Transgenic zebrafish reporter lines reveal conserved Toll‐like receptor signaling potential in embryonic myeloid leukocytes and adult immune cell lineages

No abstract is available for this paper.

• Publication year

  2009

• Venue

  Journal of Leukocyte Biology

• Publication date

  2009-05-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1189/jlb.0708405PMID 19218482
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• TLRs and innate immunity.

  2009cited by this paper
• Zebrafish TRIF, a Golgi-Localized Protein, Participates in IFN Induction and NF-κB Activation1

  2008cited by this paper
• Live imaging of emerging hematopoietic stem cells and early thymus colonization.

  2008influential reference
• Vaccinia Virus Infection Modulates the Hematopoietic Cell Compartments in the Bone Marrow

  2008cited by this paper
• CD41+ cmyb+ precursors colonize the zebrafish pronephros by a novel migration route to initiate adult hematopoiesis

  2008cited by this paper
• Developmental expression of Toll-like receptors-2 and -4 in preterm baboon lung.

  2008cited by this paper
• Origins and unconventional behavior of neutrophils in developing zebrafish.

  2008cited by this paper
• Identification and real-time imaging of a myc-expressing neutrophil population involved in inflammation and mycobacterial granuloma formation in zebrafish.

  2008cited by this paper
• Immunology and zebrafish: spawning new models of human disease.

  2008cited by this paper
• Intestinal alkaline phosphatase detoxifies lipopolysaccharide and prevents inflammation in zebrafish in response to the gut microbiota.

  2007cited by this paper
• TLR agonists induce the differentiation of human bone marrow CD34+ progenitors into CD11c+ CD80/86+ DC capable of inducing a Th1‐type response

  2007cited by this paper
• The family of five: TIR-domain-containing adaptors in Toll-like receptor signalling

  2007cited by this paper
• Definitive hematopoiesis initiates through a committed erythromyeloid progenitor in the zebrafish embryo

  2007cited by this paper
• Dichotomous role of the macrophage in early Mycobacterium marinum infection of the zebrafish.

  2007cited by this paper
• Toll‐like receptors: key activators of leucocytes and regulator of haematopoiesis

  2007cited by this paper
• Toll-like receptors and innate immunity in gut homeostasis and pathology

  2007cited by this paper
• Toll-like receptors: emerging concepts in kidney disease

  2007cited by this paper
• Live imaging of chronic inflammation caused by mutation of zebrafish Hai1

  2007cited by this paper
• Expression and function of Toll-like receptors in T lymphocytes.

  2007cited by this paper
• The zebrafish lysozyme C promoter drives myeloid-specific expression in transgenic fish

  2007cited by this paper
• In vivo imaging and genetic analysis link bacterial motility and symbiosis in the zebrafish gut

  2007cited by this paper
• Immaturity of infection control in preterm and term newborns is associated with impaired toll-like receptor signaling.

  2007cited by this paper
• A transgenic zebrafish model of neutrophilic inflammation.

  2006cited by this paper
• Ontogeny of the immune system of fish.

  2006cited by this paper
• Imaging macrophage chemotaxis in vivo: studies of microtubule function in zebrafish wound inflammation.

  2006cited by this paper
• Immunophenotype and functions of fetal baboon bone-marrow derived dendritic cells.

  2006cited by this paper
• MyD88 and NOS2 are essential for toll-like receptor 4-mediated survival effect in cardiomyocytes.

  2006cited by this paper
• Resolution of inflammation by retrograde chemotaxis of neutrophils in transgenic zebrafish

  2006cited by this paper
• Tracing hematopoietic precursor migration to successive hematopoietic organs during zebrafish development.

  2006cited by this paper
• Toll-like receptors on hematopoietic progenitor cells stimulate innate immune system replenishment.

  2006cited by this paper
• MyD88 Innate Immune Function in a Zebrafish Embryo Infection Model

  2006cited by this paper
• Tolls for B cells

  2006cited by this paper
• Global analysis of hematopoietic and vascular endothelial gene expression by tissue specific microarray profiling in zebrafish.

