GABA(A)-receptor subtypes: a new pharmacology.

No abstract is available for this paper.

• Publication year

  2001

• Venue

  Current opinion in pharmacology (Print)

• Publication date

  2001-02-01

• Fields of study

  Medicine, Psychology

• Identifiers
  DOI 10.1016/S1471-4892(01)00008-XPMID 11712530
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Mechanism of action of the hypnotic zolpidem in vivo

  2000cited by this paper
• Agents in Development for Anxiety Disorders

  2000cited by this paper
• Sedative but not anxiolytic properties of benzodiazepines are mediated by the GABAA receptor α1 subtype

  2000cited by this paper
• GABA synchronizes clock cells within the suprachiasmatic circadian clock.

  2000cited by this paper
• Inhibitory threshold for critical-period activation in primary visual cortex

  2000cited by this paper
• Molecular and neuronal substrate for the selective attenuation of anxiety.

  2000cited by this paper
• Zaleplon displays a selectivity to recombinant GABAA receptors different from zolipdem, zopiclone and benzodiazepines

  1999cited by this paper
• Benzodiazepine actions mediated by specific γ-aminobutyric acidA receptor subtypes

  1999cited by this paper
• Reciprocal inhibitory connections and network synchrony in the mammalian thalamus.

  1999cited by this paper
• Local GABA circuit control of experience-dependent plasticity in developing visual cortex.

  1998cited by this paper
• Pharmacology of recombinant γ‐aminobutyric acidA receptors rendered diazepam‐insensitive by point‐mutated α‐subunits

  1998cited by this paper
• Synapse‐specific localization of NMDA and GABAA receptor subunits revealed by antigen‐retrieval immunohistochemistry

  1998cited by this paper
• Cortical plasticity: from synapses to maps.

  1998cited by this paper
• Anxiolytic-like effects of PNU-101017, a partial agonist at the benzodiazepine receptor

  1997cited by this paper
• Differential synaptic localization of two major gamma-aminobutyric acid type A receptor alpha subunits on hippocampal pyramidal cells.

  1996cited by this paper
• Characterization of U-101017 as a GABA(A) receptor ligand of dual functionality.

  1996cited by this paper
• Laminar compartmentalization of GABAA-receptor subtypes in the spinal cord: an immunohistochemical study

  1996cited by this paper
• Comparison of the pharmacological profiles of the hypnotic drugs, zaleplon and zolpidem.

  1996cited by this paper
• Temporal information transformed into a spatial code by a neural network with realistic properties

  1995cited by this paper
• GABAA-Receptors: Drug Binding Profile and Distribution of Receptors Containing the α2-Subunit in Situ

  1993cited by this paper
• Current potentiation by diazepam but not GABA sensitivity is determined by a single histidine residue.

  1993cited by this paper
• A single histidine in GABAA receptors is essential for benzodiazepine agonist binding.

  1992cited by this paper
• The selectivity of zolpidem and alpidem for the α1-subunit of the GABAA receptor

  1992cited by this paper

• I2-DMSO mediated multi-component cascade cyclization to construct pyrazolo[3,4-b]pyrrolo[3,4-d]pyridine-6-one skeleton

  2025cites this paper
• Ethanol-induced rapid eye movement sleep suppression in rats: Comparison with subtype-selective GABAA receptor compounds

  2025cites this paper
• The Effects of Indirect and Direct Modulation of Endocannabinoid System Function on Anxiety-Related Behavior in Mice Assessed in the Elevated Plus Maze Test

  2025cites this paper
• The Case for Clinical Trials with Novel GABAergic Drugs in Diabetes Mellitus and Obesity

  2022cites this paper
• Targeting GABA to Cure Anxiety Disorder in Various Methods

  2022cites this paper
• Electrophysiology of ionotropic GABA receptors

  2021cites this paper
• Etifoxine does not impair muscle tone and motor function in rats as assessed by in vivo and in vitro methods.

  2020cites this paper
• Amino Acid Neurotransmitters

  2019cites this paper
• Development of 1,3-thiazole analogues of imidazopyridines as potent positive allosteric modulators of GABAA receptors.

