Interaction of Pyk2 and PTP-PEST with leupaxin in prostate cancer cells.

No abstract is available for this paper.

• Publication year

  2007

• Venue

  American Journal of Physiology - Cell Physiology

• Publication date

  2007-06-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1152/AJPCELL.00503.2006PMID 17329398
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Paxillin.

  2020cited by this paper
• Cell–matrix adhesion

  2007cited by this paper
• Association of leupaxin with Src in osteoclasts.

  2007cited by this paper
• Hic-5/ARA55, a LIM domain-containing nuclear receptor coactivator expressed in prostate stromal cells.

  2006cited by this paper
• RAFTK/Pyk2 mediates LPA-induced PC12 cell migration.

  2006cited by this paper
• Overexpression of the ZIP1 zinc transporter induces an osteogenic phenotype in mesenchymal stem cells.

  2006cited by this paper
• PTP-PEST Couples Membrane Protrusion and Tail Retraction via VAV2 and p190RhoGAP*

  2006influential reference
• RhoC GTPase is required for PC-3 prostate cancer cell invasion but not motility

  2006influential reference
• Loss of proline‐rich tyrosine kinase 2 function induces spreading and motility of epithelial prostate cells

  2006cited by this paper
• Front and back by Rho and Rac

  2006cited by this paper
• Phosphorylation of RhoGDI by Src regulates Rho GTPase binding and cytosol-membrane cycling.

  2006cited by this paper
• Regulation of Cell Adhesion by Protein-tyrosine Phosphatases

  2006cited by this paper
• Lysophosphatidic acid stimulates PC‐3 prostate cancer cell matrigel invasion through activation of RhoA and NF‐κB activity

  2006influential reference
• Recognition and activation of Rho GTPases by Vav1 and Vav2 guanine nucleotide exchange factors.

  2005cited by this paper
• Action of the Src family kinase inhibitor, dasatinib (BMS-354825), on human prostate cancer cells.

  2005cited by this paper
• RhoGDI: multiple functions in the regulation of Rho family GTPase activities.

  2005influential reference
• Paxillin is essential for PTP-PEST-dependent regulation of cell spreading and motility: a role for paxillin kinase linker

  2005cited by this paper
• Role of NF-κB signaling in hepatocyte growth factor/scatter factor-mediated cell protection

  2005cited by this paper
• Rho family GTPases are activated during HGF-stimulated prostate cancer-cell scattering.

  2005cited by this paper
• Leupaxin binds to PEST domain tyrosine phosphatase PEP

  2005cited by this paper
• Expression of the zinc transporter ZIP1 in osteoclasts.

  2005cited by this paper
• Coupling of RAFTK/Pyk2 kinase with c-Abl and their role in the migration of breast cancer cells.

  2004cited by this paper
• Interleukin-8 confers androgen-independent growth and migration of LNCaP: differential effects of tyrosine kinases Src and FAK

  2004cited by this paper
• Vav proteins, masters of the world of cytoskeleton organization.

  2004cited by this paper
• Deregulation of the Rho GTPase, Rac1, suppresses cyclin-dependent kinase inhibitor p21CIP1 levels in androgen-independent human prostate cancer cells

  2004cited by this paper
• The interplay between Src and integrins in normal and tumor biology

  2004cited by this paper
• Rapid signalling pathway activation by androgens in epithelial and stromal cells.

  2004cited by this paper
• Paxillin: adapting to change.

  2004cited by this paper
• Requirement of RhoA activity for increased nuclear factor kappaB activity and PC-3 human prostate cancer cell invasion.

  2003influential reference
• The Group 3 LIM domain protein paxillin potentiates androgen receptor transactivation in prostate cancer cell lines.

  2003cited by this paper
• Protease-activated receptor mediated RhoA signaling and cytoskeletal reorganization in LNCaP cells.

  2003cited by this paper
• PYK2 and FAK in osteoclasts.

  2003cited by this paper
• Pyrrolopyrimidine c-Src inhibitors reduce growth, adhesion, motility and invasion of prostate cancer cells in vitro.

