Varicella-Zoster virus: pathogenesis, immunity, and clinical management in hematopoietic cell transplant recipients.

New information about the mechanisms of varicella-zoster virus (VZV) pathogenesis and the host response to the virus has improved our understanding of the threat that VZV reactivation may pose after hematopoietic cell transplantation (HCT). Antiviral therapy compensates for some of the deficiencies in VZV immunity in HCT recipients, and inactivated varicella vaccine may be useful for the early reconstitution of adaptive immunity to VZV after HCT.

• Publication year

  2000

• Venue

  Biology of Blood and Marrow Transplantation

• Publication date

  2000-05-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1016/S1083-8791(00)70004-8PMID 10871147
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Modulation of Major Histocompatibility Class II Protein Expression by Varicella-Zoster Virus

  2000cited by this paper
• Infection of Human T Lymphocytes with Varicella-Zoster Virus: an Analysis with Viral Mutants and Clinical Isolates

  2000cited by this paper
• Varicella zoster virus infections following allogeneic bone marrow transplantation: frequency, risk factors, and clinical outcome.

  2000cited by this paper
• Viral gene expression in rat trigeminal ganglia following neonatal infection with varicella‐zoster virus

  1999cited by this paper
• Quantitation of Latent Varicella-Zoster Virus and Herpes Simplex Virus Genomes in Human Trigeminal Ganglia

  1999cited by this paper
• Latent varicella-zoster virus is located predominantly in neurons in human trigeminal ganglia.

  1998cited by this paper
• Infection of cells with varicella-zoster virus down-regulates surface expression of class I major histocompatibility complex antigens.

  1998cited by this paper
• Attenuation of the Vaccine Oka Strain of Varicella-Zoster Virus and Role of Glycoprotein C in Alphaherpesvirus Virulence Demonstrated in the SCID-hu Mouse

  1998cited by this paper
• The ORF47 and ORF66 putative protein kinases of varicella-zoster virus determine tropism for human T cells and skin in the SCID-hu mouse.

  1998cited by this paper
• Aberrant intracellular localization of Varicella-Zoster virus regulatory proteins during latency.

  1998cited by this paper
• Early reconstitution of immunity and decreased severity of herpes zoster in bone marrow transplant recipients immunized with inactivated varicella vaccine.

  1997cited by this paper
• Recognition of the latency-associated immediate early protein IE63 of varicella-zoster virus by human memory T lymphocytes.

  1997cited by this paper
• Granulysin, a new human cytolytic granule-associated protein with possible involvement in cell-mediated cytotoxicity.

  1997cited by this paper
• Expression of protein encoded by varicella-zoster virus open reading frame 63 in latently infected human ganglionic neurons.

  1996cited by this paper
• The varicella vaccine. Prevention of herpes zoster.

  1996cited by this paper
• PREVENTION OF HERPES ZOSTER

  1996cited by this paper
• European survey of herpesvirus resistance to antiviral drugs in bone marrow transplant recipients. Infectious Diseases Working Party of the European Group for Blood and Marrow Transplantation (EBMT).

  1996cited by this paper
• Varicella-zoster virus

  1996cited by this paper
• Immune responses to varicella-zoster virus.

  1996cited by this paper
• The patterns of varicella zoster virus encephalitis.

  1996cited by this paper
• Varicella-zoster virus (VZV) transcription during latency in human ganglia: detection of transcripts mapping to genes 21, 29, 62, and 63 in a cDNA library enriched for VZV RNA

  1996cited by this paper
• Configuration of latent varicella-zoster virus DNA

  1995cited by this paper
• Herpes simplex virus turns off the TAP to evade host immunity

  1995cited by this paper
• Foscarnet-resistant multidermatomal zoster in a patient with AIDS.

  1995cited by this paper
• Myelitis due to varicella-zoster virus in an immunocompromised patient without a cutaneous rash.

