Effective biomodulation by leucovorin of high-dose infusion fluorouracil given as a weekly 24-hour infusion: results of a randomized trial in patients with advanced colorectal cancer.

No abstract is available for this paper.

• Publication year

  1998

• Venue

  Journal of Clinical Oncology

• Publication date

  1998-02-01

• Fields of study

  Medicine

• Identifiers
  DOI 10.1200/JCO.1998.16.2.418PMID 9469324
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Randomized trial comparing monthly low-dose leucovorin and fluorouracil bolus with bimonthly high-dose leucovorin and fluorouracil bolus plus continuous infusion for advanced colorectal cancer: a French intergroup study.

  1997cited by this paper
• Fluorouracil and leucovorin with or without interferon alfa-2b in advanced colorectal cancer: analysis of a prospective randomized phase III trial. Hellenic Cooperative Oncology Group.

  1996cited by this paper
• 5-Fluorouracil versus 5-fluorouracil plus alpha-interferon as treatment of metastatic colorectal carcinoma. A randomized study.

  1996cited by this paper
• Phase III randomized study to compare interferon alfa-2a in combination with fluorouracil versus fluorouracil alone in patients with advanced colorectal cancer.

  1996cited by this paper
• Phase III study of bolus versus infusion fluorouracil with or without cisplatin in advanced colorectal cancer.

  1996cited by this paper
• Modulation of high-dose infusional fluorouracil by low-dose methotrexate in patients with advanced or metastatic colorectal cancer: final results of a randomized European Organization for Research and Treatment of Cancer Study.

  1996cited by this paper
• Randomized trial assessing the addition of interferon alpha-2a to fluorouracil and leucovorin in advanced colorectal cancer. Colorectal Cancer Working Party of the United Kingdom Medical Research Council.

  1996cited by this paper
• Royal Marsden phase III trial of fluorouracil with or without interferon alfa-2b in advanced colorectal cancer.

  1995cited by this paper
• Phase II study of fluorouracil and its modulation in advanced colorectal cancer: a Southwest Oncology Group study.

  1995cited by this paper
• Interferon-alpha does not improve the antineoplastic efficacy of high-dose infusional 5-fluorouracil plus folinic acid in advanced colorectal cancer. First results of a randomized multicenter study by the Association of Medical Oncology of the German Cancer Society (AIO).

  1995cited by this paper
• Failure of orally administered dipyridamole to enhance the antineoplastic activity of fluorouracil in combination with leucovorin in patients with advanced colorectal cancer: a prospective randomized trial.

  1995cited by this paper
• Impact of protracted venous infusion fluorouracil with or without interferon alfa-2b on tumor response, survival, and quality of life in advanced colorectal cancer.

  1995cited by this paper
• 'Tomudex' (ZD1694): results of a randomised trial in advanced colorectal cancer demonstrate efficacy and reduced mucositis and leucopenia. The 'Tomudex' Colorectal Cancer Study Group.

  1995cited by this paper
• Weekly therapy with folinic acid (FA) and high-dose 5-fluorouracil (5-FU) 24-hour infusion in pretreated patients with metastatic colorectal carcinoma. A multicenter study by the Association of Medical Oncology of the German Cancer Society (AIO).

  1994cited by this paper
• Meta-analysis of randomized trials testing the biochemical modulation of fluorouracil by methotrexate in metastatic colorectal cancer. Advanced Colorectal Cancer Meta-Analysis Project.

  1994cited by this paper
• Randomized comparison of two schedules of fluorouracil and leucovorin in the treatment of advanced colorectal cancer.

  1994cited by this paper
• Meta-analysis of randomized trials testing the biochemical modulation of fluorouracil by methotrexate in metastatic colorectal cancer

  1994cited by this paper
• Interim analyses and stopping rules in cancer clinical trials.

  1993cited by this paper
• Phase I trial of 5-fluorouracil by 24-hour infusion weekly

  1993cited by this paper
• Phase I trial of low-dose, prolonged continuous infusion fluorouracil plus interferon-alfa: evidence for enhanced fluorouracil toxicity without pharmacokinetic perturbation.

  1993cited by this paper
• Phase I and plasma pharmacokinetic study of infusional fluorouracil combined with recombinant interferon alfa-2b in patients with advanced cancer.

