Microtubule Dynamic Instability Controls Podosome Patterning in Osteoclasts through EB1, Cortactin, and Src

No abstract is available for this paper.

• Publication year

  2013

• Venue

  Molecular and Cellular Biology

• Publication date

  2013-10-21

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1128/MCB.00578-13PMID 24144981PMCID PMC3911273
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Disruption of the dynein‐dynactin complex unveils motor‐specific functions in osteoclast formation and bone resorption

  2013cited by this paper
• End-binding proteins and Ase1/PRC1 define local functionality of structurally distinct parts of the microtubule cytoskeleton.

  2013cited by this paper
• Regulation of bone resorption and sealing zone formation in osteoclasts occurs through protein kinase b–mediated microtubule stabilization

  2013cited by this paper
• Cortactin Tyrosine Phosphorylation Promotes Its Deacetylation and Inhibits Cell Spreading

  2012cited by this paper
• EBs Recognize a Nucleotide-Dependent Structural Cap at Growing Microtubule Ends

  2012cited by this paper
• ATAT1/MEC-17 acetyltransferase and HDAC6 deacetylase control a balance of acetylation of alpha-tubulin and cortactin and regulate MT1-MMP trafficking and breast tumor cell invasion.

  2012cited by this paper
• The 'ins' and 'outs' of podosomes and invadopodia: characteristics, formation and function

  2011cited by this paper
• Tctex-1, a Novel Interaction Partner of Rab3D, Is Required for Osteoclastic Bone Resorption

  2011cited by this paper
• LIS1 Regulates Osteoclast Formation and Function through Its Interactions with Dynein/Dynactin and Plekhm1

  2011cited by this paper
• Cortactin deficiency is associated with reduced neutrophil recruitment but increased vascular permeability in vivo

  2011cited by this paper
• HDAC6 is required for invadopodia activity and invasion by breast tumor cells.

  2011influential reference
• Differential Distribution of Posttranslationally Modified Microtubules in Osteoclasts

  2011cited by this paper
• Class IIb HDAC6 regulates endothelial cell migration and angiogenesis by deacetylation of cortactin

  2011cited by this paper
• Regulation of Sealing Ring Formation by L-plastin and Cortactin in Osteoclasts*

  2010cited by this paper
• Analysis of Microtubule Dynamic Instability Using a Plus End Growth Marker

  2010cited by this paper
• Myosin X Regulates Sealing Zone Patterning in Osteoclasts through Linkage of Podosomes and Microtubules*

  2010cited by this paper
• Actin, microtubules, and vimentin intermediate filaments cooperate for elongation of invadopodia

  2010cited by this paper
• Plus-end-tracking proteins and their interactions at microtubule ends.

  2010cited by this paper
• Oncogenic Src requires a wild-type counterpart to regulate invadopodia maturation

  2010cited by this paper
• Calpain-6, a Target Molecule of Glucocorticoids, Regulates Osteoclastic Bone Resorption via Cytoskeletal Organization and Microtubule Acetylation

  2010cited by this paper
• Regulation of microtubule dynamics by inhibition of the tubulin deacetylase HDAC6

  2009influential reference
• N-WASP and cortactin are involved in invadopodium-dependent chemotaxis to EGF in breast tumor cells.

  2009cited by this paper
• Actin machinery and mechanosensitivity in invadopodia, podosomes and focal adhesions

  2009cited by this paper
• ATP‐induced osteoclast function: the formation of sealing‐zone like structure and the secretion of lytic granules via microtubule‐deacetylation under the control of Syk

  2009cited by this paper
• c-Cbl and Cbl-b act redundantly to protect osteoclasts from apoptosis and to displace HDAC6 from beta-tubulin, stabilizing microtubules and podosomes.

  2009cited by this paper
• Cortactin promotes migration and platelet-derived growth factor-induced actin reorganization by signaling to Rho-GTPases.

  2009cited by this paper
• Mammalian end binding proteins control persistent microtubule growth

  2009cited by this paper
• Lysine Acetylation Targets Protein Complexes and Co-Regulates Major Cellular Functions

  2009cited by this paper
• Dynamin Reduces Pyk2 Y402 Phosphorylation and Src Binding in Osteoclasts

  2009cited by this paper
• Dynamic microtubules regulate dendritic spine morphology and synaptic plasticity.

  2009cited by this paper
• Deacetylation of cortactin by SIRT1 promotes cell migration

  2009cited by this paper
• Cortactin regulates cofilin and N-WASp activities to control the stages of invadopodium assembly and maturation

  2009cited by this paper
• An EB1-binding motif acts as a microtubule tip localization signal.

