Dopamine Receptors and Neurodegeneration.

Dopamine (DA) is one of the major neurotransmitters and participates in a number of functions such as motor coordination, emotions, memory, reward mechanism, neuroendocrine regulation etc. DA exerts its effects through five DA receptors that are subdivided in 2 families: D1-like DA receptors (D1 and D5) and the D2-like (D2, D3 and D4). All DA receptors are widely expressed in the central nervous system (CNS) and play an important role in not only in physiological conditions but also pathological scenarios. Abnormalities in the DAergic system and its receptors in the basal ganglia structures are the basis Parkinson's disease (PD), however DA also participates in other neurodegenerative disorders such as Huntington disease (HD) and multiple sclerosis (MS). Under pathological conditions reorganization of DAergic system has been observed and most of the times, those changes occur as a mechanism of compensation, but in some cases contributes to worsening the alterations. Here we review the changes that occur on DA transmission and DA receptors (DARs) at both levels expression and signals transduction pathways as a result of neurotoxicity, inflammation and in neurodegenerative processes. The better understanding of the role of DA receptors in neuropathological conditions is crucial for development of novel therapeutic approaches to treat alterations related to neurodegenerative diseases.

• Publication year

  2015

• Venue

  Aging and Disease

• Publication date

  2015-10-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.14336/AD.2015.0330PMID 26425390PMCID PMC4567218
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• D1-like dopamine receptors downregulate Na+-K+-ATPase activity and increase cAMP production in the posterior gills of the blue crab Callinectes sapidus.

  2014cited by this paper
• Effect of chronic treatment with angiotensin type 1 receptor antagonists on striatal dopamine levels in normal rats and in a rat model of Parkinson's disease treated with L-DOPA.

  2014cited by this paper
• Brain antigen-reactive CD4+ T cells are sufficient to support learning behavior in mice with limited T cell repertoire.

  2014cited by this paper
• Angiotensin type 1 receptor blockage reduces l-dopa-induced dyskinesia in the 6-OHDA model of Parkinson's disease. Involvement of vascular endothelial growth factor and interleukin-1β.

  2014cited by this paper
• Brain renin-angiotensin system and dopaminergic cell vulnerability

  2014cited by this paper
• Aging-related dysregulation of dopamine and angiotensin receptor interaction.

  2014cited by this paper
• Inhibition of Adenylyl Cyclase Type 5 Prevents l-DOPA-Induced Dyskinesia in an Animal Model of Parkinson's Disease

  2014influential reference
• Localized changes to glycogen synthase kinase-3 and collapsin response mediator protein-2 in the Huntington's disease affected brain.

  2014influential reference
• D3 dopamine receptors interact with dopamine D1 but not D4 receptors in the GABAergic terminals of the SNr of the rat.

  2013influential reference
• Adrenergic and Dopaminergic Modulation of Immunity in Multiple Sclerosis: Teaching Old Drugs New Tricks?

  2013cited by this paper
• Transient and rapid activation of Akt/GSK‐3β and mTORC1 signaling by D3 dopamine receptor stimulation in dorsal striatum and nucleus accumbens

  2013cited by this paper
• Presynaptic CaMKIIα modulates dopamine D3 receptor activation in striatonigral terminals of the rat brain in a Ca²⁺ dependent manner.

  2013cited by this paper
• Therapeutic approach for neuronal disease by regulating renin-angiotensin system.

  2013cited by this paper
• Signaling through dynamic linkers as revealed by PKA

  2013cited by this paper
• Dopamine Receptor D3 Expressed on CD4+ T Cells Favors Neurodegeneration of Dopaminergic Neurons during Parkinson’s Disease

  2013influential reference
• Regulation of dopamine D₃ receptor in the striatal regions and substantia nigra in diffuse Lewy body disease.

  2013cited by this paper
• Drainage of Cells and Soluble Antigen from the CNS to Regional Lymph Nodes

  2013cited by this paper
• Dopamine‐Angiotensin interactions in the basal ganglia and their relevance for Parkinson's disease

  2013cited by this paper
• Multiple signaling routes involved in the regulation of adenylyl cyclase and extracellular regulated kinase by dopamine D(2) and D(3) receptors.

  2013cited by this paper
• The angiotensin converting enzyme inhibitor captopril protects nigrostriatal dopamine neurons in animal models of parkinsonism.

