Changes in cytoplasmic pH and in membrane potential in thrombin-stimulated human platelets.

No abstract is available for this paper.

• Publication year

  1981

• Venue

  European Journal of Biochemistry

• Publication date

  1981-11-01

• Fields of study

  Biology, Medicine, Chemistry

• Identifiers
  DOI 10.1111/J.1432-1033.1981.TB05703.XPMID 7318826
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Transmembrane potential changes associated with superoxide release from human granulocytes

  1981cited by this paper
• The internal pH of mast cell granules

  1980cited by this paper
• Electrochemical proton gradient in inverted membrane vesicles from Escherichia coli.

  1980cited by this paper
• Correlation between membrane potential changes and superoxide production in human granulocytes stimulated by phorbol myristate acetate. Evidence for defective activation in chronic granulomatous disease.

  1980cited by this paper
• Spectrophotometric measurements of transmembrane potential and pH gradients in chromaffin granules

  1980cited by this paper
• Left Stellectomy in the Prevention of Ventricular Fibrillation Caused by Acute Myocardial Ischemia in Conscious Dogs with Anterior Myocardial Infarction

  1980cited by this paper
• Rapid Separation of Cytosol and Particle Fraction of Human Platelets by Digitonin‐induced Cell Damage

  1980cited by this paper
• Intracellular pH: Methods and Applications

  1979cited by this paper
• Intracellular pH measurements in Ehrlich ascites tumor cells utilizing spectroscopic probes generated in situ.

  1979cited by this paper
• The relation between dicarbocyanine dye fluorescence and the membrane potential of human red blood cells set at varying Donnan equilibria

  1979cited by this paper
• Platelet interaction with active and TLCK-inactivated α-thrombin

  1979cited by this paper
• Use of a lipophilic cation for determination of membrane potential in neuroblastoma-glioma hybrid cell suspensions.

  1979cited by this paper
• Platelet interaction with active and TLCK-inactivated alpha-thrombin.

  1979cited by this paper
• Effects of amiloride on the response of human platelets to bovine alphathrombin.

  1978cited by this paper
• Effects of amiloride on the response of human platelets to bovine α thrombin

  1978cited by this paper
• The internal pH of isolated serotonin containing granules of pig platelets.

  1978cited by this paper
• Use of dyes to estimate the electrical potential of the mitochondrial membrane.

  1978cited by this paper
• Separation of human platelets from plasma proteins including factor VIII VWF by a combined albumin gradient-gel filtration method using HEPES buffer.

  1978cited by this paper
• Probes of transmembrane potentials in platelets: changes in cyanine dye fluorescence in response to aggregation stimuli.

  1978cited by this paper
• Mechanism of potential-dependent light absorption changes of lipid bilayer membranes in the presence of cyanine and oxonol dyes

  1977cited by this paper
• Generation of a transmembrane electric potential during respiration by Azotobacter vinelandii membrand vesicles

  1977cited by this paper
• Mechanisms of platelet shape change, aggregation, and release induced by collagen, thrombin, or A23,187.

  1977cited by this paper
• The electrochemical proton gradient in Escherichia coli membrane vesicles.

  1977cited by this paper
• The use of fluorescent probe to monitor alterations in trans-membrane potential in single cell suspensions.

  1976cited by this paper
• Binding of Thrombin to Human Platelets and its Possible Significance

  1976cited by this paper
• Direct evidence for intracellular divalent cation redistribution associated with platelet shape change.

  1976cited by this paper
• A method for measuring the internal pH in illuminated chloroplasts based on the stimulation of proton uptake by amines.

  1976cited by this paper
• Light-induced pH Gradients in Isolated Spinach Chloroplasts

  1976cited by this paper
• Biochemistry of the platelet release reaction.

  1975cited by this paper
• Preparation and partial characterization of two forms of bovine thrombin.

  1975cited by this paper
• On the determination of the transmembrane pH difference in bacterial chromatophores using 9-aminoacridine.

  1974cited by this paper
• Determination of membrane potentials in human and Amphiuma red blood cells by means of a fluorescent probe

  1974cited by this paper
• Studies on the mechanism by which cyanine dyes measure membrane potential in red blood cells and phosphatidylcholine vesicles.

  1974cited by this paper
• Determination of pH in chloroplasts. 2. Fluorescent amines as a probe for the determination of pH in chloroplasts.

  1972cited by this paper
• Determination of ΔpH in Chloroplasts

  1972cited by this paper
• The response of fluorescent amines to pH gradients across liposome membranes.

