The new pig on the block: modelling cancer in pigs

No abstract is available for this paper.

• Publication year

  2013

• Venue

  Transgenic research

• Publication date

  2013-06-08

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1007/s11248-013-9720-9PMID 23748932
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Genomic responses in mouse models poorly mimic human inflammatory diseases

  2013cited by this paper
• Permanent Neonatal Diabetes in INSC94Y Transgenic Pigs

  2013cited by this paper
• RNA guides genome engineering

  2013cited by this paper
• Inactivation and Inducible Oncogenic Mutation of p53 in Gene Targeted Pigs

  2012cited by this paper
• A porcine model of familial adenomatous polyposis.

  2012cited by this paper
• Efficient TALEN-mediated gene knockout in livestock

  2012cited by this paper
• Analysing stratified medicine business models and value systems: innovation-regulation interactions.

  2012cited by this paper
• Antibody therapy of cancer

  2012cited by this paper
• Analyses of pig genomes provide insight into porcine demography and evolution

  2012cited by this paper
• The role of mutant p53 in human cancer

  2011cited by this paper
• High efficiency of BRCA1 knockout using rAAV-mediated gene targeting: developing a pig model for breast cancer

  2011cited by this paper
• Efficient Immunoglobulin Gene Disruption and Targeted Replacement in Rabbit Using Zinc Finger Nucleases

  2011cited by this paper
• Beyond knockout rats

  2011cited by this paper
• Homozygous and heterozygous p53 knockout rats develop metastasizing sarcomas with high frequency.

  2011cited by this paper
• The productivity crisis in pharmaceutical R&D

  2011cited by this paper
• Advances in porcine genomics and proteomics--a toolbox for developing the pig as a model organism for molecular biomedical research.

  2010cited by this paper
• Varying phenotypes in swine versus murine transgenic models constitutively expressing the same human Sonic hedgehog transcriptional activator, K5-HGLI2ΔN

  2010cited by this paper
• [Antibody therapy in cancer].

  2010cited by this paper
• Estimates of worldwide burden of cancer in 2008: GLOBOCAN 2008

  2010cited by this paper
• Deconstructing the Drug Development Process: The New Face of Innovation

  2010cited by this paper
• Tumour-initiating cells: challenges and opportunities for anticancer drug discovery

  2009cited by this paper
• Translation of new cancer treatments from pet dogs to humans

  2008cited by this paper
• Modelling breast cancer: one size does not fit all

  2007cited by this paper
• Maximizing mouse cancer models

  2007cited by this paper
• Genetic induction of tumorigenesis in Swine

  2007cited by this paper
• Cystic fibrosis mouse models.

  2007cited by this paper
• Swine in the laboratory: surgery, anesthesia, imaging, and experimental techniques

  2007cited by this paper
• A Tumor-mimic Model for Evaluating the Accuracy of HIFU Preclinical Studies: An In Vivo Study

  2007cited by this paper
• The porcine immune system--differences compared to man and mouse and possible consequences for infections by Salmonella serovars.

  2007cited by this paper
• Species differences between mouse, rat, dog, monkey and human CYP-mediated drug metabolism, inhibition and induction

  2006cited by this paper
• N-Nitrosodiethylamine-Induced Pig Liver Hepatocellular Carcinoma Model: Radiological and Histopathological Studies

  2006cited by this paper
• Age and manifestation related symptoms in familial adenomatous polyposis

  2005cited by this paper
• A network of genetic events sufficient to convert normal human cells to a tumorigenic state.

  2005cited by this paper
• Development of exophytic tumor model for laparoscopic partial nephrectomy: technique and initial experience.

  2005cited by this paper
• Trp53R172H and KrasG12D cooperate to promote chromosomal instability and widely metastatic pancreatic ductal adenocarcinoma in mice.

  2005cited by this paper
• Clinical and histopathological characterization of cutaneous melanomas in the melanoblastoma-bearing Libechov minipig model.

  2004cited by this paper
• Species- and cell type-specific requirements for cellular transformation.

