Outcomes of transplantation of livers from donation after circulatory death donors in the UK: a cohort study

Objectives Outcomes of liver transplantations from donation after circulatory death (DCD) donors may be inferior to those achieved with donation after brain death (DBD) donors. The impact of using DCD donors is likely to depend on specific national practices. We compared risk-adjusted graft loss and recipient mortality after transplantation of DCD and DBD livers in the UK. Design Prospective cohort study. Multivariable Cox regression and propensity score matching were used to estimate risk-adjusted HR. Setting 7 liver transplant centres in the National Health Service (NHS) hospitals in England and Scotland. Participants Adults who received a first elective liver transplant between January 2005 and December 2010 who were identified in the UK Liver Transplant Audit. Interventions Transplantation of DCD and DBD livers. Outcomes Graft loss and recipient mortality. Results In total, 2572 liver transplants were identified with 352 (14%) from DCD donors. 3-year graft loss (95% CI) was higher with DCD livers (27.3%, 21.8% to 33.9%) than with DBD livers (18.2%, 16.4% to 20.2%). After adjustment with regression, HR for graft loss was 2.3 (1.7 to 3.0). Similarly, 3-year mortality was higher with DCD livers (19.4%, 14.5% to 25.6%) than with DBD livers (14.1%, 12.5% to 16.0%) with an adjusted HR of 2.0 (1.4 to 2.8). Propensity score matching gave similar results. Centre-specific adjusted HRs for graft loss and recipient mortality seemed to differ among transplant centres, although statistical evidence is weak (p value for interaction 0.08 and 0.24, respectively). Conclusions Graft loss and recipient mortality were about twice as high with DCD livers as with DBD livers in the UK. Outcomes after DCD liver transplantation may vary between centres. These results should inform policies for the use of DCD livers.

• Publication year

  2013

• Venue

  BMJ Open

• Publication date

  2013-08-01

• Fields of study

  Medicine

• Identifiers
  DOI 10.1136/bmjopen-2013-003287PMID 24002984PMCID 3773642
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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