Replicative fitness of transmitted HIV-1 drives acute immune activation, proviral load in memory CD4+ T cells, and disease progression

No abstract is available for this paper.

• Publication year

  2015

• Venue

  Proceedings of the National Academy of Sciences of the United States of America

• Publication date

  2015-02-17

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1073/pnas.1421607112PMID 25730868PMCID PMC4378387
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Simian Immunodeficiency Virus Infections Dynamics in Pathogenic and Nonpathogenic T Memory Stem Cell + Divergent CD4

  2014cited by this paper
• A restriction enzyme based cloning method to assess the in vitro replication capacity of HIV-1 subtype C Gag-MJ4 chimeric viruses.

  2014cited by this paper
• Particle infectivity of HIV-1 full-length genome infectious molecular clones in a subtype C heterosexual transmission pair following high fidelity amplification and unbiased cloning.

  2014cited by this paper
• Limited HIV Infection of Central Memory and Stem Cell Memory CD4+ T Cells Is Associated with Lack of Progression in Viremic Individuals

  2014cited by this paper
• Virulence and Pathogenesis of HIV-1 Infection: An Evolutionary Perspective

  2014influential reference
• Inflammatory cytokines drive CD4+ T-cell cycling and impaired responsiveness to interleukin 7: implications for immune failure in HIV disease.

  2014cited by this paper
• Immunogenetics of HIV disease

  2013influential reference
• HIV-1 infection induces strong production of IP-10 through TLR7/9-dependent pathways

  2013cited by this paper
• Cell death by pyroptosis drives CD4 T-cell depletion in HIV-1 infection

  2013cited by this paper
• Selection bias at the heterosexual HIV-1 transmission bottleneck

  2013cited by this paper
• Superior T memory stem cell persistence supports long-lived T cell memory.

  2013cited by this paper
• Role of Transmitted Gag CTL Polymorphisms in Defining Replicative Capacity and Early HIV-1 Pathogenesis

  2012influential reference
• Soluble mediators of inflammation in HIV and their implications for therapeutics and vaccine development.

  2012cited by this paper
• Acute Plasma Biomarkers of T Cell Activation Set-Point Levels and of Disease Progression in HIV-1 Infection

  2012cited by this paper
• Cumulative Impact of Host and Viral Factors on HIV-1 Viral-Load Control during Early Infection

  2012influential reference
• TRIM5 is an innate immune sensor for the retrovirus capsid lattice

  2011cited by this paper
• Plasma levels of soluble CD14 independently predict mortality in HIV infection.

  2011cited by this paper
• A human memory T-cell subset with stem cell-like properties

  2011cited by this paper
• Low levels of SIV infection in sooty mangabey central-memory CD4+ T-cells is associated with limited CCR5 expression

  2011cited by this paper
• Programmed death-1–induced interleukin-10 production by monocytes impairs CD4+ T cell activation during HIV infection

  2010cited by this paper
• Differential Association of Programmed Death-1 and CD57 with Ex Vivo Survival of CD8+ T Cells in HIV Infection1

  2009cited by this paper
• HIV reservoir size and persistence are driven by T cell survival and homeostatic proliferation

  2009cited by this paper
• Global genomic analysis reveals rapid control of a robust innate response in SIV-infected sooty mangabeys.

  2009cited by this paper
• Visualizing Antigen-Specific and Infected Cells in Situ Predicts Outcomes in Early Viral Infection

  2009cited by this paper
• IL-10 is up-regulated in multiple cell types during viremic HIV infection and reversibly inhibits virus-specific T cells.

  2009cited by this paper
• Redefining chronic viral infection.

  2009cited by this paper
• Inflammatory Genital Infections Mitigate a Severe Genetic Bottleneck in Heterosexual Transmission of Subtype A and C HIV-1

  2009cited by this paper
• Induction of a Striking Systemic Cytokine Cascade prior to Peak Viremia in Acute Human Immunodeficiency Virus Type 1 Infection, in Contrast to More Modest and Delayed Responses in Acute Hepatitis B and C Virus Infections

  2009influential reference
• Relationship between T cell activation and CD4+ T cell count in HIV-seropositive individuals with undetectable plasma HIV RNA levels in the absence of therapy.

