Mouse Models of Prostate Cancer

The development and optimization of high-throughput screening methods has identified a multitude of genetic changes associated with human disease. The use of immunodeficient and genetically engineered mouse models that mimic the human disease has been crucial in validating the importance of these genetic pathways in prostate cancer. These models provide a platform for finding novel therapies to treat human patients afflicted with prostate cancer as well as those who have debilitating bone metastases. In this paper, we focus on the historical development and phenotypic descriptions of mouse models used to study prostate cancer. We also comment on how closely each model recapitulates human prostate cancer.

• Publication year

  2011

• Venue

  Prostate Cancer

• Publication date

  2011-02-23

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1155/2011/895238PMID 22111002PMCID 3221286
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• The hallmarks of cancer

  2012cited by this paper
• The complexities of identifying a cell of origin for human prostate cancer.

  2011cited by this paper
• Gene targeting: Enter the rat

  2010cited by this paper
• Prostate cancer from basal cells

  2010cited by this paper
• A tale of two cells: discovering the origin of prostate cancer.

  2010cited by this paper
• NKX3.1 activates cellular response to DNA damage.

  2010cited by this paper
• Of Mice and Humans: Are They the Same?—Implications in Cancer Translational Research

  2010cited by this paper
• Altering the Genome by Homologous Recombination

  2010cited by this paper
• Hepsin cooperates with MYC in the progression of adenocarcinoma in a prostate cancer mouse model

  2010cited by this paper
• Loss of Androgen Receptor-Dependent Growth Suppression by Prostate Cancer Cells Can Occur Independently from Acquiring Oncogenic Addiction to Androgen Receptor Signaling

  2010cited by this paper
• Brca2 and Trp53 Deficiency Cooperate in the Progression of Mouse Prostate Tumourigenesis

  2010cited by this paper
• Stat5 promotes metastatic behavior of human prostate cancer cells in vitro and in vivo.

  2010cited by this paper
• Modeling prostate cancer: a perspective on transgenic mouse models

  2010cited by this paper
• Molecular genetics of prostate cancer: new prospects for old challenges.

  2010cited by this paper
• An update of the Gleason grading system.

  2010cited by this paper
• Telomeres and telomerase in cancer.

  2010cited by this paper
• Production of p53 gene knockout rats by homologous recombination in embryonic stem cells

  2010cited by this paper
• Identification of a Cell of Origin for Human Prostate Cancer

  2010cited by this paper
• Generating knockout rats by transposon mutagenesis in spermatogonial stem cells

  2010cited by this paper
• Molecular characterization of the Gγ‐globin‐Tag transgenic mouse model of hormone refractory prostate cancer: Comparison to human prostate cancer

  2010cited by this paper
• Cooperativity of TMPRSS2-ERG with PI3-kinase pathway activation in prostate oncogenesis

  2009cited by this paper
• The Discovery of Common Recurrent Transmembrane Protease Serine 2 (TMPRSS2)-Erythroblastosis Virus E26 Transforming Sequence (ETS) Gene Fusions in Prostate Cancer: Significance and Clinical Implications

  2009cited by this paper
• Metastasis: from dissemination to organ-specific colonization

  2009cited by this paper
• K-ras and Wnt signaling synergize to accelerate prostate tumorigenesis in the mouse.

  2009influential reference
• Prostate cancer in dogs: comparative and clinical aspects.

  2009cited by this paper
• Osteotropic cancers: from primary tumor to bone.

  2009cited by this paper
• Activation of β‐Catenin in mouse prostate causes HGPIN and continuous prostate growth after castration

  2009cited by this paper
• A luminal epithelial stem cell that is a cell of origin for prostate cancer

  2009influential reference
• Simultaneous haploinsufficiency of Pten and Trp53 tumor suppressor genes accelerates tumorigenesis in a mouse model of prostate cancer.

  2009cited by this paper
• Knockout Rats via Embryo Microinjection of Zinc-Finger Nucleases

  2009cited by this paper
• Aberrant ERG expression cooperates with loss of PTEN to promote cancer progression in the prostate

  2009cited by this paper
• Prostate stem cells and benign prostatic hyperplasia

  2008cited by this paper
• Efficient tumor formation by single human melanoma cells

  2008cited by this paper
• A causal role for ERG in neoplastic transformation of prostate epithelium

  2008cited by this paper
• Efficient tumour formation by single human melanoma cells

  2008cited by this paper
• The current state of preclinical prostate cancer animal models

  2008influential reference
• Down-regulation of p57Kip2 induces prostate cancer in the mouse.