  1972cited by this paper
• Determination of DeltapH in Chloroplasts. 2. Fluorescent Amines as a Probe for the Determination of DeltapH in Chloroplasts

  1972cited by this paper
• On the mechanism of the energy‐dependent quenching of atebrin fluorescence in isolated chloroplasts

  1971cited by this paper
• ALTERATION OF THE RESPONSE OF PLATELETS TO SURFACE STIMULI BY PYRAZOLE COMPOUNDS

  1967cited by this paper
• Some Effects of Fibrinogen Degradation Products (FDP) on Blood Platelets

  1966cited by this paper

• A prevalent neglect of environmental control in mammalian cell culture calls for best practices

  2021cites this paper
• Effect of fluoride on sodium-proton exchanger activity, intracellular pH and calcium concentration in human non-stimulated platelets.

  2013cites this paper
• Mitochondrially Mediated Integrin αIIbβ3 Protein Inactivation Limits Thrombus Growth*

  2013cites this paper
• Ein Cytochrom P450 2C8/9-abhängig gebildeter EDHF hyperpolarisiert Thrombozyten und hemmt deren Adhäsion an Endothelzellen

  2008cites this paper
• Electrolytes and pH changes in pre-eclamptic rats.

  2007cites this paper
• Inhibitory mechanisms of low concentrations of oxidized low-density lipoprotein on platelet aggregation.

  2006cites this paper
• TRPC4 expression determines sensitivity of the platelet-type capacitative Ca2+ entry channel to intracellular alkalosis

  2006cites this paper
• Mechanisms of regulation of the Na+/H+ exchanger

  2005cites this paper
• Abnormal pH-sensing of platelet Na+/H+ exchanger in patients with cardiac syndrome X.

  2005cites this paper
• Mechanisms of antiplatelet and antithrombotic activity of midazolam in in vitro and in vivo studies.

  2004cites this paper
• Involvement of the Antiplatelet Activity of Magnesium Sulfate in Suppression of Protein Kinase C and the Na+/H+ Exchanger

  2004cites this paper
• Morphine-Potentiated Platelet Aggregation in in vitro and Platelet Plug Formation in in vivo Experiments

  2003cites this paper
• Inhibitory mechanisms of kinetin, a plant growth-promoting hormone, in platelet aggregation

  2003cites this paper
• Morphine-potentiated platelet aggregation in in vitro and platelet plug formation in in vivo experiments.

  2003cites this paper
• Role of Sodium in ADP- and Megakaryocyte Spreading Thrombin-induced

  2002cites this paper
• The hyperaggregability of platelets from normal pregnancy is mediated through thromboxane A2 and cyclic AMP pathways.

  2002cites this paper
• Intracellular alkalinization augments platelet aggregation due to increase in cytosolic free-Ca 2+

  2002cites this paper
• Influences of pH on human platelet metabolism

  2001cites this paper
• Influences of pH on human platelet metabolism.

  2001cites this paper
• Repression of starch degradation under anaerobic conditions by irregularly high levels of ATP in Chlamydomonas sp. MGA161.

  2001cites this paper
• Radiation and/or Hyperthermia Sensitivity of Human Melanoma Cells Grown for Several Days in Media with Reduced pH

  1999cites this paper
• Flow Cytometry: Use of Multiparameter Kinetics to Evaluate Several Activation Parameters Simultaneously in Individual Living Cells

  1999cites this paper
• Biochemistry of Platelet Activation

  1999cites this paper
• Sodium-Hydrogen Exchange and Platelet Function

  1999cites this paper
• On-Line Monitoring of Intracellular Properties and Its Use in Bioreactor Operation

  1998cites this paper
• Stimulus responses and amyloid precursor protein processing in DAMI megakaryocytes.

  1997cites this paper
• Diacylglycerol mediates the thrombin‐induced, protein kinase C and Ca2+ independent activation of the Na+/H+ exchanger in platelets

  1997cites this paper
• Na+/H+ Exchange in Platelets

  1997cites this paper
• Arachidonic acid activates a proton conductance pathway and the Na+/H+ exchanger in platelets.

  1996cites this paper
• Spatial distribution and temporal change in cytosolic pH and [Ca2+] in resting and activated single human platelets.

  1995cites this paper
• Regulation of platelet function by sodium-hydrogen exchange.

  1995cites this paper
• Na(+)-independent Active H(+) Extrusion and HCO(3)(-)/C1(-) Exchange Contribute to Cytoplasmic pH Regulation in the Human Platelet.

