Lesion of the pedunculopontine nucleus reverses hyperactivity of the subthalamic nucleus and substantia nigra pars reticulata in a 6‐hydroxydopamine rat model

No abstract is available for this paper.

• Publication year

  2006

• Venue

  European Journal of Neuroscience

• Publication date

  2006-10-01

• Fields of study

  Medicine, Chemistry

• Identifiers
  DOI 10.1111/j.1460-9568.2006.05106.xPMID 17042796
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Bilateral deep brain stimulation of the pedunculopontine nucleus for Parkinson's disease

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• Implantation of human pedunculopontine nucleus: a safe and clinically relevant target in Parkinson's disease

  2005cited by this paper
• Unilateral lesion of the pedunculopontine nucleus induces hyperactivity in the subthalamic nucleus and substantia nigra in the rat

  2005cited by this paper
• Pedunculopontine nucleus stimulation improves akinesia in a Parkinsonian monkey

  2004cited by this paper
• Inhibitory substantia nigra inputs to the pedunculopontine neurons

  2004cited by this paper
• Cholinergic neuronal loss in the basal forebrain and mesopontine tegmentum of progressive supranuclear palsy and corticobasal degeneration

  2003cited by this paper
• Five-year follow-up of bilateral stimulation of the subthalamic nucleus in advanced Parkinson's disease.

  2003cited by this paper
• The pedunculopontine nucleus projection to the parafascicular nucleus of the thalamus: an electrophysiological investigation in the rat

  2003cited by this paper
• Synaptic organization of the rat parafascicular nucleus, with special reference to its afferents from the superior colliculus and the pedunculopontine tegmental nucleus.

  2003cited by this paper
• Pedunculopontine tegmental stimulation evokes striatal dopamine efflux by activation of acetylcholine and glutamate receptors in the midbrain and pons of the rat

  2003cited by this paper
• Effect of ipsilateral subthalamic nucleus lesioning in a rat parkinsonian model: study of behavior correlated with neuronal activity in the pedunculopontine nucleus.

  2003cited by this paper
• Depletion of mesopontine cholinergic and sparing of raphe neurons in multiple system atrophy

  2002cited by this paper
• Determination of acetylcholine and dopamine content in thalamus and striatum after excitotoxic lesions of the pedunculopontine tegmental nucleus in rats.

  2002cited by this paper
• Unilateral lesion of the nigrostriatal pathway induces an increase of neuronal activity of the pedunculopontine nucleus, which is reversed by the lesion of the subthalamic nucleus in the rat

  2001cited by this paper
• Time-course of changes in firing rates and firing patterns of subthalamic nucleus neuronal activity after 6-OHDA-induced dopamine depletion in rats.

  2001cited by this paper
• The pedunculopontine nucleus and Parkinson's disease.

  2000cited by this paper
• Protection against dopaminergic nigrostriatal cell death by excitatory input ablation

  2000cited by this paper
• Metabolic activity of excitatory parafascicular and pedunculopontine inputs to the subthalamic nucleus in a rat model of Parkinson's disease.

  2000cited by this paper
• Organization of somatic motor inputs from the frontal lobe to the pedunculopontine tegmental nucleus in the macaque monkey.

  2000cited by this paper
• Electrophysiological characteristics of substantia nigra neurons in organotypic cultures: spontaneous and evoked activities

  2000influential reference
• Afferent modulation of dopamine neuron firing patterns.

  1999cited by this paper
• Neurophysiological identification of the subthalamic nucleus in surgery for Parkinson's disease

  1998cited by this paper
• Electrical stimulation of the subthalamic nucleus in advanced Parkinson's disease.

  1998cited by this paper
• Consequences of Nigrostriatal Denervation on the Functioning of the Basal Ganglia in Human and Nonhuman Primates: An In Situ Hybridization Study of Cytochrome Oxidase Subunit I mRNA

  1997cited by this paper
• On the relationships between the striatum and the pedunculopontine tegmental nucleus.