  2008cited by this paper
• Conditional deletion of insulin-like growth factor-I receptor in prostate epithelium.

  2008cited by this paper
• Prostate cancer induces bone metastasis through Wnt-induced bone morphogenetic protein-dependent and independent mechanisms.

  2008cited by this paper
• Role of the TMPRSS2-ERG gene fusion in prostate cancer.

  2008cited by this paper
• Laminin-332 Is a Substrate for Hepsin, a Protease Associated with Prostate Cancer Progression*

  2008cited by this paper
• Dissociation of epithelial and neuroendocrine carcinoma lineages in the transgenic adenocarcinoma of mouse prostate model of prostate cancer.

  2008cited by this paper
• The use of xenograft models for the selection of cancer treatments with the EGFR as an example.

  2008cited by this paper
• Generation of a prostate from a single adult stem cell

  2008cited by this paper
• Chromosomally unstable mouse tumours have genomic alterations similar to diverse human cancers

  2007cited by this paper
• Progression of Prostate Cancer from a Subset of p63-Positive Basal Epithelial Cells in FG/Tag Transgenic Mice

  2007cited by this paper
• Increased prostate cell proliferation and loss of cell differentiation in mice lacking prostate epithelial androgen receptor

  2007cited by this paper
• Inactivation of Apc in the mouse prostate causes prostate carcinoma.

  2007influential reference
• Vitamin D Inhibits the Formation of Prostatic Intraepithelial Neoplasia in Nkx3.1; Pten Mutant Mice

  2006cited by this paper
• Molecular markers of prostate cancer.

  2006cited by this paper
• Blockade of transforming growth factor-β signaling in tumor-reactive CD8+ T cells activates the antitumor immune response cycle

  2006cited by this paper
• The age of cancer.

  2006cited by this paper
• Conditional expression of human 15-lipoxygenase-1 in mouse prostate induces prostatic intraepithelial neoplasia: the FLiMP mouse model.

  2006cited by this paper
• Estimates of the cancer incidence and mortality in Europe in 2006.

  2006cited by this paper
• Synergy of p53 and Rb deficiency in a conditional mouse model for metastatic prostate cancer.

  2006influential reference
• Prostatic intraepithelial neoplasia and adenocarcinoma in mice expressing a probasin-Neu oncogenic transgene.

  2006influential reference
• Emergence of androgen independence at early stages of prostate cancer progression in Nkx3.1; Pten mice.

  2006cited by this paper
• Know thy mouse.

  2006cited by this paper
• Knockin of SV40 Tag oncogene in a mouse adenocarcinoma of the prostate model demonstrates advantageous features over the transgenic model

  2005cited by this paper
• In vivo models of prostate cancer metastasis to bone.

  2005cited by this paper
• Osteoblasts in prostate cancer metastasis to bone

  2005cited by this paper
• Activation of Signal Transducer and Activator of Transcription-5 in Prostate Cancer Predicts Early Recurrence

  2005cited by this paper
• Cell lines used in prostate cancer research: a compendium of old and new lines--part 2.

  2005cited by this paper
• Cell lines used in prostate cancer research: a compendium of old and new lines--part 1.

  2005cited by this paper
• Targeted biallelic inactivation of Pten in the mouse prostate leads to prostate cancer accompanied by increased epithelial cell proliferation but not by reduced apoptosis.

  2005cited by this paper
• Molecular pathology of prostate cancer

  2005cited by this paper
• A novel knock-in prostate cancer model demonstrates biology similar to that of human prostate cancer and suitable for preclinical studies.

  2005cited by this paper
• Prostate cancer cells promote osteoblastic bone metastases through Wnts.

  2005cited by this paper
• Primary cell cultures as models of prostate cancer development.

  2005cited by this paper
• TGF-ß Signaling in Fibroblasts Modulates the Oncogenic Potential of Adjacent Epithelia

  2004cited by this paper
• Conditional Deletion of Rb Causes Early Stage Prostate Cancer

  2004cited by this paper
• Histological, immunophenotypic and histomorphometric characterization of prostate cancer bone metastases.

  2004cited by this paper
• Early onset of neoplasia in the prostate and skin of mice with tissue-specific deletion of Pten.

  2004cited by this paper
• Hepsin is highly over expressed in and a new candidate for a prognostic indicator in prostate cancer.

  2004cited by this paper
• The role of fibroblast growth factors and their receptors in prostate cancer.

  2004cited by this paper
• Prostate Pathology of Genetically Engineered Mice: Definitions and Classification. The Consensus Report from the Bar Harbor Meeting of the Mouse Models of Human Cancer Consortium Prostate Pathology Committee

  2004cited by this paper
• Hepsin promotes prostate cancer progression and metastasis.