  2013influential reference
• Abnormal burst patterns of single neurons recorded in the substantia nigra reticulata of behaving 140 CAG Huntington's disease mice.

  2012cited by this paper
• Pre‐synaptic dopamine D3 receptor mediates cocaine‐induced structural plasticity in mesencephalic dopaminergic neurons via ERK and Akt pathways

  2012cited by this paper
• Calcyon Forms a Novel Ternary Complex with Dopamine D1 Receptor through PSD-95 Protein and Plays a Role in Dopamine Receptor Internalization*

  2012cited by this paper
• Comparison of the binding and functional properties of two structurally different D2 dopamine receptor subtype selective compounds.

  2012cited by this paper
• Expression of angiotensinogen and receptors for angiotensin and prorenin in the monkey and human substantia nigra: an intracellular renin–angiotensin system in the nigra

  2012influential reference
• Brain angiotensin and dopaminergic degeneration: relevance to Parkinson's disease.

  2012influential reference
• The Prevalence of Juvenile Huntington's Disease: A Review of the Literature and Meta-Analysis

  2012cited by this paper
• AKT/GSK3 signaling pathway and schizophrenia

  2012cited by this paper
• Stimulation of Dopamine Receptor D5 Expressed on Dendritic Cells Potentiates Th17-Mediated Immunity

  2012influential reference
• Binding of losartan to angiotensin AT1 receptors increases dopamine D1 receptor activation.

  2012influential reference
• Dopamine- and cAMP-regulated Phosphoprotein of 32-kDa (DARPP-32)-dependent Activation of Extracellular Signal-regulated Kinase (ERK) and Mammalian Target of Rapamycin Complex 1 (mTORC1) Signaling in Experimental Parkinsonism*

  2012cited by this paper
• Generation of reactive oxygen species in 1-methyl-4-phenylpyridinium (MPP+) treated dopaminergic neurons occurs as an NADPH oxidase-dependent two-wave cascade

  2011cited by this paper
• Dopamine D4 receptor, but not the ADHD-associated D4.7 variant, forms functional heteromers with the dopamine D2S receptor in the brain

  2011influential reference
• L-DOPA-Induced Dyskinesia and Abnormal Signaling in Striatal Medium Spiny Neurons: Focus on Dopamine D1 Receptor-Mediated Transmission

  2011cited by this paper
• Upregulation of D2-class signaling in dopamine-denervated striatum is in part mediated by D3 receptors acting on Ca V 2.1 channels via PIP2 depletion.

  2011cited by this paper
• Serotonin and dopamine striatal innervation in Parkinson's disease and Huntington's chorea.

  2011cited by this paper
• L-DOPA-induced dyskinesia in hemiparkinsonian rats is associated with up-regulation of adenylyl cyclase type V/VI and increased GABA release in the substantia nigra reticulata.

  2011influential reference
• The effects of neuropsychiatric drugs on glycogen synthase kinase-3 signaling.

  2011cited by this paper
• Aging, Angiotensin system and dopaminergic degeneration in the substantia nigra.

  2011cited by this paper
• Signaling Pathways Leading to Phosphorylation of Akt and GSK-3β by Activation of Cloned Human and Rat Cerebral D2 and D3 Receptors

  2011cited by this paper
• Pharmacology of signaling induced by dopamine D(1)-like receptor activation.

  2010cited by this paper
• Multiple sclerosis immunology

  2010cited by this paper
• mTOR signaling: at the crossroads of plasticity, memory and disease.

  2010cited by this paper
• Mutant huntingtin and glycogen synthase kinase 3‐β accumulate in neuronal lipid rafts of a presymptomatic knock‐in mouse model of Huntington's disease

  2010cited by this paper
• Renin-angiotensin system blockade and cardiovascular and renal protection.

  2010cited by this paper
• Increased sensitivity to kainic acid in a genetic model of reduced NMDA receptor function.

  2010cited by this paper
• Dopamine D1 receptors, regulation of gene expression in the brain, and neurodegeneration.

  2010cited by this paper
• Location of Prorenin Receptors in Primate Substantia Nigra: Effects on Dopaminergic Cell Death

  2010cited by this paper
• Angiotensin II sustains brain inflammation in mice via TGF-beta.

  2010cited by this paper
• Dopamine receptor D1/D5 gene expression in the medial prefrontal cortex predicts impulsive choice in rats.