  1997cited by this paper
• Glutamatergic inputs from the pedunculopontine nucleus to midbrain dopaminergic neurons in primates: Phaseolus vulgaris‐leucoagglutinin anterograde labeling combined with postembedding glutamate and GABA immunohistochemistry

  1996influential reference
• Subthalamic Nucleus Lesion in Rats Prevents Dopaminergic Nigral Neuron Degeneration After Striatal 6‐OHDA Injection: Behavioural and Immunohistochemical Studies

  1996cited by this paper
• Increased subthalamic neuronal activity after nigral dopaminergic lesion independent of disinhibition via the globus pallidus.

  1996cited by this paper
• Burst and oscillation as disparate neuronal properties.

  1996cited by this paper
• Metabolic activity of the basal ganglia in parkinsonian syndromes in human and non-human primates: a cytochrome oxidase histochemistry study.

  1996cited by this paper
• Cholinergic, GABAergic, and glutamate-enriched inputs from the mesopontine tegmentum to the subthalamic nucleus in the rat

  1995cited by this paper
• Effect on parkinsonian signs and symptoms of bilateral subthalamic nucleus stimulation

  1995cited by this paper
• The pedunculopontine tegmental nucleus: where the striatum meets the reticular formation.

  1995cited by this paper
• Pedunculopontine nucleus in the squirrel monkey: Projections to the basal ganglia as revealed by anterograde tract‐tracing methods

  1994influential reference
• The primate subthalamic nucleus. II. Neuronal activity in the MPTP model of parkinsonism.

  1994influential reference
• Reversal of Rigidity and Improvement in Motor Performance by Subthalamic High‐frequency Stimulation in MPTP‐treated Monkeys

  1993cited by this paper
• Afferent connections of the laterodorsal and the pedunculopontine tegmental nuclei in the rat: A retro‐ and antero‐grade transport and immunohistochemical study

  1992cited by this paper
• Afferent projections to the cholinergic pedunculopontine tegmental nucleus and adjacent midbrain extrapyramidal area in the albino rat. I. Retrograde tracing studies

  1992cited by this paper
• The pedunculopontine nucleus.

  1991cited by this paper
• Abnormal spontaneous activity of globus pallidus neurons in monkeys with MPTP-induced parkinsonism.

  1991cited by this paper
• Nigropedunculopontine projection in the rat: An Anterograde tracing study with phaseolus vulgaris‐leucoagglutinin (PHA‐L)

  1991cited by this paper
• Local cerebral glucose utilization in monkeys with hemiparkinsonism induced by intracarotid infusion of the neurotoxin MPTP

  1990cited by this paper
• The effects of dopamine-depleting brain lesions on the electrophysiological activity of rat substantia nigra dopamine neurons.

  1990cited by this paper
• Primate models of movement disorders of basal ganglia origin.

  1990cited by this paper
• Reversal of experimental parkinsonism by lesions of the subthalamic nucleus.

  1990cited by this paper
• Functional architecture of basal ganglia circuits: neural substrates of parallel processing.

  1990cited by this paper
• Evidence for a cholinergic projection from the pedunculopontine tegmental nucleus to the rostral ventrolateral medulla in the rat.

  1990cited by this paper
• Neuronal activities in brain-stem cholinergic nuclei related to tonic activation processes in thalamocortical systems

  1990cited by this paper
• Neural mechanisms underlying parkinsonian symptoms based upon regional uptake of 2-deoxyglucose in monkeys exposed to 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine.

  1989cited by this paper
• The pedunculopontine nucleus in Parkinson's disease

  1989cited by this paper
• The functional anatomy of basal ganglia disorders.

  1989cited by this paper
• Origin of ascending and spinal pathways from the nucleus tegmenti pedunculopontinus in the rat

  1989cited by this paper
• Projections of brainstem core cholinergic and non-cholinergic neurons of cat to intralaminar and reticular thalamic nuclei.