  2009cited by this paper
• Multiple regulatory inputs converge on cortactin to control invadopodia biogenesis and extracellular matrix degradation

  2008cited by this paper
• Tracking the ends: a dynamic protein network controls the fate of microtubule tips

  2008cited by this paper
• Adhesion structures and their cytoskeleton-membrane interactions at podosomes of osteoclasts in culture

  2008cited by this paper
• Cortactin branches out: roles in regulating protrusive actin dynamics.

  2008cited by this paper
• The tyrosine kinase activity of c-Src regulates actin dynamics and organization of podosomes in osteoclasts.

  2008cited by this paper
• Src phosphorylation of cortactin enhances actin assembly

  2007cited by this paper
• Shaping the actin cytoskeleton using microtubule tips.

  2007cited by this paper
• HDAC6 modulates cell motility by altering the acetylation level of cortactin.

  2007cited by this paper
• The Architecture of the Adhesive Apparatus of Cultured Osteoclasts: From Podosome Formation to Sealing Zone Assembly

  2007cited by this paper
• Syk, c-Src, the alphavbeta3 integrin, and ITAM immunoreceptors, in concert, regulate osteoclastic bone resorption.

  2007cited by this paper
• Reconstitution of a microtubule plus-end tracking system in vitro

  2007cited by this paper
• Cortactin is an essential regulator of matrix metalloproteinase secretion and extracellular matrix degradation in invadopodia.

  2007cited by this paper
• Dissecting the functional domain requirements of cortactin in invadopodia formation.

  2007cited by this paper
• Defective microtubule-dependent podosome organization in osteoclasts leads to increased bone density in Pyk2−/− mice

  2007cited by this paper
• Syk, c-Src, the αvβ3 integrin, and ITAM immunoreceptors, in concert, regulate osteoclastic bone resorption

  2007cited by this paper
• Co-localization of cortactin and phosphotyrosine identifies active invadopodia in human breast cancer cells.

  2006cited by this paper
• Involvement of the Src-cortactin pathway in podosome formation and turnover during polarization of cultured osteoclasts

  2006influential reference
• Cortactin has an essential and specific role in osteoclast actin assembly.

  2006cited by this paper
• In situ fluorescence analysis demonstrates active siRNA exclusion from the nucleus by Exportin 5

  2006cited by this paper
• Dynamic interactions of cortactin and membrane type 1 matrix metalloproteinase at invadopodia: defining the stages of invadopodia formation and function.

  2006cited by this paper
• Substrate and functional diversity of lysine acetylation revealed by a proteomics survey.

  2006cited by this paper
• Effects of tyrosine phosphorylation of cortactin on podosome formation in A7r5 vascular smooth muscle cells.

  2006cited by this paper
• Cortactin regulates podosome formation: roles of the protein interaction domains.

  2006cited by this paper
• Podosome and sealing zone: specificity of the osteoclast model.

  2006cited by this paper
• Microtubule Plus End: A Hub of Cellular Activities

  2006cited by this paper
• Critical role of cortactin in actin ring formation and osteoclastic bone resorption

  2006cited by this paper
• The kinesin KIF1C and microtubule plus ends regulate podosome dynamics in macrophages.

  2006cited by this paper
• A novel Rho-mDia2-HDAC6 pathway controls podosome patterning through microtubule acetylation in osteoclasts

  2005influential reference
• Podosomes at a glance

  2005cited by this paper
• Endocytic trafficking in actively resorbing osteoclasts

  2004cited by this paper
• EB1 and APC bind to mDia to stabilize microtubules downstream of Rho and promote cell migration

  2004cited by this paper
• Src Kinase Activity Is Essential for Osteoclast Function*

  2004cited by this paper
• From Lysosomes to the Plasma Membrane

  2003cited by this paper
• Dynamic changes in the osteoclast cytoskeleton in response to growth factors and cell attachment are controlled by β3 integrin

  2003cited by this paper
• Domain-selective small-molecule inhibitor of histone deacetylase 6 (HDAC6)-mediated tubulin deacetylation

  2003influential reference
• Podosomes: adhesion hot-spots of invasive cells.

  2003cited by this paper
• HDAC‐6 interacts with and deacetylates tubulin and microtubules in vivo

  2003cited by this paper
• Podosomes display actin turnover and dynamic self-organization in osteoclasts expressing actin-green fluorescent protein.

  2003influential reference
• Macrophage podosomes assemble at the leading lamella by growth and fragmentation

  2003cited by this paper
• A Cortactin-CD2-associated Protein (CD2AP) Complex Provides a Novel Link between Epidermal Growth Factor Receptor Endocytosis and the Actin Cytoskeleton*

  2003cited by this paper
• Cortactin tyrosine phosphorylation requires Rac1 activity and association with the cortical actin cytoskeleton.

