Structural and Molecular Mechanisms of Gap Junction Remodeling in Epicardial Border Zone Myocytes following Myocardial Infarction

No abstract is available for this paper.

• Publication year

  2009

• Venue

  Circulation Research

• Publication date

  2009-05-08

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1161/CIRCRESAHA.108.190454PMID 19342602PMCID PMC2892879
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Dynamic changes in conduction velocity and gap junction properties during development of pacing-induced heart failure.

  2007cited by this paper
• Gap junction remodelling in human heart failure is associated with increased interaction of connexin43 with ZO-1

  2007cited by this paper
• Characterization of the pH-dependent Interaction between the Gap Junction Protein Connexin43 Carboxyl Terminus and Cytoplasmic Loop Domains*

  2007cited by this paper
• The Gap Junction Protein Connexin32 Interacts with the Src Homology 3/Hook Domain of Discs Large Homolog 1*

  2007cited by this paper
• EH domain of EHD1

  2007cited by this paper
• Connexin phosphorylation as a regulatory event linked to gap junction channel assembly.

  2005cited by this paper
• Zonula occludens-1 alters connexin43 gap junction size and organization by influencing channel accretion.

  2005cited by this paper
• Structural and molecular pathology of the heart in Carvajal syndrome.

  2004cited by this paper
• Structural Changes in the Carboxyl Terminus of the Gap Junction Protein Connexin43 Indicates Signaling between Binding Domains for c-Src and Zonula Occludens-1*

  2004cited by this paper
• pH-dependent dimerization of the carboxyl terminal domain of Cx43.

  2004cited by this paper
• Regulation of Connexin43 Protein Complexes by Intracellular Acidification

  2004cited by this paper
• The effects of connexin phosphorylation on gap junctional communication.

  2004cited by this paper
• Remodeling of Gap Junctional Channel Function in Epicardial Border Zone of Healing Canine Infarcts

  2003cited by this paper
• c-Src Regulates the Interaction between Connexin-43 and ZO-1 in Cardiac Myocytes*

  2001cited by this paper
• Phosphorylation of Connexin43 on Serine368 by Protein Kinase C Regulates Gap Junctional Communication

  2000cited by this paper
• Dephosphorylation and Intracellular Redistribution of Ventricular Connexin43 During Electrical Uncoupling Induced by Ischemia

  2000cited by this paper
• Dissection of the Molecular Basis of pp60v-src Induced Gating of Connexin 43 Gap Junction Channels

  1999cited by this paper
• Direct Association of the Gap Junction Protein Connexin-43 with ZO-1 in Cardiac Myocytes*

  1998cited by this paper
• The gap junction protein connexin43 interacts with the second PDZ domain of the zona occludens-1 protein.

  1998cited by this paper
• Disturbed connexin43 gap junction distribution correlates with the location of reentrant circuits in the epicardial border zone of healing canine infarcts that cause ventricular tachycardia.

  1997cited by this paper
• Intracellular acidosis activates c-Src.

  1997cited by this paper
• Two binding orientations for peptides to the Src SH3 domain: development of a general model for SH3-ligand interactions.

  1995cited by this paper
• Altered patterns of gap junction distribution in ischemic heart disease. An immunohistochemical study of human myocardium using laser scanning confocal microscopy.

  1991cited by this paper
• Structural and Electrophysiological Changes in the Epicardial Border Zone of Canine Myocardial Infarcts during Infarct Healing

  1985cited by this paper

• Cx45 regulation by kinases and impact of expression in heart failure.

  2025cites this paper
• The Knockout of PEX11a Results in Mild Peroxisomal Dysfunction and Lowered Cardiac Recovery Following Langendorff-Mediated Ischemia–Reperfusion in Mice

  2025cites this paper
• Downregulation of EB1 impedes Cx43 localization and cardiac conduction after hypothermic ischemia-reperfusion in rats

  2025cites this paper
• Translationally controlled tumor protein interacts with connexin 43 and facilitates intercellular coupling between cardiomyocytes

  2025cites this paper
• Preoperative Activation of c-Src Kinase in Atrial Tissue in Patients Developing Postoperative Atrial Fibrillation

  2025cites this paper
• Inhibition of Pyk2 prevents Cx43 remodeling and cardiomyocyte injury during hypoxic and adrenergic stress.

