Inflammatory cytokines drive CD4+ T-cell cycling and impaired responsiveness to interleukin 7: implications for immune failure in HIV disease.

No abstract is available for this paper.

• Publication year

  2014

• Venue

  Journal of Infectious Diseases

• Publication date

  2014-08-15

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1093/infdis/jiu125PMID 24585897PMCID PMC4172041
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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  2007influential reference
• Abnormal activation and cytokine spectra in lymph nodes of people chronically infected with HIV-1.

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  2001influential reference
• Interleukin-7 receptor expression on CD8(+) T cells is reduced in HIV infection and partially restored with effective antiretroviral therapy.

  2001cited by this paper
• A potential role for interleukin-7 in T-cell homeostasis.

  2001cited by this paper
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  2001cited by this paper
• Factors influencing T-cell turnover in HIV-1-seropositive patients.

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  1997cited by this paper
• Antiretroviral therapy suppresses the constitutive production of interleukin-1 associated with human immunodeficiency virus infection.

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• Increased interleukin-6 production is associated with disease progression in HIV infection.

  1991cited by this paper
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  1991cited by this paper
• Neopterin and alpha and beta interleukin-1 levels in sera of patients with human immunodeficiency virus infection

  1989cited by this paper
• Role of interleukin 1 in antigen-specific T cell proliferation.

  1984cited by this paper

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