Metabolic and structural evidence for the existence of a third species of polyphosphoinositide in cells: D-phosphatidyl-myo-inositol 3-phosphate.

No abstract is available for this paper.

• Publication year

  1989

• Venue

  Biochemical Journal

• Publication date

  1989-04-01

• Fields of study

  Biology, Medicine, Chemistry

• Identifiers
  DOI 10.1042/BJ2590267PMID 2541684PMCID PMC1138500
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Type I phosphatidylinositol kinase makes a novel inositol phospholipid, phosphatidylinositol-3-phosphate

  1988cited by this paper
• L-myo-inositol 1,4,5,6-tetrakisphosphate (3-hydroxy)kinase.

  1988cited by this paper
• Synthesis of myo-inositol 1,3,4,5,6-pentakisphosphate from inositol phosphates generated by receptor activation.

  1988cited by this paper
• An inositol tetrakisphosphate-containing phospholipid in activated neutrophils

  1988cited by this paper
• Evidence for two distinct phosphatidylinositol kinases in fibroblasts. Implications for cellular regulation.

  1987cited by this paper
• Novel aspects of gonadotropin-releasing hormone action on inositol polyphosphate metabolism in cultured pituitary gonadotrophs.

  1987cited by this paper
• Metabolism of D-myo-inositol 1,3,4,5-tetrakisphosphate by rat liver, including the synthesis of a novel isomer of myo-inositol tetrakisphosphate.

  1987cited by this paper
• Regulation of inositol trisphosphate accumulation by muscarinic cholinergic and H1-histamine receptors on human astrocytoma cells. Differential induction of desensitization by agonists.

  1987cited by this paper
• The metabolism of inositol 1,3,4-trisphosphate to inositol 1,3-bisphosphate.

  1987cited by this paper
• Rapid formation of inositol 1,3,4,5-tetrakisphosphate and inositol 1,3,4-trisphosphate in rat parotid glands may both result indirectly from receptor-stimulated release of inositol 1,4,5-trisphosphate from phosphatidylinositol 4,5-bisphosphate.

  1986cited by this paper
• Phosphatidylinositol metabolism and polyoma-mediated transformation.

  1986cited by this paper
• Inositol 1,3,4,5-tetrakisphosphate and not phosphatidylinositol 3,4-bisphosphate is the probable precursor of inositol 1,3,4-trisphosphate in agonist-stimulated parotid gland.

  1986cited by this paper
• Rapid formation of inositol 1,3,4,5-tetrakisphosphate following muscarinic receptor stimulation of rat cerebral cortical slices.

  1985cited by this paper
• Inositol tetrakis- and pentakisphosphates in GH4 cells.

  1985cited by this paper
• Association of phosphatidylinositol kinase activity with polyoma middle-T competent for transformation

  1985cited by this paper
• Inositol trisphosphate, a novel second messenger in cellular signal transduction

  1984cited by this paper
• Characterization of the hormone-sensitive phosphatidylinositol pool in WRK-1 cells.

  1983cited by this paper
• Muscarinic cholinergic receptor-mediated activation of phosphodiesterase.

  1982cited by this paper
• Alkaline O leads to N-transacylation. A new method for the quantitative deacylation of phospholipids.

  1981cited by this paper
• Stimulation of hydrolysis of phosphatidic acid by cholinergic agents in guinea pig synaptosomes.

  1974cited by this paper
• Analogue computer analysis of tracer flow patterns through the glycolytic and related pathway in erythrocytes and other intact metabolic systems.

  1968cited by this paper
• The structure of triphosphoinositide from beef brain.

  1966cited by this paper
• THE CHROMATOGRAPHIC SEPARATION OF POLYPHOSPHOINOSITIDES AND STUDIES ON THEIR TURNOVER IN VARIOUS TISSUES.

  1964cited by this paper
• On the metabolism of the brain phosphoinositide complex.

  1962cited by this paper
• Myo-inositol phosphates obtained by alkaline hydrolysis of beef brain phosphoinositide.

  1961cited by this paper
• Complete characterization of the myo-inositol polyphosphates from beef brain phosphoinositide.