  1995cited by this paper
• Tropism of varicella-zoster virus for human CD4+ and CD8+ T lymphocytes and epidermal cells in SCID-hu mice

  1995cited by this paper
• Valaciclovir compared with acyclovir for improved therapy for herpes zoster in immunocompetent adults

  1995cited by this paper
• Reactivated and latent varicella-zoster virus in human dorsal root ganglia.

  1995cited by this paper
• Famciclovir for the Treatment of Acute Herpes Zoster: Effects on Acute Disease and Postherpetic Neuralgia: A Randomized, Double-Blind, Placebo-Controlled Trial

  1995cited by this paper
• Visceral varicella zoster infection after bone marrow transplantation without skin involvement and the use of PCR for diagnosis.

  1995cited by this paper
• Phenotypic and genotypic characterization of acyclovir-resistant varicella-zoster viruses isolated from persons with AIDS.

  1994cited by this paper
• Varicella‐zoster virus myelitis

  1994cited by this paper
• Varicella zoster infection after bone marrow transplantation: incidence, risk factors and complications.

  1994cited by this paper
• Fatal noncutaneous visceral infection with varicella-zoster virus in a patient with lymphoma after autologous bone marrow transplantation.

  1993cited by this paper
• The neuropathology of herpes zoster with particular reference to postherpetic neuralgia and its pathogenesis

  1993cited by this paper
• Viral infections in leukemia and bone marrow transplant patients.

  1993cited by this paper
• Investigation of the pathogenesis of varicella-zoster virus infection in guinea pigs by using polymerase chain reaction.

  1993cited by this paper
• Inappropriate antidiuretic hormone secretion (SIADH) preceding skin manifestations of disseminated varicella zoster virus infection post-BMT.

  1993cited by this paper
• Varicella zoster infections in bone marrow transplants.

  1993cited by this paper
• Abdominal presentation of varicella zoster infection after bone marrow transplantation.

  1992cited by this paper
• Subclinical varicella-zoster virus viremia, herpes zoster, and T lymphocyte immunity to varicella-zoster viral antigens after bone marrow transplantation.

  1992cited by this paper
• Herpes zoster: pathogenesis and latency.

  1992cited by this paper
• Equivalent recognition of a varicella-zoster virus immediate early protein (IE62) and glycoprotein I by cytotoxic T lymphocytes of either CD4+ or CD8+ phenotype.

  1991cited by this paper
• Early herpes zoster infection in adult patients with Hodgkin's disease undergoing autologous bone marrow transplant.

  1991cited by this paper
• Abdominal presentation of varicella-zoster infection in recipients of allogeneic bone marrow transplantation.

  1991cited by this paper
• Viral infections associated with bone marrow transplantation.

  1990cited by this paper
• Studies on transfer of varicella-zoster-virus specific T-cell immunity from bone marrow donor to recipient.

  1990cited by this paper
• Antiviral Agents and Viral Diseases of Man

  1990cited by this paper
• Investigation of varicella-zoster virus infection of lymphocytes by in situ hybridization

  1989cited by this paper
• The prophylactic role of intravenous and long-term oral acyclovir after allogeneic bone marrow transplantation.

  1989cited by this paper
• Titration of igg antibodies against varicella zoster virus before bone marrow transplantation is not predictive of future zoster

  1989cited by this paper
• Herpes zoster infection after autologous bone marrow transplantation.

  1989cited by this paper
• Herpes zoster infection after autologous bone marrow transplantation

  1989cited by this paper
• The risk of zoster after varicella vaccination in children with leukemia.

  1988cited by this paper
• Prevention of herpes zoster in patients by long-term oral acyclovir after allogeneic bone marrow transplantation.

  1988cited by this paper
• Rapid reappearance of large granular lymphocytes (LGL) with concomitant reconstitution of natural killer (NK) activity after human bone marrow transplantation (BMT)

  1987cited by this paper
• Clinical and subclinical reactivations of varicella-zoster virus in immunocompromised patients.

  1986cited by this paper
• Early and late interstitial pneumonia following human bone marrow transplantation.