  2006cited by this paper
• Distinct signals from the microbiota promote different aspects of zebrafish gut differentiation.

  2006influential reference
• Expression of Toll-like receptors in the kidney: their potential role beyond infection.

  2006cited by this paper
• Lipopolysaccharide Improves Cardiomyocyte Survival and Function after Serum Deprivation*

  2005cited by this paper
• Control of B-cell responses by Toll-like receptors

  2005cited by this paper
• Monocyte Toll-Like Receptor 4 Expression and LPS-Induced Cytokine Production Increase during Gestational Aging

  2005cited by this paper
• Hematopoiesis in the yolk sac: more than meets the eye.

  2005cited by this paper
• Development and maturation of the immune system in zebrafish, Danio rerio: a gene expression profiling, in situ hybridization and immunological study.

  2004cited by this paper
• Toll-like receptor gene family and TIR-domain adapters in Danio rerio.

  2004cited by this paper
• Recognition of commensal microflora by toll-like receptors is required for intestinal homeostasis.

  2004cited by this paper
• Toll-like receptor 2 enhances ZO-1-associated intestinal epithelial barrier integrity via protein kinase C.

  2004cited by this paper
• A transposon-mediated gene trap approach identifies developmentally regulated genes in zebrafish.

  2004cited by this paper
• Expression analysis of the Toll-like receptor and TIR domain adaptor families of zebrafish.

  2004influential reference
• Bacterial infection of human hematopoietic stem cells induces monocytic differentiation.

  2004cited by this paper
• The use of zebrafish to understand immunity.

  2004cited by this paper
• The ‘definitive’ (and ‘primitive’) guide to zebrafish hematopoiesis

  2004cited by this paper
• A Toll-like Receptor That Prevents Infection by Uropathogenic Bacteria

  2004cited by this paper
• In vivo tracking of T cell development, ablation, and engraftment in transgenic zebrafish.

  2004cited by this paper
• TIR domain-containing adaptors define the specificity of TLR signaling.

  2004cited by this paper
• Innate immunity: an overview.

  2004cited by this paper
• The Toll-IL-1 receptor adaptor family grows to five members.

  2003cited by this paper
• Zebrafish embryos as a model host for the real time analysis of Salmonella typhimurium infections

  2003cited by this paper
• Making a zebrafish kidney: a tale of two tubes.

  2003cited by this paper
• Escherichia coli LPS-induced LV dysfunction: role of toll-like receptor-4 in the adult heart.

  2002cited by this paper
• Rapidly maturing variants of the Discosoma red fluorescent protein (DsRed)

  2002cited by this paper
• Tissue Expression of Human Toll-Like Receptors and Differential Regulation of Toll-Like Receptor mRNAs in Leukocytes in Response to Microbes, Their Products, and Cytokines

  2002influential reference
• Rapidly maturing variants of the Discosoma red fluorescent protein (DsRed)

  2002cited by this paper
• In vivo imaging of embryonic vascular development using transgenic zebrafish.

  2002cited by this paper
• Cardiac inflammation and innate immunity in septic shock: is there a role for toll-like receptors?

  2002cited by this paper
• Real-time visualization of mycobacterium-macrophage interactions leading to initiation of granuloma formation in zebrafish embryos.

  2002cited by this paper
• Tumor Necrosis Factor- a (TNF- a ) Plays a Protective Role in Acute Viral Myocarditis in Mice A Study Using Mice Lacking TNF- a

  2001cited by this paper
• Tumor necrosis factor-alpha (TNF-alpha) plays a protective role in acute viralmyocarditis in mice: A study using mice lacking TNF-alpha.