  2008cited by this paper
• Poor Initial CD4+ Recovery With Antiretroviral Therapy Prolongs Immune Depletion and Increases Risk for AIDS and Non-AIDS Diseases

  2008cited by this paper
• Inflammatory and Coagulation Biomarkers and Mortality in Patients with HIV Infection

  2008cited by this paper
• Transmission of HIV-1 Gag immune escape mutations is associated with reduced viral load in linked recipients

  2008influential reference
• Immune activation and AIDS pathogenesis.

  2008cited by this paper
• Progressive CD4+ central–memory T cell decline results in CD4+ effector–memory insufficiency and overt disease in chronic SIV infection

  2007cited by this paper
• PD-1 expression on HIV-specific T cells is associated with T-cell exhaustion and disease progression

  2006influential reference
• Microbial translocation is a cause of systemic immune activation in chronic HIV infection

  2006cited by this paper
• Upregulation of PD-1 expression on HIV-specific CD8+ T cells leads to reversible immune dysfunction

  2006influential reference
• Microbial translocation is a cause of systemic immune activation in chronic HIV infection

  2006cited by this paper
• Immune activation set point during early HIV infection predicts subsequent CD4+ T-cell changes independent of viral load.

  2004cited by this paper
• T cell activation is associated with lower CD4+ T cell gains in human immunodeficiency virus-infected patients with sustained viral suppression during antiretroviral therapy.

  2003influential reference
• Most antiviral CD8 T cells during chronic viral infection do not express high levels of perforin and are not directly cytotoxic.

  2003cited by this paper
• Disrupting T-cell homeostasis: how HIV-1 infection causes disease.

  2003cited by this paper
• Reservoirs for HIV-1: mechanisms for viral persistence in the presence of antiviral immune responses and antiretroviral therapy.

  2000cited by this paper
• HLA B*5701 is highly associated with restriction of virus replication in a subgroup of HIV-infected long term nonprogressors.

  2000cited by this paper
• Shorter survival in advanced human immunodeficiency virus type 1 infection is more closely associated with T lymphocyte activation than with plasma virus burden or virus chemokine coreceptor usage.

  1999influential reference
• Declining morbidity and mortality among patients with advanced human immunodeficiency virus infection. HIV Outpatient Study Investigators.

  1998cited by this paper
• Declining morbidity and mortality among patients with advanced human immunodeficiency virus infection.

  1998cited by this paper
• Activation and cell cycle antigens in CD4+ and CD8+ T cells correlate with plasma human immunodeficiency virus (HIV-1) RNA level in HIV-1 infection.

  1998cited by this paper
• Identification of a reservoir for HIV-1 in patients on highly active antiretroviral therapy.

  1997cited by this paper
• Acquired immunodeficiency syndrome (AIDS)-free time after human immunodeficiency virus type 1 (HIV-1) seroconversion in homosexual men. Multicenter AIDS Cohort Study Group.

  1989cited by this paper
• CD4 counts as predictors of opportunistic pneumonias in human immunodeficiency virus (HIV) infection.

  1989cited by this paper
• Pathogenesis

  1869cited by this paper

• Prediction of recent HIV-1 infections using Shannon entropy analysis of HIV-1 group-specific antigen protein sequence

  2026cites this paper
• Autovaccination revisited: potential to boost antiviral immunity and facilitate HIV-1 cure/remission in children

  2025cites this paper
• Endocervix exhibits greater susceptibility to HIV-1 infection compared to ectocervix following ex vivo exposure to Transmitted/Founder HIV-1 variants

  2025cites this paper
• Subtype AD Recombinant HIV-1 Transmitted/Founder Viruses Are Less Sensitive to Type I Interferons than Subtype D

  2025cites this paper
• Comparison of viral phenotype and inflammatory biomarker responses in acute HIV-1 subtype A and C infections

  2025cites this paper
• HIV-1 Gag-protease-driven replicative capacity influences T-cell metabolism, cytokine induction, and viral cell-to-cell spread

  2025influential citation
• Sustained aviremia despite anti-retroviral therapy non-adherence in male children after in utero HIV transmission