  1986cited by this paper
• Treatment of varicella-zoster virus infection in severely immunocompromised patients. A randomized comparison of acyclovir and vidarabine.

  1986cited by this paper
• Fulminant varicella hepatitis following bone marrow transplantation.

  1985cited by this paper
• Infection with varicella-zoster virus after marrow transplantation.

  1985influential reference
• Laboratory diagnosis of viral infections

  1985cited by this paper
• Phenotype of recovering lymphoid cell populations after marrow transplantation

  1985cited by this paper
• Endonuclease analysis of viral DNA from varicella and subsequent zoster infections in the same patient.

  1984cited by this paper
• Acyclovir treatment of varicella-zoster virus infection in the compromised host.

  1984cited by this paper
• Herpes virus infections: clinical manifestations and therapeutic strategies in immunocompromised patients.

  1984cited by this paper
• Acyclovir halts progression of herpes zoster in immunocompromised patients.

  1983cited by this paper
• Analysis of late infections after human bone marrow transplantation: role of genotypic nonidentity between marrow donor and recipient and of nonspecific suppressor cells in patients with chronic graft-versus-host disease.

  1982cited by this paper
• Cell-mediated immunity to varicella-zoster virus after allogeneic marrow transplant.

  1980cited by this paper
• Pathogenesis of varicella-zoster angiitis in the CNS.

  1980cited by this paper
• Human leukocyte interferon for the treatment of herpes zoster in patients with cancer.

  1978cited by this paper

• A Case of Herpes Zoster Triggered by a Centipede Bite

  2025cites this paper
• Small Molecule Compounds Inhibit Varicella-Zoster Virus Replication by Targeting the Portal Protein–Capsid Interface

  2025cites this paper
• Assessment of cellular and humoral immunity against varicella-zoster virus in adult allogeneic hematopoietic cell transplant recipients: a cross-sectional study assessing cellular immunity after administration of an adjuvanted recombinant zoster vaccine.

  2025cites this paper
• Prevalence of VZV Reactivation and Effectiveness of Vaccination with Recombinant Adjuvanted Zoster Vaccine in Allogeneic Hematopoietic Stem Cell Recipients—A Single-Center Analysis

  2025cites this paper
• Systematic review and meta-analysis of recombinant herpes zoster vaccine in immunocompromised populations

  2024cites this paper
• Risk factors for herpes zoster infections: a systematic review and meta-analysis unveiling common trends and heterogeneity patterns

  2024cites this paper
• Neuroimaging of the Most Common Meningitis and Encephalitis of Adults: A Narrative Review

  2024cites this paper
• Lymphocyte counts predict optimal timing of chemotherapy reinitiation after antivirus treatment for herpes zoster in children with leukemia

  2024cites this paper
• Post-infectious central nervous system vasculitides in adults: an underdiagnosed and treatable disease

  2024cites this paper
• Low-Dose Acyclovir Reduces the Reactivation of Herpes Simplex and Varicella Zoster Viruses After Allogeneic Stem Cell Transplantation

  2024cites this paper
• The Role of T Cells and Innate Immunity in Long-Term Immunity and Vaccine Development for COVID-19

  2023cites this paper
• Long-term incidence of varicella zoster virus disease in adults receiving single-unit cord blood transplantation.

  2022cites this paper
• Low‐dose acyclovir for prophylaxis of varicella‐zoster virus reactivation after hematopoietic stem cell transplantation in children

  2022cites this paper
• Visceral disseminated varicella zoster virus infection following COVID‐19 vaccination in an allogeneic stem cell transplant recipient

  2022cites this paper
• Review of de novo uveitis in older adults presenting to a large tertiary centre

  2021cites this paper
• Immunogenicity of Inactivated Varicella Zoster Vaccine in Autologous Hematopoietic Stem Cell Transplant Recipients and Patients With Solid or Hematologic Cancer

  2020cites this paper
• Summary of the 2019 BMT CTN Myeloma Intergroup Workshop on Minimal Residual Disease and Immune Profiling.

