A fully noninvasive and robust experimental protocol for longitudinal fMRI studies in the rat

No abstract is available for this paper.

• Publication year

  2006

• Venue

  NeuroImage

• Publication date

  2006-02-15

• Fields of study

  Medicine, Computer Science, Psychology

• Identifiers
  DOI 10.1016/j.neuroimage.2005.08.028PMID 16223588
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Confounding effects of anesthesia on functional activation in rodent brain: a study of halothane and alpha-chloralose anesthesia.

  2005cited by this paper
• Functional MRI of the rodent somatosensory pathway using multislice echo planar imaging

  2004influential reference
• Imaging oxygen consumption in forepaw somatosensory stimulation in rats under isoflurane anesthesia

  2004cited by this paper
• Interpreting the BOLD signal.

  2004cited by this paper
• Functional Magnetic Resonance Imaging and Somatosensory Evoked Potentials in Rats with a Neonatally Induced Freeze Lesion of the Somatosensory Cortex

  2004influential reference
• A review of the physiological effects of alpha2-agonists related to the clinical use of medetomidine in small animal practice.

  2003influential reference
• Regional Cerebral Blood Flow and BOLD Responses in Conscious and Anesthetized Rats under Basal and Hypercapnic Conditions: Implications for Functional MRI Studies

  2003cited by this paper
• Experimental model for functional magnetic resonance imaging of somatic sensory cortex in the unanesthetized rat

  2003influential reference
• Essential principles and practices

  2003cited by this paper
• Animal anaesthesia for in vivo magnetic resonance

  2003influential reference
• Correlation between Brain Reorganization, Ischemic Damage, and Neurologic Status after Transient Focal Cerebral Ischemia in Rats: A Functional Magnetic Resonance Imaging Study

  2003cited by this paper
• Functional magnetic resonance imaging of tonic pain and vasopressor effects in rats.

  2002cited by this paper
• Functional magnetic resonance imaging of reorganization in rat brain after stroke

  2001cited by this paper
• Effects of anesthesia on functional activation of cerebral blood flow and metabolism

  2001influential reference
• Comparing BOLD fMRI signal changes in the awake and anesthetized rat during electrical forepaw stimulation.

  2001influential reference
• Blood Pressure Changes Induced by Arterial Blood Withdrawal Influence Bold Signal in Anesthesized Rats at 7 Tesla: Implications for Pharmacologic MRI

  2001cited by this paper
• Transcutaneous blood gas monitoring in the rat.

  2001cited by this paper
• Bicuculline‐induced brain activation in mice detected by functional magnetic resonance imaging

  2001cited by this paper
• Transcutaneous blood gas monitoring in the rat

  2001cited by this paper
• Blood Pressure Changes Induced by Arterial Blood Withdrawal Influence Bold Signal in Anesthesized Rats at 7 Tesla: Implications for Pharmacologic MRI

  2001cited by this paper
• Functional MRI of calcium‐dependent synaptic activity: Cross correlation with CBF and BOLD measurements

  2000cited by this paper
• Simultaneous Blood Oxygenation Level-Dependent and Cerebral Blood Flow Functional Magnetic Resonance Imaging during Forepaw Stimulation in the Rat

  1999cited by this paper
• Hemodynamic effects of medetomidine in the dog: a dose titration study.

  1998cited by this paper
• Recovery of the rodent brain after cardiac arrest: A functional mri study

  1998cited by this paper
• Functional MRI of the rat somatosensory cortex: Effects of hyperventilation

  1998cited by this paper
• Imaging brain activity in conscious animals using functional MRI.

  1998influential reference
• In Vivo Effects of Dexmedetomidine on Laser‐Doppler Flow and Pial Arteriolar Diameter

  1998cited by this paper
• Brainmapping of α‐chloralose anesthetized rats with T2*‐weighted imaging: distinction between the representation of the forepaw and hindpaw in the somatosensory cortex

  1998cited by this paper
• Stimulate: A GUI based fMRI analysis software package

  1996cited by this paper
• Variation of functional MRI signal in response to frequency of somatosensory stimulation in α‐chloralose anesthetized rats

  1996cited by this paper
• The Biology and Medicine of Rabbits and Rodents, 4th ed.

  1996cited by this paper
• Individual variation and lateral asymmetry of the rat primary somatosensory cortex

  1995influential reference
• Dynamic Magnetic Resonance Imaging of the Rat Brain during Forepaw Stimulation

  1994cited by this paper
• Characterization of CBF response to somatosensory stimulation: model and influence of anesthetics.