  2001cited by this paper
• Role of TLR-2 in the Activation of Nuclear Factor κB by Oxidative Stress in Cardiac Myocytes*

  2001cited by this paper
• Tumor Necrosis Factor-α (TNF-α) Plays a Protective Role in Acute Viral Myocarditis in Mice

  2001cited by this paper
• Lipopolysaccharide Stimulates the MyD88-Independent Pathway and Results in Activation of IFN-Regulatory Factor 3 and the Expression of a Subset of Lipopolysaccharide-Inducible Genes1

  2001cited by this paper
• Ontogeny of Toll-Like Receptors Tlr2 and Tlr4 in Mice

  2001cited by this paper
• Morphologic and functional characterization of granulocytes and macrophages in embryonic and adult zebrafish.

  2001cited by this paper
• Concurrent expression of recombination activating genes 1 and 2 in zebrafish olfactory sensory neurons

  2001influential reference
• In vivo expression of proinflammatory mediators in the adult heart after endotoxin administration: the role of toll-like receptor-4.

  2001cited by this paper
• CD14-independent activation of cardiomyocyte signal transduction by bacterial endotoxin.

  2000cited by this paper
• Cellular responses to bacterial cell wall components are mediated through MyD88-dependent signaling cascades.

  2000cited by this paper
• Unresponsiveness of MyD88-deficient mice to endotoxin.

  1999cited by this paper
• Toll4 (TLR4) expression in cardiac myocytes in normal and failing myocardium.

  1999cited by this paper
• Ontogeny and behaviour of early macrophages in the zebrafish embryo.

  1999cited by this paper
• LPS-induced TNF-alpha release from and apoptosis in rat cardiomyocytes: obligatory role for CD14 in mediating the LPS response.

  1998cited by this paper
• Stages of embryonic development of the zebrafish

  1995cited by this paper
• The zebrafish book : a guide for the laboratory use of zebrafish (Danio rerio)

  1995influential reference
• Whole-mount in situ hybridizations on zebrafish embryos using a mixture of digoxigenin- and fluorescein-labelled probes.

  1994cited by this paper
• Nucleotide sequence and expression of a cDNA encoding MyD88, a novel myeloid differentiation primary response gene induced by IL6.

  1990cited by this paper
• Dissection of the immediate early response of myeloid leukemia cells to terminal differentiation and growth inhibitory stimuli.

  1990cited by this paper

• A light-regulated circadian timer optimizes neutrophil bactericidal activity to boost daytime immunity.

  2025cites this paper
• Oncogenic Ras activation in permissive somatic cells triggers rapid-onset phenotypic plasticity and elicits a tumor-promoting neutrophil response.

  2025cites this paper
• A zebrafish gene with sequence similarities to human uromodulin and GP2 displays extensive evolutionary diversification among teleost and confers resistance to bacterial infection

  2024cites this paper
• The innate immune regulator MyD88 dampens fibrosis during zebrafish heart regeneration

  2024cites this paper
• Placental neutrophil reverse trans-migration and maternal serum neutrophil extracellular trap expression in HIV infection co-morbid pre-eclampsia in women of African ancestry

  2024cites this paper
• Uricase-Deficient Larval Zebrafish with Elevated Urate Levels Demonstrate Suppressed Acute Inflammatory Response to Monosodium Urate Crystals and Prolonged Crystal Persistence

  2022cites this paper
• Laser-mediated osteoblast ablation triggers a pro-osteogenic inflammatory response regulated by reactive oxygen species and glucocorticoid signaling in zebrafish.

  2022cites this paper
• Zebrafish: an underutilized tool for discovery in host-microbe interactions.

  2022cites this paper
• Identification and Characterization of Zebrafish Tlr4 Coreceptor Md-2

  2021cites this paper
• Microbial recognition regulates intestinal epithelial growth in homeostasis and disease

  2021cites this paper
• Genetic Approaches Using Zebrafish to Study the Microbiota–Gut–Brain Axis in Neurological Disorders

  2021cites this paper
• Neutrophil in Reverse Migration: Role in Sepsis

  2021cites this paper
• Zebrafish models of acute leukemias: Current models and future directions

  2020cites this paper
• Review of inflammation in fish and value of the zebrafish model.