  2020cites this paper
• Risk Factors for Herpes Zoster Infection: A Meta-Analysis

  2020influential citation
• Varicella-zoster virus infection in children with autologous hematopoietic cell transplantation: A retrospective, single-center study in Korea.

  2020cites this paper
• Summary of the Third Annual BMT CTN Myeloma Intergroup Workshop on Minimal Residual Disease and Immune Profiling.

  2020cites this paper
• Low-Dose Acyclovir Prophylaxis for Varicella zoster Reactivation in Autologous Hematopoietic Cell Transplantation Recipients

  2019cites this paper
• Summary of the Second Annual BMT CTN Myeloma Intergroup Workshop on Minimal Residual Disease and Immune Profiling.

  2019cites this paper
• Effectiveness of acyclovir prophylaxis against varicella zoster virus disease after allogeneic hematopoietic cell transplantation: A systematic review and meta‐analysis

  2019cites this paper
• Prophylaxis and Management of Infectious Complications After Hematopoietic Cell Transplantation

  2019cites this paper
• Edinburgh Research Explorer Impact of Zostavax Vaccination on T-Cell Accumulation and Cutaneous Gene Expression in the Skin of Older Humans After Varicella Zoster Virus Antigen-Specific Challenge

  2018cites this paper
• Herpes zoster incidence and cost in patients receiving autologous hematopoietic stem-cell transplant

  2018cites this paper
• Inactivated varicella zoster vaccine in autologous haemopoietic stem-cell transplant recipients: an international, multicentre, randomised, double-blind, placebo-controlled trial.

  2018cites this paper
• Impact of Zostavax Vaccination on T-Cell Accumulation and Cutaneous Gene Expression in the Skin of Older Humans After Varicella Zoster Virus Antigen–Specific Challenge

  2018cites this paper
• Varicella Zoster Virus Reactivation in Adult Survivors of Hematopoietic Cell Transplantation: How Do We Best Protect Our Patients?

  2018cites this paper
• Infections due to alphaherpesviruses in early post-transplant period after allogeneic haematopoietic stem cell transplantation: Results of a 5-year survey.

  2017cites this paper
• Robust gene expression changes in the ganglia following subclinical reactivation in rhesus macaques infected with simian varicella virus

  2017cites this paper
• Herpes Zoster in Autologous Hematopoietic Cell Transplant Recipients in the Era of Acyclovir or Valacyclovir Prophylaxis and Novel Treatment and Maintenance Therapies.

  2017cites this paper
• Varicella zoster virus infection after allogeneic hematopoietic cell transplantation in children using a relatively short duration of acyclovir prophylaxis

  2017cites this paper
• Predicting risk factors for varicella zoster virus infection and postherpetic neuralgia after hematopoietic cell transplantation using ordered logistic regression analysis

  2017cites this paper
• Respiratory Viral Infections in Solid Organ and Hematopoietic Stem Cell Transplantation

  2017cites this paper
• The Successful Treatment of a Cord Blood Transplant Recipient with Varicella Zoster Virus Meningitis, Radiculitis and Myelitis with Foscarnet

  2017cites this paper
• Uncovering Mechanisms of Varicella Zoster Virus Pathogenesis Using a Rhesus Macaque Model

  2016cites this paper
• Brincidofovir treatment of acyclovir‐resistant disseminated varicella zoster virus infection in an immunocompromised host

  2016cites this paper
• Advances in Epidemiological Studies of Herpes Zoster

  2015cites this paper
• Low-dose acyclovir prophylaxis for the prevention of herpes simplex virus and varicella zoster virus diseases after autologous hematopoietic stem cell transplantation

  2015cites this paper
• Varicella zoster virus reactivation after autologous SCT is a frequent event and associated with favorable outcome in myeloma patients

  2015cites this paper
• Infections in Recipients of Hematopoietic Stem Cell Transplants

  2014cites this paper
• Impact of the duration of antiviral prophylaxis on rates of varicella-zoster virus reactivation disease in autologous hematopoietic cell transplantation recipients

  2014cites this paper
• Prophylactic role of long-term ultra-low-dose acyclovir for varicella zoster virus disease after allogeneic hematopoietic stem cell transplantation.