  2024cites this paper
• Phenotypic Characterization of Subtype A and Recombinant AC Transmitted/Founder Viruses from a Rwandan HIV-1 Heterosexual Transmission Cohort

  2024cites this paper
• HLA-A*23 Is Associated With Lower Odds of Acute Retroviral Syndrome in Human Immunodeficiency Virus Type 1 Infection: A Multicenter Sub-Saharan African Study

  2024cites this paper
• Slow progression of pediatric HIV associates with early CD8+ T cell PD-1 expression and a stem-like phenotype

  2023cites this paper
• Genotypic and Phenotypic Characterization of Replication-Competent HIV-2 Isolated from Controllers and Progressors

  2023cites this paper
• Accelerating Bayesian inference of dependency between mixed-type biological traits

  2023cites this paper
• Impact of early antiretroviral therapy, early life immunity and immune sex differences on HIV disease and posttreatment control in children

  2023cites this paper
• Expression of RNA-m6A-related genes correlates with the HIV latent reservoir level and the CD4+ and CD8+T cell profiles of patients with AIDS.

  2023cites this paper
• Genetic variation of the HIV-1 subtype C transmitted/founder viruses long terminal repeat elements and the impact on transcription activation potential and clinical disease outcomes

  2023cites this paper
• Hamiltonian zigzag accelerates large-scale inference for conditional dependencies between complex biological traits

  2022cites this paper
• Hamiltonian zigzag speeds up large-scale learning of direct effects among mixed-type biological traits

  2022cites this paper
• Accelerating Bayesian inference of dependency between complex biological traits

  2022cites this paper
• The apparent interferon resistance of transmitted HIV-1 is possibly a consequence of enhanced replicative fitness

  2022cites this paper
• Role of Early Life Cytotoxic T Lymphocyte and Natural Killer Cell Immunity in Paediatric HIV Cure/Remission in the Anti-Retroviral Therapy Era

  2022influential citation
• Phylogenetic estimation of the viral fitness landscape of HIV-1 set-point viral load

  2022cites this paper
• Transmitted HIV-1 is more virulent in heterosexual individuals than men-who-have-sex-with-men

  2022cites this paper
• Characterization of Near Full-Length Transmitted/Founder HIV-1 Subtype D and A/D Recombinant Genomes in a Heterosexual Ugandan Population (2006–2011)

  2022cites this paper
• HIV-1 infection and the lack of viral control are associated with greater expression of interleukin-21 receptor on CD8+ T cells

  2021cites this paper
• HIV-1 Gag-Pol Sequences from Ugandan Early Infections Reveal Sequence Variants Associated with Elevated Replication Capacity

  2021cites this paper
• Intrahost evolution of the HIV-2 capsid correlates with progression to AIDS

  2021cites this paper
• The Interferon Resistance of Transmitted HIV-1 is a Consequence of Enhanced Replicative Fitness

  2021cites this paper
• Evolutionary modeling reveals enhanced mutational flexibility of HCV subtype 1b compared with 1a

  2021cites this paper
• An HLA-I signature favouring KIR-educated Natural Killer cells mediates immune control of HIV in children and contrasts with the HLA-B-restricted CD8+ T-cell-mediated immune control in adults

  2021cites this paper
• High seroprevalence of Leishmania infantum is linked to immune activation in people with HIV: a two-stage cross-sectional study in Bahia, Brazil

  2021cites this paper
• Addressing an HIV cure in LMIC

  2021cites this paper
• Subtype-specific differences in Gag-protease replication capacity of HIV-1 isolates from East and West Africa

  2021cites this paper
• Immunogenetic determinants of heterosexual HIV-1 transmission: Key findings and lessons from two distinct African cohorts

  2021cites this paper
• Evaluation of chimeric antigen receptor T cell therapy in non-human primates infected with SHIV or SIV

  2021cites this paper
• Evolutionary modelling of HCV subtypes provides rationale for their different disease outcomes

  2021cites this paper
• Key Positions of HIV-1 Env and Signatures of Vaccine Efficacy Show Gradual Reduction of Population Founder Effects at the Clade and Regional Levels