  2019cites this paper
• Amino Acid Neurotransmitters: Glutamate, GABA, and the Pharmacology of Benzodiazepines

  2019cites this paper
• The potential effect of pandan wangi leaf “pandanus amaryllifolius roxb.’” from indonesia as time sleep inductor

  2019cites this paper
• Reduced GABAergic Signaling at the Axon Initial Segment Decreases Vigilance State Transitioning

  2019cites this paper
• Identification of Carassius auratus gibelio liver cell proteins interacting with the GABAA receptor γ2 subunit using a yeast two-hybrid system

  2018cites this paper
• Autocrine GABA signaling distinctively regulates phenotypic activation of mouse pulmonary macrophages.

  2018cites this paper
• Neurochemical Markers in the Mammalian Brain: Structure, Roles in Synaptic Communication, and Pharmacological Relevance.

  2017cites this paper
• Abuse-related effects of subtype-selective GABAA receptor positive allosteric modulators in an assay of intracranial self-stimulation in rats

  2017influential citation
• Utility of passiflora incarnata homoeopathic mother tincture in general anxiety disorder: A pilot study

  2017cites this paper
• A versatile optical tool for studying synaptic GABAA receptor trafficking

  2017cites this paper
• Synthesis of new heterocyclic compounds based on pyrazolopyridine scaffold and evaluation of their neuroprotective potential in MPP+-induced neurodegeneration.

  2017cites this paper
• Dissociating variations in attention with schizotypy and anxiety

  2017cites this paper
• Optogenetic analyses of inhibitory neurotransmission in the mouse spinal dorsal horn

  2017cites this paper
• Sex Hormone Effects on the Nervous System and Their Impact on Muscle Strength and Motor Performance in Women

  2017cites this paper
• Overstimulation of the inhibitory nervous system plays a role in the pathogenesis of neuromuscular and neurological diseases: a novel hypothesis

  2016cites this paper
• Analysis of β-Subunit-dependent GABAA Receptor Modulation and Behavioral Effects of Valerenic Acid Derivatives

  2016cites this paper
• Molecular Biomarkers and Network Analyses of Neuron-type Connectivity Reveal Cloaked Insights into Hippocampal Function

  2016cites this paper
• Benzodiazepines and Anxiety Disorders: From Laboratory to Clinic

  2016cites this paper
• Using anxiolytics in epilepsy: neurobiological, neuropharmacological and clinical aspects.

  2016influential citation
• Open Peer Review

  2016cites this paper
• Model-based meta-analysis of the effects of non-selective and α1-selective GABAA receptor agonists in healthy volunteers

  2015cites this paper
• Indium(III) chloride/silica gel catalyzed synthesis of pyrazolo[3,4-b]pyrrolo[3,4-d]pyridines

  2015cites this paper
• The 5-HT 7 receptor as a potential target for treating drug and alcohol abuse

  2015cites this paper
• The role of neurotrophins in bipolar disorder.

  2015cites this paper
• GABAA Receptor α and γ Subunits Shape Synaptic Currents via Different Mechanisms*

  2014cites this paper
• A predicted binding site for cholesterol on the GABAA receptor.

  2014cites this paper
• Synthesis of pyrazolo[3,4-b]pyrrolo[3,4-d]pyridine derivatives via Aza-Diels–Alder reaction: evaluation of torsion effect of pyrazoylimines

  2014cites this paper
• Aprendizagem de escolha alimentar em pombos (Columba livia) e imunorreação para as proteínas Zenk e sinapsina I no hipocampo : efeitos do antagonista de receptores GABAB, faclofeno

  2014cites this paper
• Effects of time of estrogen deprivation on anxiety-like behavior and GABAA receptor plasticity in ovariectomized rats.

  2013cites this paper
• Sniffer patch laser uncaging response (SPLURgE): an assay of regional differences in allosteric receptor modulation and neurotransmitter clearance.

