Structure of an E6AP-UbcH7 complex: insights into ubiquitination by the E2-E3 enzyme cascade.

No abstract is available for this paper.

• Publication year

  1999

• Venue

  Science

• Publication date

  1999-11-12

• Fields of study

  Biology, Medicine, Chemistry

• Identifiers
  DOI 10.1126/SCIENCE.286.5443.1321PMID 10558980
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Structural basis for the specificity of ubiquitin C‐terminal hydrolases

  1999cited by this paper
• Substrate Targeting Minireview in the Ubiquitin System

  1999cited by this paper
• Functional Domains of the Rsp5 Ubiquitin-Protein Ligase

  1999cited by this paper
• Regulation of the Src family tyrosine kinase Blk through E6AP-mediated ubiquitination.

  1999cited by this paper
• Crystal structure of the cyclin-specific ubiquitin-conjugating enzyme from clam, E2-C, at 2.0 A resolution.

  1999cited by this paper
• Identification of Determinants in E2 Ubiquitin-conjugating Enzymes Required for hect E3 Ubiquitin-Protein Ligase Interaction*

  1999cited by this paper
• Identification of HHR23A as a Substrate for E6-associated Protein-mediated Ubiquitination*

  1999cited by this paper
• Genetics of Angelman syndrome.

  1999cited by this paper
• E3-Ubiquitin Ligase/E6-AP Links Multicopy Maintenance Protein 7 to the Ubiquitination Pathway by a Novel Motif, the L2G Box*

  1998cited by this paper
• Crystal Structure of the Saccharomyces cerevisiae Ubiquitin-conjugating Enzyme Rad6 at 2.6 Å Resolution*

  1998cited by this paper
• Characterization of Human hect Domain Family Members and Their Interaction with UbcH5 and UbcH7*

  1998cited by this paper
• Mutation analysis of UBE3A in Angelman syndrome patients.

  1998cited by this paper
• The Role of E6AP in the Regulation of p53 Protein Levels in Human Papillomavirus (HPV)-positive and HPV-negative Cells*

  1998cited by this paper
• Crystal structure of a class I ubiquitin conjugating enzyme (Ubc7) from Saccharomyces cerevisiae at 2.9 angstroms resolution.

  1997cited by this paper
• Crystal Structure of Murine/Human Ubc9 Provides Insight into the Variability of the Ubiquitin-conjugating System*

  1997cited by this paper
• The human E6-AP gene (UBE3A) encodes three potential protein isoforms generated by differential splicing.

  1997cited by this paper
• Imprinted expression of the murine Angelman syndrome gene, Ube3a, in hippocampal and Purkinje neurons

  1997cited by this paper
• Physical Interaction between Specific E2 and Hect E3 Enzymes Determines Functional Cooperativity*

  1997cited by this paper
• [20] Processing of X-ray diffraction data collected in oscillation mode.

  1997cited by this paper
• Ubiquitin-dependent protein degradation.

  1996cited by this paper
• UBE3A/E6-AP mutations cause Angelman syndrome

  1996cited by this paper
• Surface hydrophobic residues of multiubiquitin chains essential for proteolytic targeting.

  1996cited by this paper
• Cloning of Human Ubiquitin-conjugating Enzymes UbcH6 and UbcH7 (E2-F1) and Characterization of Their Interaction with E6-AP and RSP5 (*)

  1996cited by this paper
• A family of proteins structurally and functionally related to the E6-AP ubiquitin-protein ligase.

  1995cited by this paper
• Protein ubiquitination involving an E1–E2–E3 enzyme ubiquitin thioester cascade

  1995cited by this paper
• Identification of a human ubiquitin-conjugating enzyme that mediates the E6-AP-dependent ubiquitination of p53.

  1994cited by this paper
• Cloning and expression of the cDNA for E6-AP, a protein that mediates the interaction of the human papillomavirus E6 oncoprotein with p53

  1993cited by this paper
• Tertiary structures of class I ubiquitin-conjugating enzymes are highly conserved: crystal structure of yeast Ubc4.

  1993cited by this paper
• Localization of the E6-AP regions that direct human papillomavirus E6 binding, association with p53, and ubiquitination of associated proteins

  1993cited by this paper
• Three-dimensional structure of a ubiquitin-conjugating enzyme (E2).

  1993cited by this paper
• The ubiquitin-conjugation system.

  1992cited by this paper
• A program to produce both detailed and schematic plots of protein structures

  1991cited by this paper
• Protein folding and association: Insights from the interfacial and thermodynamic properties of hydrocarbons

  1991cited by this paper

• Differential higher-order superassembly of HECT-type UBE3 ligases controlled by calcium signals

  2026cites this paper
• Lock, relax, load, and shoot: a molecular perspective on Nedd4 regulation.

  2026cites this paper
• E2 variants for probing E3 ubiquitin ligase activities

  2026cites this paper
• Flexible Fitting to Infer Atomistic-Precision Models of Large-Amplitude Conformational Dynamics in Biomolecules from High-Speed Atomic Force Microscopy Imaging

  2025cites this paper
• E2 conjugating enzymes: A silent but crucial player in Ubiquitin Biology.

  2025cites this paper
• Therapeutic potential of allosteric HECT E3 ligase inhibition

  2025cites this paper
• ATP functions as a pathogen-associated molecular pattern to activate the E3 ubiquitin ligase RNF213

  2025cites this paper
• Targeting ubiquitination in disease and therapy

  2025cites this paper
• Structural basis of ubiquitin ligase Nedd4-2 autoinhibition and regulation by calcium and 14-3-3 proteins

  2025cites this paper
• Structural visualization of HECT-type E3 ligase Ufd4 accepting and transferring ubiquitin to form K29/K48-branched polyubiquitination

  2025cites this paper
• Ion channel inhibition by targeted recruitment of NEDD4-2 with divalent nanobodies

  2025cites this paper
• Structural ubiquitin contributes to K48 linkage specificity of the HECT ligase Tom1.