  2010cited by this paper
• Dopamine D(2)-class receptor supersensitivity as reflected in Ca2+ current modulation in neostriatal neurons.

  2009cited by this paper
• Dopamine and angiotensin as renal counterregulatory systems controlling sodium balance

  2009cited by this paper
• Role of the renin-angiotensin system in autoimmune inflammation of the central nervous system

  2009cited by this paper
• Role of dopamine in the physiology of T-cells and dendritic cells.

  2009influential reference
• Changes in striatal dopamine D2 receptor binding in pre‐clinical Huntington’s disease

  2009cited by this paper
• Colocalization of dopamine receptor subtypes with dopamine and cAMP-regulated phosphoprotein (DARPP-32) in rat brain.

  2009cited by this paper
• The inflammatory response in the MPTP model of Parkinson’s disease is mediated by brain angiotensin: relevance to progression of the disease

  2009influential reference
• Dopamine Regulates the Expression of the Glutamate Transporter GLT1 but Not GLAST in Developing Striatal Astrocytes

  2009cited by this paper
• Increased oxidative stress in patients with amyotrophic lateral sclerosis/Parkinsonism‐dementia complex in the Kii peninsula, Japan

  2009cited by this paper
• Blocking angiotensin-converting enzyme induces potent regulatory T cells and modulates TH1- and TH17-mediated autoimmunity

  2009cited by this paper
• Glutamate toxicity in the striatum of the R6/2 Huntington's disease transgenic mice is age-dependent and correlates with decreased levels of glutamate transporters.

  2009cited by this paper
• The role of GSK‐3 in synaptic plasticity

  2008cited by this paper
• Identification of Dopamine D1–D3 Receptor Heteromers

  2008cited by this paper
• A rational mechanism for combination treatment of Huntington's disease using lithium and rapamycin.

  2008cited by this paper
• Therapy with interferon-beta modulates endogenous catecholamines in lymphocytes of patients with multiple sclerosis.

  2008cited by this paper
• Role of receptor heterodimers in the development of L-dopa-induced dyskinesias in the 6-hydroxydopamine rat model of Parkinson's disease.

  2008cited by this paper
• Brain angiotensin enhances dopaminergic cell death via microglial activation and NADPH-derived ROS.

  2008influential reference
• Polyglutamine-Modulated Striatal Calpain Activity in YAC Transgenic Huntington Disease Mouse Model: Impact on NMDA Receptor Function and Toxicity

  2008cited by this paper
• Changes in striatal dopamine D2 receptor binding in preclinical Huntington's disease

  2008cited by this paper
• Dopamine D3 receptor‐preferring agonists increase dendrite arborization of mesencephalic dopaminergic neurons via extracellular signal‐regulated kinase phosphorylation

  2008cited by this paper
• 6-OHDA-induced hemiparkinsonism and chronic L-DOPA treatment increase dopamine D1-stimulated [(3)H]-GABA release and [(3)H]-cAMP production in substantia nigra pars reticulata of the rat.

  2008influential reference
• AT2 receptors: Functional relevance in cardiovascular disease

  2008cited by this paper
• Calcium-sensitive adenylyl cyclases in depression and anxiety: behavioral and biochemical consequences of isoform targeting.

  2008influential reference
• Dopamine 5 receptor mediates Ang II type 1 receptor degradation via a ubiquitin-proteasome pathway in mice and human cells.

  2008influential reference
• Antagonizing dopamine D1-like receptor inhibits Th17 cell differentiation: preventive and therapeutic effects on experimental autoimmune encephalomyelitis.

  2008cited by this paper
• The Akt-GSK-3 signaling cascade in the actions of dopamine.

  2007cited by this paper
• Mechanism of 6‐hydroxydopamine neurotoxicity: the role of NADPH oxidase and microglial activation in 6‐hydroxydopamine‐induced degeneration of dopaminergic neurons

  2007cited by this paper
• Is inhibition of the renin-angiotensin system a new treatment option for Alzheimer's disease?

  2007cited by this paper
• Dopaminergic Signaling and Striatal Neurodegeneration in Huntington's Disease

  2007cited by this paper
• Dopamine D1 receptor activation regulates sodium channel‐dependent EPSP amplification in rat prefrontal cortex pyramidal neurons

  2007influential reference
• Regulation of Akt Signaling by D2 and D3 Dopamine Receptors In Vivo

  2007cited by this paper
• Dopamine, serotonin and noradrenaline changes in the striatum of C57BL mice following myelin oligodendrocyte glycoprotein (MOG) 35-55 and complete Freund adjuvant (CFA) administration.

