Activity of MDM2, a ubiquitin ligase, toward p53 or itself is dependent on the RING finger domain of the ligase

No abstract is available for this paper.

• Publication year

  2000

• Venue

  Oncogene

• Publication date

  2000-03-09

• Fields of study

  Biology, Medicine, Chemistry

• Identifiers
  DOI 10.1038/sj.onc.1203464PMID 10723139
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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• Rbx1, a component of the VHL tumor suppressor complex and SCF ubiquitin ligase.

  1999influential reference
• Reconstitution of G1 cyclin ubiquitination with complexes containing SCFGrr1 and Rbx1.

  1999cited by this paper
• The tyrosine kinase negative regulator c-Cbl as a RING-type, E2-dependent ubiquitin-protein ligase.

  1999cited by this paper
• The E2–E3 interaction in the N‐end rule pathway: the RING‐H2 finger of E3 is required for the synthesis of multiubiquitin chain

  1999cited by this paper
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  1999cited by this paper
• Activation of the ATM kinase by ionizing radiation and phosphorylation of p53.

  1998cited by this paper
• The ubiquitin–proteasome pathway: on protein death and cell life

  1998cited by this paper
• Enhanced phosphorylation of p53 by ATM in response to DNA damage.

  1998cited by this paper
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  1997cited by this paper
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  1997cited by this paper
• Oncoprotein MDM2 is a ubiquitin ligase E3 for tumor suppressor p53

  1997cited by this paper
• Regulation of p53 stability by Mdm2

  1997cited by this paper
• p53: puzzle and paradigm.

  1996cited by this paper
• The p53-associated protein MDM2 contains a newly characterized zinc-binding domain called the RING finger.

  1994cited by this paper
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  1993cited by this paper
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