  1988cited by this paper
• Pedunculopontine tegmental nucleus of the rat: Cytoarchitecture, cytochemistry, and some extrapyramidal connections of the mesopontine tegmentum

  1987cited by this paper
• Neuronal loss in the pedunculopontine tegmental nucleus in Parkinson disease and in progressive supranuclear palsy.

  1987cited by this paper
• Organization and efferent projections of nucleus tegmenti pedunculopontinus pars compacta with special reference to its cholinergic aspects.

  1984cited by this paper
• Anatomical and electrophysiological studies on the reciprocal projections between the subthalamic nucleus and nucleus tegmenti pedunculopontinus in the rat.

  1983influential reference
• The afferent and efferent connections of the feline nucleus tegmenti pedunculopontinus, pars compacta

  1983cited by this paper
• The subcortical afferents to caudate nucleus and putamen in primate: a fluorescence retrograde double labeling study.

  1983influential reference
• The rat brain in stereotaxic coordinates: Authors: George Paxinos & Charles Watson Academic Press Australia, 1982 Softback, 154 pages (including 71 plates), 35.00 Aust $

  1983influential reference
• Demonstration of a unique population of neurons with NADPH-diaphorase histochemistry.

  1983influential reference

• Brainstem Neuroadaptations in Rodent Models of Parkinson's Disease

  2025cites this paper
• Nigral stimulation for freezing of gait: kinematic gait parameters inform optimization of stimulation frequency

  2025cites this paper
• Oral Transport, Penetration, and Aspiration in PD: Insights from a RCT on STN + SNr Stimulation

  2024cites this paper
• Dystonia-like behaviors and impaired sensory–motor integration following neurotoxic lesion of the pedunculopontine tegmental nucleus in mice

  2023cites this paper
• Hypotensive Effect of Electric Stimulation of Caudal Ventrolateral Medulla in Freely Moving Rats

  2023cites this paper
• People With Parkinson’s Disease and Freezing of Gait Show Abnormal Low Frequency Activity of Antagonistic Leg Muscles

  2022cites this paper
• Muscarinic and NMDA Receptors in the Substantia Nigra Play a Role in Reward-Related Learning

  2022cites this paper
• Gaps and roadmap of novel neuromodulation targets for treatment of gait in Parkinson’s disease

  2022cites this paper
• Gaps and roadmap of novel neuromodulation targets for treatment of gait in Parkinson’s disease

  2022cites this paper
• Hypothetical Mechanism of Resting Tremor in Parkinson’s Disease

  2022cites this paper
• Pedunculopontine Nucleus Dysconnectivity Correlates With Gait Impairment in Parkinson’s Disease: An Exploratory Study

  2022cites this paper
• Nervonic acid amends motor disorder in a mouse model of Parkinson’s disease

  2021cites this paper
• Connectivity and Functionality of the Globus Pallidus Externa Under Normal Conditions and Parkinson's Disease

  2021cites this paper
• Nervonic Acid Ameliorates Motor Disorder in Mice with Parkinson’s Disease

  2021cites this paper
• Role of Acetylcholine and GABAergic Inhibitory Transmission in Seizure Pattern Generation in Neural Networks Integrating the Neocortex, Hippocampus, Basal Ganglia, and Thalamus

  2020cites this paper
• New players in basal ganglia dysfunction in Parkinson's disease.

  2020cites this paper
• [The history of Freezing-of-gait in Parkinson's disease - from phenomena to symptom].

  2020cites this paper
• Effects of pedunculopontine nucleus deep brain stimulation on gait disorders in Parkinson's Disease: A meta-analysis of the literature.

  2020cites this paper
• Deep brain stimulation of the pedunculopontine nucleus modulates subthalamic pathological oscillations.

  2019cites this paper
• Pedunculopontine nucleus: An integrative view with implications on Deep Brain Stimulation.

  2019cites this paper
• Freezing of gait: understanding the complexity of an enigmatic phenomenon.