  2003cited by this paper
• Pyk2 regulates multiple signaling events crucial for macrophage morphology and migration

  2003cited by this paper
• Leupaxin Is a Critical Adaptor Protein in the Adhesion Zone of the Osteoclast

  2003cited by this paper
• Characterization of a Novel Negative Regulator (DOC-2/DAB2) of c-Src in Normal Prostatic Epithelium and Cancer*

  2003cited by this paper
• Transforming growth factor-beta-induced mobilization of actin cytoskeleton requires signaling by small GTPases Cdc42 and RhoA.

  2002cited by this paper
• Nuclear translocation of cell adhesion kinase beta/proline-rich tyrosine kinase 2.

  2002cited by this paper
• Paxillin Associates with Poly(A)-binding Protein 1 at the Dense Endoplasmic Reticulum and the Leading Edge of Migrating Cells*

  2002cited by this paper
• The role of alpha(v)beta(3) in prostate cancer progression.

  2002cited by this paper
• Meta-analysis of microarrays: interstudy validation of gene expression profiles reveals pathway dysregulation in prostate cancer.

  2002cited by this paper
• Paxillin null embryonic stem cells are impaired in cell spreading and tyrosine phosphorylation of focal adhesion kinase

  2002cited by this paper
• Androgen modulation of adhesion and antiadhesion molecules in PC-3 prostate cancer cells expressing androgen receptor.

  2002cited by this paper
• Proline-rich tyrosine kinase 2 regulates proliferation and differentiation of prostate cells.

  2002cited by this paper
• Sex steroid hormones act as growth factors.

  2002cited by this paper
• PTP-PEST controls motility through regulation of Rac1

  2002cited by this paper
• Transcriptional activation of the c-fos gene by a LIM protein, Hic-5.

  2002cited by this paper
• Mitogenic action of LPA in prostate.

  2002cited by this paper
• The Role of αvβ3 in Prostate Cancer Progression

  2002cited by this paper
• Nuclear Translocation of Cell Adhesion Kinase β/Proline-rich Tyrosine Kinase 2

  2002cited by this paper
• Suppression of Androgen Receptor Transactivation by Pyk2 via Interaction and Phosphorylation of the ARA55 Coregulator*

  2002cited by this paper
• Alterations in the focal adhesion kinase/Src signal transduction pathway correlate with increased migratory capacity of prostate carcinoma cells

  2001cited by this paper
• Variations of Proline-Rich Kinase Pyk2 Expression Correlate with Prostate Cancer Progression

  2001cited by this paper
• The LD4 motif of paxillin regulates cell spreading and motility through an interaction with paxillin kinase linker (PKL)

  2001cited by this paper
• PTP‐PEST, a scaffold protein tyrosine phosphatase, negatively regulates lymphocyte activation by targeting a unique set of substrates

  2001cited by this paper
• Tumor bone diseases: molecular mechanisms and opportunities for novel treatments.

  2001cited by this paper
• Inhibition of the Catalytic Activity of Cell Adhesion Kinase β by Protein-tyrosine Phosphatase-PEST-mediated Dephosphorylation*

  2001cited by this paper
• Accumulation of Focal Adhesion Protein Hic-5 in the Nucleus by Hydrogen Peroxide

  2001cited by this paper
• Paxillin: a focal adhesion-associated adaptor protein

  2001cited by this paper
• CAKβ/Pyk2 Activates Src

  2001cited by this paper
• Paxillin interactions.

  2000cited by this paper
• Substrate Specificity of αvβ3Integrin-mediated Cell Migration and Phosphatidylinositol 3-Kinase/AKT Pathway Activation*

  2000cited by this paper
• The Noncatalytic Domain of Protein-tyrosine Phosphatase-PEST Targets Paxillin for Dephosphorylation in Vivo *

  2000cited by this paper
• Integrins and signaling in osteoclast function.

  2000cited by this paper
• RAFTK/Pyk2-mediated cellular signalling.

  2000cited by this paper
• Vav2 Is an Activator of Cdc42, Rac1, and RhoA*

  2000cited by this paper
• Focal adhesion kinase functions as a receptor-proximal signaling component required for directed cell migration

  2000cited by this paper
• Rho-kinase inhibitor retards migration and in vivo dissemination of human prostate cancer cells.

  2000cited by this paper
• Calcium signals in prostate cancer cells: specific activation by bone-matrix proteins.

