Use of polyclonal immunoglobulins as adjunctive therapy for sepsis or septic shock *

No abstract is available for this paper.

• Publication year

  2007

• Venue

  Critical Care Medicine

• Publication date

  2007-12-01

• Fields of study

  Medicine

• Identifiers
  DOI 10.1097/01.CCM.0000295263.12774.97PMID 18074464
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• [Diagnosis and therapy of sepsis: guidelines of the German Sepsis Society Inc. and the German Interdisciplinary Society for Intensive and Emergency Medicine].

  2006cited by this paper
• Immunomodulation, Part III : Intravenous Immunoglobulin

  2006cited by this paper
• Immunoglobulin treatment in sepsis--is the answer "no"?

  2006cited by this paper
• IgMA-enriched immunoglobulin in neutropenic patients with sepsis syndrome and septic shock: A randomized, controlled, multiple-center trial*

  2006cited by this paper
• Diagnose und Therapie der Sepsis

  2006cited by this paper
• Exchange transfusion or intravenous immunoglobulin therapy as an adjunct to antibiotics for neonatal sepsis in developing countries: a pilot study

  2006cited by this paper
• [Diagnosis and therapy of sepsis. Guidelines of the German Sepsis Society Inc. and the German Interdisciplinary Society for Intensive and Emergency Medicine].

  2006cited by this paper
• EFFECTS OF HIGH-DOSE OF INTRAVENOUS IMMUNOGLOBULIN AND ANTIBIOTICS ON SURVIVAL FOR SEVERE SEPSIS UNDERGOING SURGERY

  2005influential reference
• Intravenous polyclonal immunoglobulin administration to sepsis syndrome patients: a prospective study in a pediatric intensive care unit.

  2005influential reference
• Clinical experience with polyclonal IgM-enriched immunoglobulins in a group of patients affected by sepsis after cardiac surgery.

  2005cited by this paper
• Use of IgM and IgA-enriched immunoglobulins in the treatment of severe sepsis and septic shock. Clinical experience.

  2004cited by this paper
• IgM-enriched immunoglobulin (pentaglobin) positively influences the course of post-surgical intra-abdominal infections.

  2004cited by this paper
• Polyclonal immunoglobulin for treatment of bacterial sepsis: a systematic review.

  2004cited by this paper
• Intravenous immunoglobulin G therapy in streptococcal toxic shock syndrome: a European randomized, double-blind, placebo-controlled trial.

  2003influential reference
• Interaction revisited: the difference between two estimates

  2003cited by this paper
• Measuring inconsistency in meta-analyses

  2003cited by this paper
• The effects of IgM-enriched immunoglobulin preparations in patients with severe sepsis [ISRCTN28863830]

  2002cited by this paper
• The effects of IgM-enriched immunoglobulin preparations in patients with severe sepsis: another point of view

  2002influential reference
• Intravenous immunoglobulin for treating sepsis and septic shock.

  2002influential reference
• Should immunonutrition become routine in critically ill patients? A systematic review of the evidence.

  2001cited by this paper
• Practice parameters for hemodynamic support of sepsis in adult patients in sepsis. Task Force of the American College of Critical Care Medicine, Society of Critical Care Medicine.

  1999cited by this paper
• Multicenter randomized placebo controlled trial of therapy with intravenous immunoglobulin in decreasing mortality due to neonatal sepsis.

  1999influential reference
• Immunoglobulin M-enriched human intravenous immunoglobulin prevents complement activation in vitro and in vivo in a rat model of acute inflammation.

  1999cited by this paper
• Acute-phase proteins and other systemic responses to inflammation.

  1999cited by this paper
• Intravenous immunoglobulin therapy for streptococcal toxic shock syndrome--a comparative observational study. The Canadian Streptococcal Study Group.

  1999cited by this paper
• Bacterial lipopolysaccharide (LPS)‐specific antibodies in commercial human immunoglobulin preparations: superior antibody content of an IgM‐enriched product

  1998cited by this paper
• The significance of immunoglobulins in the treatment of patients with sepsis and septic shock.

  1998cited by this paper
• High doses of immunoglobulins decrease mortality rate of surgical patients with severe intraabdominal infections and sepsis.

  1998cited by this paper
• Protective capacity of a IgM/IgA-enriched polyclonal immunoglobulin-G preparation in endotoxemia

  1998cited by this paper
• Varying titers of neutralizing antibodies to streptococcal superantigens in different preparations of normal polyspecific immunoglobulin G: implications for therapeutic efficacy.