  1995cites this paper
• The role of platelets in essential hypertension.

  1995cites this paper
• Identification and Characterization of Functional Secretory Cells: Advantages of Multiparameter Flow Cytometry Kinetics

  1994cites this paper
• Effect of cytoplasmic pH on Ca2+‐stimulated eicosanoid biosynthesis in human platelets

  1994cites this paper
• Different pathways for control of Na+/H+ exchange via activation of the thrombin receptor.

  1994cites this paper
• Regulation of inositol 1,4,5-trisphosphate receptors.

  1993influential citation
• Changes in cytoplasmic pH in platelets activated through the high- and moderate-affinity receptor pathways by highly purified human alpha-thrombin.

  1993cites this paper
• The Ca2+-extruding ATPase of the human platelet creates and responds to cytoplasmic pH changes, consistent with a 2 Ca2+/nH+ exchange mechanism

  1993cites this paper
• Thrombin and NaF, but not epinephrine, raise cytosolic free Na+ in human platelets.

  1993cites this paper
• Effect of epinephrine on the regulation of Na+/H+ exchange in human platelets.

  1993cites this paper
• Non-age related differences in thrombin responses by platelets from male patients with advanced Alzheimer's disease.

  1993cites this paper
• Intracellular pH based controlled cultivation of yeast cells: I. Measurement methodology

  1993cites this paper
• Antiplatelet protease, kistomin, selectively cleaves human platelet glycoprotein Ib.

  1993cites this paper
• Receptor-operated Ca2+ signaling and crosstalk in stimulus secretion coupling.

  1993cites this paper
• Molecular link between membrane cholesterol and Na+/H+ exchange within human platelets

  1992cites this paper
• Thrombin receptors on human platelets.

  1992cites this paper
• Rapid Ca2+ extrusion via the Na+/Ca2+ exchanger of the human platelet

  1992cites this paper
• Growth hormone regulates ammoniagenesis in canine renal proximal tubule segments.

  1992cites this paper
• Structure and function of inositol triphosphate receptors

  1991cites this paper
• Cytosolic calcium determination: a fluorometric technique

  1991cites this paper
• The efflux of 86Rb and [3H]5-HT from human platelets during continuous perfusion: effects of potassium-induced membrane depolarization and thrombin stimulation.

  1991cites this paper
• Regulation of the phosphoinositide cycle by Na+/H+ exchange and intracellular pH in human platelets.

  1991cites this paper
• Cytotoxic T lymphocyte (CTL)-mediated cytolysis proceeds in the absence of Na+/H+ antiport activity: regulation of cytosolic pH by the Na+/H+ antiport in a cloned CTL.

  1991cites this paper
• Estimation of carrier density and turnover rate of the Na+/H+ exchanger in human platelets using 5-(N-methyl-N-[3H]isobutyl)- amiloride.

  1991cites this paper
• ADP induced blood platelet activation: a review.

  1991cites this paper
• Structure and function of inositol trisphosphate receptors.

  1991cites this paper
• The Na+/H+ exchanger role in the intracellular pH regulation of human platelets.

  1991cites this paper
• PPACK-thrombin inhibits thrombin-induced platelet aggregation and cytoplasmic acidification but does not inhibit platelet shape change.

  1990cites this paper
• Thrombin-induced cytosolic alkalinization in human platelets occurs without an apparent involvement of HCO3−/Cl− exchange

  1990cites this paper
• Influence of hypercapnia and hypoxia on rabbit platelet aggregation.

  1990cites this paper
• Stimulation by thrombin increases the cytosolic free Na+ concentration in human platelets. Studies with the novel fluorescent cytosolic Na+ indicator sodium-binding benzofuran isophthalate.

  1990cites this paper
• Mechanisms of platelet activation and inhibition.

  1990cites this paper
• Calcium signaling in human platelets.

  1990cites this paper
• The binding of radioiodinated thrombin to rat promegakaryoblasts.

  1990cites this paper
• Na+/H+ exchange modulates Ca2+ mobilization in human platelets stimulated by ADP and the thromboxane mimetic U 46619.

  1990cites this paper
• Initial responses of a clonal osteoblast-like cell line, MOB 3-4, to phosphatidic acid in vitro.

  1990cites this paper
• Simultaneous flow cytometric measurements of thrombin-induced cytosolic pH and Ca2+ fluxes in human platelets.