  2020cites this paper
• Chemokine Receptors and Phagocyte Biology in Zebrafish

  2020influential citation
• Identification and characterization of zebrafish Tlr4 co-receptor Md-2

  2019cites this paper
• Investigating the role of MyD88-NF-kB signalling in regulating the inflammatory response to the emerging pre-neoplastic cells

  2019influential citation
• Liposome-Mediated Drug Delivery in Larval Zebrafish to Manipulate Macrophage Function

  2019cites this paper
• Zebrafish Tools To Combat Acute Myeloid Leukaemia – The Nucleoporin 98 kiloDalton—Homeobox A9 (NUP98-HOXA9) Fusion Oncogene Drives Myeloproliferation By Upregulating DNA (Cytosine-5-)-Methyltransferase 1 (dnmt1)

  2018cites this paper
• Blocking fatty acid–fueled mROS production within macrophages alleviates acute gouty inflammation

  2018cites this paper
• Macrophages enhance Vegfa-driven angiogenesis in an embryonic zebrafish tumour xenograft model

  2018cites this paper
• Modeling Infectious Diseases in the Context of a Developing Immune System.

  2017cites this paper
• Innate immune cells and bacterial infection in zebrafish.

  2017cites this paper
• Intravital Imaging of Myeloid Cells: Inflammatory Migration and Resident Patrolling

  2016cites this paper
• Reverse Migration of Neutrophils: Where, When, How, and Why?

  2016cites this paper
• A Zebrafish Model for Chlamydia Infection with the Obligate Intracellular Pathogen Waddlia chondrophila

  2016cites this paper
• Neutrophil migration in infection and wound repair: going forward in reverse

  2016cites this paper
• Recent advances in understanding neutrophils

  2016cites this paper
• Immune cell dynamics in the CNS: Learning from the zebrafish

  2015cites this paper
• The influence of genetic polymorphisms in TLR4 and TIRAP, and their expression levels in peripheral blood, on susceptibility to sepsis

  2015influential citation
• Neutrophils in host defense: new insights from zebrafish

  2015cites this paper
• Assessment of biocompatibility of 3D printed photopolymers using zebrafish embryo toxicity assays

  2015cites this paper
• Repositioning drugs for inflammatory disease – fishing for new anti-inflammatory agents

  2014cites this paper
• Comparative studies of Toll-like receptor signalling using zebrafish.

  2014cites this paper
• Macrophage-pathogen interactions in infectious diseases: new therapeutic insights from the zebrafish host model

  2014cites this paper
• Mitochondrial metabolism, reactive oxygen species, and macrophage function-fishing for insights

  2014cites this paper
• The progress and promise of zebrafish as a model to study mast cells.

  2014cites this paper
• RNA sequencing of FACS-sorted immune cell populations from zebrafish infection models to identify cell specific responses to intracellular pathogens.

  2014cites this paper
• Regulation of innate immune responses by transmembrane interactions: lessons from the TLR family.

  2014cites this paper
• Using zebrafish as a model to study acute and chronic mucosal inflammation

  2014cites this paper
• Live imaging epidermal cell metabolism during inflammation: a new immunometabolic role for epidermal keratinocytes

  2014cites this paper
• Epidermal cells help coordinate leukocyte migration during inflammation through fatty acid-fuelled matrix metalloproteinase production

  2014cites this paper
• HNF1β is essential for nephron segmentation during nephrogenesis.

  2013cites this paper
• Immunoresponsive gene 1 augments bactericidal activity of macrophage-lineage cells by regulating β-oxidation-dependent mitochondrial ROS production.

  2013cites this paper
• Functional analysis of a zebrafish myd88 mutant identifies key transcriptional components of the innate immune system

  2013cites this paper
• Novel descriptive and model based statistical approaches in immunology and signal transduction

  2013cites this paper
• Microsystems manufacturing technologies for pharmaceutical toxicity testing

  2013cites this paper
• Additive manufacturing of lab-on-a-chip devices: promises and challenges

  2013cites this paper
• Optimization and Pharmacological Validation of a Leukocyte Migration Assay in Zebrafish Larvae for the Rapid In Vivo Bioactivity Analysis of Anti-Inflammatory Secondary Metabolites

  2013influential citation
• Mechanisms of mu opioid receptor mediated protection from multiple models of acute injury

  2012cites this paper
• Infection-responsive expansion of the hematopoietic stem and progenitor cell compartment in zebrafish is dependent upon inducible nitric oxide.