  2020cites this paper
• Association between the cytokine storm, immune cell dynamics, and viral replicative capacity in hyperacute HIV infection

  2020cites this paper
• Early HIV infection is associated with reduced proportions of gamma delta T subsets as well as high creatinine and urea levels

  2020cites this paper
• Dual CD4-based CAR T cells with distinct costimulatory domains mitigate HIV pathogenesis in vivo

  2020cites this paper
• Ex vivo rectal explant model reveals potential opposing roles of Natural Killer cells and Marginal Zone-like B cells in HIV-1 infection

  2020cites this paper
• Transmitted HIV-1 is more pathogenic in heterosexual individuals than homosexual men

  2020cites this paper
• Infection with multiple HIV-1 founder variants is associated with lower viral replicative capacity, faster CD4+ T cell decline and increased immune activation during acute infection

  2020cites this paper
• Cohort Profile: IAVI’s HIV epidemiology and early infection cohort studies in Africa to support vaccine discovery

  2020cites this paper
• Dual CD4-based CAR T cells with distinct costimulatory domains mitigate HIV pathogenesis in vivo

  2020cites this paper
• Utilizing Computational Machine Learning Tools to Understand Immunogenic Breadth in the Context of a CD8 T-Cell Mediated HIV Response

  2020cites this paper
• Sex-specific innate immune selection of HIV-1 in utero is associated with increased female susceptibility to infection

  2020cites this paper
• Epigenetics, N-myrystoyltransferase-1 and casein kinase-2-alpha modulates the increased replication of HIV-1 CRF02_AG, compared to subtype-B viruses

  2019cites this paper
• Variable infectivity and conserved engagement in cell-to-cell viral transfer by HIV-1 Env from Clade B transmitted founder clones.

  2019cites this paper
• Delayed disease progression in HIV‐2: the importance of TRIM5α and the retroviral capsid

  2019cites this paper
• Virologic Aspects of Mucosal Transmission

  2019cites this paper
• Low Replication Capacity Virus is Preferentially Transmitted in Mother-to-Child-Transmission but not in Adult-to-Adult-Transmission of HIV-1

  2019cites this paper
• HIV long-term non-progressors elite controllers: an interplay between host, immune and viral factors

  2019cites this paper
• Protective HLA alleles are associated with reduced LPS levels in acute HIV infection with implications for immune activation and pathogenesis

  2019cites this paper
• Gradual decrease in the inter-population diversity of HIV-1 Env among group M lineages worldwide

  2019cites this paper
• Accumulated mutations by 6 months of infection collectively render transmitted/founder HIV-1 significantly less fit.

  2019influential citation
• In-depth validation of total HIV-1 DNA assays for quantification of various HIV-1 subtypes

  2018cites this paper
• Characterisation of HIV-1 subtype C envelope functional determinants of dual infected individuals

  2018influential citation
• The impact of HIV-1 within-host evolution on transmission dynamics.

  2018cites this paper
• Rapid HIV disease progression following superinfection in an HLA-B*27:05/B*57:01-positive transmission recipient

  2018cites this paper
• Viral Characteristics Associated with the Clinical Nonprogressor Phenotype Are Inherited by Viruses from a Cluster of HIV-1 Elite Controllers

  2018cites this paper
• The phylogenomics of evolving virus virulence

  2018cites this paper
• Impact des inhibiteurs de l'intégrase sur la constitution et la compartimentalisation du réservoir viral

  2018cites this paper
• Monitoring HIV DNA and cellular activation markers in HIV-infected humanized mice under cART

  2018cites this paper
• HLA Class I Downregulation by HIV-1 Variants from Subtype C Transmission Pairs

  2018influential citation
• HIV-1 subtype CRF01_AE and B differ in utilization of low levels of CCR5, Maraviroc susceptibility and potential N-glycosylation sites.