  2014cites this paper
• Clinical features and risk factors for developing varicella zoster virus dissemination following hematopoietic stem cell transplantation

  2014influential citation
• Varicella zoster virus encephalomyelitis as a late complication following haematopoietic stem cell transplantation

  2014cites this paper
• A phase 1/2 study of an adjuvanted varicella-zoster virus subunit vaccine in autologous hematopoietic cell transplant recipients.

  2014cites this paper
• Development of an IFN-γ ELISpot assay to assess varicella-zoster virus-specific cell-mediated immunity following umbilical cord blood transplantation.

  2014cites this paper
• Antimicrobial prophylaxis and outpatient management of fever and neutropenia in adults treated for malignancy: American Society of Clinical Oncology clinical practice guideline.

  2013cites this paper
• Visceral varicella zoster virus infection after allogeneic stem cell transplantation

  2013cites this paper
• Varicella vaccination after fingolimod: A case report.

  2013cites this paper
• Allotype analysis to distinguish the origin of varicella-zoster virus immunoglobulin G after allogeneic stem cell transplantation.

  2013cites this paper
• Varicella Zoster Virus Infection during Chemotherapy in Solid Cancer Patients

  2012cites this paper
• Reconstitution of Protective Immune Responses against Cytomegalovirus and Varicella Zoster Virus Does Not Require Disease Development in Pediatric Recipients of Umbilical Cord Blood Transplantation

  2012cites this paper
• Varicella zoster virus meningoencephalitis after allogeneic hematopoietic stem cell transplantation

  2012cites this paper
• Attenuation of the Adaptive Immune Response in Rhesus Macaques Infected with Simian Varicella Virus Lacking Open Reading Frame 61

  2012cites this paper
• Varicella-zoster virus glycoproteins B and E are major targets of CD4+ and CD8+ T cells reconstituting during zoster after allogeneic transplantation

  2012cites this paper
• Mass spectrometric identification of Varicella-Zoster Virus (VZV) proteins recognized by human T cells

  2012influential citation
• Natural and adoptive T-cell immunity against herpes family viruses after allogeneic hematopoietic stem cell transplantation.

  2011cites this paper
• Complementary and contrasting roles of NK cells and T cells in pediatric umbilical cord blood transplantation

  2011cites this paper
• A randomized, double-blind, placebo-controlled trial of valacyclovir prophylaxis to prevent zoster recurrence from months 4 to 24 after BMT

  2011cites this paper
• CD4 T Cell Immunity Is Critical for the Control of Simian Varicella Virus Infection in a Nonhuman Primate Model of VZV Infection

  2011cites this paper
• One‐year low‐dose valacyclovir as prophylaxis for varicella zoster virus disease after allogeneic hematopoietic stem cell transplantation. A prospective study of the Japan Hematology and Oncology Clinical Study Group

  2010cites this paper
• Characterisation of immune responses to varicella vaccination in relation to clinical outcome

  2010cites this paper
• Adult Immunization in Women and Men

  2010cites this paper
• Étude de l’immunité antivaricelleuse chez l’enfant transplanté au moyen de moelle osseuse ou de sang de cordon ombilical

  2010influential citation
• Infections in Recipients of Hematopoietic Cell Transplantation

  2010cites this paper
• Serological array for the diagnosis of viral infection of the central nervous system

  2010cites this paper
• Gender Male Male Female Male Male Female Cause of death Squamous cell carcinoma Alzheimer ’ s , mild tangles Epilepsy , cerebral palsy Non-small cell carcinoma Bronchpneumonia Vasculopathy

  2010cites this paper
• Varicella Zoster: Het probleem van virus reactivatie vanuit latentie.