  2019cites this paper
• Role of the pedunculopontine nucleus in controlling gait and sleep in normal and parkinsonian monkeys

  2018cites this paper
• Restoration of Mitochondrial Dysfunction in 6-Hydroxydopamine Induced Parkinson’s disease: a Complete Review

  2017cites this paper
• PPNa-DBS for gait and balance disorders in Parkinson’s disease: a double-blind, randomised study

  2015cites this paper
• No parkinsonism in SCA2 and SCA3 despite severe neurodegeneration of the dopaminergic substantia nigra.

  2015cites this paper
• Sleep Disorders in Parkinsonian Macaques: Effects of l-Dopa Treatment and Pedunculopontine Nucleus Lesion

  2014cites this paper
• Modelling the effects of deep brain stimulation in the pedunculopontine tegmental nucleus in Parkinson’s disease

  2014influential citation
• The effect of low frequency stimulation of the pedunculopontine tegmental nucleus on basal ganglia in a rat model of Parkinson's disease.

  2014cites this paper
• Modèle progressif de la maladie de parkinson après dysfonctionnement aigu des transporteurs du glutamate dans la substance noire chez le rat.

  2013influential citation
• Rôle du noyau subthalamique dans les processus motivationnels et la dépendance à la cocaïne

  2013cites this paper
• Nigral stimulation for resistant axial motor impairment in Parkinson’s disease? A randomized controlled trial

  2013cites this paper
• Études de la subthalamotomie comme traitement des dyskinésies chez le primate parkinsonien

  2013cites this paper
• EL NÚCLEO PEDUNCULOPONTINO Y SU RELACIÓN CON LA FISIOPATOLOGÍA DE LA ENFERMEDAD DE PARKINSON The Pedunculopontine Nucleus and its Relationship to the Pathophysiology of Parkinson's Disease

  2012cites this paper
• Deep brain stimulation of the pedunculopontine tegmental nucleus modulates neuronal hyperactivity and enhanced beta oscillatory activity of the subthalamic nucleus in the rat 6-hydroxydopamine model.

  2012cites this paper
• Allosteric modulation of the group III mGlu4 receptor provides functional neuroprotection in the 6‐hydroxydopamine rat model of Parkinson's disease

  2012cites this paper
• Technology for Brain-Machine Interfaces

  2012cites this paper
• Subthalamic nucleus stimulation restores the efferent cortical drive to muscle in parallel to functional motor improvement

  2012cites this paper
• Intrinsic and integrative properties of substantia nigra pars reticulata neurons.

  2011cites this paper
• Blockade of mGluR5 reverses abnormal firing of subthalamic nucleus neurons in 6-hydroxydopamine partially lesioned rats.

  2011cites this paper
• The pedunculopontine nucleus as a target for deep brain stimulation

  2011cites this paper
• Glutamatergic and cholinergic pedunculopontine neurons innervate the thalamic parafascicular nucleus in rats: changes following experimental parkinsonism

  2011cites this paper
• Pedunculopontine nucleus deep brain stimulation in Parkinson’s disease

  2011cites this paper
• Combined STN/SNr-DBS for the treatment of refractory gait disturbances in Parkinson's disease: study protocol for a randomized controlled trial

  2011cites this paper
• [Effects and mechanism of low frequency stimulation of pedunculopontine nucleus on spontaneous discharges of ventrolateral thalamic nucleus in rats].

  2011cites this paper
• The effects of chronic levodopa treatments on the neuronal firing properties of the subthalamic nucleus and substantia nigra reticulata in hemiparkinsonian rhesus monkeys.

  2011cites this paper
• c-Fos expression after deep brain stimulation of the pedunculopontine tegmental nucleus in the rat 6-hydroxydopamine Parkinson model.