  2013cites this paper
• New GABA amides activating GABAA-receptors

  2013cites this paper
• Investigation of new GABAA receptor ligands for their receptor subtype selectivity Verfasserin

  2013cites this paper
• Chronic blockade of cannabinoid CB2 receptors induces anxiolytic‐like actions associated with alterations in GABAA receptors

  2012cites this paper
• Fast Times: Excitatory Effect of GABA in Axonal Compartments in the Cerebellar Molecular Layer

  2012cites this paper
• GABAA receptors increase excitability and conduction velocity of cerebellar parallel fiber axons.

  2012cites this paper
• Insomnia Pharmacotherapy

  2012cites this paper
• Gabra5-gene haplotype block associated with behavioral properties of the full agonist benzodiazepine chlordiazepoxide.

  2012cites this paper
• Fast synaptic inhibition in spinal sensory processing and pain control.

  2012cites this paper
• Structural and electronic effects of the C2’ substituent in 1,4–benzodiazepines

  2011cites this paper
• Neurosteroids and GABA-A Receptor Function

  2011cites this paper
• In vitro neuropharmacological evaluation of penitrem-induced tremorgenic syndromes: importance of the GABAergic system.

  2011cites this paper
• Light it up: Highly efficient multigene delivery in mammalian cells

  2011cites this paper
• Absence of tolerance to the anticonvulsant and neuroprotective effects of imidazenil against DFP-induced seizure and neuronal damage.

  2011influential citation
• Part I. Unified pharmacophore protein models of the benzodiazepine receptor subtypes. Part II. Subtype selective ligands for alpha5 Gaba(A) /BZ receptors

  2011cites this paper
• Anticonvulsant, anxiolytic, and non-sedating actions of imidazenil and other imidazo-benzodiazepine carboxamide derivatives.

  2010cites this paper
• Pharmacological profile of three different γ-butyrolactone derivatives in mice

  2010cites this paper
• Age-related decline of functional inhibition in rat cortex.

  2010cites this paper
• γ-butyrolactone derivatives in mice

  2010cites this paper
• Fast Inhibitory Transmission of Pain in the Spinal Cord

  2009cites this paper
• Multiplexed labeling of viable cells for high‐throughput analysis of glycine receptor function using flow cytometry

  2009cites this paper
• Neuronal plasticity after ischemic preconditioning and TIA-like preconditioning ischemic periods

  2009cites this paper
• Quantitative analyses of [11C]Ro15-4513 binding to subunits of GABAA/benzodiazepine receptor in the living human brain

  2009cites this paper
• Selective influence on contextual memory: physiochemical properties associated with selectivity of benzodiazepine ligands at GABAA receptors containing the alpha5 subunit.

  2008cites this paper
• Ethyl 8-fluoro-6-(3-nitrophenyl)-4H-imidazo[1,5-a][1,4]benzodiazepine-3-carboxylate as novel, highly potent, and safe antianxiety agent.

  2008cites this paper
• Novel treatment approaches for refractory anxiety disorders

  2008cites this paper
• Efficacy and Safety of Sleep-Promoting Agents

  2008cites this paper
• Imidazenil: a low efficacy agonist at alpha1- but high efficacy at alpha5-GABAA receptors fail to show anticonvulsant cross tolerance to diazepam or zolpidem.

  2008cites this paper
• the of pharmacodynamic effects of newly designed gaba a ergic agents in early phase drug

  2008cites this paper
• GABAA/Benzodiazepine receptor binding in patients with schizophrenia using [11C]Ro15-4513, a radioligand with relatively high affinity for α5 subunit

  2008cites this paper
• Pharmacodynamic and pharmacokinetic effects of MK-0343, a GABAA α2,3 subtype selective agonist, compared to lorazepam and placebo in healthy male volunteers

  2008cites this paper
• GABAA/Benzodiazepine receptor binding in patients with schizophrenia using [11C]Ro15-4513, a radioligand with relatively high affinity for alpha5 subunit.

  2008cites this paper
• Neurosteroid: Molecular Mechanisms of Action on the GABAA Receptor

  2008cites this paper
• Noni as an anxiolytic and sedative: a mechanism involving its gamma-aminobutyric acidergic effects.