  2003cited by this paper
• Actin‐Related Protein 2/3 Complex Is Required for Actin Ring Formation

  2003cited by this paper
• Genetic regulation of osteoclast development and function

  2003cited by this paper
• In vivo destabilization of dynamic microtubules by HDAC6‐mediated deacetylation

  2002cited by this paper
• Inhibition of Osteoclast Function by Adenovirus Expressing Antisense Protein-tyrosine Kinase 2*

  2001cited by this paper
• Src-catalyzed Phosphorylation of c-Cbl Leads to the Interdependent Ubiquitination of Both Proteins*

  2001cited by this paper
• Cbl Associates with Pyk2 and Src to Regulate Src Kinase Activity, αvβ3 Integrin-Mediated Signaling, Cell Adhesion, and Osteoclast Motility

  2001cited by this paper
• Convergence of αvβ3Integrin–And Macrophage Colony Stimulating Factor–Mediated Signals on Phospholipase Cγ in Prefusion Osteoclasts

  2001cited by this paper
• Adenomatous Polyposis Coli (APC) Protein Moves along Microtubules and Concentrates at Their Growing Ends in Epithelial Cells

  2000cited by this paper
• A Functional Link between Dynamin and the Actin Cytoskeleton at Podosomes

  2000cited by this paper
• Microtubule-dependent formation of podosomal adhesion structures in primary human macrophages.

  2000cited by this paper
• EB3, a novel member of the EB1 family preferentially expressed in the central nervous system, binds to a CNS-specific APC homologue

  2000cited by this paper
• Signaling pathways and structural domains required for phosphorylation of EMS1/cortactin.

  1999cited by this paper
• Impaired osteoclastic bone resorption leads to osteopetrosis in cathepsin-K-deficient mice.

  1998cited by this paper
• Rescue of osteoclast function by transgenic expression of kinase-deficient Src in src-/- mutant mice.

  1997cited by this paper
• Substrate Recognition by Osteoclast Precursors Induces C-src/Microtubule Association

  1997cited by this paper
• Nanomolar concentrations of nocodazole alter microtubule dynamic instability in vivo and in vitro.

  1997cited by this paper
• Differentiation dependent expression of tensin and cortactin in chicken osteoclasts.

  1995cited by this paper
• Targeted disruption of the c-src proto-oncogene leads to osteopetrosis in mice.

  1991cited by this paper
• Monoclonal antibodies to individual tyrosine-phosphorylated protein substrates of oncogene-encoded tyrosine kinases.

  1990cited by this paper
• Osteoclast cytosolic calcium, regulated by voltage-gated calcium channels and extracellular calcium, controls podosome assembly and bone resorption

  1990cited by this paper
• Adhesion patterns and cytoskeleton of rabbit osteoclasts on bone slices and glass

  1988cited by this paper
• Polarized secretion of lysosomal enzymes: co-distribution of cation- independent mannose-6-phosphate receptors and lysosomal enzymes along the osteoclast exocytic pathway

  1988cited by this paper

• NEK7 phosphorylation of cortactin modulates the migratory capacity of cells expressing EML4-ALK V3

  2025cites this paper
• Selective disruption of microtubule formation at the nuclear envelope impairs the bone resorption capacity of osteoclasts

  2025cites this paper
• The Role of Runx2 in Microtubule Dynamics and Its Effects on Osteoblast Migration.

  2025cites this paper
• In Vitro Cell Culture Model for Osteoclast Activation during Estrogen Withdrawal

  2024cites this paper
• α-lipoic acid modulates prostate cancer cell growth and bone cell differentiation

  2024cites this paper
• The emerging role of microtubules in invasion plasticity

  2023cites this paper
• Dysfunction in parkin aggravates inflammatory bone erosion by reinforcing osteoclast activity

  2023cites this paper
• Terminally differentiated osteoclasts organize centrosomes into large clusters for microtubule nucleation and bone resorption

  2022cites this paper
• Super-resolution microscopy reveals nanoscale architecture and regulation of podosome clusters in primary macrophages

  2022cites this paper
• Tyrosine Kinase Src Is a Regulatory Factor of Bone Homeostasis

  2022cites this paper
• Novel Role of Prereplication Complex Component Cell Division Cycle 6 in Retinal Neovascularization

  2022cites this paper
• ARID1A knockdown in human endothelial cells directly induces angiogenesis by regulating angiopoietin-2 secretion and endothelial cell activity.

