Requirement for β-Catenin in Anterior-Posterior Axis Formation in Mice

The anterior-posterior axis of the mouse embryo is defined before formation of the primitive streak, and axis specification and subsequent anterior development involves signaling from both embryonic ectoderm and visceral endoderm. Τhe Wnt signaling pathway is essential for various developmental processes, but a role in anterior-posterior axis formation in the mouse has not been previously established. β-Catenin is a central player in the Wnt pathway and in cadherin-mediated cell adhesion. We generated β-catenin–deficient mouse embryos and observed a defect in anterior-posterior axis formation at embryonic day 5.5, as visualized by the absence of Hex and Hesx1 and the mislocation of cerberus-like and Lim1 expression. Subsequently, no mesoderm and head structures are generated. Intercellular adhesion is maintained since plakoglobin substitutes for β-catenin. Our data demonstrate that β-catenin function is essential in anterior-posterior axis formation in the mouse, and experiments with chimeric embryos show that this function is required in the embryonic ectoderm.

• Publication year

  2000

• Venue

  Journal of Cell Biology

• Publication date

  2000-02-07

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1083/JCB.148.3.567PMID 10662781PMCID 2174807
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• E-Cadherin and APC Compete for the Interaction with -Catenin and the Cytoskeleton

  2002cited by this paper
• The C-terminal transactivation domain of β-catenin is necessary and sufficient for signaling by the LEF-1/β-catenin complex in Xenopus laevis

  1999cited by this paper
• Axis Development and Early Review Asymmetry in Mammals

  1999cited by this paper
• Beta-catenin regulates expression of cyclin D1 in colon carcinoma cells.

  1999cited by this paper
• β-Catenin regulates expression of cyclin D1 in colon carcinoma cells

  1999cited by this paper
• Anterior endomesoderm specification in Xenopus by Wnt/beta-catenin and TGF-beta signalling pathways.

  1999cited by this paper
• Direct regulation of the Xenopus engrailed-2 promoter by the Wnt signaling pathway, and a molecular screen for Wnt-responsive genes, confirm a role for Wnt signaling during neural patterning in Xenopus.

  1999influential reference
• The oncogenic activation of β-catenin

  1999cited by this paper
• Anterior Endomesoderm Specification in Xenopusby Wnt/-catenin and TGF- Signalling Pathways

  1999cited by this paper
• Requirement for Wnt3 in vertebrate axis formation

  1999cited by this paper
• Pattern formation in zebrafish--fruitful liaisons between embryology and genetics.

  1999cited by this paper
• The C-terminal transactivation domain of beta-catenin is necessary and sufficient for signaling by the LEF-1/beta-catenin complex in Xenopus laevis.

  1999cited by this paper
• The EGF-CFC protein one-eyed pinhead is essential for nodal signaling.

  1999cited by this paper
• Conservation of intracellular Wnt signaling components in dorsal-ventral axis formation in zebrafish

  1999cited by this paper
• The oncogenic activation of beta-catenin.

  1999cited by this paper
• Nuclear beta-catenin and the development of bilateral symmetry in normal and LiCl-exposed chick embryos.

  1999influential reference
• Hot papers in cell biology - J. Behrens, J.P. von Kries, M. Kuehl, L. Bruhn, D. Wedlich, R. Grosschedl, W. Birchmeier: "Functional interaction of beta-catenin with the transcription factor LEF-1" - Comments by Walter Birchmeier

  1999cited by this paper
• Axin, a negative regulator of the Wnt signaling pathway, forms a complex with GSK‐3β and β‐catenin and promotes GSK‐3β‐dependent phosphorylation of β‐catenin

  1998cited by this paper
• The type I activin receptor ActRIB is required for egg cylinder organization and gastrulation in the mouse.

  1998cited by this paper
• Visceral endoderm-restricted translation of Otx1 mediates recovery of Otx2 requirements for specification of anterior neural plate and normal gastrulation.

  1998cited by this paper
• From cortical rotation to organizer gene expression: toward a molecular explanation of axis specification in Xenopus

  1998cited by this paper
• Function of zebrafish beta-catenin and TCF-3 in dorsoventral patterning.

  1998cited by this paper
• Sequential roles for Otx2 in visceral endoderm and neuroectoderm for forebrain and midbrain induction and specification.