  1993cited by this paper
• Systemic Infusion Versus Bolus Chemotherapy with 5‐Fluorouracil in Measurable Metastatic Colorectal Cancer

  1992cited by this paper
• Modulation of fluorouracil by leucovorin in patients with advanced colorectal cancer: evidence in terms of response rate. Advanced Colorectal Cancer Meta-Analysis Project.

  1992cited by this paper
• Chemotherapeutic strategies in metastatic colorectal cancer: an overview of current clinical trials.

  1992cited by this paper
• Influence of interferon alfa-2b with or without folinic acid on pharmacokinetics of fluorouracil.

  1992cited by this paper
• Interaction between 5-fluorouracil, [6RS]leucovorin, and recombinant human interferon-alpha 2a in cultured colon adenocarcinoma cells.

  1991cited by this paper
• A phase I, II study of high‐dose 5‐fluorouracil and high‐dose leucovorin with low‐dose phosphonacetyl‐L‐aspartic acid in patients with advanced malignancies

  1991cited by this paper
• A phase II study of weekly 24-hour infusion with high-dose fluorouracil with leucovorin in colorectal carcinoma.

  1991cited by this paper
• A pilot study of interferon alfa-2a in combination with fluorouracil plus high-dose leucovorin in metastatic gastrointestinal carcinoma.

  1991cited by this paper
• Antineoplastic activity of the combination of interferon and cytotoxic agents against experimental and human malignancies: a review.

  1990cited by this paper
• Interaction of gamma interferon and 5-fluorouracil in the H630 human colon carcinoma cell line.

  1990cited by this paper
• Fluorouracil and recombinant alfa-2a-interferon: an active regimen against advanced colorectal carcinoma.

  1989cited by this paper
• A prospective randomized comparison of continuous infusion fluorouracil with a conventional bolus schedule in metastatic colorectal carcinoma: a Mid-Atlantic Oncology Program Study.

  1989cited by this paper
• Applications of dose intensity to problems in chemotherapy of breast and colorectal cancer.

  1987cited by this paper
• Biochemical and pharmacologic basis for potentiation of 5-fluorouracil action by leucovorin.

  1987cited by this paper
• Inhibition of cell division by interferons. The relationship between changes in utilization of thymidine for DNA synthesis and control of proliferation in Daudi cells.

  1983cited by this paper
• Design and analysis of randomized clinical trials requiring prolonged observation of each patient. II. analysis and examples.

  1977cited by this paper
• On closed testing procedures with special reference to ordered analysis of variance

  1976cited by this paper
• Nonparametric Estimation from Incomplete Observations

  1958cited by this paper

• Exploring Gut Microbiome Composition and Circulating Microbial DNA Fragments in Patients with Stage II/III Colorectal Cancer: A Comprehensive Analysis

  2024cites this paper
• Prospects of new targeted nanotherapy combining liponiosomes with berberine to combat colorectal cancer development: an in vivo experimental model.

  2023cites this paper
• Multicenter phase II study of FOLFIRI plus bevacizumab after discontinuation of oxaliplatin-based regimen for advanced or recurrent colorectal cancer (CR0802)

  2015cites this paper
• Sequencing of treatment in advanced unresectable colorectal cancer.

  2013cites this paper
• Phase I a nd P harmacokinetic T rial o f W eekly O ral Fluorouracil G iven W ith E niluracil a nd Low-Dose L eucovorin t o P atients W ith S olid T umors

  2013cites this paper
• A randomised phase III intergroup trial comparing high-dose infusional 5-fluorouracil with or without folinic acid with standard bolus 5-fluorouracil/folinic acid in the adjuvant treatment of stage III colon cancer: the Pan-European Trial in Adjuvant Colon Cancer 2 study.

  2013cites this paper
• Resistance to the Anti-EGFR Therapy, Beyond KRAS, in Patients with Metastatic Colorectal Cancer

  2013cites this paper
• [Prokaryotic expression, purification and enzymatic properties of nuclease P1].

  2012cites this paper
• Divergent regulation of zinc metallopeptidases by shear stress in macrovascular endothelial cells via an NADPH oxidase - superoxide pathway

  2012cites this paper
• A Survival Analysis of the Liver-First Reversed Management of Advanced Simultaneous Colorectal Liver Metastases: A LiverMetSurvey-Based Study

  2012cites this paper
• Fibroblast growth factor-2, chemoresistance and colorectal cancer

  2012cites this paper
• Triplet chemotherapy in patients with metastatic colorectal cancer: toward the best way to safely administer a highly active regimen in clinical practice.