  2012cites this paper
• RNA-Seq profiling of leukocyte populations and mycobacterium-infected cells from wild type and ptpn6-deficient zebrafish larvae

  2012cites this paper
• The interaction between maternal stress and the ontogeny of the innate immune system during teleost embryogenesis: implications for aquaculture practice.

  2012cites this paper
• Animal Models of Human Pathology 2012

  2012cites this paper
• Myelopoiesis and Myeloid Leukaemogenesis in the Zebrafish

  2012cites this paper
• Molecular regulation of interferon antiviral response in fish.

  2012cites this paper
• Regulatory mechanisms of innate immune signaling in zebrafish embryos

  2012cites this paper
• In vivo real-time visualization of leukocytes and intracellular hydrogen peroxide levels during a zebrafish acute inflammation assay.

  2012cites this paper
• Pathogen Recognition and Activation of the Innate Immune Response in Zebrafish

  2012cites this paper
• Drift-Diffusion Analysis of Neutrophil Migration during Inflammation Resolution in a Zebrafish Model

  2012influential citation
• Regulation of immunity and disease resistance by commensal microbes and chromatin modifications during zebrafish development

  2012cites this paper
• Rac2 in the zebrafish (Danio rerio) with a focus on neutrophils

  2012cites this paper
• A model 450 million years in the making: zebrafish and vertebrate immunity

  2012cites this paper
• Miniaturized Embryo Array for Automated Trapping, Immobilization and Microperfusion of Zebrafish Embryos

  2012influential citation
• Think Small: Zebrafish as a Model System of Human Pathology

  2012cites this paper
• Host-Pathogen Interactions Made Transparent with the Zebrafish Model

  2011cites this paper
• Spatiotemporal photolabeling of neutrophil trafficking during inflammation in live zebrafish

  2011cites this paper
• Bacterial Stimulation of Intestinal Proliferation via the Wnt Pathway in Zebrafish

  2011influential citation
• Infectious disease studies in zebrafish : the fish pathogen Edwardsiella tarda as a model system

  2011cites this paper
• Identification of adult nephron progenitors capable of kidney regeneration in zebrafish

  2011cites this paper
• Zebrafish mast cells possess an FcɛRI-like receptor and participate in innate and adaptive immune responses.

  2011cites this paper
• Expression profiling of the response to Edwardsiella tarda infection in a zebrafish myd88 knockout mutant

  2011cites this paper
• The inflammatory bowel disease (IBD) susceptibility genes NOD1 and NOD2 have conserved anti-bacterial roles in zebrafish

  2011cites this paper
• Simultaneous intravital imaging of macrophage and neutrophil behaviour during inflammation using a novel transgenic zebrafish

  2011cites this paper
• Comparative Study of Skin Graft Tolerance and Rejection in the Frog Xenopus Laevis

  2011cites this paper
• Epithelial cell proliferation in the developing zebrafish intestine is regulated by the Wnt pathway and microbial signaling via Myd88

  2010cites this paper
• Cancer and inflammation studies using zebrafish cell lines

  2010cites this paper
• Live imaging innate immune cell behavior during normal development, wound healing and infection

  2010cites this paper
• Toll-like Receptor signaling in zebrafish cell lines

  2010cites this paper
• Evidence of molecular toll-like receptor mechanisms in teleosts

  2010cites this paper
• Innate immune signalling of the zebrafish embryo

  2010cites this paper
• A high-throughput chemically induced inflammation assay in zebrafish

  2010cites this paper
• Functional analysis of zebrafish innate immune responses to inflammatory signals

  2010cites this paper
• Using in vivo zebrafish models to understand the biochemical basis of neutrophilic respiratory disease.

  2009cites this paper