  1998cited by this paper
• Mutations in the homeobox gene HESX1/Hesx1 associated with septo-optic dysplasia in human and mouse

  1998cited by this paper
• Functional interaction of an axin homolog, conductin, with beta-catenin, APC, and GSK3beta.

  1998cited by this paper
• De Novo hair follicle morphogenesis and hair tumors in mice expressing a truncated beta-catenin in skin.

  1998cited by this paper
• Differential molecular interactions of beta-catenin and plakoglobin in adhesion, signaling and cancer.

  1998cited by this paper
• Expression of the mouse cerberus-related gene, Cerr1, suggests a role in anterior neural induction and somitogenesis.

  1998cited by this paper
• The tumor suppressor gene Smad4/Dpc4 is required for gastrulation and later for anterior development of the mouse embryo.

  1998cited by this paper
• Function of zebrafish β-catenin and TCF-3 in dorsoventral patterning

  1998cited by this paper
• Hex: a homeobox gene revealing peri-implantation asymmetry in the mouse embryo and an early transient marker of endothelial cell precursors.

  1998cited by this paper
• Smad2 signaling in extraembryonic tissues determines anterior-posterior polarity of the early mouse embryo.

  1998cited by this paper
• Evidence for a frizzled-mediated wnt pathway required for zebrafish dorsal mesoderm formation.

  1998cited by this paper
• Failure of egg cylinder elongation and mesoderm induction in mouse embryos lacking the tumor suppressor smad2.

  1998cited by this paper
• Identification of c-MYC as a target of the APC pathway.

  1998cited by this paper
• De Novo Hair Follicle Morphogenesis and Hair Tumors in Mice Expressing a Truncated β-Catenin in Skin

  1998cited by this paper
• Depletion of epithelial stem-cell compartments in the small intestine of mice lacking Tcf-4

  1998cited by this paper
• Axin, a negative regulator of the Wnt signaling pathway, forms a complex with GSK-3beta and beta-catenin and promotes GSK-3beta-dependent phosphorylation of beta-catenin.

  1998cited by this paper
• Regulation of the Hedgehog and Wingless signalling pathways by the F-box/WD40-repeat protein Slimb

  1998cited by this paper
• Cripto is required for correct orientation of the anterior–posterior axis in the mouse embryo

  1998influential reference
• Misexpression of Cwnt8C in the mouse induces an ectopic embryonic axis and causes a truncation of the anterior neuroectoderm.

  1997cited by this paper
• nodal expression in the primitive endoderm is required for specification of the anterior axis during mouse gastrulation.

  1997cited by this paper
• The Amino-terminal Domain of Desmoplakin Binds to Plakoglobin and Clusters Desmosomal Cadherin–Plakoglobin Complexes

  1997cited by this paper
• The roles of maternal alpha-catenin and plakoglobin in the early Xenopus embryo.

  1997cited by this paper
• Wnt signaling: a common theme in animal development.

  1997cited by this paper
• Establishment of the Dorso-ventral Axis in Xenopus Embryos Is Presaged by Early Asymmetries in β-Catenin That Are Modulated by the Wnt Signaling Pathway

  1997cited by this paper
• Characterization of the interactions of alpha-catenin with alpha-actinin and beta-catenin/plakoglobin.

  1997cited by this paper
• β‐catenin is a target for the ubiquitin–proteasome pathway

  1997cited by this paper
• Patterning the Xenopus blastula.

  1997cited by this paper
• The mouse Fused locus encodes Axin, an inhibitor of the Wnt signaling pathway that regulates embryonic axis formation.

  1997cited by this paper
• An a-E-catenin gene trap mutation defines its function in preimplantation development ( cell adhesion y blastocyst y epithelial cells )

  1997cited by this paper
• Mouse gastrulation: the formation of a mammalian body plan.

  1997cited by this paper
• Cerberus-like is a secreted factor with neutralizing activity expressed in the anterior primitive endoderm of the mouse gastrula.

  1997cited by this paper
• Analysis of the Signaling Activities of Localization Mutants of β-Catenin during Axis Specification in Xenopus

  1997cited by this paper
• Armadillo coactivates transcription driven by the product of the Drosophila segment polarity gene dTCF.

