The intracellular polymerization of sickle hemoglobin and its relevance to sickle cell disease.

No abstract is available for this paper.

• Publication year

  1981

• Venue

  Blood

• Publication date

  1981-12-01

• Fields of study

  Biology, Medicine, Chemistry

• Identifiers
  DOI 10.1182/BLOOD.V58.6.1057.BLOODJOURNAL5861057PMID 7030432
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Aggregation and crystallization of hemoglobins A, S, and C. Probable formation of different nuclei for gelation and crystallization.

  1981cited by this paper
• Oxygen binding to sickle cell hemoglobin.

  1981cited by this paper
• Polymerization of hemoglobin in sickle trait erythrocytes and lysates.

  1981cited by this paper
• Interaction of sickle cell hemoglobin with erythrocyte membranes.

  1981cited by this paper
• Excluded volume as a determinant of macromolecular structure and reactivity

  1981cited by this paper
• The effect of erythrocyte membrane preparations on the polymerization of sickle hemoglobin.

  1981cited by this paper
• Separate mechanisms of deformability loss in ATP-depleted and Ca-loaded erythrocytes.

  1981cited by this paper
• Analysis of factors regulating erythrocyte deformability.

  1980cited by this paper
• Solid-like behaviour of unsheared sickle haemoglobin gels and the effects of shear

  1980cited by this paper
• A study of induced hyponatremia in the prevention and treatment of sickle-cell crisis.

  1980cited by this paper
• Beta-chain contact sites in the haemoglobin S polymer.

  1980cited by this paper
• Nucleation-controlled aggregation of deoxyhemoglobin S. Participation of hemoglobin A in the aggregation of deoxyhemoglobin S in concentrated phosphate buffer.

  1980cited by this paper
• Kinetic studies on photolysis-induced gelation of sickle cell hemoglobin suggest a new mechanism.

  1980cited by this paper
• Ektacytometric analysis of factors regulating red cell deformability.

  1980cited by this paper
• Deoxygenated sickle hemoglobin: phase transformation from fiber to a new monoclinic crystalline form.

  1980cited by this paper
• Abnormal adherence of sickle erythrocytes to cultured vascular endothelium: possible mechanism for microvascular occlusion in sickle cell disease.

  1980cited by this paper
• Deformability of oxygenated irreversibly sickled cells.

  1980cited by this paper
• Solubilization of hemoglobin S by other hemoglobins.

  1980cited by this paper
• Erythrocyte adherence to endothelium in sickle-cell anemia. A possible determinant of disease severity.

  1980cited by this paper
• Determination of deoxyhemoglobin S polymer in sickle erythrocytes upon deoxygenation.

  1980cited by this paper
• Ligand-linked phase equilibria of sickle cell hemoglobin.

  1980cited by this paper
• Noncovalent inhibitors of sickle hemoglobin gelation: effects of aliphatic alcohols, amides, and ureas.

  1980cited by this paper
• Effect of cetiedil on erythrocyte sickling: new type of antisickling agent that may affect erythrocyte membranes.

  1980cited by this paper
• Nucleation-controlled aggregation of deoxyhemoglobin S. Participation of hemoglobin F in the aggregation of deoxyhemoglobin S in concentrated phosphate buffer.

  1980cited by this paper
• Cetiedil: its potential usefulness in sickle cell disease.

  1980cited by this paper
• X-ray diffraction studies of fibers and crystals of deoxygenated sickle cell hemoglobin.

  1979cited by this paper
• Red blood cell deformability and hemolytic anemias.

  1979cited by this paper
• Carbon-13-proton nuclear magnetic double-resonance study of deoxyhemoglobin S gelation.

  1979cited by this paper
• Membrane abnormalities of irreversibly sickled cells.

  1979cited by this paper
• Recent developments in the molecular genetics of human hemoglobin.

  1979cited by this paper
• Cellular and molecular regulation of hemoglobin switching

  1979cited by this paper
• Spin-label studies of membrane-associated denatured hemoglobin in normal and sickle cells.

  1979cited by this paper
• Ligand binding and the gelation of sickle cell hemoglobin.

  1979cited by this paper
• Hemoglobin aggregation in oxygenated sickle cells studied by carbon‐13 rotating frame spin–lattice relaxation in the presence of an off‐resonance radiofrequency field

  1979cited by this paper
• Functional properties of human hemoglobin bound to the erythrocyte membrane.

  1979cited by this paper
• Thermodynamic study of the crystallization of sickle-cell deoxyhemoglobin (hemoglobin S solubility/saturation concentration/enthalpy of crystallization/entropy of crystallization).

  1979cited by this paper
• Adhesion of normal and sickle erythrocytes to endothelial monolayer cultures.

  1979cited by this paper
• Three-dimensional reconstruction of the 14-filament fibers of hemoglobin S.

  1979cited by this paper
• 13C NMR quantitation of polymer in deoxyhemoglobin S gels.

  1979cited by this paper
• Quantitative assessment of the noncovalent inhibition of sickle hemoglobin gelation by phenyl derivatives and other known agents.

  1979cited by this paper
• alpha Chain mutations with opposite effects on the gelation of hemoglobin S.

