Plasmodesmata-Mediated Cell-to-Cell Communication in the Shoot Apical Meristem: How Stem Cells Talk

Positional information is crucial for the determination of plant cell fates, and it is established based on coordinated cell-to-cell communication, which in turn is essential for plant growth and development. Plants have evolved a unique communication pathway, with tiny channels called plasmodesmata (PD) spanning the cell wall. PD interconnect most cells in the plant and generate a cytoplasmic continuum, to mediate short- and long-distance trafficking of various molecules. Cell-to-cell communication through PD plays a role in transmitting positional signals, however, the regulatory mechanisms of PD-mediated trafficking are still largely unknown. The induction and maintenance of stem cells in the shoot apical meristem (SAM) depends on PD-mediated cell-to-cell communication, hence, it is an optimal model for dissecting the regulatory mechanisms of PD-mediated cell-to-cell communication and its function in specifying cell fates. In this review, we summarize recent knowledge of PD-mediated cell-to-cell communication in the SAM, and discuss mechanisms underlying molecular trafficking through PD and its role in plant development.

• Publication year

  2017

• Venue

  Plants

• Publication date

  2017-03-01

• Fields of study

  Biology, Medicine, Environmental Science

• Identifiers
  DOI 10.3390/plants6010012PMID 28257070PMCID 5371771
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Choline transporter‐like1 (CHER1) is crucial for plasmodesmata maturation in Arabidopsis thaliana

  2017cited by this paper
• Plasmodesmata enable multicellularity: new insights into their evolution, biogenesis, and functions in development and immunity.

  2017cited by this paper
• CLAVATA-WUSCHEL signaling in the shoot meristem

  2016cited by this paper
• Auxin Acts through MONOPTEROS to Regulate Plant Cell Polarity and Pattern Phyllotaxis

  2016cited by this paper
• Plasmodesmata Localizing Proteins Regulate Transport and Signaling during Systemic Acquired Immunity in Plants.

  2016cited by this paper
• Receptor Complex Mediated Regulation of Symplastic Traffic.

  2016cited by this paper
• Integrating Hormone- and Micromolecule-Mediated Signaling with Plasmodesmal Communication.

  2016cited by this paper
• Phloem Transport of the Receptor DWARF14 Protein Is Required for Full Function of Strigolactones1

  2016influential reference
• Ready, aim, shoot: stem cell regulation of the shoot apical meristem.

  2016cited by this paper
• Defining the Path from Stem Cells to Differentiated Tissue.

  2016cited by this paper
• Symplastic communication in organ formation and tissue patterning.

  2016cited by this paper
• Plant Stem Cells.

  2016cited by this paper
• Tissue patterning and cellular mechanics

  2015cited by this paper
• The cytosol must flow: intercellular transport through plasmodesmata.

  2015cited by this paper
• The never-ending story: from pluripotency to plant developmental plasticity

  2015cited by this paper
• O cell, where art thou? The mechanisms of shoot meristem patterning.

  2015cited by this paper
• Specific Membrane Lipid Composition Is Important for Plasmodesmata Function in Arabidopsis

  2015cited by this paper
• Mechanical stress contributes to the expression of the STM homeobox gene in Arabidopsis shoot meristems

  2015cited by this paper
• The movement of the non-cell-autonomous transcription factor, SHORT-ROOT relies on the endomembrane system.

  2014cited by this paper
• Identification of phloem-mobile mRNA

  2014cited by this paper
• Intercellular protein movement: deciphering the language of development.

  2014cited by this paper
• Roles and regulation of plant cell walls surrounding plasmodesmata.

  2014cited by this paper
• A regulatory framework for shoot stem cell control integrating metabolic, transcriptional, and phytohormone signals.

  2014cited by this paper
• Small RNAs as positional signal for pattern formation.

  2014cited by this paper
• Plasmodesmata in integrated cell signalling: insights from development and environmental signals and stresses.

  2014influential reference
• Plant and animal stem cells: similar yet different

  2014cited by this paper
• The C2-domain protein QUIRKY and the receptor-like kinase STRUBBELIG localize to plasmodesmata and mediate tissue morphogenesis in Arabidopsis thaliana

  2014influential reference
• The angiosperm phloem sieve tube system: a role in mediating traits important to modern agriculture.