  2007cited by this paper
• Critical Involvement of cAMP/DARPP-32 and Extracellular Signal-Regulated Protein Kinase Signaling in l-DOPA-Induced Dyskinesia

  2007influential reference
• Angiotensin type-1-receptor antagonists reduce 6-hydroxydopamine toxicity for dopaminergic neurons.

  2007influential reference
• Angiotensin type 1 receptor antagonist losartan, reduces MPTP-induced degeneration of dopaminergic neurons in substantia nigra

  2007cited by this paper
• Pathways of neurodegeneration and experimental models of basal ganglia disorders: downstream effects of mitochondrial inhibition.

  2006cited by this paper
• L-DOPA inhibits depolarization-induced [3H]GABA release in the dopamine-denervated globus pallidus of the rat: the effect is dopamine independent and mediated by D2-like receptors

  2006cited by this paper
• Time-Course of Brain Oxidative Damage Caused by Intrastriatal Administration of 6-Hydroxydopamine in a Rat Model of Parkinson’s Disease

  2006cited by this paper
• Dopamine D3 Receptor Agonist Delivery to a Model of Parkinson's Disease Restores the Nigrostriatal Pathway and Improves Locomotor Behavior

  2006cited by this paper
• Reduction of dopaminergic degeneration and oxidative stress by inhibition of angiotensin converting enzyme in a MPTP model of parkinsonism.

  2006influential reference
• Structure and dynamics of PKA signaling proteins.

  2006cited by this paper
• Immunopathogenesis and immunotherapy of multiple sclerosis

  2006influential reference
• Antipsychotics alter the protein expression levels of beta-catenin and GSK-3 in the rat medial prefrontal cortex and striatum.

  2005cited by this paper
• Increased D1 dopamine receptor signaling in levodopa‐induced dyskinesia

  2005influential reference
• Angiotensin II-dependent induction of AT(2) receptor expression after renal ablation.

  2005influential reference
• Angiotensin‐converting enzyme inhibition reduces oxidative stress and protects dopaminergic neurons in a 6‐hydroxydopamine rat model of Parkinsonism

  2005influential reference
• A possible role for dopamine D3 receptor stimulation in the induction of neurogenesis in the adult rat substantia nigra.

  2005cited by this paper
• Angiotensin II blocks memory consolidation through an AT2 receptor-dependent mechanism

  2005cited by this paper
• Dopamine by itself activates either D2, D3 or D1/D5 dopaminergic receptors in normal human T-cells and triggers the selective secretion of either IL-10, TNFα or both

  2005cited by this paper
• Interferon-γ and interferon-β affect endogenous catecholamines in human peripheral blood mononuclear cells: Implications for multiple sclerosis

  2005cited by this paper

• Cysteine carbon dots/Au3+ system for dual-mode detection of epinephrine and discrimination of different catecholamines with PCA.

  2026cites this paper
• Memantine mitigates radiation-induced cognitive impairment by modulating AKT/GSK3β signaling.

  2026cites this paper
• A structural overview of G-protein-coupled receptors in neurological disorders.

  2026cites this paper
• Neurotransmitters and Immunity: Molecular Mechanisms, Biological Functions, Diseases, and Potential Therapeutic Targets

  2025cites this paper
• Integrative Analysis of Metabolome and Proteome in the Cerebrospinal Fluid of Patients with Multiple System Atrophy

  2025cites this paper
• Function and mechanism of dopamine receptor D2 (DRD2) in neuroinflammation and behavioral disorders in C57BL/6J mice infected with Toxoplasma gondii TgCtWh6 strain.

  2025cites this paper
• Discovery of dopamine D1 receptor antagonists from Stephania epigaea using label-free cell phenotypic assays.

