal absorption spectrum of 1-methyluracil.

  1970cited by this paper
• Stereochemistry of cooperative effects in haemoglobin.

  1970cited by this paper
• Piezo-Optical Birefringence Modulators: New Use for a Long-Known Effect

  1969cited by this paper
• The binding of carbon monoxide by human hemoglobin. Proof of validity of the spectrophotometric method and direct determination of the equilibrium.

  1968cited by this paper
• Single-crystal spectra of ferrimyoglobin complexes in polarized light.

  1968cited by this paper
• Blood oxygen dissociation curves in sickle cell disease.

  1967cited by this paper
• Structure and Properties of Hemoglobin Charlem, a Human Hemoglobin Variant with Amino Acid Substitutions in 2 Residues of the β-Polypeptide Chain

  1967cited by this paper
• Structure and properties of hemoglobin C-Harlem, a human hemoglobin variant with amino acid substitutions in 2 residues of the beta-polypeptide chain.

  1967cited by this paper
• ON THE NATURE OF ALLOSTERIC TRANSITIONS: A PLAUSIBLE MODEL.

  1965cited by this paper
• Studies on the destruction of red blood cells. XII. Factors influencing the role of S hemoglobin in the pathologic physiology of sickle cell anemia and related disorders.

  1957cited by this paper
• Protein interactions. Aggregation of globular proteins

  1953cited by this paper
• Studies on abnormal hemoglobins. VIII. The gelling phenomenon of sickle cell hemoglobin: its biologic and diagnostic significance.

  1953cited by this paper
• Physical chemistry of protein solutions; derivation of the equations for the osmotic pressure.

  1946cited by this paper
• A theory of partial osmotic pressures and membrane equilibria, with special reference to the application of Dalton's Law to hæmoglobin solutions in the presence of salts

  1928cited by this paper
• SICKLE CELL ANEMIA: REPORT OF A CASE GREATLY IMPROVED BY SPLENECTOMY. EXPERIMENTAL STUDY OF SICKLE CELL FORMATION

  1927cited by this paper
• THE HEMOGLOBIN SYSTEM VI. THE OXYGEN DISSOCIATION CURVE OF HEMOGLOBIN

  1925cited by this paper

• MWC allosteric model explains unusual hemoglobin-oxygen binding curves from sickle cell drug binding

  2021cites this paper
• Hemoglobin S polymerization and sickle cell disease: A retrospective on the occasion of the 70th anniversary of Pauling's Science paper

  2019cites this paper
• The Biophysical Basis of Drug Therapy for Sickle Cell Disease

  2018cites this paper
• Universality of supersaturation in protein-fiber formation

  2016cites this paper
• Calibrating Sickle Cell Disease.

  2016cites this paper
• The growth of sickle hemoglobin polymers.

  2011cites this paper
• Approche biomimétique de la vaso-occlusion dans la drépanocytose: production de vésicules et microfluidique

  2011cites this paper
• Fiber depolymerization: fracture, fragments, vanishing times, and stochastics in sickle hemoglobin.

  2009cites this paper
• OPTIMIZACIÓN DE LA POLIMERIZACIÓN DE LA HEMOGLOBINA S EN FUNCIÓN DE LA DESOXIGENACIÓN Y LA TEMPERATURA

  2009cites this paper
• Universal metastability of sickle hemoglobin polymerization.

  2008cites this paper
• Polymerization and Sickle Cell Disease: A Molecular View

  2004cites this paper
• Sickle hemoglobin fibers: mechanisms of depolymerization.

  2002cites this paper
• EFFECTS OF DEOXYGENATION IN SICKLE CELL ANEMIA By DAVID G. MORIO A THESIS PRESENTED TO THE GRADUATE SCHOOL OF THE UNIVERSITY OF FLORIDA IN PARTIAL FULFILLMENT OF THE REQUIREMENTS FOR THE DEGREE OF MASTER OF SCIENCE UNIVERSITY OF FLORIDA

  2000cites this paper
• Sickle hemoglobin polymer melting in high concentration phosphate buffer.

  1999cites this paper
• RHEOLOGY OF BLOOD CELLS IN SICKLE CELL DISEASE

  1997cites this paper
• A study of the mechanisms of slow religation to sickle cell hemoglobin polymers following laser photolysis.

  1996cites this paper
• Solubility of sickle hemoglobin measured by a kinetic micromethod.

  1996cites this paper
• EFFECTS OF DEOXYGENATION IN SICKLE CELL ANEMIA

  1996cites this paper
• Carbon Monoxide Religation Kinetics to Hemoglobin S Polymers following Ligand Photolysis (*)

  1995cites this paper
• Fragility and structure of hemoglobin S fibers and gels and their consequences for gelation kinetics and rheology.

  1994cites this paper
• Fragility and structure of hemoglobin S fibers and gels and their consequences for gelation kinetics and rheology

  1994cites this paper
• Sparing effect of hemoglobin F and hemoglobin A2 on the polymerization of hemoglobin S at physiologic ligand saturations.

  1993cites this paper
• Sickle cell disease pathophysiology.

  1993cites this paper
• 3 Sickle cell disease pathophysiology

  1993cites this paper
• Time course of chemical and structural events in protein crystals measured by microspectrophotometry

  1992cites this paper
• Polymerization and solubility of Ni(II)-Fe(II) hybrid Hb S.

  1991cites this paper
• Sickle cell hemoglobin polymerization.

  1990cites this paper
• The influence of oxygen tension, temperature, and hemoglobin concentration on the rheologic properties of sickle erythrocytes.

  1990cites this paper
• Monomer diffusion into polymer domains in sickle hemoglobin.