  2014cited by this paper
• Callose homeostasis at plasmodesmata: molecular regulators and developmental relevance

  2014cited by this paper
• A mechanistic framework for noncell autonomous stem cell induction in Arabidopsis

  2014influential reference
• Transcription factor-mediated cell-to-cell signalling in plants.

  2014cited by this paper
• Shoot meristems of deciduous woody perennials: self-organization and morphogenetic transitions.

  2014cited by this paper
• LYM2-dependent chitin perception limits molecular flux via plasmodesmata

  2013cited by this paper
• A protodermal miR394 signal defines a region of stem cell competence in the Arabidopsis shoot meristem.

  2013influential reference
• MicroRNAs inhibit the translation of target mRNAs on the endoplasmic reticulum in Arabidopsis.

  2013cited by this paper
• A Developmental Framework for Complex Plasmodesmata Formation Revealed by Large-Scale Imaging of the Arabidopsis Leaf Epidermis[W]

  2013cited by this paper
• Moderation of Arabidopsis root stemness by CLAVATA1 and ARABIDOPSIS CRINKLY4 receptor kinase complexes.

  2013cited by this paper
• Salicylic Acid Regulates Plasmodesmata Closure during Innate Immune Responses in Arabidopsis[C][W]

  2013cited by this paper
• Symplastic intercellular connectivity regulates lateral root patterning.

  2013cited by this paper
• Cytokinin signalling inhibitory fields provide robustness to phyllotaxis

  2013influential reference
• Intact microtubules are required for the intercellular movement of the SHORT-ROOT transcription factor.

  2013cited by this paper
• Characterization of temperature-sensitive mutants reveals a role for receptor-like kinase SCRAMBLED/STRUBBELIG in coordinating cell proliferation and differentiation during Arabidopsis leaf development.

  2012cited by this paper
• Mechanism of Small RNA Movement

  2012cited by this paper
• Cytokinin signaling as a positional cue for patterning the apical–basal axis of the growing Arabidopsis shoot meristem

  2012cited by this paper
• A superfamily of actin-binding proteins at the actin-membrane nexus of higher plants.

  2012cited by this paper
• The SHORT-ROOT protein acts as a mobile, dose-dependent signal in patterning the ground tissue

  2012cited by this paper
• Plasmodesmata paradigm shift: regulation from without versus within.

  2012cited by this paper
• Redox States of Plastids and Mitochondria Differentially Regulate Intercellular Transport via Plasmodesmata1[OA]

  2012cited by this paper
• SCARECROW reinforces SHORT-ROOT signaling and inhibits periclinal cell divisions in the ground tissue by maintaining SHR at high levels in the endodermis

  2012cited by this paper
• FTIP1 Is an Essential Regulator Required for Florigen Transport

  2012cited by this paper
• Cell-to-cell communication in plants, animals, and fungi: a comparative review

  2012cited by this paper
• Chilling of Dormant Buds Hyperinduces FLOWERING LOCUS T and Recruits GA-Inducible 1,3-β-Glucanases to Reopen Signal Conduits and Release Dormancy in Populus[W][OA]

  2011cited by this paper
• A Plasmodesmata-Localized Protein Mediates Crosstalk between Cell-to-Cell Communication and Innate Immunity in Arabidopsis[C][W][OA]

  2011cited by this paper
• Chaperonins Facilitate KNOTTED1 Cell-to-Cell Trafficking and Stem Cell Function

  2011cited by this paper
• WUSCHEL protein movement mediates stem cell homeostasis in the Arabidopsis shoot apex.

  2011cited by this paper
• Structure-Function Analysis of STRUBBELIG, an Arabidopsis Atypical Receptor-Like Kinase Involved in Tissue Morphogenesis

  2011cited by this paper
• Arabidopsis Plasmodesmal Proteome

  2011influential reference
• Arabidopsis Argonaute10 specifically sequesters miR166/165 to regulate shoot apical meristem development.

  2011cited by this paper
• An essential protein that interacts with endosomes and promotes movement of the SHORT-ROOT transcription factor.

  2011cited by this paper
• DNA methylation mediated by a microRNA pathway.