  1979cited by this paper
• The effect of non-aggregating proteins upon the gelation of sickle cell hemoglobin: model calculations and data analysis.

  1979cited by this paper
• Crystallization of deoxyhemoglobin S by fiber alignment and fusion.

  1979cited by this paper
• Oxygen equilibrium of emulsified solutions of normal and sickle hemoglobin.

  1979cited by this paper
• Gelation of sickle cell hemoglobin in mixtures with normal adult and fetal hemoglobins.

  1979cited by this paper
• Oxygen binding to sickle cell hemoglobin.

  1979cited by this paper
• Irreversibly sickled cells and red cell survival in sickle cell anemia: a study with both DF32P and 51CR.

  1978cited by this paper
• Rheology of Sickle Cells and Erythrocyte Content

  1978cited by this paper
• Sickle-cell anemia: molecular and cellular bases of therapeutic approaches (first of three parts).

  1978cited by this paper
• Inhibition of sickle hemoglobin gelation by amino acids and related compounds.

  1978cited by this paper
• Sickle hemoglobin gelation. Reaction order and critical nucleus size.

  1978cited by this paper
• Physical Chemistry: Principles and Applications in Biological Sciences

  1978cited by this paper
• Sickle-cell anemia: molecular and cellular bases of therapeutic approaches (second of three parts).

  1978cited by this paper
• Intermolecular effects in the polymerization of hemoglobin S.

  1978cited by this paper
• Temperature dependence of nonideality in concentrated solutions of hemoglobin.

  1978cited by this paper
• Monovalent cation composition and ATP and lipid content of irreversibly sickled cells.

  1978cited by this paper
• THE ROLE OF SPECTRIN AND ACTIN IN IRREVERSIBLY SICKLED CELLS: UNSICKLING OF “IRREVERSIBLY” SICKLED GHOSTS BY CONDITIONS WHICH INTERFERE WITH SPECTRIN-ACTIN POLYMERIZATION

  1978cited by this paper
• Requirements for therapeutic inhibition of sickle haemoglobin gelation

  1978cited by this paper
• Sickle-cell anemia: molecular and cellular bases of therapeutic approaches (third of three parts).

  1978cited by this paper
• Oxygen Delivery to Muscle Cells during Capillary Occlusion by Sickled Erythrocytes

  1978cited by this paper
• Microvascular Blood Flow of Sickled Erythrocytes A Dynamic Morphologic Study

  1978cited by this paper
• Three-dimensional reconstruction of the fibres of sickle cell haemoglobin

  1978cited by this paper
• [Sickle-cell anemia].

  1977cited by this paper
• Effects of amino acids on gelation kinetics and solubility of sickle hemoglobin.

  1977cited by this paper
• Location and bond type of intermolecular contacts in the polymerisation of haemoglobin S

  1977cited by this paper
• Kinetics of hemoglobin S gelation followed by continuously sensitive low-shear viscosity.

  1977cited by this paper
• Interaction of hemoglobin with red blood cell membranes as shown by a fluorescent chromophore.

  1977cited by this paper
• Hemoglobin-water interactions in normal and sickle erythrocytes by proton magnetic resonance T1p measurements.

  1977cited by this paper
• Suppression of irreversibly sickled erythrocytes by zinc therapy in sickle cell anemia.

  1977cited by this paper
• Inhibition of sickle cell hemoglobin gelation by some aromatic compounds.

  1977cited by this paper
• Thermodynamics of gelation of sickle cell deoxyhemoglobin.

  1977cited by this paper
• Non-ideality and the thermodynamics of sickle-cell hemoglobin gelation.

  1977cited by this paper
• Crystallization of sickle hemoglobin from gently agitated solutions--an alternative to gelation.

  1977cited by this paper
• Analysis of non-ideal behavior in concentrated hemoglobin solutions.

  1977cited by this paper
• RED CELL MEMBRANE INJURY IN SICKLE CELL ANAEMIA

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• Editorial: Delay time of gelation: a possible determinant of clinical severity in sickle cell disease.

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  1976cited by this paper
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  1976cited by this paper
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  1976cited by this paper
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• Effect of oxygen concentration on trasverse water proton relaxation times in erythrocytes homozygous and heterozygous for hemoglonin S.

  1976cited by this paper
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  1976cited by this paper
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  1976cited by this paper
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  1975cited by this paper
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  1975cited by this paper
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  1975cited by this paper
• The kinetics of the sol-gel transformation of deoxyhemoglobin S by continuous monitoring of viscosity.

  1975cited by this paper
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  1975cited by this paper
• The binding of hemoglobin to membranes of normal and sickle erythrocytes.

  1975cited by this paper
• The kinetics of the sol-gel transformation of deoxyhemoglobin S by continuous monitoring of viscosity.

  1975cited by this paper
• Evaluation of the water environments in deoxygenated sickle cells by longitudinal and transverse water proton relaxation rates.

  1975cited by this paper
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  1974cited by this paper
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  1974cited by this paper
• A thermodynamic model for gelation of sickle-cell hemoglobin.

  1974cited by this paper
• Structure of sickled erythrocytes and of sickle-cell hemoglobin fibers.

  1973cited by this paper
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  1973cited by this paper
• Membrane alterations associated with hemoglobinopathies.

  1970cited by this paper

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