  2025cites this paper
• Evaluation of Tyrosine Kinase Inhibitors Loaded Injectable Hydrogels for Improving Connexin43 Gap Junction Intercellular Communication.

  2024cites this paper
• IL6/adiponectin/HMGB1 feedback loop mediates adipocyte and macrophage crosstalk and M2 polarization after myocardial infarction

  2024cites this paper
• Post translational modifications of connexin 43 in ventricular arrhythmias after myocardial infarction

  2024cites this paper
• Inhibition of Pyk2 Improves Cx43 Intercalated Disc Localization, Infarct Size, and Cardiac Function in Rats With Heart Failure

  2023cites this paper
• CCR2 inhibitor strengthens the adiponectin effects against myocardial injury after infarction

  2023cites this paper
• Regulation of Cx43 Gap Junction Intercellular Communication by Bruton’s Tyrosine Kinase and Interleukin-2-Inducible T-Cell Kinase

  2023cites this paper
• Axin2 depletion in macrophages alleviated senescence and increased immune response after myocardial infarction

  2023cites this paper
• The intercalated disc: a unique organelle for electromechanical synchrony in cardiomyocytes.

  2023cites this paper
• Aucubin supplementation alleviate diabetes induced-disruption of blood-testis barrier and testicular damage via stabilizing cell junction integrity.

  2022cites this paper
• The caspase-1 inhibitor VX765 upregulates connexin 43 expression and improves cell–cell communication after myocardial infarction via suppressing the IL-1β/p38 MAPK pathway

  2022cites this paper
• Ventricular Arrhythmias in Acute Myocardial Ischaemia. Focus on the Ageing and Sex.

  2022cites this paper
• Effect of sotagliflozin on ventricular arrhythmias in mice with myocardial infraction.

  2022cites this paper
• SIRT1 activation and its effect on intercalated disc proteins as a way to reduce doxorubicin cardiotoxicity

  2022cites this paper
• Challenges and future scope of exosomes in the treatment of cardiovascular diseases

  2022cites this paper
• Cellular crosstalk in cardioprotection: where and when do reactive oxygen species play a role?

  2021cites this paper
• Relevance of mitochondrial oxidative stress to arrhythmias: Innovative concepts to target treatments.

  2021cites this paper
• Mitochondrial Ion Channels in Cardiac Function.

  2021cites this paper
• Biomaterials-assisted spheroid engineering for regenerative therapy

  2021cites this paper
• Peptidic Connexin43 Therapeutics in Cardiac Reparative Medicine

  2021cites this paper
• Canonical and Non-Canonical Roles of Connexin43 in Cardioprotection

  2020cites this paper
• Metformin therapy confers cardioprotection against the remodeling of gap junction in tachycardia-induced atrial fibrillation dog model.

  2020cites this paper
• Src Regulation of Cx43 Phosphorylation and Gap Junction Turnover

  2020cites this paper
• Intercellular Communication in the Heart: Therapeutic Opportunities for Cardiac Ischemia.

  2020cites this paper
• Methods for histological characterization of cryo-induced myocardial infarction in a rat model.

  2020cites this paper
• Chronic sigma-1 receptor activation ameliorates ventricular remodeling and decreases susceptibility to ventricular arrhythmias after myocardial infarction in rats.

  2020cites this paper
• Inhibition of Pyk2 and Src activity improves Cx43 gap junction intercellular communication.

  2020cites this paper
• Role of Oxidative Stress in the Genesis of Ventricular Arrhythmias

  2020cites this paper
• Lymphatic Function and Dysfunction in the Context of Sex Differences.