  1993influential reference
• A review of laboratory animal anesthesia with chloral hydrate and chloralose.

  1993cited by this paper
• Brain magnetic resonance imaging with contrast dependent on blood oxygenation.

  1990cited by this paper
• Cardiovascular actions of medetomidine and their reversal by atipamezole.

  1989cited by this paper
• Cardiovascular actions of medetomidine and their reversal by atipamezole.

  1989cited by this paper
• Functional Activation of Cerebral Blood Flow and Metabolism before and after Global Ischemia of Rat Brain

  1988cited by this paper
• The Rat Brain in Stereotaxic Coordinates

  1983influential reference
• Biology and Medicine of Rabbits and Rodents

  1983cited by this paper
• The Rat Brain in Stereotaxic Coordinates

  1983influential reference
• Water diuretic and natriuretic effect of clonidine in the rat.

  1979cited by this paper
• Cerebral Blood Flow Autoregulation in the Rat

  1978cited by this paper

• Complementarity of BOLD and ADC‐fMRI in Mapping Brain Visual Processing in the Rat

  2026cites this paper
• Losing brain networks during death

  2025cites this paper
• To intubate or not? Balancing anesthesia in rodent fMRI: strategies to mitigate confounding effects.

  2025cites this paper
• Activation mapping in multi-center retrospective rat sensory-evoked functional MRI datasets using a unified pipeline

  2025cites this paper
• Complementary BOLD- and ADC-fMRI explore the role of lateral superior colliculus in flicker fusion frequency

  2025influential citation
• Isoflurane anesthesia alters 31P magnetic resonance spectroscopy markers compared to awake mouse brain

  2025cites this paper
• High-dose medetomidine increases functional connectivity in the fear-related regions after electrical stimulation

  2025cites this paper
• Pigs’ brain responses to stroking after long-term positive human interactions: An fMRI exploratory study

  2025cites this paper
• Age-related effects on the association between alcohol use, severity and resting-state fMRI: a rat study comparing adolescent-onset and adult-onset drinking.

  2025cites this paper
• Mapping cerebral perfusion in mice under various anesthesia levels using highly sensitive BOLD MRI with transient hypoxia

  2024cites this paper
• Stroke-induced neuroplasticity in spiny mice in the absence of tissue regeneration

  2024cites this paper
• Chemogenetic inhibition of dopaminergic neurons reduces stimulus-induced dopamine release, thereby altering the hemodynamic response function in the prefrontal cortex

  2024cites this paper
• Somatosensory-evoked response induces extensive diffusivity and kurtosis changes associated with neural activity in rodents

  2024influential citation
• An anesthetic protocol for preserving functional network structure in the marmoset monkey brain

  2024cites this paper
• Resting-state brain network remodeling after different nerve reconstruction surgeries: a functional magnetic resonance imaging study in brachial plexus injury rats

  2024cites this paper
• Intrinsic macroscale oscillatory modes driving long range functional connectivity in female rat brains detected by ultrafast fMRI

  2023cites this paper
• The impact of vasomotion on analysis of rodent fMRI data

  2023cites this paper
• Altered Neural Pathways and Related Brain Remodeling: A Rat Study Using Different Nerve Reconstructions

  2023cites this paper
• Subject classification and cross-time prediction based on functional connectivity and white matter microstructure features in a rat model of Alzheimer’s using machine learning

  2023influential citation
• Long‐term ANT‐DBS effects in pilocarpine‐induced epileptic rats: A combined 9.4T MRI and histological study

  2023cites this paper
• Hemodynamic responses in the rat hippocampus are simultaneously controlled by at least two independently acting neurovascular coupling mechanisms

  2023cites this paper
• Extensive topographic remapping and functional sharpening in the adult rat visual pathway upon first visual experience

  2023cites this paper
• Intrinsic macroscale oscillatory modes driving long range functional connectivity detected with ultrafast fMRI

  2022cites this paper
• A companion to the preclinical common data elements and case report forms for in vivo rodent neuroimaging: A report of the TASK3‐WG3 Neuroimaging Working Group of the ILAE/AES Joint Translational Task Force

  2022cites this paper
• Supraspinal Sensorimotor and Pain-Related Reorganization after a Hemicontusion Rat Cervical Spinal Cord Injury

  2021influential citation
• An Investigation of the Impacts of Three Anesthetic Regimens on Task-Functional Magnetic Resonance Imaging and Functional Connectivity Resting-State Functional Magnetic Resonance Imaging in Sprague Dawley and Wistar Rats

  2021cites this paper
• Functional quantitative susceptibility mapping (fQSM) of rat brain during flashing light stimulation