  2025cites this paper
• Unveiling new perspectives about the onset of neurological and cognitive deficits in cerebral malaria: exploring cellular and neurochemical mechanisms

  2025cites this paper
• Insights into Convergent Evolution From Studying Amino Acid Patterns in Independent Lineages of Birds

  2025cites this paper
• Pramipexole Exerts Beneficial Effects in a Rat Model of Acetic Acid-Induced Colitis via Modulating Inflammation

  2025cites this paper
• Conditional Deletion of Translin/Trax in Dopaminergic Neurons Reveals No Impact on Psychostimulant Behaviors or Adiposity

  2025cites this paper
• Polystyrene nanoplastics act as endocrine disruptors altering neurotransmitter levels and locomotor activity via estrogen receptor during early zebrafish development.

  2025cites this paper
• The role of L-DOPA in neurological and neurodegenerative complications: a review

  2025cites this paper
• Temporal Features of Gamma Activity of Hyper-direct Pathway Regulated by Dopamine Receptors in the Dyskinetic Rat

  2025cites this paper
• Therapeutic Role of Heterocyclic Compounds in Neurodegenerative Diseases: Insights from Alzheimer’s and Parkinson’s Diseases

  2025cites this paper
• Evidence for the Link Between Non-Motor Symptoms, Kinematic Gait Parameters, and Physical Function in People with Parkinson’s Disease

  2025cites this paper
• Effects of Physical Therapy on Ankle Proprioception and Postural Control in People with Parkinson’s: A Semi-experimental Clinical Trial

  2025cites this paper
• The conundrum of the connection between severe psychiatric disorders and dementia

  2025cites this paper
• Combinatorial mechanisms specify cellular location and neurotransmitter identity during regeneration of planarian neurons

  2025cites this paper
• 6-Paradol mitigates rotenone-induced Parkinson’s disease via shutting TNFR-1/RIPK1/RIPK3/MLKL cascade and enhancement of PPARγ/PGC-1α/TFAM axis

  2025cites this paper
• A toxic gain-of-function variant in MAPK8IP3 provides insights into JIP3 cellular roles

  2025cites this paper
• Weizmannia coagulans BC99 Improve Cognitive Impairment Induced by Chronic Sleep Deprivation via Inhibiting the Brain and Intestine’s NLRP3 Inflammasome

  2025cites this paper
• Real-time auditory feedback for improving gait and walking in people with Parkinson’s disease: a pilot and feasibility trial

  2024cites this paper
• Beyond PDE4 inhibition: A comprehensive review on downstream cAMP signaling in the central nervous system.

  2024cites this paper
• Slow-wave sleep is associated with nucleus accumbens volume in elderly adults

  2024influential citation
• Review—Catalytic Electrochemical Biosensors for Dopamine: Design, Performance, and Healthcare Applications

  2024cites this paper
• Exploring the Genetic Contribution in Obesity: an overview of dopaminergic system genes.

  2024cites this paper
• Neurotoxicity of glyphosate: focus on molecular mechanisms probably associated with alterations in cognition and behavior.

  2024cites this paper
• The neurobiological effects of senescence on dopaminergic system: a comprehensive review.

  2024cites this paper
• Drug Development for Alzheimer’s and Parkinson’s Disease: Where Do We Go Now?

  2024cites this paper
• Unlocking the functional potential of Nitraria schoberi extracts using chemical fingerprinting, biological efficiencies, in silico and network pharmacological approaches

  2024cites this paper
• Endogenous retroviruses in multiple sclerosis: a network-based etiopathogenic model.

  2024cites this paper
• Pramipexole improves depression-like behavior in diabetes mellitus with depression rats by inhibiting NLRP3 inflammasome-mediated neuroinflammation and preventing impaired neuroplasticity.

  2024cites this paper
• MicroRNA dysregulation in glutamate and dopamine pathways of schizophrenia: From molecular pathways to diagnostic and therapeutic approaches.

  2024cites this paper
• Opportunities and perspectives of small molecular phosphodiesterase inhibitors in neurodegenerative diseases.

  2024cites this paper
• A COMPREHENSIVE REVIEW ON NEUROTRANSMITTERS, ITS BIOLOGICAL IMPORTANCE AND METHODS OF ANALYSIS

  2023cites this paper
• Dopamine depletion alters neuroplasticity-related signaling in the rat hippocampus

  2023cites this paper
• TDP-43 is a potential marker of dopaminergic neuronal damage caused by atrazine exposure.

  2023cites this paper
• Neuro-protective potentials of N-acetylcysteine and zinc against di(2-ethylhexyl)-phthalate-induced neuro-histopathology and dys-regulations of Dopamine and Glutamate in rat brain

  2023cites this paper
• Dopamine-Regulated Plasticity in MoO3 Synaptic Transistors.