  1961cited by this paper

• Achieving Absolute Molar Lipid Concentrations: A Phospholipidomics Cross-Validation Study

  2022cites this paper
• Defining the molecular mechanisms mediating class IA phosphoinositide 3-kinase (PI3K) regulation and their role in human disease

  2019cites this paper
• Studies of Malarial Parasite Chloroquine Resistance Transporter and Kinase Proteins: Key Targets for Evolving Drug Therapies

  2017cites this paper
• Phosphatidylinositol 4-kinases: Function, structure, and inhibition.

  2015cites this paper
• The imidazo[1,2-a]pyridine ring system as a scaffold for potent dual phosphoinositide-3-kinase (PI3K)/mammalian target of rapamycin (mTOR) inhibitors.

  2015cites this paper
• Mechanistic Analysis of Differential SignalTransduction Mediated by the Insulin ReceptorSubstrate Proteins IRS-1 and IRS-2: A Dissertation

  2014cites this paper
• Discovery of InsP6-kinases as InsP6-dephosphorylating enzymes provides a new mechanism of cytosolic InsP6 degradation driven by the cellular ATP/ADP ratio.

  2014cites this paper
• Phosphoinositides: tiny lipids with giant impact on cell regulation.

  2013cites this paper
• Phosphoinositides and vesicular membrane traffic.

  2012cites this paper
• PI3K signalling: the path to discovery and understanding

  2012cites this paper
• Phosphoinositide 3-kinases-a historical perspective.

  2012cites this paper
• First came the link between phosphoinositides and Ca2+ signalling, and then a deluge of other phosphoinositide functions.

  2009cites this paper
• Quantification of multiple phosphatidylinositol 4-kinase isozyme activities in cell extracts.

  2009cites this paper
• Endosomal Phosphoinositides and Human Diseases

  2008influential citation
• Sequential actions of myotubularin lipid phosphatases regulate endosomal PI(3)P and growth factor receptor trafficking.

  2008cites this paper
• Quantification of PtdIns(3,4,5)P(3) dynamics in EGF-stimulated carcinoma cells: a comparison of PH-domain-mediated methods with immunological methods.

  2008cites this paper
• Evolution of the diverse biological roles of inositols.

  2007cites this paper
• Visualization of PtdIns3P dynamics in living plant cells.

  2006cites this paper
• D-3 phosphoinositides of the ciliate Tetrahymena: characterization and study of their regulatory role in lysosomal enzyme secretion.

  2005cites this paper
• Characterization of MTMR3: an inositol lipid 3-phosphatase with novel substrate specificity

  2001cites this paper
• Measurement of Phosphoinositide 3-Kinase Activation by Interleukins

  2001cites this paper
• Phosphoinositide 3‐kinase: a key biochemical signal for cell migration in response to chemokines

  2000cites this paper
• SAC1 Encodes a Regulated Lipid Phosphoinositide Phosphatase, Defects in Which Can Be Suppressed by the Homologous Inp52p and Inp53p Phosphatases*

  2000cites this paper
• Complementation Analysis in PtdInsPKinase-deficient Yeast Mutants Demonstrates ThatSchizosaccharomyces pombe and Murine Fab1p Homologues Are Phosphatidylinositol 3-Phosphate 5-Kinases*

  1999cites this paper
• Separation of polyphosphoinositides using normal-phase high-performance liquid chromatography and evaporative light scattering detection or electrospray mass spectrometry.

  1997cites this paper
• Osmotic stress activates phosphatidylinositol-3,5-bisphosphate synthesis

  1997cites this paper
• Role of phosphoinositide 3-kinase in platelet responses to platelet-activating factor

  1997cites this paper
• Phosphoinositide 3-kinase activation and platelet function.

  1996cites this paper
• D-3 phosphoinositide metabolism in cells treated with platelet-derived growth factor.

  1996cites this paper
• Inositol phosphates in barley (Hordeum vulgare L.) aleurone tissue are stereochemically similar to the products of breakdown of InsP6 in vitro by wheat-bran phytase.

  1996cites this paper
• Effects of growth factors on phosphatidylinositol‐3 kinase in astroglial cells

  1995cites this paper
• Evidence for substrate-cycling of 3-, 3,4-, 4-, and 4,5-phosphorylated phosphatidylinositols in plants.