  2010cited by this paper
• Biology of callose (β-1,3-glucan) turnover at plasmodesmata

  2010cited by this paper
• Plasmodesmal receptor-like kinases identified through analysis of rice cell wall extracted proteins

  2010cited by this paper
• Plasmodesmata during development: re-examination of the importance of primary, secondary, and branched plasmodesmata structure versus function

  2010cited by this paper
• Closure of plasmodesmata in maize (Zea mays) at low temperature: a new mechanism for inhibition of photosynthesis.

  2010cited by this paper
• Inhibitors of myosin, but not actin, alter transport through Tradescantia plasmodesmata

  2010cited by this paper
• gorgon, a novel missense mutation in the SHOOT MERISTEMLESS gene, impairs shoot meristem homeostasis in Arabidopsis.

  2010cited by this paper
• A non-cell-autonomous mechanism for the control of plant architecture and epidermal differentiation involves intercellular trafficking of BREVIPEDICELLUS protein.

  2009cited by this paper
• Callose synthesis in higher plants

  2009cited by this paper
• A signaling module controlling the stem cell niche in Arabidopsis root meristems.

  2009cited by this paper
• The ARGONAUTE10 gene modulates shoot apical meristem maintenance and establishment of leaf polarity by repressing miR165/166 in Arabidopsis.

  2009cited by this paper
• Multiple feedback loops through cytokinin signaling control stem cell number within the Arabidopsis shoot meristem

  2009cited by this paper
• A feedback mechanism controlling SCRAMBLED receptor accumulation and cell-type pattern in Arabidopsis.

  2008cited by this paper
• Two-Dimensional Patterning by a Trapping/Depletion Mechanism: The Role of TTG1 and GL3 in Arabidopsis Trichome Formation

  2008cited by this paper
• A Quantitative and Dynamic Model for Plant Stem Cell Regulation

  2008cited by this paper
• Specific Targeting of a Plasmodesmal Protein Affecting Cell-to-Cell Communication

  2008cited by this paper
• Cytokinin and auxin interaction in root stem-cell specification during early embryogenesis

  2008cited by this paper
• Vascular signalling mediated by ZWILLE potentiates WUSCHEL function during shoot meristem stem cell development in the Arabidopsis embryo

  2008cited by this paper
• Widespread Translational Inhibition by Plant miRNAs and siRNAs

  2008cited by this paper
• Symplastic domains in the Arabidopsis shoot apical meristem correlate with PDLP1 expression patterns

  2008cited by this paper
• The Arabidopsis receptor-like kinase STRUBBELIG mediates inter-cell-layer signaling during floral development.

  2008cited by this paper
• Presumable role of plasmodesmata in floral signal transduction in shoot apical meristems of rudbeckia and perilla plants

  2007cited by this paper
• A plasmodesmata-associated beta-1,3-glucanase in Arabidopsis.

  2007cited by this paper
• Conserved factors regulate signalling in Arabidopsis thaliana shoot and root stem cell organizers

  2007cited by this paper
• Control of shoot and root meristem function by cytokinin.

  2007cited by this paper
• Techniques for Imaging Intercellular Transport

  2007cited by this paper
• A plasmodesmata-associated β-1,3-glucanase in Arabidopsis

  2007cited by this paper
• The role of the SCRAMBLED receptor-like kinase in patterning the Arabidopsis root epidermis.

  2007cited by this paper
• WUSCHEL controls meristem function by direct regulation of cytokinin-inducible response regulators

  2005cited by this paper
• STRUBBELIG defines a receptor kinase-mediated signaling pathway regulating organ development in Arabidopsis.

  2005cited by this paper
• A novel cell-to-cell trafficking assay indicates that the KNOX homeodomain is necessary and sufficient for intercellular protein and mRNA trafficking.

  2005cited by this paper
• Positional Signaling Mediated by a Receptor-like Kinase in Arabidopsis

  2005cited by this paper
• Developmental regulation and significance of KNOX protein trafficking in Arabidopsis

  2003cited by this paper
• The Arabidopsis ACR4 gene plays a role in cell layer organisation during ovule integument and sepal margin development

  2003cited by this paper
• The shoot apical meristem restores its symplasmic organization during chilling-induced release from dormancy.

  2001cited by this paper
• Non-targeted and targeted protein movement through plasmodesmata in leaves in different developmental and physiological states.