  2004cited by this paper
• A census of human cancer genes

  2004cited by this paper
• Biochemical characterization of a new melanoma model – the minipig MeLiM strain

  2003cited by this paper
• Pathology of mouse models of intestinal cancer: consensus report and recommendations.

  2003cited by this paper
• Targeted disruption of the α1,3-galactosyltransferase gene in cloned pigs

  2002cited by this paper
• Targeted disruption of the alpha1,3-galactosyltransferase gene in cloned pigs.

  2002cited by this paper
• Spontaneous regression of cutaneous melanoma in sinclair swine is associated with defective telomerase activity and extensive telomere erosion.

  2000cited by this paper
• Production of gene-targeted sheep by nuclear transfer from cultured somatic cells

  2000cited by this paper
• Production of Transgenic Pig Carrying MMTV/v-Ha-ras

  1999cited by this paper
• Tumour suppressor gene mutations in humans and mice: parallels and contrasts

  1998cited by this paper
• Regression by differentiation in the Sinclair swine model of cutaneous melanoma

  1997cited by this paper
• p53 protein stability in tumour cells is not determined by mutation but is dependent on Mdm2 binding

  1997cited by this paper
• Human factor IX transgenic sheep produced by transfer of nuclei from transfected fetal fibroblasts.

  1997cited by this paper
• Tumor spectrum analysis in p53-mutant mice.

  1994cited by this paper
• APC mutations occur early during colorectal tumorigenesis

  1992cited by this paper
• Identification and characterization of the familial adenomatous polyposis coli gene

  1991cited by this paper
• Identification of FAP locus genes from chromosome 5q21.

  1991cited by this paper
• Spontaneous neoplasms of pigs--a study of 31 cases.

  1978cited by this paper
• An unusual case of lymphosarcoma in a pig.

  1973cited by this paper
• Diseases of aged swine.

  1970cited by this paper
• Lymphosarcoma (leukemia) in cattle, sheep and pigs in Great Britain

  1968cited by this paper

• Genome editing: An insight into disease resistance, production efficiency, and biomedical applications in livestock

  2024cites this paper
• Tumor microenvironment in a minipig model of spinal cord glioma

  2023cites this paper
• Methylation Genome-Wide Profiling in Lowly and Highly Efficient Somatic Cell Nuclear Transfer in Pigs

  2023cites this paper
• Judgment Bias During Gestation in Domestic Pigs

  2022cites this paper
• Large Animal Models of Breast Cancer

  2022cites this paper
• Tumor targeting with bacterial Shiga toxin B-subunit in genetic porcine models for colorectal cancer and osteosarcoma.

  2022cites this paper
• Methylation genome wide profiling in lowly and highly efficient adipose somatic cell nuclear transfer in pigs

  2022cites this paper
• Importance of the pig as a human biomedical model

  2021cites this paper
• Large Animal Models of Glioma: Current Status and Future Prospects

  2021cites this paper
• 25th ANNIVERSARY OF CLONING BY SOMATIC-CELL NUCLEAR TRANSFER Twenty-five years after Dolly: how far have we come?

  2021cites this paper
• Evaluation of early post-natal pig mammary gland development and human breast cancer gene expression.

  2021cites this paper
• Efficient Generation of P53 Biallelic Mutations in Diannan Miniature Pigs Using RNA-Guided Base Editing

  2021cites this paper
• Twenty-five years after Dolly - How far have we come?

  2021cites this paper
• Judgement Bias During Pregnancy in Domestic Pigs

  2021cites this paper
• Newly emerged engineering of in vitro 3D tumor models using biomaterials for chemotherapy

  2020cites this paper
• Porcine ubiquitin-like protein MNSFβ promotes cell apoptosis and covalently binds to BCL-G to enhance staurosporine-induced apoptosis

  2020cites this paper
• Induction of pancreatic neoplasia in the KRAS/TP53 Oncopig

  2020cites this paper
• A short life on the farm: aging and longevity in agricultural, large-bodied mammals

  2020cites this paper
• Lentiviral Vector Induced Modeling of High-Grade Spinal Cord Glioma in Minipigs

  2020cites this paper
• Applications and advances of CRISPR/Cas9 in animal cancer model.