  1990cites this paper
• 2,3-Diphosphoglycerate and intracellular pH as interdependent determinants of the physiologic solubility of deoxyhemoglobin S.

  1990cites this paper
• Theoretical description of the spatial dependence of sickle hemoglobin polymerization.

  1990cites this paper
• Current Perspectives on the Kinetics of Hemoglobin S Gelation

  1989cites this paper
• Kinetic Models and the Pathophysiology of Sickle Cell Disease a

  1989cites this paper
• Correlation of polarized absorption spectroscopic and X-ray diffraction studies of crystalline cytosolic aspartate aminotransferase of pig hearts.

  1988cites this paper
• Dependence on pH of formation and oxygen affinity of hemoglobin S fibers in the presence and absence of phosphates and polyphosphates.

  1987cites this paper
• Hemoglobin S gelation and sickle cell disease.

  1987cites this paper
• Delay time of hemoglobin S polymerization prevents most cells from sickling in vivo.

  1987cites this paper
• Increasing haemoglobin oxygen affinity to prevent sickling: abnormal haemoglobin variants as models

  1986cites this paper
• Covalent binding of glutathione to hemoglobin. I. Inhibition of hemoglobin S polymerization.

  1986cites this paper
• Kinetics of sickle hemoglobin polymerization. III. Nucleation rates determined from stochastic fluctuations in polymerization progress curves.

  1986cites this paper
• Deoxygenated sickle hemoglobin. Modulation of its solubility by 2,3-diphosphoglycerate and other allosteric polyanions.

  1985cites this paper
• Naturally crystalline hemoglobin of the nematode Mermis nigrescens. An in situ microspectrophotometric study of chemical properties and dichroism.

  1985cites this paper
• Hemoglobin S polymerization: primary determinant of the hemolytic and clinical severity of the sickling syndromes.

  1985cites this paper
• Sickle hemoglobin polymerization in solution and in cells.

  1985cites this paper
• Kinetics of sickle hemoglobin polymerization. II. A double nucleation mechanism.

  1985cites this paper
• Kinetics of sickle hemoglobin polymerization. I. Studies using temperature-jump and laser photolysis techniques.

  1985cites this paper
• Synthesis of pyridine derivatives of L-phenylalanine as antisickling reagents.

  1984cites this paper
• Polymerization in erythrocytes containing S and non-S hemoglobins.

  1984influential citation
• Sickle cell disease: the proportion of liganded haemoglobin needed to prevent crises

  1983cites this paper
• Cardiorespiratory adjustments in chronic sickle cell anemia.

  1983cites this paper
• Intracellular polymerization of sickle hemoglobin. Effects of cell heterogeneity.

  1983cites this paper
• Oxygen binding by sickle cell hemoglobin polymers.

  1982cites this paper
• Evidence of the incorporation of normally nonaggregating hemoglobins into crystalline aggregates of deoxy hemoglobin S.

  1982cites this paper
• Effect of liganded hemoglobin S and hemoglobin A on the aggregation of deoxy-hemoglobin S.

  1982cites this paper
• Determination of sickle hemoglobin polymer in SS and AS erythrocytes.

  1982cites this paper
• DifferentiaI PoIarization Spectroscopy on Single Crystals of Transition Metal Complexes

  1982cites this paper
• Recent results from single‐cell microspectrophotometry: Cone pigments in frog, fish, and monkey

  1982cites this paper
• The Effect of Oxygen Saturation on the Intracellular Polymerization of Sickle Hemoglobin

  1982cites this paper
• Hemoglobin solubility as a function of fractional oxygen saturation for hemoglobins in polyethylene glycol: a sickle hemoglobin model.

  1981cites this paper
• Polymerization of hemoglobin in sickle trait erythrocytes and lysates.

  1981cites this paper
• Methods for the study of sickling and hemoglobin S gelation.

  1981cites this paper
• Polarized absorption and linear dichroism spectroscopy of hemoglobin.

  1981cites this paper
• The intracellular polymerization of sickle hemoglobin and its relevance to sickle cell disease.

  1981cites this paper
• Oxygen binding to sickle cell hemoglobin.

  1981cites this paper
• [48] Oxygen binding to sickle cell hemoglobin

  1981cites this paper
• Oxygen Binding and the Gelation of Sickle Cell Hemoglobin

  1981cites this paper
• Contacts Between Molecular Surfaces in Crystals of Deoxygenated Human Hemoglobins A, C, F, and S

  1981cites this paper
• The Effect of Additive Conformation on Enhancement of Deoxyhemoglobin Polymerization

  1981cites this paper
• Molecular complex of lumiflavin and 2-aminobenzoic acid: crystal structure, crystal spectra, and solution properties.

  1981cites this paper
• The physical chemistry of the gelation of sickle hemoglobin.

  1980cites this paper
• Determination of deoxyhemoglobin S polymer in sickle erythrocytes upon deoxygenation.

  1980cites this paper
• Effect of other hemoglobins on gelation of sickle cell hemoglobin.

  1980cites this paper
• Kinetic studies on photolysis-induced gelation of sickle cell hemoglobin suggest a new mechanism.

  1980cites this paper
• Ligand-linked phase equilibria of sickle cell hemoglobin.

  1980cites this paper
• Hemoglobin gelation.

  1980cites this paper
• Gelation of sickle cell hemoglobin in mixtures with normal adult and fetal hemoglobins.

  1979cites this paper
• 13C NMR quantitation of polymer in deoxyhemoglobin S gels.

  1979cites this paper
• The effect of non-aggregating proteins upon the gelation of sickle cell hemoglobin: model calculations and data analysis.

  1979cites this paper