  1997cited by this paper
• Activation of β-Catenin-Tcf Signaling in Colon Cancer by Mutations in β-Catenin or APC

  1997cited by this paper
• A beta-catenin/XTcf-3 complex binds to the siamois promoter to regulate dorsal axis specification in Xenopus.

  1997cited by this paper
• An alpha-E-catenin gene trap mutation defines its function in preimplantation development.

  1997cited by this paper
• The Xenopus homeobox gene twin mediates Wnt induction of goosecoid in establishment of Spemann's organizer.

  1997influential reference
• beta-catenin is a target for the ubiquitin-proteasome pathway.

  1997cited by this paper
• Characterization of the interactions of α-catenin with α-actinin and β-catenin / plakoglobin

  1997cited by this paper
• Formation and function of Spemann's organizer.

  1997cited by this paper
• The roles of maternal α-catenin and plakoglobin in the early Xenopus embryo

  1997cited by this paper
• Armadillo and dTCF: a marriage made in the nucleus.

  1997cited by this paper
• Stabilization of beta-catenin by genetic defects in melanoma cell lines.

  1997cited by this paper
• A role for Siamois in Spemann organizer formation.

  1997cited by this paper
• Stabilization of β-Catenin by Genetic Defects in Melanoma Cell Lines

  1997cited by this paper
• Functional interaction of β-catenin with the transcription factor LEF-1

  1996cited by this paper
• Single Amino Acid Substitutions in Proteins of the armadillo Gene Family Abolish Their Binding to -Catenin (*)

  1996cited by this paper
• Beta-catenin translocation into nuclei demarcates the dorsalizing centers in frog and fish embryos.

  1996cited by this paper
• Binding of GSK3β to the APC-β-Catenin Complex and Regulation of Complex Assembly

  1996cited by this paper
• Targeted mutation of plakoglobin in mice reveals essential functions of desmosomes in the embryonic heart

  1996cited by this paper
• Maternal beta-catenin establishes a 'dorsal signal' in early Xenopus embryos.

  1996cited by this paper
• Embryonic heart and skin defects in mice lacking plakoglobin.

  1996cited by this paper
• Single amino acid substitutions in proteins of the armadillo gene family abolish their binding to alpha-catenin.

  1996cited by this paper
• A new mouse member of the Wnt gene family, mWnt-8, is expressed during early embryogenesis and is ectopically induced by retinoic acid.

  1996cited by this paper
• XTcf-3 transcription factor mediates beta-catenin-induced axis formation in Xenopus embryos.

  1996cited by this paper
• Rpx: a novel anterior-restricted homeobox gene progressively activated in the prechordal plate, anterior neural plate and Rathke's pouch of the mouse embryo.

  1996cited by this paper
• Nuclear localization of β-catenin by interaction with transcription factor LEF-1

  1996cited by this paper
• The axis-inducing activity, stability, and subcellular distribution of beta-catenin is regulated in Xenopus embryos by glycogen synthase kinase 3.

  1996cited by this paper
• Functional interaction of beta-catenin with the transcription factor LEF-1.

  1996cited by this paper
• Binding of GSK3beta to the APC-beta-catenin complex and regulation of complex assembly.

  1996cited by this paper
• Embryonic axis induction by the armadillo repeat domain of beta- catenin: evidence for intracellular signaling

  1995cited by this paper
• Identification of Plakoglobin Domains Required for Association with N-cadherin and α-Catenin (*)

  1995cited by this paper
• Lack of beta-catenin affects mouse development at gastrulation.

  1995cited by this paper
• Requirement for LIml in head-organizer function

  1995cited by this paper
• A targeted mutation in the mouse E-cadherin gene results in defective preimplantation development.

  1995cited by this paper
• Visceral endoderm-1 (VE-1): an antigen marker that distinguishes anterior from posterior embryonic visceral endoderm in the early post-implantation mouse embryo.

  1995cited by this paper
• Identification of plakoglobin domains required for association with N-cadherin and alpha-catenin.

  1995cited by this paper
• An HMG-box-containing T-cell factor required for thymocyte differentiation

  1995cited by this paper
• Development of several organs that require inductive epithelial-mesenchymal interactions is impaired in LEF-1-deficient mice.

  1994cited by this paper
• Overexpression of cadherins and underexpression of beta-catenin inhibit dorsal mesoderm induction in early Xenopus embryos.