  1995cites this paper
• The Mechanism of Muscarinic Receptor‐Stimulated Phosphatidylinositol Resynthesis in 1321N1 Astrocytoma Cells and Its Inhibition by Li+

  1995cites this paper
• Interfacial catalysis by phosphoinositide 3'-hydroxykinase.

  1995cites this paper
• A phosphatidylinositol (PI) kinase gene family in Dictyostelium discoideum: biological roles of putative mammalian p110 and yeast Vps34p PI 3-kinase homologs during growth and development

  1995cites this paper
• Quantification of polyphosphoinositides using selected ion monitoring electrospray mass spectrometry

  1995cites this paper
• Colworth Medal Lecture. Molecules mediating signals.

  1995cites this paper
• RANTES-activated human T lymphocytes. A role for phosphoinositide 3-kinase.

  1995cites this paper
• Identification of a phosphatidylinositol 3-hydroxy kinase in plant cells: association with the cytoskeleton.

  1994cites this paper
• Phosphatidylinositol 3,4,5-trisphosphate is formed from phosphatidylinositol 4,5-bisphosphate in thrombin-stimulated platelets.

  1994cites this paper
• Phosphoinositide metabolism in airway smooth muscle.

  1994cites this paper
• The inhibition of phosphoinositide synthesis and muscarinic-receptor-mediated phospholipase C activity by Li+ as secondary, selective, consequences of inositol depletion in 1321N1 cells.

  1994cites this paper
• Phosphoinositidase C, Inositol Polyphosphates and Force Generation of Airways Smooth Muscle

  1994cites this paper
• TOR1 and TOR2 are structurally and functionally similar but not identical phosphatidylinositol kinase homologues in yeast.

  1994cites this paper
• Structure, regulation and function of phosphoinositide 3-kinases.

  1994cites this paper
• Phosphoinositide metabolism, aging and Alzheimer's disease.

  1994cites this paper
• Agonist-stimulated synthesis of phosphatidylinositol(3,4,5)-trisphosphate: a new intracellular signalling system?

  1993cites this paper
• Subcellular distribution of agonist-stimulated phosphatidylinositol synthesis in 1321 N1 astrocytoma cells.

  1993cites this paper
• Role of Phosphatidylinositol 3-Kinase in Growth Factor and Oncogene Signaling

  1993cites this paper
• The detection, purification, structural characterization, and metabolism of diphosphoinositol pentakisphosphate(s) and bisdiphosphoinositol tetrakisphosphate(s).

  1993cites this paper
• Pathway of synthesis of 3,4- and 4,5-phosphorylated phosphatidylinositols in the duckweed Spirodela polyrhiza L.

  1993cites this paper
• Characterization of phosphatidylinositol-4-phosphate 5-kinase activities from bovine brain membranes.

  1993cites this paper
• Analysis of inositol metabolites produced by Saccharomyces cerevisiae in response to glucose stimulation.

  1993cites this paper
• Effects of inositol starvation on the levels of inositol phosphates and inositol lipids in Neurospora crassa.

  1993cites this paper
• SIGNAL TRANSDUCTION IN OSTEOBLASTS AND OSTEOCLASTS

  1993cites this paper
• Tyrosine Phosphorylation/Dephosphorylation and Downstream Signalling

  1993cites this paper
• Granulocyte macrophage‐colony stimulating factor stimulates both association and activation of phosphoinositide 3OH‐kinase and src‐related tyrosine kinase(s) in human myeloid derived cells.

  1993cites this paper
• The characteristics, capacity and receptor regulation of inositol uptake in 1321N1 astrocytoma cells.

  1993cites this paper
• Phosphatidylinositol 3-kinase: A Novel Signal Transduction Pathway?

  1992cites this paper
• Inositol phosphate biochemistry.

  1992cites this paper
• Purification and characterization of human erythrocyte phosphatidylinositol 4-kinase. Phosphatidylinositol 4-kinase and phosphatidylinositol 3-monophosphate 4-kinase are distinct enzymes.

  1992cites this paper
• The inositol phosphates in WRK1 rat mammary tumour cells.

  1992cites this paper
• The stereoselective recognition of substrates by phosphoinositide kinases. Studies using synthetic stereoisomers of dipalmitoyl phosphatidylinositol.

  1992cites this paper
• Phosphatidylinositol 3-kinase is activated by nerve growth factor and epidermal growth factor in PC12 cells.