  2007cites this paper
• Novel 3-iodo-8-ethoxypyrazolo[5,1-c][1,2,4]benzotriazine 5-oxide as promising lead for design of alpha5-inverse agonist useful tools for therapy of mnemonic damage.

  2007cites this paper
• Characterization of two classes of benzodiazepine binding sites in Schistosoma mansoni

  2007cites this paper
• Ethanol acts directly on extrasynaptic subtypes of GABAA receptors to increase tonic inhibition.

  2007influential citation
• Alterations in GABAA Receptor α2 Subunit mRNA Expression following Reproductive Experience in Rats

  2007cites this paper
• Effects of neuroactive steroids on the recombinant GABAA receptor in Xenopus oocyte

  2007cites this paper
• Pharmacodynamic and pharmacokinetic effects of TPA023, a GABAA α2,3 subtype-selective agonist, compared to lorazepam and placebo in healthy volunteers

  2007cites this paper
• Adolescent cortical development: a critical period of vulnerability for addiction.

  2007cites this paper
• Pharmacodynamic and pharmacokinetic effects of TPA023, a GABA(A) alpha(2,3) subtype-selective agonist, compared to lorazepam and placebo in healthy volunteers.

  2007cites this paper
• Radiosynthesis and biological evaluation of an 18F-labeled derivative of the novel pyrazolopyrimidine sedative-hypnotic agent indiplon.

  2007cites this paper
• Title Contributions of the GABA ( A ) receptor alpha 6 subunit to phasic and tonic inhibition revealed by a naturally occurring polymorphism in the alpha 6 gene

  2006cites this paper
• Both α2 and α3 GABAA receptor subtypes mediate the anxiolytic properties of benzodiazepine site ligands in the conditioned emotional response paradigm

  2006cites this paper
• Anxiolytic-like activity of SB-205384 in the elevated plus-maze test in mice.

  2006cites this paper
• Changes in neocortical and hippocampal GABAA receptor subunit distribution during brain maturation and aging.

  2006cites this paper
• Benzodiazepine receptor ligands. 8: synthesis and pharmacological evaluation of new pyrazolo[5,1-c] [1,2,4]benzotriazine 5-oxide 3- and 8-disubstituted: high affinity ligands endowed with inverse-agonist pharmacological efficacy.

  2006cites this paper
• Group II metabotropic glutamate (mGlu2/3) receptors

  2006cites this paper
• Interaction of novel condensed triazine derivatives with central and peripheral type benzodiazepine receptors: synthesis, in vitro pharmacology and modelling.

  2006cites this paper
• GABAergic phthalide dimers from Angelica sinensis (Oliv.) Diels.

  2006cites this paper
• Design, synthesis, and pharmacological evaluation of new neuroactive pyrazolo[3,4-b]pyrrolo[3,4-d]pyridine derivatives with in vivo hypnotic and analgesic profile.

  2006cites this paper
• GABAA receptors as targets for novel anxiolytic drugs

  2006cites this paper
• Contributions of the GABAA receptor alpha6 subunit to phasic and tonic inhibition revealed by a naturally occurring polymorphism in the alpha6 gene.

  2006cites this paper
• GABA(A) receptor subtypes as targets for neuropsychiatric drug development.

  2006cites this paper
• Anxiolytic-like effects of mGlu2/3 receptor agonists LY354740 and LY379268: comparison of male and female rats

  2006cites this paper
• Safety of Insomnia Pharmacotherapy

  2006cites this paper
• Striatal Information Signaling and Integration in Globus Pallidus: Timing Matters

  2006cites this paper
• Genomic and Post-Genomic Tools for Studying Synapse Biology

  2006cites this paper
• Contributions of the GABAA Receptor α6 Subunit to Phasic and Tonic Inhibition Revealed by a Naturally Occurring Polymorphism in the α6 Gene

  2006cites this paper
• Molecular mechanisms underlying the modulation of exocytotic noradrenaline release via presynaptic receptors.

  2006cites this paper
• Molecular organization and assembly of the central inhibitory postsynapse.

  2006cites this paper
• The GABA-benzodiazepine receptor complex: structure, function, and role in anxiety.

  2005cites this paper