  2023cites this paper
• Exploring neurotransmitters and their receptors for breast cancer prevention and treatment

  2023cites this paper
• Inflammation, Dopaminergic Brain and Bilirubin

  2023cites this paper
• Unveiling the Neural Environment in Cancer: Exploring the Role of Neural Circuit Players and Potential Therapeutic Strategies

  2023cites this paper
• Network pharmacology, molecular docking, and experimental validation to explore the potential mechanism of Long Mu Qing Xin mixture for the treatment of attention deficit hyperactivity disorder

  2023cites this paper
• Activity-dependent constraints on catecholamine signaling

  2023cites this paper
• Phenothiazine derivatives and their impact on the necroptosis and necrosis processes. A review.

  2023cites this paper
• Oral bioavailability and neuroprotective effect of a novel food-grade formulation of fisetin using fenugreek-galactomannan hydrogel scaffolds

  2023cites this paper
• The clinically-approved compounds, pramipexole and dexpramipexole, reverse chronic allodynia from sciatic nerve damage in mice, and alter IL-1β and IL-10 expression from immune cell culture.

  2023cites this paper
• Neuroprotective effect of secukinumab against rotenone induced Parkinson's disease in rat model: Involvement of IL-17, HMGB-1/TLR4 axis and BDNF/TrKB cascade.

  2023cites this paper
• Prelimbic Cortical Stimulation with L-methionine Enhances Cognition through Hippocampal DNA Methylation and Neuroplasticity Mechanisms

  2023cites this paper
• The World of GPCR dimers – Mapping dopamine receptor D2 homodimers in different activation states and configuration arrangements

  2023cites this paper
• Psychosis in Parkinson's Disease: Looking Beyond Dopaminergic Treatments.

  2022cites this paper
• Pathogenesis of sepsis-associated encephalopathy: more than blood–brain barrier dysfunction

  2022cites this paper
• Dopamine D3 Receptors: A Potential Target to Treat Motivational Deficits in Parkinson's Disease.

  2022cites this paper
• Characterizing aripiprazole and its ester derivatives, Lauroxil and Cavoxil, in interaction with dopamine D2 receptor: molecular docking and dynamics simulations with physicochemical appraisals

  2022cites this paper
• Dopamine plays a critical role in the olfactory adaptive learning pathway in Caenorhabditis elegans

  2022cites this paper
• The Dopamine System: Insights between Kidney and Brain

  2022cites this paper
• Assessing the impact of different penalty factors of the Bayesian reconstruction algorithm Q.Clear on in vivo low count kinetic analysis of [11C]PHNO brain PET-MR studies

  2022cites this paper
• The role of intracerebral dopamine D1 and D2 receptors in sleep‐wake cycles and general anesthesia

  2022cites this paper
• Acid-Sensing Ion Channel 2: Function and Modulation

  2022cites this paper
• Activation of Dopamine 4 Receptor Subtype Enhances Gamma Oscillations in Hippocampal Slices of Aged Mice

  2022cites this paper
• Dopamine, Immunity, and Disease

  2022cites this paper
• Cannabidiol inhibits methamphetamine-induced dopamine release via modulation of the DRD1-MeCP2-BDNF-TrkB signaling pathway

  2022cites this paper
• Alteration of Autophagy and Glial Activity in Nilotinib-Treated Huntington’s Disease Patients

  2022cites this paper
• Neurotransmitters and molecular chaperones interactions in cerebral malaria: Is there a missing link?

  2022cites this paper
• The role of crm-1 in ionizing radiation-induced nervous system dysfunction in Caenorhabditis elegans

  2022cites this paper
• DRDs and Brain Derived Neurotrophic Factor share a common therapeutic ground: A novel bioinformatic approach sheds new light towards pharmacological treatment of Cognitive and Behavioral Disorders

  2022cites this paper
• Titanium dioxide-multiwalled carbon nanotube/polyimide composite film modified electrodes for simultaneous voltammetric detection of ascorbic acid, uric acid and dopamine as biomarker molecules

  2022cites this paper
• Potential Mechanisms for Why Not All Antipsychotics Are Able to Occupy Dopamine D3 Receptors in the Brain in vivo

  2022cites this paper
• Genetic control of RNA editing in Neurodegenerative disease

  2022cites this paper
• Association between ADHD and vision problems. A systematic review and meta-analysis

  2022cites this paper
• Dopamine Receptor-Mediated Binding and Cellular Uptake of Polydopamine-Coated Nanoparticles.

