Adenomatous polyposis coli (APC): a multi-functional tumor suppressor gene

No abstract is available for this paper.

• Publication year

  2007

• Venue

  Journal of Cell Science

• Publication date

  2007-10-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1242/jcs.03485PMID 17881494
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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• Aneuploidy acts both oncogenically and as a tumor suppressor.

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• Chromosomal instability by β-catenin/TCF transcription in APC or β-catenin mutant cells

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• Chromosomal instability by beta-catenin/TCF transcription in APC or beta-catenin mutant cells.

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• Mining the Wnt pathway for cancer therapeutics

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• Loss of APC induces polyploidy as a result of a combination of defects in mitosis and apoptosis

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• Regulated Binding of Adenomatous Polyposis Coli Protein to Actin*

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• Mad2 overexpression promotes aneuploidy and tumorigenesis in mice.

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• Testing hypotheses for the functions of APC family proteins using null and truncation alleles in Drosophila

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• 腺腫性結腸ポリープ癌抑制遺伝子のショウジョウバエ相同体はβ‐カテニンをダウンレギュレートするが,その接合体発現はアルマジロ蛋白質の調節に必須ではない

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