  2021cites this paper
• Fasting prevents medetomidine‐induced hyperglycaemia and alterations of neurovascular coupling in the somatosensory cortex of the rat during noxious stimulation

  2021cites this paper
• Systematic Review: Anesthetic Protocols and Management as Confounders in Rodent Blood Oxygen Level Dependent Functional Magnetic Resonance Imaging (BOLD fMRI)—Part B: Effects of Anesthetic Agents, Doses and Timing

  2021influential citation
• Brief neuronal afterdischarges in the rat hippocampus lead to transient changes in oscillatory activity and to a very long-lasting decline in BOLD signals without inducing a hypoxic state

  2021cites this paper
• Characterization of brain-wide somatosensory BOLD fMRI in mice under dexmedetomidine/isoflurane and ketamine/xylazine

  2021cites this paper
• Light-field Microscopy for Fast Volumetric Brain Imaging.

  2021cites this paper
• Brain functional networks associated with social bonding in monogamous voles

  2021cites this paper
• Perinatal SSRI exposure affects brain functional activity associated with whisker stimulation in adolescent and adult rats

  2021cites this paper
• Psychosocial impairment following mild blast-induced traumatic brain injury in rats.

  2021cites this paper
• Functional connectivity is preserved but reorganized across several anesthetic regimes

  2020cites this paper
• The Pharmacokinetics of Medetomidine Administered Subcutaneously during Isoflurane Anaesthesia in Sprague-Dawley Rats

  2020cites this paper
• Effect of Intramuscular Medetomidine Administration on Tear Flow in Rats

  2020cites this paper
• Investigation of robust visual reaction and functional connectivity in the rat brain induced by rocuronium bromide with functional MRI.

  2020cites this paper
• Dynamic functional connectivity and graph theory metrics in a rat model of temporal lobe epilepsy reveal a preference for brain states with a lower functional connectivity, segregation and integration.

  2020cites this paper
• PIRACY: An Optimized Pipeline for Functional Connectivity Analysis in the Rat Brain

  2020cites this paper
• Synchronous nonmonotonic changes in functional connectivity and white matter integrity in a rat model of sporadic Alzheimer’s disease

  2020cites this paper
• A longitudinal, multi-parametric functional MRI study to determine age-related changes in the rodent brain

  2020cites this paper
• A rapid-onset diffusion functional MRI signal reflects neuromorphological coupling dynamics

  2020cites this paper
• Spatio-temporal alterations in functional connectivity and white matter microstructure resulting from glucose hypometabolism in a rat model of sporadic Alzheimer’s disease

  2020cites this paper
• Temporal stability of fMRI in medetomidine-anesthetized rats

  2019cites this paper
• Anesthesia differentially modulates neuronal 1 and vascular contributions to the BOLD signal 2 3

  2019cites this paper
• Mild Blast-Induced Traumatic Brain Injury Model

  2019cites this paper
• Light-Emitting Diode Photobiomodulation After Cerebral Ischemia

  2019cites this paper
• Spontaneous BOLD waves – A novel hemodynamic activity in Sprague-Dawley rat brain detected by functional magnetic resonance imaging

  2019cites this paper
• Effects of Hemodynamic Response Function Selection on Rat fMRI Statistical Analyses

  2019cites this paper
• Anesthesia differentially modulates neuronal and vascular contributions to the BOLD signal

  2019cites this paper
• Alterations in the functional brain network in a rat model of epileptogenesis: A longitudinal resting state fMRI study

  2019cites this paper
• Functional resting-state brain connectivity is accompanied by dynamic correlations of application-dependent [18F]FDG PET-tracer fluctuations

  2019cites this paper
• Dexmedetomidine — commonly used in resting-state and neurovascular coupling studies — is prone to inducing seizures in rats but not in wild type mice

  2019influential citation
• Dexmedetomidine – Commonly Used in Functional Imaging Studies – Increases Susceptibility to Seizures in Rats But Not in Wild Type Mice

  2019cites this paper
• Online Quantification of Lactate Concentration in Microdialysate During Cerebral Activation Using 1H-MRS and Sensitive NMR Microcoil

  2019cites this paper
• Imaging Functional Recovery Following Ischemic Stroke: Clinical and Preclinical fMRI Studies

  2019cites this paper
• Layer-specific connectivity revealed by diffusion-weighted functional MRI in the rat thalamocortical pathway

  2019cites this paper
• Evaluation of nuisance removal for functional MRI of rodent brain

  2019cites this paper
• Physiological Considerations of Functional Magnetic Resonance Imaging in Animal Models.

