Inhibition of glucose transport in PC12 cells by the atypical antipsychotic drugs risperidone and clozapine, and structural analogs of clozapine.

No abstract is available for this paper.

• Publication year

  2001

• Venue

  Brain Research

• Publication date

  2001-12-27

• Fields of study

  Medicine, Chemistry

• Identifiers
  DOI 10.1016/S0006-8993(01)03026-8PMID 11743975
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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  1998cited by this paper
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  1998cited by this paper
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  1997cited by this paper
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  1997cited by this paper
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  1994cited by this paper
• Severe hyperglycemia associated with high doses of clozapine.

  1994cited by this paper
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  1993cited by this paper
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  1993cited by this paper
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  1993cited by this paper
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  1992cited by this paper
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  1992cited by this paper
• Clozapine-induced weight gain: prevalence and clinical relevance.

  1992cited by this paper
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  1991cited by this paper
• Influence of patient-related variables on clozapine plasma levels.

  1990cited by this paper
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  1990cited by this paper
• Effects of insulin on peripheral and splanchnic glucose metabolism in noninsulin-dependent (type II) diabetes mellitus.

  1985cited by this paper
• Proteolytic and chemical dissection of the human erythrocyte glucose transporter.

  1984cited by this paper
• Nonketotic hyperglycemia associated with loxapine and amoxapine: case report.

  1983cited by this paper
• Cytochalasin B binding sites and glucose transport carrier in human erythrocyte ghosts.

  1977cited by this paper
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  1971cited by this paper
• Phenothiazines and diabetes in hospitalized women.

  1968cited by this paper
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  1964cited by this paper
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  1963cited by this paper
• Some actions of chlorpromazine.

  1956cited by this paper
• HYPERGLYCEMIA AND GLYCOSURIA FOLLOWING CHLORPROMAZINE THERAPY

  1956cited by this paper
• Glycemic Effects of Chlorpromazine in the Mouse, Hamsterand Rat

  1955cited by this paper

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  2019cites this paper
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  2019cites this paper
• Antipsychotics and glucose metabolism: how brain and body collide.

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  2019cites this paper
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• Current Views on Dopaminergic Drugs Affecting Glucose Homeostasis.

  2019cites this paper
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  2018cites this paper
• Clozapine-induced Insulin-resistant Hyperglycemia in a Diabetic Patient

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  2017cites this paper
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  2016cites this paper
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• [Diabetes mellitus associated with atypical antipsychotic medications: case report and review of the literature].

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  2004cites this paper
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  2004cites this paper
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  2004cites this paper
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  2004cites this paper
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  2004cites this paper
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