  1998cited by this paper
• [The therapy of gram-negative septicotoxic diseases with pentaglobin, an immunoglobulin with an elevated IgM content (a prospective, randomized clinical study)].

  1996cited by this paper
• High-dose intravenous IgG for treatment of severe surgical infections

  1996influential reference
• Intravenous immunoglobulin in the treatment of full-term and premature newborns with sepsis.

  1996influential reference
• Comparison of two types of intravenous immunoglobulins in the treatment of neonatal sepsis

  1995cited by this paper
• INTRAVENOUS IMMUNOGLOBULIN FOR TREATMENT OF SALMONELLA TYPHIMURIUM INFECTIONS IN PRETERM NEONATES

  1994influential reference
• Intravenous Immunoglobulin in the Treatment of Salmonella Typhimurium Infections in Preterm Neonates

  1994cited by this paper
• Treatment of gram-negative septic shock with an immunoglobulin preparation: a prospective, randomized clinical trial.

  1993influential reference
• Antiendotoxic Therapy with Polyclonal and Polyvalent Immunoglobulins: In Vitro and In Vivo Studies

  1993cited by this paper
• The use of IgM-enriched intravenous immunoglobulin for the treatment of neonatal sepsis in preterm infants.

  1993influential reference
• Intravenous immune globulin therapy for early-onset sepsis in premature neonates.

  1992cited by this paper
• [Intravenous immunoglobulin in the treatment of neonatal septicemia].

  1992influential reference
• Treatment of septic thrombocytopenia with immune globulin

  1991cited by this paper
• Supplemental immunoglobulin (ivIgG) treatment in 163 patients with sepsis and septic shock — An observational study as a prerequisite for placebo-controlled clinical trials

  1991cited by this paper
• Effect on neutrophil kinetics and serum opsonic capacity of intravenous administration of immune globulin to neonates with clinical signs of early-onset sepsis.

  1991cited by this paper
• Treatment of Gram‐negative septic shock with an immunoglobulin preparation: A prospective, randomized clinical trial

  1991cited by this paper
• Effects of high-dose IgG on survival of surgical patients with sepsis scores of 20 or greater.

  1991cited by this paper
• [Immunoglobulin therapy of postoperative sepsis].

  1990cited by this paper
• Respiratory diseases from hard metal or cobalt exposure. Solving the enigma.

  1989cited by this paper
• Opsonic activity of a new intravenous immunoglobulin preparation: Pentaglobin compared with sandoglobulin.

  1989cited by this paper
• Veinoglobulines en réanimation chirurgicale pédiatrique.

  1989cited by this paper
• Rules of evidence and clinical recommendations on the use of antithrombotic agents.

  1989cited by this paper
• Adjuvante Therapie mit Pseudomonas-Immunglobulin

  1989cited by this paper
• [Venoglobulins in pediatric surgical resuscitation].

  1989cited by this paper
• [Adjuvant therapy with pseudomonas immunoglobulin in artificially ventilated patients at a surgical intensive care unit].

  1989cited by this paper
• Rules of evidence and clinical recommendations on the use of antithrombotic agents.

  1989cited by this paper
• Immunoglobulin therapy in patients with endotoxemia and postoperative sepsis--a prospective randomized study.

  1988influential reference
• Intravenous immunoglobulins in association with antibiotics: a therapeutic trial in septic intensive care unit patients.

  1988influential reference
• IgM-enriched intravenous immunoglobulin therapy in neonatal sepsis.

  1988influential reference
• Cooperative group of additional immunoglobulin therapy in severe bacterial infections: Results of a multicenter randomized controlled trial in cases of diffuse fibrinopurulent peritonitis

  1987cited by this paper
• Einfluß einer adjuvanten Immunglobulintherapie auf Infektionen bei Patienten einer operativen Intensiv-Therapie-Station

  1986cited by this paper
• Immunoglobulin supplementation in prevention or treatment of neonatal sepsis.

  1986cited by this paper
• Meta-analysis in clinical trials.

  1986cited by this paper
• [Effect of adjuvant immunoglobulin therapy on infections in patients in an surgical intensive care unit. Results of a randomized controlled study].

  1986cited by this paper
• Intravenous gamma-globulin in the treatment of neonatal sepsis with special reference to group B streptococci and pharmacokinetics.

  1986cited by this paper
• [Immunoglobulin substitution in the treatment of neonatal septicemia].