  1994cited by this paper
• Distinct cadherin—catenin complexes in Ca2+ dependent cell—cell adhesion

  1994cited by this paper
• Identification of the plakoglobin-binding domain in desmoglein and its role in plaque assembly and intermediate filament anchorage

  1994cited by this paper
• Tumor-suppressor gene products in cell contacts: the cadherin-APC-armadillo connection.

  1994cited by this paper
• E-cadherin null mutant embryos fail to form a trophectoderm epithelium.

  1994cited by this paper
• E-cadherin and APC compete for the interaction with beta-catenin and the cytoskeleton

  1994cited by this paper
• Dynamics of cadherin/catenin complex formation: novel protein interactions and pathways of complex assembly

  1994cited by this paper
• Overexpression of cadherins and underexpression of β-catenin inhibit dorsal mesoderm induction in early Xenopus embryos

  1994cited by this paper
• Cancer, catenins, and cuticle pattern: a complex connection.

  1993cited by this paper

• CTNNB1 syndrome mouse models

  2025influential citation
• Wnt/Beta-katenin Sinyal Yolunun Preimplantasyon, İmplantasyon, Desidualizasyon ve Plasentasyondaki Kritik Rolü

  2025cites this paper
• Functional attributes of the anterior mesendoderm in patterning the anterior neural structures during head formation in the mouse.

  2025cites this paper
• Towards an integrated view and understanding of embryonic signalling during murine gastrulation.

  2025cites this paper
• H3K4me3 regulates the transcription of RSPO3 in dermal papilla cells to influence hair follicle morphogenesis and development

  2025cites this paper
• Dependence of cell fate potential and cadherin switching on primitive streak coordinate during differentiation of human pluripotent stem cells

  2025cites this paper
• Coordinating tissue development to build body and brain: Lessons from the gastrula organiser and its derivatives.

  2025cites this paper
• EMG1 cooperates with GRHL3 in β-catenin-mediated surface ectoderm differentiation to regulate neural tube closure.

  2025cites this paper
• Signaling Pathways in Human Blastocyst Development: From Molecular Mechanisms to In Vitro Optimization

  2025cites this paper
• Targeting Wnt-driven metabolic adaptations in cancer: integrating glycolysis, glutaminolysis, IDO1-mediated immune evasion, and therapeutic delivery strategies

  2025cites this paper
• GRHL and PGR control WNT4 expression in the mammary gland via 3D looping of conserved and species-specific enhancers

  2025cites this paper
• The pericardium forms as a distinct structure during heart formation

  2025cites this paper
• Trophectoderm-like cells from EPS cells enable generating EPS cell-derived post-implantation embryoids that complete gastrulation.

  2025cites this paper
• Maternal control of embryonic dorsal organizer in vertebrates.

  2025cites this paper
• Calcium signaling is required for anterior patterning in the mouse embryo

  2025cites this paper
• Origin, fate and function of extraembryonic tissues during mammalian development

  2024cites this paper
• The Wnt-dependent master regulator NKX1-2 controls mouse pre-implantation development

  2024cites this paper
• The control of transitions along the main body axis.

  2024cites this paper
• β-catenin mediates endodermal commitment of human ES cells via distinct transactivation functions

  2024cites this paper
• BPA Exposure Affects Mouse Gastruloids Axial Elongation by Perturbing the Wnt/β-Catenin Pathway

  2024cites this paper
• Molecular Pathways and Animal Models of Defects in Situs.

  2024cites this paper
• Signaling Pathways Governing Cardiomyocyte Differentiation

  2024cites this paper
• Patterning in stratified epithelia depends on cell–cell adhesion

  2024cites this paper
• Canonical and Non-Canonical Wnt Signaling Generates Molecular and Cellular Asymmetries to Establish Embryonic Axes

  2024cites this paper
• Differentiation of Pluripotent Stem Cells for Disease Modeling: Learning from Heart Development

  2024cites this paper
• CD146, a therapeutic target involved in cell plasticity

  2024cites this paper
• The pericardium forms as a distinct structure during heart formation

  2024cites this paper
• Optogenetic control of Wnt signaling models cell-intrinsic embryogenic patterning using 2D human pluripotent stem cell culture

  2023cites this paper
• Genetically Engineered Mice Unveil In Vivo Roles of the Mediator Complex

  2023cites this paper
• Novel biphasic mechanism of the canonical Wnt signalling component PYGO2 promotes cardiomyocyte differentiation from hUC-MSCs

  2023cites this paper
• Congenital heart defects in CTNNB1 syndrome: Raising clinical awareness

  2023cites this paper
• Transformation of Pluripotency States during Morphogenesis of Mouse and Human Epiblast

  2023cites this paper
• The embryonic patterning gene Dbx1 governs the survival of the auditory midbrain via Tcf7l2-Ap2δ transcriptional cascade

  2023cites this paper
• Efficient and rapid fluorescent protein knock-in with universal donors in mouse embryonic stem cells.