  2000cited by this paper
• FAK integrates growth-factor and integrin signals to promote cell migration

  2000cited by this paper
• A simple method for the rapid generation of recombinant adenovirus vectors

  2000cited by this paper
• RhoGAPs and RhoGDIs, (His)stories of two families.

  1999cited by this paper
• Prostatic carcinoma cell migration via alpha(v)beta3 integrin is modulated by a focal adhesion kinase pathway.

  1999cited by this paper
• Protein Tyrosine Phosphatase-PEST Regulates Focal Adhesion Disassembly, Migration, and Cytokinesis in Fibroblasts

  1999influential reference
• Direct Association of Protein-tyrosine Phosphatase PTP-PEST with Paxillin*

  1998cited by this paper
• Growth factor involvement in progression of prostate cancer.

  1998cited by this paper
• Alendronate blocks TGF-β1 stimulated collagen 1 degradation by human prostate PC-3 ML cells

  1998cited by this paper
• Molecules in focus Paxillin

  1998cited by this paper
• Leupaxin Is a Novel LIM Domain Protein That Forms a Complex with PYK2*

  1998cited by this paper
• PYK2 in osteoclasts is an adhesion kinase, localized in the sealing zone, activated by ligation of alpha(v)beta3 integrin, and phosphorylated by src kinase.

  1998cited by this paper
• RAFTK, a Novel Member of the Focal Adhesion Kinase Family, Is Phosphorylated and Associates with Signaling Molecules upon Activation of Mature T Lymphocytes

  1997cited by this paper
• Regulation and activation of focal adhesion kinase and paxillin during the adhesion, proliferation, and differentiation of prostatic epithelial cells in vitro and in vivo.

  1996influential reference
• A role for Pyk2 and Src in linking G-protein-coupled receptors with MAP kinase activation

  1996cited by this paper
• Primary sequence of paxillin contains putative SH2 and SH3 domain binding motifs and multiple LIM domains: identification of a vinculin and pp125Fak-binding region.

  1994cited by this paper
• Transforming growth factor beta down-regulates Src family protein tyrosine kinase signaling pathways.

  1994cited by this paper
• Development of skeletal metastasis by human prostate cancer in athymic nude mice

  1988cited by this paper
• Transforming Growth Factor- (cid:1) –induced Mobilization of Actin Cytoskeleton Requires Signaling by Small GTPases Cdc42 and RhoA

  year unknowncited by this paper

• STAT3 mediates ECM stiffness-dependent progression in ovarian cancer

  2024cites this paper
• Extracellular Matrix- and Integrin Adhesion Complexes-Related Genes in the Prognosis of Prostate Cancer Patients’ Progression-Free Survival

  2023cites this paper
• Phosphorylation/dephosphorylation of protein tyrosine phosphatase (PTP)-PEST at Serine 39 is crucial for cell migration.

  2022cites this paper
• Exogenous extracellular matrix proteins decrease cardiac fibroblast activation in stiffening microenvironment through CAPG

  2021cites this paper
• Murine leupaxin deletion results in spontaneous weight gain, tissue inflammation, and integrin signaling defects

  2020cites this paper
• A kindlin-3–leupaxin–paxillin signaling pathway regulates podosome stability

  2019cites this paper
• The role of protein tyrosine phosphatases in prostate cancer biology.

  2019cites this paper
• High-level expression of protein tyrosine phosphatase non-receptor 12 is a strong and independent predictor of poor prognosis in prostate cancer

  2019cites this paper
• [Small interfering RNA-mediated LPXN silencing suppresses proliferation and enhances drug sensitivity of human acute monocytic leukemia SHI-1 cells in vitro].