  2010cites this paper
• Low-dose acyclovir against reactivation of varicella zoster virus after unrelated cord blood transplantation.

  2010cites this paper
• Characterization of the Host Immune Response in Human Ganglia after Herpes Zoster

  2010cites this paper
• Herpes zoster vaccine for the elderly: boosting immunity.

  2010cites this paper
• Incidence and risk of postherpetic neuralgia after varicella zoster virus infection in hematopoietic cell transplantation recipients: Hokkaido Hematology Study Group.

  2009influential citation
• Cytomegalovirus and varicella–zoster virus vaccines in hematopoietic stem cell transplantation

  2009cites this paper
• Chapter 10 Prophylaxis

  2009cites this paper
• Management of HSV, VZV and EBV infections in patients with hematological malignancies and after SCT: guidelines from the Second European Conference on Infections in Leukemia

  2009cites this paper
• Incidence and risk of postherpetic neuralgia after varicella zoster virus infection in hematopoietic cell transplantation recipients : Hokkaido Hematology Study Group Running title : PHN after VZV infection in HCT recipients

  2009influential citation
• Recommendations of the Advisory Committee on Immunization Practices (ACIP)

  2008cites this paper
• Varicella-zoster virus disease is more frequent after cord blood than after bone marrow transplantation.

  2008cites this paper
• Prevention of herpes zoster: recommendations of the Advisory Committee on Immunization Practices (ACIP).

  2008cites this paper
• Recovery of varicella-zoster virus-specific T cell immunity after T cell-depleted allogeneic transplantation requires symptomatic virus reactivation.

  2008cites this paper
• The Efficacy of Vaccines to Prevent Infectious Diseases in the Elderly

  2007cites this paper
• Herpes zoster

  2007cites this paper
• Safety of vaccinating sibling donors with live-attenuated varicella zoster vaccine before hematopoietic stem cell transplantation

  2007cites this paper
• Long‐term ultra‐low‐dose acyclovir against varicella‐zoster virus reactivation after allogeneic hematopoietic stem cell transplantation

  2007cites this paper
• Varicella-zoster virus infection under administration of ganciclovir after allogeneic bone marrow transplantation

  2006influential citation
• Long-term acyclovir for prevention of varicella zoster virus disease after allogeneic hematopoietic cell transplantation--a randomized double-blind placebo-controlled study.

  2006cites this paper
• Relationship between Preexisting Anti-Varicella-Zoster Virus (VZV) Antibody and Clinical VZV Reactivation in Hematopoietic Stem Cell Transplantation Recipients

  2006influential citation
• Chickenpox and Zoster in Marrow Transplant Recipients

  2006cites this paper
• Management of the Bone Marrow Transplant Patient

  2006cites this paper
• Relationship between pre-existing anti-varicella zoster virus ( VZV ) antibody and clinical VZV reactivation in hematopoietic stem cell transplantation recipients Running title : pre-existing anti-VZV and VZV reactivation after HSCT

  2006influential citation
• The effect of low-dose aciclovir on reactivation of varicella zoster virus after allogeneic haemopoietic stem cell transplantation

  2005cites this paper
• Varicella-zoster reactivation in a patient receiving routine revaccinations after an allogeneic hemopoietic progenitors transplant.

  2005cites this paper
• Postexposure Prophylaxis Against Varicella-Zoster Virus Infection Among Recipients of Hematopoietic Stem Cell Transplant: Unresolved Issues

  2004cites this paper
• Chronic graft-vs-host disease.

  2003cites this paper
• Herpesvirus Infections in Organ Transplant Recipients

  2003cites this paper
• USE OF AN INACTIVATED VARICELLA VACCINE IN RECIPIENTS OF HEMATOPOIETIC-CELL TRANSPLANTS

  2002cites this paper
• Clinical practice. Long-term care after hematopoietic-cell transplantation in adults.

  2002cites this paper
• Use of an inactivated varicella vaccine in recipients of hematopoietic-cell transplants.

  2002cites this paper