  2021cites this paper
• Cortactin Contributes to Activity-Dependent Modulation of Spine Actin Dynamics and Spatial Memory Formation

  2021cites this paper
• Trabecular bone organoids: a micron-scale ‘humanised’ prototype designed to study the effects of microgravity and degeneration

  2021cites this paper
• EB1 Restricts Breast Cancer Cell Invadopodia Formation and Matrix Proteolysis via FAK

  2021cites this paper
• Primary myeloid cell proteomics and transcriptomics: importance of β-tubulin isotypes for osteoclast function

  2020cites this paper
• Regulation of invadosomes by microtubules: Not only a matter of railways.

  2020cites this paper
• The osteoclast cytoskeleton – current understanding and therapeutic perspectives for osteoporosis

  2020cites this paper
• Functional Regeneration of the Sensory Root via Axonal Invasion

  2020cites this paper
• Dock5 is a new regulator of microtubule dynamic instability in osteoclasts

  2019cites this paper
• Dock5 is a new regulator of microtubule dynamic instability through GSK3β inhibition in osteoclasts

  2019cites this paper
• Role of the captured retroviral envelope syncytin-B gene in the fusion of osteoclast and giant cell precursors and in bone resorption, analyzed ex vivo and in vivo in syncytin-B knockout mice

  2019influential citation
• Microtubules at focal adhesions – a double-edged sword

  2019cites this paper
• Plectin stabilizes microtubules during osteoclastic bone resorption by acting as a scaffold for Src and Pyk2.

  2019cites this paper
• Kif1c regulates osteoclastic bone resorption as a downstream molecule of p130Cas

  2019cites this paper
• Osteoclast Cytoskeleton, Podosome, Motility, Attachment, and Signaling by Receptors

  2019cites this paper
• Quantitative proteomics and transcriptomics exploration of primary myeloid cells: importance of ß tubulin isotypes for bone resorption

  2019cites this paper
• Combined strategy of siRNA and osteoclast actin cytoskeleton automated imaging to identify novel regulators of bone resorption shows a non-mitotic function for anillin

  2018cites this paper
• Dynamics of the sealing zone in cultured osteoclasts

  2017cites this paper
• Regulation of osteoclast differentiation and actin ring formation by the cytolinker protein plectin.

  2017cites this paper
• The Actin-Binding Protein PPP1r18 Regulates Maturation, Actin Organization, and Bone Resorption Activity of Osteoclasts

  2017cites this paper
• Expression of typical osteoclast markers by PBMCs after PEG-induced fusion as a model for studying osteoclast differentiation

  2017influential citation
• TSC1 regulates osteoclast podosome organization and bone resorption through mTORC1 and Rac1/Cdc42

  2017cites this paper
• S100A4 regulates macrophage invasion by distinct myosin-dependent and myosin-independent mechanisms

  2017cites this paper
• Microtubules in 3D cell motility

  2017cites this paper
• Class II and IV HDACs function as inhibitors of osteoclast differentiation

  2017cites this paper
• Cortactin function in invadopodia

  2017cites this paper
• Cortactin: Cell Functions of A Multifaceted Actin-Binding Protein.

  2017cites this paper
• Coordination of Actin- and Microtubule-Based Cytoskeletons Supports Transport of Spermatids and Residual Bodies/Phagosomes During Spermatogenesis in the Rat Testis.

  2016influential citation
• The Actin‐Binding Protein Cofilin and Its Interaction With Cortactin Are Required for Podosome Patterning in Osteoclasts and Bone Resorption In Vivo and In Vitro

  2016cites this paper
• Tensin 3 is a new partner of Dock5 that controls osteoclast podosome organization and activity

  2016cites this paper
• Podosome dynamics and location in vascular smooth muscle cells require CLASP‐dependent microtubule bending

  2016influential citation
• The Microtubule Plus End Tracking Protein TIP150 Interacts with Cortactin to Steer Directional Cell Migration*

  2016cites this paper
• KIF1C control of podosome formation in vascular smooth muscle cells

  2016cites this paper
• EB1 regulates tubulin and actin cytoskeletal networks at the sertoli cell blood-testis barrier in male rats: an in vitro study.

  2015cites this paper
• Cytoplasmic hnRNPK interacts with GSK3β and is essential for the osteoclast differentiation

  2015cites this paper
• Podosome-regulating kinesin KIF1C translocates to the cell periphery in a CLASP-dependent manner

  2014influential citation
• Tools of the trade: podosomes as multipurpose organelles of monocytic cells

  2014influential citation
• Comparative transcriptomics reveals RhoE as a novel regulator of actin dynamics in bone-resorbing osteoclasts

  2014cites this paper
• Microtubule acetylation regulates dynamics of KIF1C-powered vesicles and contact of microtubule plus ends with podosomes.

  2014cites this paper
• Podosome organization drives osteoclast-mediated bone resorption

  2014cites this paper