  2023cites this paper
• Overview of junctional complexes during mammalian early embryonic development

  2023cites this paper
• Wnt Pathway in Pancreatic Development and Pathophysiology

  2023cites this paper
• Generation of glucocorticoid-producing cells derived from human pluripotent stem cells

  2023cites this paper
• Wnt signaling in stem cells during development and cell lineage specification.

  2023cites this paper
• The role of Wnt signaling in the development of the epiblast and axial progenitors.

  2023cites this paper
• In Vitro Embryogenesis and Gastrulation Using Stem Cells in Mice and Humans

  2023cites this paper
• 3D-cultured blastoids model human embryogenesis from pre-implantation to early gastrulation stages.

  2023cites this paper
• Canonical Wnt signaling regulates soft palate development through mediating ciliary homeostasis.

  2023cites this paper
• A Mouse Model for the Rapid and Binomial Assessment of Putative WNT/β-Catenin Signalling Inhibitors

  2023cites this paper
• Tissue tension permits β-catenin phosphorylation to drive mesoderm specification in human embryonic stem cells

  2023cites this paper
• Alopecia areata-like pattern of baldness: the most recent update and the expansion of novel phenotype and genotype in the CTNNB1 gene

  2023cites this paper
• Embriyonik Gelişim Sırasında Vücut Eksenlerinin Oluşumu

  2023cites this paper
• Embryonic β-Catenin Is Required for Priming of the Uterus to Implantation.

  2023cites this paper
• How might we build limbs in vitro informed by the modular aspects and tissue-dependency in limb development?

  2023cites this paper
• Harnessing the Power of Stem Cell Models to Study Shared Genetic Variants in Congenital Heart Diseases and Neurodevelopmental Disorders

  2022cites this paper
• Spatial molecular anatomy of germ layers in the gastrulating cynomolgus monkey embryo.

  2022cites this paper
• Identification of a novel de novo mutation in the CTNNB1 gene in an Iranian patient with intellectual disability

  2022cites this paper
• A hypomorphic mutation in Pold1 disrupts the coordination of embryo size expansion and morphogenesis during gastrulation

  2022cites this paper
• The negative regulation of gene expression by microRNAs as key driver of inducers and repressors of cardiomyocyte differentiation

  2022cites this paper
• Impact of Oxidative Stress on Embryogenesis and Fetal Development.

  2022cites this paper
• Genomic and phenotypic characterization of 404 individuals with neurodevelopmental disorders caused by CTNNB1 variants.

  2022cites this paper
• Bioactive supplements influencing bovine in vitro embryo development.

  2022cites this paper
• Differential regulation of alternate promoter regions in Sox17 during endodermal and vascular endothelial development

  2022cites this paper
• Disruption of β-catenin-mediated negative feedback reinforces cAMP-induced neuronal differentiation in glioma stem cells

  2022cites this paper
• Plakoglobin is a mechanoresponsive regulator of naive pluripotency

  2022cites this paper
• Armadillo regulates nociceptive sensitivity in the absence of injury

  2022cites this paper
• Human Induced Pluripotent Stem Cell-Derived Vascular Cells: Recent Progress and Future Directions

  2021cites this paper
• YAP establishes epiblast responsiveness to inductive signals for germ cell fate

  2021cites this paper
• Specification and role of extraembryonic endoderm lineages in the periimplantation mouse embryo.

  2021cites this paper
• Bioengineered embryoids mimic post-implantation development in vitro

  2021cites this paper
• Molecular Regulation of Paused Pluripotency in Early Mammalian Embryos and Stem Cells

  2021cites this paper
• Multi-layered regulation of neuroectoderm differentiation by retinoic acid in a primitive streak-like context

  2021cites this paper
• Role of TGFβ1 and WNT6 in FGF2 and BMP4-driven endothelial differentiation of murine embryonic stem cells

  2021cites this paper
• Non-viral approaches for somatic cell reprogramming into cardiomyocytes.