  1990cites this paper
• Agonist‐evoked changes in cytosolic pH and calcium concentration in human platelets: studies in physiological bicarbonate.

  1990cites this paper
• Sodium fluoride prevents receptor- and protein kinase C-mediated activation of the human platelet Na+/H+ exchanger without inhibiting its basic pHi-regulating activity.

  1990cites this paper
• [Methods of measuring the transmembrane electrical potential in cells].

  1990cites this paper
• Cytoplasmic Ca2+ is necessary for thrombin-induced platelet activation.

  1989cites this paper
• Effects of recombinant human granulocyte‐macrophage colony‐stimulating factor (GM‐CSFrh) on transmembrane electrical potentials in granulocytes: Relationship between enhancement of ligand‐mediated depolarization and augmentation of superoxide anion (O  −2 ) production

  1989cites this paper
• Potentiation by adrenaline of thrombin‐induced elevation of pHi is not essential for synergistic activation of human platelets

  1989cites this paper
• Effects of separate proteolytic and high-affinity binding activities of human thrombin on rapid platelet activation. A quenched-flow study.

  1989cites this paper
• Na+/H+ exchange in PAF-stimulated platelets.

  1989cites this paper
• Involvement of intracellular pH elevation in the effect of 1,25-dihydroxyvitamin D3 on HL-60 cells.

  1989cites this paper
• Ouabain Enhances Basal and Stimulus-Induced Cytoplasmic Calcium Concentrations in Platelets

  1989cites this paper
• Fluoride-induced cytoplasmic acidification: possible role of protein kinase C in BCECF-loaded L929 cells.

  1989cites this paper
• [5] Use of triphenylmethylphosphonium to measure membrane potentials in red blood cells

  1989cites this paper
• pH sensitivity of the thrombin-induced rise in fructose 2,6-bisphosphate content of human platelets.

  1989cites this paper
• Use of triphenylmethylphosphonium to measure membrane potentials in red blood cells.

  1989cites this paper
• Na+/H+ exchange and growth factor-induced cytosolic pH changes. Role in cellular proliferation.

  1989cites this paper
• Activation of Na+/H+ exchange and Ca2+ mobilization start simultaneously in thrombin-stimulated platelets. Evidence that platelet shape change disturbs early rises of BCECF fluorescence which causes an underestimation of actual cytosolic alkalinization.

  1989cites this paper
• An elevation in the concentration of free cytosolic calcium is sufficient to activate the oxidative burst of granulocytes primed with recombinant human granulocyte-macrophage colony-stimulating factor.

  1989cites this paper
• Intracellular pH in platelets from spontaneously hypertensive rats and Wistar‐Kyoto rats

  1988cites this paper
• Effects of changes in intracellular pH induced by platelet storage and treatment with monovalent cation ionophores on platelet functions.

  1988cites this paper
• Na+/H+ exchange as a modulator of platelet activation.

  1988cites this paper
• Flow cytometric measurements of cytoplasmic calcium changes in human platelets.

  1988cites this paper
• Triggering and Activation of Human Neutrophils

  1988cites this paper
• Amiloride analogs stimulate protein phosphorylation and serotonin release in human platelets.

  1988cites this paper
• Effect of epinephrine on rapid ADP-induced aggregation, protein phosphorylation, and cytoplasmic calcium dynamics of platelets: a quenched-flow study.

  1988cites this paper
• Protein I, a translocatable ion channel from Neisseria gonorrhoeae, selectively inhibits exocytosis from human neutrophils without inhibiting O2- generation.

  1988cites this paper
• Human platelet phospholipase A2 activity is responsive in vitro to pH and Ca2+ variations which parallel those occurring after platelet activation in vivo

  1988cites this paper
• Ca2+ mobilization can occur independent of acceleration of Na+/H+ exchange in thrombin-stimulated human platelets.

  1988cites this paper
• Role of Na+/H+ exchange in thrombin- and arachidonic acid-induced Ca2+ influx in platelets.

  1988cites this paper
• Human platelet phospholipase A2 activity is responsive in vitro to pH and Ca2+ variations which parallel those occurring after platelet activation in vivo.

  1988cites this paper
• Protein kinase C enhances Ca2+ mobilization in human platelets by activating Na+/H+ exchange.

  1988cites this paper
• Transient outward currents and changes of their gating properties after cell activation in thrombocytes of the newt.

  1987cites this paper
• A patch‐clamp study of mammalian platelets and their voltage‐gated potassium current.

  1987cites this paper