Small-fibre neuropathies—advances in diagnosis, pathophysiology and management

No abstract is available for this paper.

• Publication year

  2012

• Venue

  Nature Reviews Neurology

• Publication date

  2012-07-01

• Fields of study

  Medicine

• Identifiers
  DOI 10.1038/nrneurol.2012.97PMID 22641108
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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• Inhibiting TRPA1 ion channel reduces loss of cutaneous nerve fiber function in diabetic animals: sustained activation of the TRPA1 channel contributes to the pathogenesis of peripheral diabetic neuropathy.

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• [Autonomic peripheral neuropathy].

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• Peripheral nerve toxic effects of nitrofurantoin.

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• Gain of function NaV1.7 mutations in idiopathic small fiber neuropathy

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• Chapter 39 – Clinical–pathologic correlations

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• Unmyelinated and myelinated skin nerve damage in Guillain–Barré syndrome: Correlation with pain and recovery

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• Early diagnosis of peripheral nervous system involvement in Fabry disease and treatment of neuropathic pain: the report of an expert panel

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• Reviews

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• Skin denervation and its clinical significance in late-stage chronic kidney disease.

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• Pain perception in humans: use of intraepidermal electrical stimulation

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  2011cited by this paper
• Impaired neurovascular repair in subjects with diabetes following experimental intracutaneous axotomy.

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• Small fibre neuropathy: role in the diagnosis of diabetic sensorimotor polyneuropathy

  2011cited by this paper
• Quantitation of Sudomotor Innervation in Skin Biopsies of Patients With Diabetic Neuropathy

  2011cited by this paper
• Morphometry of dermal nerve fibers in human skin

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• Microneurographic evaluation of sympathetic activity in small fiber neuropathy.

  2011cited by this paper
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  2010cited by this paper
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• Electrically evoked nociceptive potentials for early detection of diabetic small‐fiber neuropathy

  2010cited by this paper
• Intraepidermal nerve fiber density reduction as a marker of preclinical asymptomatic small-fiber sensory neuropathy in hypothyroid patients.

  2010cited by this paper
• The cutaneous sensory system.

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• Diabetic Neuropathies: Update on Definitions, Diagnostic Criteria, Estimation of Severity, and Treatments

  2010cited by this paper
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  2010cited by this paper
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• Non‐length dependent small fiber neuropathy. A prospective case series

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• Elevated proinflammatory cytokine expression in affected skin in small fiber neuropathy

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• Corneal confocal microscopy: a novel means to detect nerve fibre damage in idiopathic small fibre neuropathy.

  2009cited by this paper
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  2009cited by this paper
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  2008cited by this paper
• The diagnostic criteria for small fibre neuropathy: from symptoms to neuropathology

  2008cited by this paper
• The epidermis: a sensory tissue.

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• Neurobiology of pain

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• Small fibre neuropathies

  2005cited by this paper
• Role of the Immune system in chronic pain

  2005cited by this paper
• Small-fiber neuropathy/neuronopathy associated with celiac disease: skin biopsy findings.

  2005cited by this paper

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  2020cites this paper
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  2020cites this paper
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