  1981cited by this paper
• Pepsin‐Treated Human Gamma Globulin in Bacterial Infections: A Randomized Study in Patients with Septicaemia and Pneumonia

  1981cited by this paper
• Serum IgM and IgA responses in influenza A infections

  1974cited by this paper
• THE IMMUNOLOGICAL DEVELOPMENT OF THE HUMAN FETUS

  1965cited by this paper

• 2025 national clinical huideline for sepsis in children

  2025cites this paper
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  2025cites this paper
• The effect of Colchicine IN Sepsis (COLINS): a study protocol for a randomized, double-blind, placebo-controlled trial

  2025cites this paper
• Renal Expression Levels of C5a Receptor and Autophagy‐related Beclin‐1 and LC3A/B Are Simultaneously Enhanced Under Immunoglobulin Treatment in a Rat Model of Sepsis

  2025cites this paper
• Adjunctive immunotherapeutic agents in patients with sepsis and septic shock: a multidisciplinary consensus of 23

  2024cites this paper
• Sepsis in 2024: A Review

  2024cites this paper
• Multifaceted Tissue-Protective Functions of Polyvalent Immunoglobulin Preparations in Severe Infections—Interactions with Neutrophils, Complement, and Coagulation Pathways

  2023cites this paper
• The immunomodulating activity of trimodulin (polyvalent IgM, IgA, IgG solution): a post hoc analysis of the phase II CIGMA trial

  2023cites this paper
• The Role of the Intravenous IgA and IgM-Enriched Immunoglobulin Preparation in the Treatment of Sepsis and Septic Shock

  2023cites this paper
• A new hope? Possibilities of therapeutic IgA antibodies in the treatment of inflammatory lung diseases

  2023cites this paper
• Clinical efficacy of IgM-enriched immunoglobulin as adjunctive therapy in neonatal and pediatric sepsis: a systematic review and meta-analysis

  2023cites this paper
• The Role of Intravenous Immunoglobulin in Decreasing the Level of Procalcitonin in Early Phase of Sepsis: A Prospective Study

  2022cites this paper
• IgM-enriched immunoglobulin improves colistin efficacy in a pneumonia model by Pseudomonas aeruginosa

  2022cites this paper
• Promising targets for immunotherapeutic approaches against Acinetobacter baumannii.

  2022cites this paper
• Comparative Effectiveness of Combined IgM-Enriched Immunoglobulin and Extracorporeal Blood Purification Plus Standard Care Versus Standard Care for Sepsis and Septic Shock after Cardiac Surgery

  2022cites this paper
• Can the Reduction of Cytokines Stop the Progression of Sepsis?

  2022influential citation
• Federal guidelines on diagnosis and treatment of community-acquired pneumonia

  2022cites this paper
• Effect of the Immunoglobulin G-A-M Treatment on Hepatic Functions and Mortality rates in Patients with Septic Shock

  2022cites this paper
• Dosing of Extracorporeal Cytokine Removal In Septic Shock (DECRISS): protocol of a prospective, randomised, adaptive, multicentre clinical trial

  2021cites this paper
• Sepsis in children: federal clinical guideline (draft)

  2021cites this paper
• Neonatal Buzağı İshal Tedavilerine İlave Probiyotik Kullanımının İmmunglobulin M (IgM) ve İmmunglobulin G (IgG) Seviyelerine Etkisi The Effect of Probiotic use on Immunglobulin M (IgM) and Immunglobulin G (IgG) Levels with Routine Treatment in Neonatal Calf Diarrhea

  2021cites this paper
• Vitamin C and Sepsis

  2021cites this paper
• Adjunctive IgM-enriched immunoglobulin therapy with a personalised dose based on serum IgM-titres versus standard dose in the treatment of septic shock: a randomised controlled trial (IgM-fat trial)

  2021cites this paper
• Septic shock due to Escherichia coli meningoencephalitis treated with immunoglobulin-M-enriched immunoglobulin preparation as adjuvant therapy: a case report

  2021cites this paper
• A hypothetical adhesin protein induces anti-biofilm antibodies against multi-drug resistant Acinetobacter baumannii.