  2001cited by this paper
• The frequency of plasmodesmata increases early in the whole shoot apical meristem of Sinapis alba L. during floral transition

  2000cited by this paper
• Subcellular localization determines the availability of non-targeted proteins to plasmodesmatal transport.

  2000cited by this paper
• Cell-to-cell transport of proteins: requirement for unfolding and characterization of binding to a putative plasmodesmal receptor

  1998cited by this paper
• SKP1 connects cell cycle regulators to the ubiquitin proteolysis machinery through a novel motif, the F-box.

  1996cited by this paper
• A member of the KNOTTED class of homeodomain proteins encoded by the STM gene of Arabidopsis

  1996cited by this paper

• Cell-to-cell translocation of florigen is inhibited by low ambient temperature through abscisic acid signaling in Arabidopsis thaliana

  2025cites this paper
• The third alpha helix of plant homeoproteins are generally cell-penetrating to plant cells

  2025influential citation
• Identification of Long-Distance Mobile mRNAs Responding to Drought Stress in Heterografted Tomato Plants

  2025cites this paper
• Florigen-producing cells express FPF1-LIKE PROTEIN 1 to accelerate flowering and stem growth in Arabidopsis.

  2025cites this paper
• Plant Colonization by Biocontrol Bacteria and Improved Plant Health: A Review.

  2025cites this paper
• DAPATKAH POHON KELAPA SAWIT PULIH PASCA PENGAMBILAN SUMBER EKSPLAN?

  2025cites this paper
• Bridging cells and stages: Plasmodesmata for the coordination of plant development.

  2025cites this paper
• Plasmodesmata dynamics in bryophyte model organisms: secondary formation and developmental modifications of structure and function

  2024cites this paper
• Emerging evidence of seed transmission of begomoviruses: implications in global circulation and disease outbreak

  2024cites this paper
• ZmCals12 impacts the maize growth and development by regulating symplastic transport

  2024cites this paper
• A review of the potential involvement of small RNAs in transgenerational abiotic stress memory in plants

  2024cites this paper
• Plasmodesmata: Channels Under Pressure.

  2024cites this paper
• Metabolic regulation of quiescence in plants

  2023cites this paper
• The mRNA mobileome: challenges and opportunities for deciphering signals from the noise

  2023cites this paper
• A resilient bunch: stem cell antiviral immunity in plants.

  2023cites this paper
• Toward Transgene-Free Transposon-Mediated Biological Mutagenesis for Plant Breeding

  2023cites this paper
• In vitro Induced Mutagenesis for Early Blight (Alternaria solani) Resistance in Potato (Solanum tuberosum L.)

  2023cites this paper
• Heavy Metal-Associated Isoprenylated Plant Proteins (HIPPs) at Plasmodesmata: Exploring the Link between Localization and Function

  2023cites this paper
• The potential of plant action potentials

  2023cites this paper
• An RNA exosome subunit mediates cell-to-cell trafficking of a homeobox mRNA via plasmodesmata

  2022cites this paper
• Role of RNA –Binding Proteins in Controlling Cell to Cell Communication and Molecular Trafficking in Plants

  2022cites this paper
• Epigenetic variation as a new plant breeding tool: A review

  2022cites this paper
• Topological properties accurately predict cell division events and organization of shoot apical meristem in Arabidopsis thaliana

  2022cites this paper
• POPEYE intercellular localization mediates cell-specific iron deficiency responses.

  2022cites this paper
• Transcription Factor DOF4.1 Regulates Seed Longevity in Arabidopsis via Seed Permeability and Modulation of Seed Storage Protein Accumulation

  2022cites this paper
• Control of root-to-shoot long-distance flow by a key ROS-regulating factor in Arabidopsis.

  2022cites this paper
• Delving deeper into the link between sugar transport, sugar signaling and vascular system development.

  2022cites this paper
• Function and Regulation of microRNA171 in Plant Stem Cell Homeostasis and Developmental Programing

  2022cites this paper
• A Forward Genetic Approach to Identify Plasmodesmal Trafficking Regulators Based on Trichome Rescue.

  2022cites this paper
• Calreticulin expression and localization in relation to exchangeable Ca2+ during pollen development in Petunia

  2022cites this paper
• Leaf Epidermis: The Ambiguous Symplastic Domain

  2021cites this paper
• Do Plasmodesmata Play a Prominent Role in Regulation of Auxin-Dependent Genes at Early Stages of Embryogenesis?