  2011cites this paper
• Combined stimulation of the substantia nigra pars reticulata and the subthalamic nucleus is effective in hypokinetic gait disturbance in Parkinson’s disease

  2011cites this paper
• Animal models of Parkinson's disease: a source of novel treatments and clues to the cause of the disease

  2011influential citation
• Emerging and Experimental Neurosurgical Treatments for Parkinson's Disease

  2011cites this paper
• THE ROLE OF INTERHEMISPHERIC PATHWAYSIN PARKINSON’S DISEASE AND DRUG-INDUCED DYSKINESIAS

  2011cites this paper
• Subthalamic Deep Brain Stimulation for Parkinson's Disease

  2011cites this paper
• [Deep brain stimulation and gait disorders in Parkinson disease].

  2010cites this paper
• EFFET DE LA STIMULATION DU NOYAU PEDONCULOPONTIN SUR LES TROUBLES DE LA MARCHE ET LE FREEZING DANS LA MALADIE DE PARKINSON : ETUDE CLINIQUE ET THERAPEUTIQUE

  2010cites this paper
• Stimulation cérébrale profonde et troubles de la marche dans la maladie de Parkinson

  2010cites this paper
• Motor activity-induced dopamine release in the substantia nigra is regulated by muscarinic receptors.

  2010cites this paper
• Effect of deep brain stimulation in the pedunculopontine nucleus on motor function in the rat 6-hydroxydopamine Parkinson model.

  2010cites this paper
• Glutamate Plasticity in an Animal Model of Parkinson’s Disease

  2009cites this paper
• Oscillatory Activity and Synchronization in the Basal Ganglia Network in Rodent Models of Parkinson’s Disease

  2009cites this paper
• Subthalamic Nucleus Stimulation for Parkinson's Disease

  2009cites this paper
• PPN Stimulation for Parkinson's Disease

  2009cites this paper
• Mean-field analysis of basal ganglia and thalamocortical dynamics.

  2009cites this paper
• Mean-field modeling of the basal ganglia-thalamocortical system. II Dynamics of parkinsonian oscillations.

  2009cites this paper
• Dopamine and the regulation of movements - significance of nigral and striatal dopamine release in normal, hemiparkinsonian and dyskinetic rats

  2009cites this paper
• Parafascicular thalamic nucleus activity in a rat model of Parkinson's disease.

  2009cites this paper
• Local administration of sarizotan into the subthalamic nucleus attenuates levodopa-induced dyskinesias in 6-OHDA-lesioned rats

  2009cites this paper
• Mean-field modeling of the basal ganglia-thalamocortical system. I Firing rates in healthy and parkinsonian states.

  2009influential citation
• Bilateral high frequency stimulation of the subthalamic nucleus normalizes COX activity in the substantia nigra of Parkinsonian rats.

  2009cites this paper
• Pathophysiology of parkinsonism.

  2008cites this paper
• [Special aspects of patient care after implantation of deep-brain-stimulator].

  2008cites this paper
• Deep brain stimulation promotes excitation and inhibition in subthalamic nucleus in Parkinson's disease

  2008cites this paper
• The basal ganglia in Parkinson's disease: Current concepts and unexplained observations

  2008cites this paper
• Activation of the subthalamic nucleus during obstinate progression in rat pups

  2008cites this paper
• Invited review Pathophysiology of Parkinsonism

  2008cites this paper
• Deep brain stimulation effect on freezing of gait

  2008cites this paper
• Stereotactic surgery of nucleus tegmenti pedunculopontini

  2008cites this paper
• High‐frequency stimulation of the subthalamic nucleus modulates the activity of pedunculopontine neurons through direct activation of excitatory fibres as well as through indirect activation of inhibitory pallidal fibres in the rat

  2007cites this paper
• The pedunculopontine nucleus and movement disorders: anatomy and the role for deep brain stimulation.

  2007cites this paper
• Dopamine lesion‐induced changes in subthalamic nucleus activity are not associated with alterations in firing rate or pattern in layer V neurons of the anterior cingulate cortex in anesthetized rats

  2007influential citation
• Open Journal of Parkinson's Disease and Treatment

  year unknowncites this paper