  2021cites this paper
• Epidemiology of intravenous immune globulin in septic shock: a retrospective cohort analysis of the Premier Healthcare Database

  2021cites this paper
• ARCHIVES OF CURRENT MEDICAL RESEARCH

  2021cites this paper
• Multicentered prospective investigator initiated study to evaluate the clinical outcomes with extracorporeal cytokine adsorption device (CytoSorb®) in patients with sepsis and septic shock

  2021cites this paper
• Rationale for Polyclonal Intravenous Immunoglobulin Adjunctive Therapy in Covid19 Patients: Report of a Structured Multidisciplinary Consensus

  2021cites this paper
• Querschnitts-Leitlinien zur Therapie mit Blutkomponenten und Plasmaderivaten

  2021cites this paper
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  2021cites this paper
• Outcome and Risk Factors of Febrile Episodes Treated with Broad Spectrum Antibiotics and Polyclonal IgM–enriched Immunoglobulin in Pediatric Oncology Hematology Patients: A Retrospective Study

  2021cites this paper
• Comparison of Adjunctive Treatment with IgMEnriched IVIG and Antibiotics Alone in Treatment of Neonatal Sepsis

  2021cites this paper
• Treatment with IgM-enriched immunoglobulin in sepsis: a matched case-control analysis.

  2021cites this paper
• Sepsis 2021: a review

  2021cites this paper
• Rationale for Polyclonal Intravenous Immunoglobulin Adjunctive Therapy in COVID-19 Patients: Report of a Structured Multidisciplinary Consensus

  2021cites this paper
• Intravenous immune globulin in septic shock: a Canadian national survey of critical care medicine and infectious disease specialist physicians

  2021cites this paper
• Experience with hemoadsorption (CytoSorb®) in the management of septic shock patients

  2020cites this paper
• Surviving Sepsis Campaign: Guidelines on the Management of Critically Ill Adults with Coronavirus Disease 2019 (COVID-19)

  2020cites this paper
• Use of Intravenous Immunoglobulins in Sepsis Therapy—A Clinical View

  2020cites this paper
• Quality assessment of meta-analyses evaluating randomized clinical trials to improve the prognosis of septic shock: an overview of systematic reviews

  2020cites this paper
• Clinical, laboratory features and prognosis of children receiving IgM-enriched immunoglobulin (3 days vs. 5 days) as adjuvant treatment for serious infectious disease in pediatric intensive care unit: a retrospective single-center experience (PIGMENT study)

  2020cites this paper
• An update on endotoxin neutralization strategies in Gram-negative bacterial infections

  2020cites this paper
• Community-acquired pneumonia: similarities and differences between European and American guidelines - A narrative review –

  2020cites this paper
• Risiken und Chancen von Immuntherapien in Zeiten der Coronavirus-2019-Pandemie

  2020cites this paper
• Best-practice IgM- and IgA-enriched immunoglobulin use in patients with sepsis

  2020cites this paper
• The Rationale for Potential Pharmacotherapy of COVID-19

  2020influential citation
• Merits and culprits of immunotherapies for neurological diseases in times of COVID-19

  2020cites this paper
• S3-Leitlinie Sepsis – Prävention, Diagnose, Therapie und Nachsorge

  2020cites this paper
• Effect of Therapeutic Plasma Exchange on Immunoglobulin Deficiency in Early and Severe Septic Shock

  2020cites this paper
• Re-Evaluating Biologic Pharmacotherapies That Target the Host Response during Sepsis

  2019cites this paper
• Progress of Research in Neonatal Sepsis

  2019cites this paper
• Advances in Sepsis Treatment

  2019cites this paper
• Effects of immunotherapy on mortality in neonates with suspected or proven sepsis: a systematic review and network meta-analysis

  2019influential citation
• The novel polyclonal Ab preparation trimodulin attenuates ex vivo endotoxin-induced immune reactions in early hyperinflammation

  2019cites this paper
• Efficacy of IgM-enriched Immunoglobulin for Vasopressor-resistant Vasoplegic Shock After Liver Transplantation

  2019cites this paper
• Mortality in Patients With Septic Shock by Multidrug Resistant Bacteria

  2019cites this paper
• Targeting the Blood-Brain Barrier to Prevent Sepsis-Associated Cognitive Impairment

  2019cites this paper
• Extracorporeal cytokine adsorption in septic shock: A proof of concept randomized, controlled pilot study

  2019cites this paper
• Regulation of dendritic cell function improves survival in experimental sepsis through immune chaperone

  2019cites this paper
• A Position Paper on IgM-Enriched Intravenous Immunoglobulin Adjunctive Therapy in Severe Acute Bacterial Infections: The TO-PIRO SCORE Proposal.