  2018cites this paper
• Acute myeloid leukemia carrying ETV6 mutations: biologic and clinical features

  2018cites this paper
• Leupaxin Promotes Bladder Cancer Proliferation, Metastasis, and Angiogenesis Through the PI3K/AKT Pathway

  2018cites this paper
• Combined mTOR and MEK inhibition is an effective therapy in a novel mouse model for angiosarcoma

  2018cites this paper
• Downregulation of LPXN expression by siRNA decreases the malignant proliferation and transmembrane invasion of SHI-1 cells

  2018cites this paper
• Role of Pyk2 in Human Cancers

  2018cites this paper
• Characterization of a Novel Mouse Model for Angiosarcoma in Which Combined Inhibition of mTOR and MEK Results in Tumor Suppression

  2017influential citation
• Transposon mutagenesis identifies genes and cellular processes driving epithelial-mesenchymal transition in hepatocellular carcinoma

  2016cites this paper
• Structural Basis for the Interaction between Pyk2-FAT Domain and Leupaxin LD Repeats

  2016cites this paper
• ETV6‐LPXN fusion transcript generated by t(11;12)(q12.1;p13) in a patient with relapsing acute myeloid leukemia with NUP98‐HOXA9

  2016cites this paper
• Transcriptome analysis of human breast cancer cell lines MCF-7 and MDA-MB-435 by RNA-Seq

  2015cites this paper
• Identification of Human Disease Genes from Interactome Network Using Graphlet Interaction

  2014cites this paper
• Regulation of the Src Kinase-associated Phosphoprotein 55 Homologue by the Protein Tyrosine Phosphatase PTP-PEST in the Control of Cell Motility*

  2013cites this paper
• Chinese a Nti鄄 Cancer a Ssociation

  2013cites this paper
• Dynamin and PTP-PEST cooperatively regulate Pyk2 dephosphorylation in osteoclasts.

  2012cites this paper
• Protein tyrosine phosphatases in cancer: friends and foes!

  2012cites this paper
• Focal Adhesion Kinases in Adhesion Structures and Disease

  2012cites this paper
• Clinicopathological significance of PTPN12 expression in human breast cancer

  2012cites this paper
• Diverse roles for the paxillin family of proteins in cancer.

  2012cites this paper
• Clinicopathological significance of PTPN12 expression in human breast cancer.

  2012cites this paper
• Identifying novel prostate cancer associated pathways based on integrative microarray data analysis

  2011cites this paper
• LIM domain‐containing adaptor, leupaxin, localizes in focal adhesion and suppresses the integrin‐induced tyrosine phosphorylation of paxillin

  2010cites this paper
• Kinases as targets in the treatment of solid tumors.

  2010cites this paper
• Protein phosphatase 1alpha associates with protein tyrosine phosphatase-PEST inducing dephosphorylation of phospho-serine 39.

  2010cites this paper
• Leupaxin is similar to paxillin in focal adhesion targeting and tyrosine phosphorylation but has distinct roles in cell adhesion and spreading

  2010influential citation
• Inside the human cancer tyrosine phosphatome

  2010cites this paper
• A Small Molecule That Inhibits the Interaction of Paxillin and α4 Integrin Inhibits Accumulation of Mononuclear Leukocytes at a Site of Inflammation*

  2010cites this paper
• FYN is overexpressed in human prostate cancer

  2009cites this paper
• Pyk2 and Cyr61 at the cross-road of cAMP-dependent signalling in invasiveness and neuroendocrine differentiation of prostate cancer

  2009cites this paper
• The LIM protein, leupaxin, is enriched in smooth muscle and functions as an SRF-cofactor to induce smooth muscle cell gene transcription

  2009cites this paper
• LPXN, a member of the paxillin superfamily, is fused to RUNX1 in an acute myeloid leukemia patient with a t(11;21)(q12;q22) translocation

  2009cites this paper
• PEST family phosphatases in immunity, autoimmunity, and autoinflammatory disorders

  2009cites this paper
• Src as a therapeutic target in men with prostate cancer and bone metastases

  2009cites this paper
• The LIM Protein Leupaxin Is Enriched in Smooth Muscle and Functions As an Serum Response Factor Cofactor to Induce Smooth Muscle Cell Gene Transcription

  2008cites this paper
• The role of focal adhesion kinase in vascular smooth muscle cell migration

  2008cites this paper
• Evidence that molecular changes in cells occur before morphological alterations during the progression of breast ductal carcinoma

  2008cites this paper
• The Role of Src Family Kinases in Prostate Cancer

  2007cites this paper
• Leupaxin Negatively Regulates B Cell Receptor Signaling*

  2007cites this paper
• Tetracycline Regulated Systems in Functional Oncogenomics

  2006cites this paper