  2017cites this paper
• HIV-1 Conserved Mosaics Delivered by Regimens with Integration-Deficient DC-Targeting Lentiviral Vector Induce Robust T Cells

  2017cites this paper
• Subtype-Specific Differences in Gag-Protease-Driven Replication Capacity Are Consistent with Intersubtype Differences in HIV-1 Disease Progression

  2017cites this paper
• Mother-to-Child HIV Transmission Bottleneck Selects for Consensus Virus with Lower Gag-Protease-Driven Replication Capacity

  2017cites this paper
• Impaired human immunodeficiency virus type 1 replicative fitness in atypical viremic non-progressor individuals

  2017cites this paper
• Impaired human immunodeficiency virus type 1 replicative fitness in atypical viremic non-progressor individuals

  2017cites this paper
• Factors Associated with the Size of HIV DNA Reservoir

  2017influential citation
• The impact of HIV-1 within-host evolution on transmission dynamics

  2017cites this paper
• Virus-Host Gene Interactions Define HIV-1 Disease Progression.

  2017influential citation
• Glance at potential future combating of diseases:Bioengineered antimicrobial organisms

  2017cites this paper
• Toward a Pan-African HIV Vaccine Development Agenda

  2017cites this paper
• Early HIV infection among persons referred for malaria parasite testing in Nigeria

  2017cites this paper
• Replication Capacity of Viruses from Acute Infection Drives HIV-1 Disease Progression

  2017cites this paper
• Balance between transmitted HLA preadapted and nonassociated polymorphisms is a major determinant of HIV-1 disease progression

  2016cites this paper
• Vector delivery-dependant effect of human tissue plasminogen activator signal peptide on vaccine induction of T cells

  2016cites this paper
• Implementation and Operational Research: Evolution of Couples' Voluntary Counseling and Testing for HIV in Rwanda: From Research to Public Health Practice

  2016cites this paper
• Immune activation during acute HIV infection and the impact of early antiretroviral therapy

  2016cites this paper
• Report of the Cent Gardes HIV Vaccines Conference, Part 2: The cellular immune response. Fondation Mérieux Conference Center, Veyrier-du-Lac, France, 25-27 October 2015.

  2016cites this paper
• Switch of predicted HIV-1 tropism in treated subjects and its association with disease progression

  2016cites this paper
• Derivation and Characterization of Pathogenic Transmitted/Founder Molecular Clones from Simian Immunodeficiency Virus SIVsmE660 and SIVmac251 following Mucosal Infection

  2016cites this paper
• Report of the Cent Gardes HIV Vaccines Conference. Part 1: The antibody response; Fondation Mérieux Conference Center, Veyrier-du-Lac, France, 25-27 October 2015.

  2016cites this paper
• Control of HIV-1 replication in vitro by vaccine-induced human CD8+ T cells through conserved subdominant Pol epitopes

  2016cites this paper
• Large Variations in HIV-1 Viral Load Explained by Shifting-Mosaic Metapopulation Dynamics

  2016cites this paper
• Broad HIV-1 inhibition in vitro by vaccine-elicited CD8+ T cells in African adults

  2016cites this paper
• Wide variation in susceptibility of transmitted/founder HIV-1 subtype C Isolates to protease inhibitors and association with in vitro replication efficiency

  2016cites this paper
• Immune activation and paediatric HIV-1 disease outcome

  2016cites this paper
• Paediatric non-progression following grandmother-to-child HIV transmission

  2016cites this paper
• Lessons from acute HIV infection

  2016cites this paper
• Role of HLA Adaptation in HIV Evolution

  2016cites this paper
• Novel Conserved-region T-cell Mosaic Vaccine With High Global HIV-1 Coverage Is Recognized by Protective Responses in Untreated Infection.

  2016cites this paper
• Broadly Neutralizing Antibody Responses in a Large Longitudinal Sub-Saharan HIV Primary Infection Cohort

  2016cites this paper
• Lessons from acute HIV infection.

  2016cites this paper
• Quantifying the effect of Vpu on the promotion of HIV-1 replication in the humanized mouse model

  2016cites this paper
• HIV-1 replication capacity: Setting the pace of disease

  2015cites this paper
• Antiretroviral Therapy in Primary HIV-1 Infection: Influences on Immune Activation and Gut Mucosal Barrier Dysfunction.

  2015cites this paper
• Targeted screening of at-risk adults for acute HIV-1 infection in sub-Saharan Africa

  2015cites this paper