  2019cites this paper
• Role of Immunoglobulin Therapy to Prevent and Treat Infections

  2018cites this paper
• Effects of the timing of administration of IgM- and IgA-enriched intravenous polyclonal immunoglobulins on the outcome of septic shock patients

  2018cites this paper
• Intravenous immunoglobulin fails to improve ARDS in patients undergoing ECMO therapy

  2018cites this paper
• IgM Natural Autoantibodies in Physiology and the Treatment of Disease.

  2018cites this paper
• A rare case of septic shock due to Neisseria meningitidis serogroup B infection despite prior vaccination in a young adult with paroxysmal nocturnal haemoglobinuria receiving eculizumab.

  2018cites this paper
• Adjunctive Therapies for Community-Acquired Pneumonia.

  2018cites this paper
• Efficacy and safety of trimodulin, a novel polyclonal antibody preparation, in patients with severe community-acquired pneumonia: a randomized, placebo-controlled, double-blind, multicenter, phase II trial (CIGMA study)

  2018cites this paper
• Management of Sepsis-Induced Immunosuppression.

  2018cites this paper
• The use of IgM‐enriched immunoglobulin in adult patients with sepsis

  2018cites this paper
• Septic shock from descending necrotizing mediastinitis – combined treatment with IgM-enriched immunoglobulin preparation and direct polymyxin B hemoperfusion: a case report

  2018cites this paper
• Shock séptico secundario a contusión pulmonar: ¿inmunomodulación sería la estrategia? Reporte de caso y revisión de la literatura

  2017cites this paper
• Influence of the serum levels of immunoglobulins on clinical outcomes in medical intensive-care patients

  2017cites this paper
• MiR-146a potentially promotes IVIg-mediated inhibition of TLR4 signaling in LPS-activated human monocytes.

  2017cites this paper
• Multidrug resistant (or antimicrobial-resistant) pathogens - alternatives to new antibiotics?

  2017cites this paper
• Surviving Sepsis Campaign: International Guidelines for Management of Sepsis and Septic Shock: 2016

  2017cites this paper
• Use of human immunoglobulins as an anti-infective treatment: the experience so far and their possible re-emerging role

  2017cites this paper
• The protective association of endogenous immunoglobulins against sepsis mortality is restricted to patients with moderate organ failure

  2017cites this paper
• Management of intra-abdominal infections: recommendations by the WSES 2016 consensus conference

  2017cites this paper
• Current and emerging evidence for immunomodulatory therapy in community-acquired pneumonia

  2017cites this paper
• Management and Novel Adjuncts of Necrotizing Soft Tissue Infections

  2017cites this paper
• Pathogen concentration integrated molecular analysis for SMARTDIAGNOS: the next generation sepsis diagnosis

  2017cites this paper
• Sepsis and septic shock: New definitions, new diagnostic and therapeutic approaches.

  2017cites this paper
• Pediatric Sepsis: Clinical Considerations

  2017cites this paper
• Pentoxifylline and Pentaglobin adjuvant therapies for neonatal nosocomial sepsis in neonates less than 1500g weight.

  2017cites this paper
• Bioartificial Therapy of Sepsis: Changes of Norepinephrine-Dosage in Patients and Influence on Dynamic and Cell Based Liver Tests during Extracorporeal Treatments

  2016cites this paper
• NLRP10 A Potential Contributor to the Anti-Inflammatory Effects of IVIg in Sepsis

  2016cites this paper
• Can Intravenous Human Immunoglobulins Reduce Mortality in Patients with (Septic) Acute Kidney Injury

  2016cites this paper
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  2016cites this paper
• Serum levels of immunoglobulins and severity of community-acquired pneumonia

  2016cites this paper
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  2016cites this paper
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  2016cites this paper
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  2016cites this paper
• Effect of Prophylactic Antifungal Protocols on the Prognosis of Liver Transplantation: A Propensity Score Matching and Multistate Model Approach

  2016cites this paper
• New aspects in the management of pneumonia

  2016cites this paper
• Effect of IgM-Enriched Immunoglobulin as Adjunctive Therapy in a Patient Following Sepsis After Open Thoracoabdominal Aortic Aneurysm Repair.

  2016cites this paper
• IgG2 as an independent risk factor for mortality in patients with community-acquired pneumonia.

  2016influential citation
• Tumorerkrankungen und Neutropenie

  2016cites this paper
• Immunotherapy of Sepsis: Blind Alley or Call for Personalized Assessment?

  2016cites this paper
• IV Immunoglobulin for Acute Lung Injury and Bacteremia in Pseudomonas aeruginosa Pneumonia*

  2016cites this paper