  2012cites this paper
• Role of nonsteroidal anti-inflammatory drug-activated gene-1 in docetaxel-induced cell death of human colorectal cancer cells with different p53 status

  2011cites this paper
• A new pharmacological approach to gastrointestinal cancer at high risk of relapse based on maintenance of the cytostatic effect

  2010cites this paper
• Colorectal cancer treatment and early response evaluation, how do we best evaluate treatment response?

  2010cites this paper
• Anti‐invasion effect of rosmarinic acid via the extracellular signal‐regulated kinase and oxidation–reduction pathway in Ls174‐T cells

  2010cites this paper
• A phase I and II trial of epirubicin, cisplatin, 24‐hour infusion 5 fluorouracil and sodium folinate in patients with advanced esophagogastric carcinomas

  2010cites this paper
• Meta-analysis of chemotherapy with irinotecan or oxaliplatin-involved regimen for untreated metastatic advanced colorectal cancer.

  2009cites this paper
• XELOX versus FOLFOX6 as an adjuvant treatment in colorectal cancer: an economic analysis

  2009cites this paper
• Treatment of colorectal liver metastases. Local ablative techniques. Clinical results. Experimental Anti-Tumor Effects.

  2009cites this paper
• Randomized study of weekly irinotecan plus high-dose 5-fluorouracil (FUIRI) versus biweekly irinotecan plus 5-fluorouracil/leucovorin (FOLFIRI) as first-line chemotherapy for patients with metastatic colorectal cancer: a Spanish Cooperative Group for the Treatment of Digestive Tumors Study.

  2009cites this paper
• Preoperative Chemoradiotherapy Allows for Local Control in Rectal Cancer – But Distant Metastases Remain an Unsolved Problem

  2009cites this paper
• A phase I study of an oral simulated FOLFOX with high dose capecitabine

  2009cites this paper
• Treatment strategies for hepatic metastasis

  2008cites this paper
• An investigation of chemoresistance of liver cancers using the comet assay and isolated organ perfusion systems

  2008cites this paper
• The use of irinotecan, oxaliplatin and raltitrexed for the treatment of advanced colorectal cancer: systematic review and economic evaluation.

  2008cites this paper
• Technology assessment report commissioned by the HTA Programme on behalf of The National Institute for Clinical Excellence

  2008cites this paper
• Economic analysis of a multicentre, randomised, phase III trial comparing FOLFOXIRI with FOLFIRI in patients with metastatic colorectal cancer in Greece

  2007cites this paper
• Apoptosis and chemo‐resistance in colorectal cancer

  2007cites this paper
• Metastatic Colorectal Cancer: The Treatment Continuum

  2007cites this paper
• Systematic review and economic evaluation of bevacizumab and cetuximab for the treatment of metastatic colorectal cancer.

  2007cites this paper
• WITHDRAWN: Irinotecan plus Weekly 5-Fluorouracil and Leucovorin as Salvage Treatment for Patients with Metastatic Colorectal Cancer: A Phase II Trial

  2007cites this paper
• Target Practice: Figuring Out Which, When, and Why to Use Systemic Therapies for Metastatic Colon Cancer

  2006cites this paper
• Hepatic arterial infusion (HAI). Comparison of 5-fluorouracil, folinic acid, interferon alpha-2b and degradable starch microspheres versus 5-fluorouracil and folinic acid in patients with non-resectable colorectal liver metastases.

  2006cites this paper
• FOLFOXIRI (folinic acid, 5-fluorouracil, oxaliplatin and irinotecan) vs FOLFIRI (folinic acid, 5-fluorouracil and irinotecan) as first-line treatment in metastatic colorectal cancer (MCC): a multicentre randomised phase III trial from the Hellenic Oncology Research Group (HORG)

  2006cites this paper
• Does reimbursement influence chemotherapy treatment for cancer patients?

  2006cites this paper
• treatment, but it does influence the kind of treatment received.

  2006cites this paper
• Increased tolerability of bimonthly 12-hour timed flat infusion 5-fluorouracil/irinotecan regimen in advanced colorectal cancer: A dose-finding study.

  2006cites this paper
• Continued Survival of More Than Ten Years, Without Resection of Metastatic Disease, in Patients With Metastatic Colorectal Cancer Treated With Biomodulated Fluorouracil: Report of Two Cases

  2006cites this paper
• Critical evaluation of current treatments in metastatic colorectal cancer.