  1992cites this paper
• Synthesis and tritium radiolabelling of fluorinated analogues of myo-inositol

  1992cites this paper
• Inositol Lipids and Signal Transduction in the Nervous System: An Update

  1992influential citation
• Phospholipases C and D in mitogenic signal transduction.

  1992cites this paper
• Regulation of D‐3 phosphoinositides during T cell activation via the T cell antigen receptor/CD3 complex and CD2 antigens

  1992cites this paper
• Identification and metabolism of phosphoinositol species formed on angiotensin II stimulation of zona fasciculata-reticularis cells from the bovine adrenal cortex.

  1992cites this paper
• Granulocyte/macrophage colony-stimulating factor affects myo-inositol metabolism in a novel manner. Implications for its priming action on human neutrophils.

  1992cites this paper
• Receptor specificity of growth factor-stimulated synthesis of 3-phosphorylated inositol lipids in Swiss 3T3 cells.

  1992cites this paper
• Activated phosphoinositide 3-kinase associates with membrane skeleton in thrombin-exposed platelets.

  1992cites this paper
• Multi-enzyme complexes associated with receptors during signal transduction.

  1992cites this paper
• 3- and 4-phosphorylated phosphatidylinositols in the aquatic plant Spirodela polyrhiza L.

  1992cites this paper
• Sensory transduction in eukaryotes. A comparison between Dictyostelium and vertebrate cells.

  1991cites this paper
• Pathway for the formation of D-3 phosphate containing inositol phospholipids in PDGF stimulated NIH 3T3 fibroblasts.

  1991cites this paper
• Pathway of phosphatidylinositol(3,4,5)-trisphosphate synthesis in activated neutrophils

  1991cites this paper
• Determination of mass changes in phosphatidylinositol 4,5-bisphosphate and evidence for agonist-stimulated metabolism of inositol 1,4,5-trisphosphate in airway smooth muscle.

  1991cites this paper
• Phosphoinositide 3-kinase: a new effector in signal transduction?

  1991cites this paper
• Identification and quantification of polyphosphoinositides produced in response to platelet-derived growth factor stimulation.

  1991cites this paper
• Characterization of two 85 kd proteins that associate with receptor tyrosine kinases, middle-T/pp60c-src complexes, and PI3-kinase.

  1991cites this paper
• Thrombin stimulates the production of phosphatidylinositol 3,4-bisphosphate in human erythroleukemia cells.

  1991cites this paper
• Inositol phospholipids and phosphates for investigation of intact cell phospholipase C substrates and products.

  1991cites this paper
• Novel polyphosphoinositides in cell growth and activation.

  1991cites this paper
• Signaling mechanisms in T cells.

  1991cites this paper
• Measurement of picomole amounts of any inositol phosphate isomer separable by h.p.l.c. by means of a bioluminescence assay.

  1991cites this paper
• G Protein Involvement in Signal Transduction

  1991cites this paper
• Sensory transduction in eukaryotes

  1991cites this paper
• Changes in inositol lipids and phosphates after stimulation of the MAS-transfected NG115-401L-C3 cell line by mitogenic and non-mitogenic stimuli.

  1990cites this paper
• Pathway for the formation of D-3 phosphate containing inositol phospholipids in intact human platelets.

  1990cites this paper
• Inositol lipids and phosphates.

  1990cites this paper
• myo-inositol metabolites as cellular signals.

  1990cites this paper
• Phosphatidylinositol-3-phosphate and inositol phosphates in mitogenesis.

  1990cites this paper
• Chapter 11 Phosphoinositide Metabolism in Lymphocyte Activation

  1990cites this paper
• Synthesis of some deoxy-fluoro analogues of myo-inositol

  1990cites this paper
• Thrombin stimulates the production of a novel polyphosphoinositide in human platelets.

  1990cites this paper
• Regulation of phosphoinositide-specific phospholipase C.

  1990cites this paper
• Thrombin-stimulated immunoprecipitation of phosphatidylinositol 3-kinase from human platelets.

  1990cites this paper
• A myo-inositol D-3 hydroxykinase activity in Dictyostelium.

  1990cites this paper
• Phosphoinositide kinases.

  1990cites this paper