  2020cites this paper
• Translating Human Cancer Sequences Into Personalized Porcine Cancer Models

  2019cites this paper
• Cancer modeling thinks big with the pig

  2019cites this paper
• Animal Biotechnology 2

  2018cites this paper
• Generation of a TP53-modified porcine cancer model by CRISPR/Cas9-mediated gene modification in porcine zygotes via electroporation

  2018cites this paper
• Of Mice, Dogs, Pigs, and Men: Choosing the Appropriate Model for Immuno-Oncology Research.

  2018cites this paper
• Translational Animal Models for Liver Cancer

  2018cites this paper
• Genetically Engineered Large Animals in Biomedicine

  2018cites this paper
• The Oncopig Cancer Model: An Innovative Large Animal Translational Oncology Platform

  2017cites this paper
• Efficient generation of P53 biallelic knockout Diannan miniature pigs via TALENs and somatic cell nuclear transfer

  2017cites this paper
• A genetically inducible porcine model of intestinal cancer

  2017cites this paper
• Ultrasound Contrast Agents for Imaging and Therapy

  2017cites this paper
• The Pig as a Large Animal Model for Studying Anti-Tumor Immune Responses

  2017cites this paper
• Aquaporins in boar and bull spermatozoa: identification and functional implications

  2017cites this paper
• Periovulatory follicular fluid levels of estradiol trigger inflammatory and DNA damage responses in oviduct epithelial cells

  2017cites this paper
• Spontaneous regression of malignant melanoma - is it based on the interplay between host immune system and melanoma antigens?

  2017cites this paper
• Metabolic programming of a Warburg effect-like phenotype in donor fibroblasts prior to somatic cell nuclear transfer

  2017cites this paper
• Transgenesis for pig models

  2016cites this paper
• A potential molecular model for studying apoptosis enhanced by the interaction of BCL-G with JAB1 in swine

  2016cites this paper
• Emerging Technologies to Create Inducible and Genetically Defined Porcine Cancer Models

  2016cites this paper
• Development and characterization of pig xenograft model for human hepatocellular carcinoma

  2016cites this paper
• Complete reduction of p53 expression by RNA interference following heterozygous knockout in porcine fibroblasts

  2016cites this paper
• Pigs as models of human cancers.

  2016cites this paper
• Engineered Swine Models of Cancer

  2016cites this paper
• Tailored Pig Models for Preclinical Efficacy and Safety Testing of Targeted Therapies

  2016cites this paper
• Nucleus transfer efficiency of ear fibroblast cells isolated from Bama miniature pigs at various ages

  2015cites this paper
• Viable pigs with a conditionally-activated oncogenic KRAS mutation

  2015cites this paper
• Nucleus transfer efficiency of ear fibroblast cells isolated from Bama miniature pigs at various ages

  2015cites this paper
• Non-invasive assessment of porcine oocyte quality by supravital staining of cumulus–oocyte complexes with lissamine green B

  2015cites this paper
• The yin and yang of kidney development and Wilms’ tumors

  2015cites this paper
• Targeted ultrasound contrast agents for ultrasound molecular imaging and therapy

  2015cites this paper
• Edinburgh Research Explorer The Yin and Yang of kidney development and Wilms’ tumours

  2015cites this paper
• Genetic engineering of pigs for the creation of translational models of human pathologies

  2015cites this paper
• Biology and Diseases of Swine

  2015cites this paper
• Modelling the multi-step process of tumorigenesis in pigs

  2015cites this paper
• Use of a Closed Culture System to Improve the Safety of Lentiviral Vector Production

  2015cites this paper
• Ovine pulmonary adenocarcinoma: a large animal model for human lung cancer.

  2015cites this paper
• Computational identification and analysis of evolutionary breakpoint regions in amniote genomes

  2014cites this paper
• Use of rodents as models of human diseases

  2014cites this paper
• Dual Fluorescent Reporter Pig for Cre Recombination: Transgene Placement at the ROSA26 Locus

  2014cites this paper
• Patent Landscape Report on Animal Genetic Resources

  2014cites this paper
• Porcine JAB1 significantly enhances apoptosis induced by staurosporine

  2013cites this paper