  2019cites this paper
• Mouse fMRI under ketamine and xylazine anesthesia: Robust contralateral somatosensory cortex activation in response to forepaw stimulation

  2018influential citation
• A Combined fMRI and Electrophysiological Approach to Study Signal Processing and Signal Propagation in the Rodent Hippocampus

  2018cites this paper
• Contributions of dopaminergic and non‐dopaminergic neurons to VTA‐stimulation induced neurovascular responses in brain reward circuits

  2018cites this paper
• Plasticity changes in forebrain activity and functional connectivity during neuropathic pain development in rats with sciatic spared nerve injury

  2018cites this paper
• Long‐term optical imaging of neurovascular coupling in mouse cortex using GCaMP6f and intrinsic hemodynamic signals

  2018cites this paper
• Physiological characterization of a robust survival rodent fMRI method.

  2017cites this paper
• Hippocampal CA3 activation alleviates fMRI-BOLD responses in the rat prefrontal cortex induced by electrical VTA stimulation

  2017cites this paper
• fMRI study of the role of glutamate NMDA receptor in the olfactory adaptation in rats: Insights into cellular and molecular mechanisms of olfactory adaptation

  2017cites this paper
• Contributions of structural connectivity and cerebrovascular parameters to functional magnetic resonance imaging signals in mice at rest and during sensory paw stimulation

  2017cites this paper
• Longitudinal, transcranial measurement of functional activation in the rat brain by diffuse correlation spectroscopy

  2017cites this paper
• Noise and non‐neuronal contributions to the BOLD signal: applications to and insights from animal studies

  2017cites this paper
• Functional networks and network perturbations in rodents

  2017cites this paper
• True and apparent optogenetic BOLD fMRI signals

  2017cites this paper
• Mapping of the brain hemodynamic responses to sensorimotor stimulation in a rodent model: A BOLD fMRI study

  2017cites this paper
• Preclinical imaging anesthesia in rodents.

  2017cites this paper
• Resting‐state functional MRI as a tool for evaluating brain hemodynamic responsiveness to external stimuli in rats

  2017cites this paper
• Brain functional connectivity and its aberrations in mouse models of autism

  2017cites this paper
• Activity and connectivity changes of central projection areas revealed by functional magnetic resonance imaging in NaV1.8-deficient mice upon cold signaling

  2017cites this paper
• Large-scale functional connectivity networks in the rodent brain

  2016cites this paper
• Novel method for functional brain imaging in awake minimally restrained rats.

  2016cites this paper
• Wavelet-based clustering of resting state MRI data in the rat.

  2016cites this paper
• A novel anesthesia regime enables neurofunctional studies and imaging genetics across mouse strains

  2016cites this paper
• Brain region and activity-dependent properties of M for calibrated fMRI

  2016cites this paper
• Implantable RF-coil with multiple electrodes for long-term EEG-fMRI monitoring in rodents.

  2016cites this paper
• Comparing the Effects of Isoflurane and Alpha Chloralose upon Mouse Physiology

  2016cites this paper
• Comparison of seven different anesthesia protocols for nicotine pharmacologic magnetic resonance imaging in rat.

  2016cites this paper
• 17O relaxation times in the rat brain at 16.4 tesla

  2016cites this paper
• Deletion of the mu opioid receptor gene in mice reshapes the reward–aversion connectome

  2016cites this paper
• Evaluating long-term consequences of adolescent antipsychotic exposure

  2016cites this paper
• Manganese-enhanced MR imaging of brain activation evoked by noxious peripheral electrical stimulation.

  2016cites this paper
• Neural changes induced by antipsychotic administration in adolescence: A review of studies in laboratory rodents

  2016cites this paper
• fMRI study of olfaction in the olfactory bulb and high olfactory structures of rats: Insight into their roles in habituation

  2016cites this paper
• Rodent Models of Stroke

  2016cites this paper
• Characterization of incisional and inflammatory pain in rats using functional tools of MRI

  2016cites this paper
• Can Mouse Imaging Studies Bring Order to Autism Connectivity Chaos?

  2016cites this paper
• Global reduction of information exchange during anesthetic-induced unconsciousness

  2016cites this paper
• Functional Magnetic Resonance Imaging of Rats with Experimental Autoimmune Encephalomyelitis Reveals Brain Cortex Remodeling

  2015cites this paper
• Assessing sensory versus optogenetic network activation by combining (o)fMRI with optical Ca2+ recordings

  2015cites this paper
• Animal Model Studies

  2015cites this paper