  2019cites this paper
• Emerging Function of Cardiac Macrophages Ushers in a New Era for the Electrophysiology of the Heart

  2019cites this paper
• Adrenomedullin Induces Cardiac Lymphangiogenesis After Myocardial Infarction and Regulates Cardiac Edema Via Connexin 43

  2019influential citation
• Phosphorylation of Cx43 residue Y313 by Src contributes to blocking the interaction with Drebrin and disassembling gap junctions.

  2019cites this paper
• Modulating cardiac conduction during metabolic ischemia with perfusate sodium and calcium in guinea pig hearts.

  2019cites this paper
• Karoshi May Be a Consequence of Overwork-Related Malignant Arrhythmia

  2019cites this paper
• Cardiac microtubules in health and heart disease

  2019cites this paper
• Involvement of sphingosine-1-phosphate receptors 2/3 in IR-induced sudden cardiac death

  2019cites this paper
• Connexin43 Carboxyl-Terminal Domain Directly Interacts with β-Catenin

  2018cites this paper
• Ion Channel Trafficking in the Heart

  2018cites this paper
• Intercalated discs: cellular adhesion and signaling in heart health and diseases

  2018cites this paper
• Protein–Protein Interactions with Connexin 43: Regulation and Function

  2018cites this paper
• Localisation Microscopy of Breast Epithelial ErbB-2 Receptors and Gap Junctions: Trafficking after γ-Irradiation, Neuregulin-1β, and Trastuzumab Application

  2017influential citation
• Mild hypothermia preserves myocardial conduction during ischemia by maintaining gap junction intracellular communication and Na+ channel function.

  2017cites this paper
• Dystrophic Cardiomyopathy: Complex Pathobiological Processes to Generate Clinical Phenotype

  2017cites this paper
• Basic Electrophysiologic Mechanisms of Sudden Cardiac Death Caused by Acute Myocardial Ischemia and Infarction.

  2017cites this paper
• Ventricular Microanatomy, Arrhythmias, and the Electrochemical Driving Force for Na+: Is There a Need for Flipped Learning?

  2017cites this paper
• Regulation of cardiac gap junctions by protein phosphatases.

  2017influential citation
• Connexins in Cardiovascular and Neurovascular Health and Disease: Pharmacological Implications

  2017influential citation
• Regulation of Connexin43 Function and Expression by Tyrosine Kinase 2*

  2016influential citation
• Connexin 43 and CaV1.2 Ion Channel Trafficking in Healthy and Diseased Myocardium

  2016cites this paper
• Immunohisto- and Cytochemistry Analysis of Connexins.

  2016cites this paper
• Secondary structural analysis of the carboxyl‐terminal domain from different connexin isoforms

  2016cites this paper
• Islands of spatially discordant APD alternans underlie arrhythmogenesis by promoting electrotonic dyssynchrony in models of fibrotic rat ventricular myocardium

  2016cites this paper
• Connexin43 Forms Supramolecular Complexes through Non-Overlapping Binding Sites for Drebrin, Tubulin, and ZO-1

  2016cites this paper
• Kinase programs spatiotemporally regulate gap junction assembly and disassembly: Effects on wound repair.

  2016cites this paper
• The "tail" of Connexin43: An unexpected journey from alternative translation to trafficking.

  2016cites this paper
• Ion Channel Trafficking

  2016cites this paper
• Identification of novel therapeutic targets for reentrant arrhythmias

  2016cites this paper
• Mechanisms of sudden cardiac death: oxidants and metabolism.

  2015cites this paper
• Domaine juxta-membranaire de la connexine43 : Détermination par RMN en solution de la structure et de l’interaction avec la tubuline et les microtubules

  2015cites this paper
• To beat or not to beat: degradation of Cx43 imposes the heart rhythm.

  2015cites this paper
• Selective Connexin43 Inhibition Prevents Isoproterenol-Induced Arrhythmias and Lethality in Muscular Dystrophy Mice

  2015cites this paper
• Taxol stabilizes gap junctions and reduces ischemic ventricular arrhythmias in rats in vivo.

  2015cites this paper
• Connexin 43 is an emerging therapeutic target in ischemia/reperfusion injury, cardioprotection and neuroprotection.