  2021cites this paper
• Early perturbation of Wnt signaling reveals patterning and invagination-evagination control points in molar tooth development.

  2021cites this paper
• Molecular mechanism involved in epithelial to mesenchymal transition.

  2021cites this paper
• Role of TGFβ1 and WNT6 in FGF2 and BMP4-driven endothelial differentiation of murine embryonic stem cells

  2021cites this paper
• Bioengineered embryoids mimic post-implantation development in vitro

  2021cites this paper
• Macrophages Derived From Human Induced Pluripotent Stem Cells: The Diversity of Protocols, Future Prospects, and Outstanding Questions

  2021cites this paper
• Self-organized signaling in stem cell models of embryos

  2021cites this paper
• In vitro and in vivo study on angiogenesis of porcine induced pluripotent stem cell-derived endothelial cells.

  2021cites this paper
• Vascular Endothelial Integrity Affects the Severity of Enterovirus-Mediated Cardiomyopathy

  2021cites this paper
• Signaling pathways influencing stem cell self-renewal and differentiation

  2021cites this paper
• The role of Sfrp and DKK proteins in cardiomyocyte development

  2021cites this paper
• Only the Co‐Transcriptional Activity of β‐Catenin Is Required for the Local Regulatory Effects in Hypertrophic Chondrocytes on Developmental Bone Modeling

  2021cites this paper
• Transcriptomic Identification of Draxin-Responsive Targets During Cranial Neural Crest EMT

  2021cites this paper
• Microarray analysis identification of key pathways and interaction network of differential gene expressions during osteogenic differentiation

  2020cites this paper
• Wnt/Beta-catenin/Esrrb signalling controls the tissue-scale reorganization and maintenance of the pluripotent lineage during murine embryonic diapause

  2020cites this paper
• Axial Stem Cells and the Formation of the Vertebrate Body

  2020cites this paper
• Reduced hydration-induced decreased caveolin-1 expression causes epithelial-to-mesenchymal transition.

  2020cites this paper
• MiR‐184 directly targets Wnt3 in cardiac mesoderm differentiation of embryonic stem cells

  2020cites this paper
• Molecular organization of cells

  2020cites this paper
• Xenogeneic-Free System for Biomanufacturing of Cardiomyocyte Progeny From Human Pluripotent Stem Cells

  2020cites this paper
• Rab7-Mediated Endocytosis Establishes Patterning of Wnt Activity through Inactivation of Dkk Antagonism

  2020cites this paper
• Mouse gastrulation: Coordination of tissue patterning, specification and diversification of cell fate.

  2020cites this paper
• Deletion of the Dishevelled family of genes disrupts anterior-posterior axis specification and selectively prevents mesoderm differentiation.

  2020influential citation
• Excessive β-Catenin in Excitatory Neurons Results in Reduced Social and Increased Repetitive Behaviors and Altered Expression of Multiple Genes Linked to Human Autism

  2020cites this paper
• Developmentally Programmed Tankyrase Activity Upregulates β-Catenin and Licenses Progression of Embryonic Genome Activation.

  2020cites this paper
• Signaling regulation during gastrulation: Insights from mouse embryos and in vitro systems.

  2020cites this paper
• Neural defects caused by total and Wnt1-Cre mediated ablation of p120ctn in mice

  2020cites this paper
• β-catenin and γ-catenin are dispensable for T lymphocytes and AML leukemic stem cells

  2020cites this paper
• Multiple Roles of sFRP2 in Cardiac Development and Cardiovascular Disease

  2020cites this paper
• β-Catenin and Associated Proteins Regulate Lineage Differentiation in Ground State Mouse Embryonic Stem Cells

  2020cites this paper
• b-catenin and g-catenin are dispensable for T lymphocytes and AML leukemic stem cells

  2020cites this paper
• Monolayer Generation of Vascular Endothelial Cells from Human Pluripotent Stem Cells.

  2019cites this paper
• The role of high mobility group of nucleosome binding proteins in stem cell biology and differentiation

  2019influential citation