  2004cited by this paper
• Chromosomal Deletions and Tumor Suppressor Genes in Prostate Cancer

  2004cited by this paper
• Prostatic intraepithelial neoplasia and intestinal metaplasia in prostates of probasin‐RAS transgenic mice

  2004cited by this paper
• Antioxidants Block Prostate Cancer in Lady Transgenic Mice

  2004cited by this paper
• Human Lymphoid and Myeloid Cell Development in NOD/LtSz-scid IL2Rγnull Mice Engrafted with Mobilized Human Hemopoietic Stem Cells 12

  2004cited by this paper
• Prostate Carcinoma Skeletal Metastases: Cross-talk between Tumor and Bone

  2004cited by this paper
• Prostate cancer cells-osteoblast interaction shifts expression of growth/survival-related genes in prostate cancer and reduces expression of osteoprotegerin in osteoblasts.

  2003cited by this paper
• Pten Dose Dictates Cancer Progression in the Prostate

  2003cited by this paper
• Models of metastatic prostate cancer: a transgenic perspective

  2003cited by this paper
• In vivo regeneration of murine prostate from dissociated cell populations of postnatal epithelia and urogenital sinus mesenchyme

  2003cited by this paper
• Molecular genetics of prostate cancer.

  2003cited by this paper
• Inducible prostate intraepithelial neoplasia with reversible hyperplasia in conditional FGFR1-expressing mice.

  2003cited by this paper
• Myc-driven murine prostate cancer shares molecular features with human prostate tumors.

  2003cited by this paper
• Nkx3.1; Pten mutant mice develop invasive prostate adenocarcinoma and lymph node metastases.

  2003cited by this paper
• Comparative biology of mouse versus human cells: modelling human cancer in mice

  2003cited by this paper
• Mouse strains for prostate tumorigenesis based on genes altered in human prostate cancer.

  2003cited by this paper
• Activation of β-catenin in prostate epithelium induces hyperplasias and squamous transdifferentiation

  2003cited by this paper
• Prostate-specific deletion of the murine Pten tumor suppressor gene leads to metastatic prostate cancer.

  2003cited by this paper
• Molecular characterization of human prostate carcinoma cell lines

  2003cited by this paper
• Animal models of bone metastasis

  2003cited by this paper
• The role of PTEN in the progression and survival of prostate cancer.

  2003cited by this paper
• Mouse models of prostate carcinogenesis.

  2002cited by this paper
• Nkx3.1 mutant mice recapitulate early stages of prostate carcinogenesis.

  2002cited by this paper
• Prostate targeting: PSP94 gene promoter/enhancer region directed prostate tissue-specific expression in a transgenic mouse prostate cancer model

  2002cited by this paper

• A spatiotemporal atlas of orchiectomy-induced androgen deprivation-mediated modulation of cellular composition and gene expression in the mouse prostate

  2025cites this paper
• A spatiotemporal atlas of orchiectomy-induced androgen deprivation-mediated modulation of cellular composition and gene expression in the mouse prostate

  2025cites this paper
• Advancing ex vivo functional whole-organ prostate gland model for regeneration and drug screening

  2025cites this paper
• Emerging Perspectives in Zinc Transporter Research in Prostate Cancer: An Updated Review

  2024cites this paper
• An orthotopic prostate cancer model for new treatment development using syngeneic or patient‐derived tumors

  2024cites this paper
• Ex vivo functional whole organ in biomedical research: a review

  2024cites this paper
• Epigenetics of Dietary Phytochemicals in Cancer Prevention: Fact or Fiction.

  2024cites this paper
• Preclinical Tumor Mouse Models for Studying Esophageal Cancer.

  2023cites this paper
• Stem cells from a malignant rat prostate cell line generate prostate cancers in vivo: a model for prostate cancer stem cell propagated tumor growth.

  2022cites this paper
• TUBB4A interacts with MYH9 to protect the nucleus during cell migration and promotes prostate cancer via GSK3β/β-catenin signalling

  2022cites this paper
• Regulation and role of CAMKK2 in prostate cancer

  2022cites this paper
• Conversion of a Non-Cancer-Selective Promoter into a Cancer-Selective Promoter

  2022cites this paper
• PTEN‐knockout regulates metabolic rewiring and epigenetic reprogramming in prostate cancer and chemoprevention by triterpenoid ursolic acid

  2022cites this paper
• An overview of the latest in state-of-the-art murine models for prostate cancer

  2021cites this paper
• Pyruvate Kinase M1 Suppresses Development and Progression of Prostate Adenocarcinoma

  2021cites this paper
• Lab Animal Models and Analogies with Humans

  2021cites this paper
• Quercetin–Resveratrol Combination for Prostate Cancer Management in TRAMP Mice

  2020cites this paper
• In vivo magnetic resonance imaging of orthotopic prostate cancer.