  2005cites this paper
• Combination of Irinotecan (CPT-11) plus 5-Fluorouracil and Leucovorin (FOLFIRI Regimen) as First Line Treatment for Elderly Patients with Metastatic Colorectal Cancer: A Phase II Trial

  2005cites this paper
• [Systemic therapy for colorectal cancer].

  2005cites this paper
• Whither irinotecan?

  2005cites this paper
• Phase III study of weekly high-dose infusional fluorouracil plus folinic acid with or without irinotecan in patients with metastatic colorectal cancer: European Organisation for Research and Treatment of Cancer Gastrointestinal Group Study 40986.

  2005cites this paper
• Pharmacological Modulation of Fluoropyrimidines

  2005cites this paper
• Original Phase JI study of weekly 24-hour intra-arterial high-dose infusion of 5-fluorouracil and folinic acid for liver metastases from colorectal carcinomas\

  2005cites this paper
• Postępy w zakresie systemowego leczenia raka jelita grubego w stadium zaawansowanym

  2005cites this paper
• Multicenter pilot study administering 5-fluorouracil, folinic acid, interferon alpha–2b and degradable starch microspheres via hepatic arterial infusion in patients with nonresectable colorectal liver metastases

  2005cites this paper
• Progress in systemic therapy of advanced colorectal cancer

  2005cites this paper
• An Alternating Regimen of Irinotecan/ 5-Fluorouracil/Folinic Acid and Oxaliplatin/ 5-Fluorouracil/Folinic Acid in Metastatic Colorectal Cancer: A Phase II Trial

  2005cites this paper
• Irinotecan and 5-FU/ leucovorin in metastatic colorectal cancer: balancing efficacy, toxicity, and logistics.

  2004cites this paper
• Second-Line Treatment of Advanced Colorectal Cancer with a Weekly Simultaneous 24-Hour Infusion of 5-Fluorouracil and Sodium-Folinate: A Multicentre Phase II Trial

  2004cites this paper
• Update on adjuvant trials in the treatment of high-risk colorectal cancer.

  2004cites this paper
• Aktuelle Therapiemöglichkeiten des kolorektalen Karzinoms

  2004cites this paper
• Weekly gemcitabine plus 24-h infusion of high-dose 5-fluorouracil/leucovorin for locally advanced or metastatic carcinoma of the biliary tract

  2004cites this paper
• First-Line Treatment Strategies to Improve Survival in Patients with Advanced Colorectal Cancer

  2004cites this paper
• Current status of clinical studies for colorectal cancer in Taiwan.

  2004cites this paper
• Kolon- und Rektumkarzinom

  2004cites this paper
• Oral fluoropyrimidines in colorectal cancer: a door open to the future?

  2004cites this paper
• High-dose chronomodulated infusion of 5-fluorouracil (5-FU) and folinic acid (FA) (FF5–16) in advanced colorectal cancer patients

  2004cites this paper
• Modulation of fluorouracil by leucovorin in patients with advanced colorectal cancer: an updated meta-analysis.

  2004cites this paper
• Multicenter pilot study of 5-fluorouracil, folinic acid, interferon alpha-2b and degradable starch microspheres via hepatic arterial infusion in patients with nonresectable colorectal liver metastases.

  2004cites this paper
• New chemotherapeutic advances in pancreatic, colorectal, and gastric cancers.

  2004cites this paper
• Application of Adjuvant Chemotherapy in Colorectal Cancer – a Survey in the Region of Essen, Germany

  2004cites this paper
• Efficacy of 5-fluorouracil-based chemotherapy in elderly patients with metastatic colorectal cancer: a pooled analysis of clinical trials.

  2004cites this paper
• Mortality associated with daily bolus 5‐fluorouracil/leucovorin administered in combination with either irinotecan or oxaliplatin

  2004cites this paper
• [Colorectal cancer: current treatment options].

  2004cites this paper
• Down-regulation of thymidylate synthase expression and its steady-state mRNA by oxaliplatin in colon cancer cells

  2004cites this paper
• Weekly high-dose 5-fluorouracil and folinic acid in metastatic pancreatic carcinoma: a phase II study of the EORTC GastroIntestinal Tract Cancer Cooperative Group.

  2004cites this paper
• Gene expression in response to anti-tumour intervention by polysaccharide-K (PSK) in colorectal carcinoma cells.