  2021cites this paper
• In search of the still unknown function of FW2.2 / CELL NUMBER REGULATOR, a major regulator of fruit size in tomato.

  2021cites this paper
• Under siege: virus control in plant meristems and progeny

  2021cites this paper
• Similarities and Differences in the GFP Movement in the Zygotic and Somatic Embryos of Arabidopsis

  2021cites this paper
• Auxin fluxes through plasmodesmata.

  2021cites this paper
• Lipid Body Dynamics in Shoot Meristems: Production, Enlargement, and Putative Organellar Interactions and Plasmodesmal Targeting

  2021cites this paper
• Genetics of Shoot Meristem and Shoot Regeneration.

  2021cites this paper
• Topological properties accurately predict cell division events and organization of Arabidopsis thaliana’s shoot apical meristem

  2021cites this paper
• Progress on medicinal plant regeneration and the road ahead

  2020cites this paper
• Direct observation of nanoparticle diffusion in cytoplasm of single plant cells realized by photoinjection with femtosecond laser amplifier

  2020cites this paper
• Plasmodesmata the Nano Bridges in Plant Cell: Are the Answer for All the Developmental Processes?

  2020cites this paper
• Small hydrophobic viral proteins involved in intercellular movement of diverse plant virus genomes

  2020cites this paper
• Symplasmic isolation marks cell fate changes during somatic embryogenesis

  2020cites this paper
• Plasmodesmata-Dependent Intercellular Movement of Bacterial Effectors

  2020cites this paper
• Regulation of Plant Morphogenesis: Generation of Anisotropy at Cellular and Tissue Levels

  2019cites this paper
• Polyploidy, the Nucleotype, and Novelty: The Impact of Genome Doubling on the Biology of the Cell

  2019cites this paper
• CLE 40 signalling regulates root stem cell fate 10 11

  2019cites this paper
• To regenerate or not to regenerate: factors that drive plant regeneration.

  2019cites this paper
• Uprising the antioxidant power of Argania spinosa L. callus through abiotic elicitation.

  2019cites this paper
• Small RNAs from Seed to Mature Plant

  2019cites this paper
• Maize Carbohydrate Partitioning Defective33 Encodes an MCTP Protein and Functions in Sucrose Export from Leaves.

  2019cites this paper
• CLE40 Signaling Regulates Root Stem Cell Fate1

  2019cites this paper
• Effect of amino acid substitution of CAPRICE on cell-to-cell movement ability in Arabidopsis root epidermis.

  2018cites this paper
• Plasmodesmal regulation during plant-pathogen interactions.

  2018cites this paper
• Conceptual and Methodological Considerations on mRNA And Proteins as Intercellular and Long-distance Signals.

  2018cites this paper
• Exploring the Role of Cell Wall-Related Genes and Polysaccharides during Plant Development

  2018cites this paper
• The Integration of Electrical Signals Originating in the Root of Vascular Plants

  2018cites this paper
• Symplasmic Intercellular Communication through Plasmodesmata

  2018cites this paper
• Long distance RNA movement.

  2018cites this paper
• Stem cells within the shoot apical meristem: identity, arrangement and communication

  2018cites this paper
• Information Processing and Distributed Computation in Plant Organs.

  2018cites this paper
• Callose balancing at plasmodesmata.

  2018cites this paper
• Gating of miRNA movement at defined cell-cell interfaces governs their impact as positional signals

  2018cites this paper
• Callose-mediated regulation of Plasmodesmata during the establishment of Medicago truncatula-Sinorhizobium meliloti symbiotic interaction

  2017cites this paper
• Calreticulin localizes to plant intra/extracellular peripheries of highly specialized cells involved in pollen-pistil interactions

  2017cites this paper
• TEACHING TOOLS IN PLANT BIOLOGYTM: LECTURE NOTES

  2017cites this paper
• Ectodomain of plasmodesmata-localized protein 5 in Arabidopsis: expression, purification, crystallization and crystallographic analysis.

  2017cites this paper
• Comparative proteomic profiling of the choline transporter‐like1 (CHER1) mutant provides insights into plasmodesmata composition of fully developed Arabidopsis thaliana leaves

  2017cites this paper