  2020cites this paper
• PTEN deletion drives aberrations of DNA methylome and transcriptome in different stages of prostate cancer

  2020cites this paper
• USP22 functions as an oncogenic driver in prostate cancer by regulating cell proliferation and DNA repair.

  2019cites this paper
• Transgenic Adenocarcinoma of the Mouse Prostate (TRAMP) model: A good alternative to study PCa progression and chemoprevention approaches

  2019cites this paper
• Prostate Structure and Function

  2019cites this paper
• A mouse model of prostate cancer bone metastasis in a syngeneic immunocompetent host

  2019cites this paper
• Epigenetics and prostate cancer: defining the timing of DNA methyltransferase deregulation during prostate cancer progression.

  2019cites this paper
• Biomarker discovery for disease progression and metastasis in prostate cancer : a multi-omic approach

  2019cites this paper
• Dynamic CTC phenotypes in metastatic prostate cancer models visualized using magnetic ranking cytometry.

  2018cites this paper
• Recent advances in prostate cancer research: large-scale genomic analyses reveal novel driver mutations and DNA repair defects

  2018cites this paper
• Identification, Histological Characterization, and Dissection of Mouse Prostate Lobes for In Vitro 3D Spheroid Culture Models.

  2018cites this paper
• Prostate-specific markers to identify rare prostate cancer cells in liquid biopsies

  2018cites this paper
• Modeling Human Prostate Cancer Progression in vitro.

  2018cites this paper
• Epigenetic alterations in TRAMP mice: epigenome DNA methylation profiling using MeDIP-seq

  2018cites this paper
• Soft agar-based selection of spontaneously transformed rat prostate epithelial cells with highly tumorigenic characteristics.

  2018cites this paper
• Quantitative Proteomics of TRAMP Mice Combined with Bioinformatics Analysis Reveals That PDGF-B Regulatory Network Plays a Key Role in Prostate Cancer Progression.

  2018cites this paper
• Development of a Mouse Model of Prostate Cancer Using the Sleeping Beauty Transposon and Electroporation

  2018cites this paper
• Overview of Genetically Engineered Mouse Models of Prostate Cancer and Their Applications in Drug Discovery

  2018cites this paper
• Function and evolution of Protein kinase A splice variant Cβ2 and its role as a biomarker in prostate cancer

  2017cites this paper
• Deletion of tumor suppressors adenomatous polyposis coli and Smad4 in murine luminal epithelial cells causes invasive prostate cancer and loss of androgen receptor expression

  2017cites this paper
• ΔNp63α promotes adhesion of metastatic prostate cancer cells to the bone through regulation of CD82

  2017cites this paper
• Vitamin D3 Prevents Calcium-Induced Progression of Early-Stage Prostate Tumors by Counteracting TRPC6 and Calcium Sensing Receptor Upregulation.

  2017cites this paper
• Pathology and Molecular Pathology of Prostate Cancer

  2017cites this paper
• The role of PIM1/PIM2 kinases in tumors of the male reproductive system

  2016cites this paper
• A simple selection-free method for detecting disseminated tumor cells (DTCs) in murine bone marrow

  2016cites this paper
• c-MYC drives histone demethylase PHF8 during neuroendocrine differentiation and in castration-resistant prostate cancer

  2016cites this paper
• Murine Prostate Micro-dissection and Surgical Castration.

  2016cites this paper
• Mouse Models in Prostate Cancer Translational Research: From Xenograft to PDX

  2016cites this paper
• Linneg Sca-1high CD49fhigh prostate cancer cells derived from the Hi-Myc mouse model are tumor-initiating cells with basal-epithelial characteristics and differentiation potential in vitro and in vivo

  2016cites this paper
• A Balanced Tissue Composition Reveals New Metabolic and Gene Expression Markers in Prostate Cancer

  2016cites this paper
• Advances in prostate cancer research models: From transgenic mice to tumor xenografting models

  2016cites this paper
• Genetic and Epigenetic Profiling of Human Prostate Cancer Cell-Subsets

  2016cites this paper
• Genetically engineered mouse models to study prostate cancer.