  2021cites this paper
• Dopamine receptor D2 on CD4+ T cells is protective against neuroinflammation and neurodegeneration in a mouse model of Parkinson's disease.

  2021cites this paper
• Why is lithium effective in alleviating bipolar disorder?

  2021cites this paper
• What happens in the top athletes mind? a review study

  2021cites this paper
• Understanding Abnormal c-JNK/p38MAPK Signaling Overactivation Involved in the Progression of Multiple Sclerosis: Possible Therapeutic Targets and Impact on Neurodegenerative Diseases

  2021cites this paper
• Role of the Dopaminergic System in the Striatum and Its Association With Functional Recovery or Rehabilitation After Brain Injury

  2021cites this paper
• Effects of dopamine transporter changes in the ventral tegmental area of the midbrain on cognitive function in aged rats.

  2021cites this paper
• Localisation of clozapine during experimental autoimmune encephalomyelitis and its impact on dopamine and its receptors

  2021cites this paper
• Exploring the structural basis and atomistic binding mechanistic of the selective antagonist blockade at D3 dopamine receptor over D2 dopamine receptor

  2021cites this paper
• Prolactin and Its Altered Action in Alzheimer’s Disease and Parkinson’s Disease

  2021cites this paper
• The neuroprotective potential of carotenoids in vitro and in vivo.

  2021cites this paper
• Discovery of eight alkaloids with D1 and D2 antagonist activity in leaves of Nelumbo nucifera Gaertn. Using FLIPR assays.

  2021cites this paper
• Crystal structure of dopamine D1 receptor in complex with G protein and a non-catechol agonist

  2021cites this paper
• Assessing the Anti-Inflammatory Activity of the Anxiolytic Drug Buspirone Using CRISPR-Cas9 Gene Editing in LPS-Stimulated BV-2 Microglial Cells

  2021cites this paper
• Tyrosine hydroxylase immunostaining in the central complex of dicondylian insects

  2021cites this paper
• Synergistic enhancement of photoluminesent intensity in monolayer molybdenum disulfide embedded with plasmonic nanostructures for catalytic sensing

  2021cites this paper
• In Vitro and In Silico Characterization of Kurarinone as a Dopamine D1A Receptor Antagonist and D2L and D4 Receptor Agonist

  2021cites this paper
• Live-Cell Imaging of Single Neurotrophin Receptor Molecules on Human Neurons in Alzheimer’s Disease

  2021cites this paper
• Structures of the human dopamine D3 receptor-Gi complexes.

  2021cites this paper
• Salvianolic Acid A Relieves Cognitive Disorder after Chronic Cerebral Ischemia: Involvement of Drd2/Cryab/NF-κB Pathway.

  2021cites this paper
• Utilization of Biotechnology, Neurotransmitter and Cytogenetic Indices in Selecting Pigeon Breeds

  2021cites this paper
• The Effects of Selective Inhibition of Histone Deacetylase 1 and 3 in Huntington’s Disease Mice

  2021cites this paper
• Docking Screens of Noncovalent Interaction Motifs of the Human Subtype-D2 Receptor-75 Schizophrenia Antipsychotic Complexes with Physicochemical Appraisal of Antipsychotics.

  2021cites this paper
• Dopamine, a co-regulatory component, bridges the central nervous system and the immune system.

  2021cites this paper
• ADHESION CONCEPT IN CANCER BIOLOGY: LOCAL AND CENTRAL MECHANISMS (PART 1)

  2021cites this paper
• Loss of Function in Dopamine D3 Receptor Attenuates Left Ventricular Cardiac Fibroblast Migration and Proliferation in vitro

  2021influential citation
• A comprehensive in silico investigation into the nsSNPs of Drd2 gene predicts significant functional consequences in dopamine signaling and pharmacotherapy

  2021cites this paper
• The Effect of Noise on the Neurobehavioral Function of the Occupational Population and the Content of Catecholamines

  2021cites this paper
• Immune and Nervous Systems Interaction in Endocrine Disruptors Toxicity: The Case of Atrazine

  2021cites this paper