  2015cites this paper
• Lentivirus-mediated RNAi knockdown of the gap junction protein, Cx43, attenuates the development of vascular restenosis following balloon injury

  2015cites this paper
• Cardiomyocyte protein trafficking: Relevance to heart disease and opportunities for therapeutic intervention.

  2015cites this paper
• Knockdown of connexin 43 attenuates balloon injury-induced vascular restenosis through the inhibition of the proliferation and migration of vascular smooth muscle cells.

  2015cites this paper
• Development and Validation of a Novel In Vitro Model for the Assessment of Heterocellular Interactions Mediated by Connexin43

  2015cites this paper
• Caveolin-1 Modulates Cardiac Gap Junction Homeostasis and Arrhythmogenecity by Regulating cSrc Tyrosine Kinase

  2014influential citation
• Inhibition of proto-oncogene c-Src tyrosine kinase: toward a new antiarrhythmic strategy?

  2014cites this paper
• Cardiac Hypertrophy: Signaling and Cellular Crosstalk

  2014cites this paper
• Influence of the scaffolding protein Zonula Occludens (ZOs) on membrane channels.

  2014cites this paper
• A 14‐3‐3 Mode‐1 Binding Motif Initiates Gap Junction Internalization During Acute Cardiac Ischemia

  2014cites this paper
• Characterization of the connexin45 carboxyl-terminal domain structure and interactions with molecular partners.

  2014cites this paper
• Regional Ion Channel Gene Expression Heterogeneity and Ventricular Fibrillation Dynamics in Human Hearts

  2014cites this paper
• Angiotensin Receptor Antagonists to Prevent Sudden Death in Heart Failure: Does the Dose Matter?

  2014cites this paper
• Connexin-43 Expression: A Therapeutic Target for the Treatment of Ventricular Tachycardia

  2014cites this paper
• c-Src kinase inhibition reduces arrhythmia inducibility and connexin43 dysregulation after myocardial infarction.

  2014cites this paper
• A History of Gap Junction Structure: Hexagonal Arrays to Atomic Resolution

  2013cites this paper
• Mitochondria and arrhythmias.

  2013cites this paper
• PKCɛ mediates serine phosphorylation of connexin43 induced by lysophosphatidylcholine in neonatal rat cardiomyocytes.

  2013cites this paper
• Mitochondria and arrhythmias

  2013cites this paper
• Immunohistochemical evaluation of cardiac connexin43 in rats exposed to low-frequency noise.

  2013cites this paper
• Mesenchymal Stem Cell-Cardiomyocyte Interactions under Defined Contact Modes on Laser-Patterned Biochips

  2013cites this paper
• Cardiac morphological changes induced by low-frequency noise in rats

  2013cites this paper
• Mitochondria Oxidative Stress, Connexin43 Remodeling, and Sudden Arrhythmic Death

  2013cites this paper
• A Connexin43 Mimetic Peptide Promotes Regenerative Healing and Improves Mechanical Properties in Skin and Heart

  2013cites this paper
• Deletion of the last five C-terminal amino acid residues of connexin43 leads to lethal ventricular arrhythmias in mice without affecting coupling via gap junction channels

  2013cites this paper
• Connexin43 Reduces Melanoma Growth within a Keratinocyte Microenvironment and during Tumorigenesis in Vivo*

  2013cites this paper
• Structural and molecular pathology of the atrium in boxer arrhythmogenic cardiomyopathy

  2012cites this paper
• Reversible atrial gap junction remodeling during hypoxia/reoxygenation and ischemia: a possible arrhythmogenic substrate for atrial fibrillation.

  2012cites this paper
• The role of gap junctions in the arrhythmias of ischemia and infarction.

  2012cites this paper
• Cardiomyocyte ATP release through pannexin 1 aids in early fibroblast activation.

  2012cites this paper
• The perinexus: a new feature of Cx43 gap junction organization.

  2012cites this paper
• The molecular mechanisms of gap junction remodeling.

  2012cites this paper
• The connexin43 carboxyl terminus and cardiac gap junction organization.

  2012cites this paper