  2004cites this paper
• Multimodale Therapiekonzepte beim Kolonkarzinom

  2003cites this paper
• Randomized phase III study of high-dose fluorouracil given as a weekly 24-hour infusion with or without leucovorin versus bolus fluorouracil plus leucovorin in advanced colorectal cancer: European organization of Research and Treatment of Cancer Gastrointestinal Group Study 40952.

  2003cites this paper
• Comparison of a 48-Hour Infusion of 5-Fluorouracil without Folinic Acid with 24-Hour Folinic Acid/5-Fluorouracil in Patients with Metastatic Colorectal Cancer Refractory to Bolus Folinic Acid/5-Fluorouracil

  2003cites this paper
• Catheter Occlusion by Calcium Carbonate during Simultaneous Infusion of 5-FU and Calcium Folinate

  2003cites this paper
• [Multimodal therapy in colon carcinoma].

  2003cites this paper
• Metastatic colorectal cancer: systemic treatment in the new millennium.

  2003cites this paper
• Weekly Gemcitabine and 24-Hour Infusional 5-Fluorouracil in Advanced Pancreatic Cancer: A Phase I–II Study

  2003cites this paper
• Phase I and pharmacokinetic study of 24-hour infusion 5-fluorouracil and leucovorin in patients with organ dysfunction.

  2003cites this paper
• Relative Role of 5-Fluorouracil Activation and Inactivation Pathways on Its Cytotoxic Effects

  2003cites this paper
• Chemotherapy options for metastatic colorectal carcinoma; First, second, third line...

  2003cites this paper
• Individual 5-FU dose adaptation in metastatic colorectal cancer: results of a phase II study using a bimonthly pharmacokinetically intensified LV5FU2 regimen

  2003cites this paper
• Phase I and pharmacokinetic study of two different schedules of oxaliplatin, irinotecan, Fluorouracil, and leucovorin in patients with solid tumors.

  2003cites this paper
• A phase II study of weekly methotrexate, cisplatin, and 24-hour infusion of high-dose 5-fluorouracil and leucovorin (MP-HDFL) in patients with metastatic and recurrent esophageal cancer-improving toxicity profile by infusional schedule and double biochemical modulation of 5-fluorouracil.

  2002cites this paper
• Influence of oxaliplatin on 5-fluorouracil plasma clearance and clinical consequences

  2002cites this paper
• A Phase II Study of Irinotecan Alternated with a Weekly Schedule of High-Dose Leucovorin and 48-Hour 5-Fluorouracil Infusion in Patients with Metastatic Colorectal Cancer

  2002cites this paper
• Current concepts in immunotherapy for the treatment of colorectal cancer.

  2002cites this paper
• High-Dose 5-Fluorouracil with Uridine-Diphosphoglucose Rescue Increases Thymidylate Synthase Inhibition but Not 5-Fluorouracil Incorporation into RNA in Murine Tumors

  2002cites this paper
• Advanced colorectal cancer treatment in Europe: what have we achieved?

  2002cites this paper
• 5-Fluorouracil and Its Biomodulation in the Management of Colorectal Cancer

  2002cites this paper
• Mesure de la qualité de vie des patients atteints de cancer colorectal métastatique : techniques et principaux résultats

  2002cites this paper
• Triplet combination with irinotecan plus oxaliplatin plus continuous-infusion fluorouracil and leucovorin as first-line treatment in metastatic colorectal cancer: a multicenter phase II trial.

  2002cites this paper
• Phase II study of irinotecan with bolus and high dose infusional 5-FU and folinic acid (modified de Gramont) for first or second line treatment of advanced or metastatic colorectal cancer

  2002cites this paper
• Irinotecan in the Treatment of Colorectal Cancer

  2002cites this paper
• A phase I study of sequential irinotecan and 5-fluorouracil/leucovorin.

  2002cites this paper
• [Measure of quality of life in patients with metastatic colorectal cancer: techniques and main results].

  2002cites this paper
• Clinical determinants of survival in patients with 5-fluorouracil-based treatment for metastatic colorectal cancer: results of a multivariate analysis of 3825 patients.

  2002cites this paper
• Lower Gastrointestinal Cancer

  2001cites this paper
• Chemotherapie des Kolonkarzinoms

  2001cites this paper
• Optimal treatment for poor prognosis isolated colorectal carcinoma liver metastases. Rationality for prospective neoadjuvant clinical trials

  2001cites this paper
• Metastatic rectal cancer.

  2001cites this paper