  2015cites this paper
• Drug discovery in prostate cancer mouse models

  2015cites this paper
• Development of an orthotopic model of human metastatic prostate cancer in the NOD-SCIDγ mouse (Mus musculus) anterior prostate

  2015cites this paper
• Quantitative volumetric imaging of normal, neoplastic and hyperplastic mouse prostate using ultrasound

  2015cites this paper
• Animal Models of Bone Metastasis

  2015cites this paper
• Concurrent Hepsin overexpression and adenomatous polyposis coli deletion causes invasive prostate carcinoma in mice

  2015cites this paper
• Prolactin-induced prostate tumorigenesis.

  2015cites this paper
• In vitro and in vivo model systems used in prostate cancer research.

  2015cites this paper
• Prostate cancer metastasis: roles of recruitment and reprogramming, cell signal network and three-dimensional growth characteristics

  2015cites this paper
• Animal Models of Metastasis

  2015cites this paper
• Carcinogenesis & Mutagenesis Pim 1 Kinase Cooperates with Hormone Treatment to Promote Bladder and Ureteral Urothelial Hyperplasia

  2014cites this paper
• Exploration of a xenograft model of human prostate cancer to predict patient treatment response

  2014cites this paper
• Deletion of Atbf1/Zfhx3 In Mouse Prostate Causes Neoplastic Lesions, Likely by Attenuation of Membrane and Secretory Proteins and Multiple Signaling Pathways

  2014cites this paper
• Pim1 Kinase Cooperates with Hormone Treatment to Promote Bladder and Ureteral Urothelial Hyperplasia

  2014cites this paper
• Activation of Wnt/β‐catenin signaling in a subpopulation of murine prostate luminal epithelial cells induces high grade prostate intraepithelial neoplasia

  2014cites this paper
• Role of androgen receptor co-repressor SLIRP in cell cycle regulation

  2014cites this paper
• Devices and systems targeted towards augmented robotic radical prostatectomy

  2013cites this paper
• Lack of an additive effect between the deletions of Klf5 and Nkx3-1 in mouse prostatic tumorigenesis.

  2013cites this paper
• FOXM1 (Forkhead box M1) in tumorigenesis: overexpression in human cancer, implication in tumorigenesis, oncogenic functions, tumor-suppressive properties, and target of anticancer therapy.

  2013cites this paper
• Experimental Models of Prostate Cancer Bone Metastasis - Establishment, characterization and imaging of xenograft bone metastasis models -

  2013cites this paper
• Different Expression Patterns and Functions of Acetylated and Unacetylated Klf5 in the Proliferation and Differentiation of Prostatic Epithelial Cells

  2013cites this paper
• Visualizing the Prostate Gland by MR Imaging in Young and Old Mice

  2013cites this paper
• Conditional Transgenic Expression of PIM1 Kinase in Prostate Induces Inflammation-Dependent Neoplasia

  2013cites this paper
• Disruption of Prostate Epithelial Differentiation Pathways and Prostate Cancer Development

  2013cites this paper
• Skeletal metastasis: treatments, mouse models, and the Wnt signaling

  2013cites this paper
• Pathogenic Intestinal Bacteria Enhance Prostate Cancer Development via Systemic Activation of Immune Cells in Mice

  2013cites this paper
• Effects of Bioactive Compounds from Different Potato Genotypes on Prostate Cancer Development in Athymic Nude Mice

  2012influential citation
• Cosmology when living near the Great Attractor

  2012cites this paper
• Elucidating Zinc Distribution In Cancerous Prostate Cells Using Novel FRET Sensors

  2012cites this paper
• Preclinical Remodeling of Human Prostate Cancer through the PTEN/AKT Pathway

  2012cites this paper
• The mouse as a model to investigate sex steroid metabolism in the normal and pathological prostate.

  2012cites this paper
• Laminin receptor specific therapeutic gold nanoparticles (198AuNP-EGCg) show efficacy in treating prostate cancer

  2012cites this paper
• Imaging , Diagnosis , Prognosis Human Prostate Cancer in a Clinically Relevant Xenograft Mouse Model : Identi fi cation of b ( 1 , 6 )-Branched Oligosaccharides as a Marker of Tumor Progression

  2012influential citation
• Human Prostate Cancer in a Clinically Relevant Xenograft Mouse Model: Identification of β(1,6)-Branched Oligosaccharides as a Marker of Tumor Progression

  2012cites this paper
• The role of 8q amplification and microRNAs in prostate cancer

  2012cites this paper
• Androgen receptor (AR) expression in prostate cancer and progression of the tumor: Lessons from cell lines, animal models and human specimens.

  2012cites this paper