  2025cites this paper
• Dysregulation of neuronal activity-dependent immediate early genes in a mouse model of Angelman syndrome

  2025cites this paper
• Structural Insights into the Trimeric Assembly of the HERC5 HECT Domain through SAXS Analysis

  2025cites this paper
• Challenges and opportunities for the diverse substrates of SPOP E3 ubiquitin ligase in cancer

  2025cites this paper
• Structure of E6AP in complex with HPV16-E6 and p53 reveals a novel ordered domain important for E3 ligase activation.

  2025cites this paper
• Undiagnosed rare disease clinic identifies a novel UBE3A variant in two sisters with Angelman syndrome: The end of a diagnostic odyssey

  2024cites this paper
• E3 ubiquitin ligase WWP2 as a promising therapeutic target for diverse human diseases.

  2024cites this paper
• Cobalamins Function as Allosteric Activators of an Angelman Syndrome‐Associated UBE3A/E6AP Variant

  2024cites this paper
• Ion channel inhibition by targeted recruitment of NEDD4–2 with divalent nanobodies

  2024cites this paper
• Ubiquitin Ligase Parkin Regulates the Stability of SARS-CoV-2 Main Protease and Suppresses Viral Replication

  2024cites this paper
• The E3 ligase SMURF1 stabilizes p27 via UbcH7 catalyzed K29-linked ubiquitin chains to promote cell migration SMURF1-UbcH7 K29 ubiquitination of p27 and cell migration

  2024cites this paper
• The glue degraders

  2024cites this paper
• The disordered negatively charged C‐terminus of the large HECT E3 ubiquitin ligase HERC2 provides structural and thermal stability to the HECT C‐lobe

  2024cites this paper
• Engineering the orthogonal ubiquitin E1-E2 pairs for identification of K27 chain linkage substrates.

  2024cites this paper
• Differences in structure, dynamics, and zinc coordination between isoforms of human ubiquitin ligase UBE3A

  2024cites this paper
• Protein semisynthesis reveals plasticity in HECT E3 ubiquitin ligase mechanisms

  2024cites this paper
• Structure of the p53 degradation complex from HPV16

  2024cites this paper
• Multiscale spatio-temporal dynamics of UBE3A gene in brain physiology and neurodevelopmental disorders.

  2024cites this paper
• The E3 ligase HUWE1 interacts with ubiquitin non‐covalently via key residues in the HECT domain

  2024cites this paper
• Structural mechanisms of autoinhibition and substrate recognition by the ubiquitin ligase HACE1

  2024cites this paper
• The membrane-associated ubiquitin ligase MARCHF8 stabilizes the human papillomavirus oncoprotein E7 by degrading CUL1 and UBE2L3 in head and neck cancer

  2024cites this paper
• Tracking of Ubiquitin Signaling through 3.5 Billion Years of Combinatorial Conjugation

  2024cites this paper
• Ubiquitination Insight from Spinal Muscular Atrophy—From Pathogenesis to Therapy: A Muscle Perspective

  2024cites this paper
• NEDD4L intramolecular interactions regulate its auto and substrate NaV1.5 ubiquitination

  2024cites this paper
• Effects of UBE3A on Cell and Liver Metabolism through the Ubiquitination of PDHA1 and ACAT1

  2023cites this paper
• The E3 ubiquitin ligase RNF216 contains a linear ubiquitin chain-determining-like domain that functions to regulate dendritic arborization and dendritic spine type in hippocampal neurons

  2023cites this paper
• The role of NEDD4 related HECT-type E3 ubiquitin ligases in defective autophagy in cancer cells: molecular mechanisms and therapeutic perspectives

  2023cites this paper
• Genome-wide characterization of ubiquitin-conjugating enzyme gene family explores its genetic effects on the oil content and yield of Brassica napus

  2023cites this paper
• The membrane-associated ubiquitin ligase MARCHF8 stabilizes the human papillomavirus oncoprotein E7 by degrading CUL1 and UBE2L3 in head and neck cancer

  2023cites this paper
• E3 ubiquitin ligases in lung cancer: Emerging insights and therapeutic opportunities.

  2023cites this paper
• Ubiquitination in plant biotic and abiotic stress

  2023cites this paper
• Bacterial ligases reveal fundamental principles of polyubiquitin specificity.

  2023cites this paper
• NEDD4 activates mitophagy by interacting with LC3 to restrain reactive oxygen species and apoptosis in Apostichopus japonicus challenged with Vibrio splendidus.

  2023cites this paper
• Cryo‐EM structure of the chain‐elongating E3 ubiquitin ligase UBR5

  2023cites this paper
• Structural insights into viral hijacking of p53 by E6 and E6AP

  2023influential citation
• Structural Dynamics of E6AP E3 Ligase HECT Domain and Involvement of a Flexible Hinge Loop in the Ubiquitin Chain Synthesis Mechanism

  2023cites this paper
• Genome-wide identification and transcriptome-based expression profiling of E2 gene family: Implication for potential roles in gonad development of Crassostrea gigas.

  2023cites this paper
• Structural Basis for the Enzymatic Activity of the HACE1 HECT‐Type E3 Ligase Through N‐Terminal Helix Dimerization

  2023cites this paper
• PHYSIOLOGICAL FUNCTIONS OF THE UBIQUITIN LIGASES NEDD4-1 AND NEDD4-2.

  2023cites this paper
• E3 ubiquitin ligase on the biological properties of hematopoietic stem cell

  2023cites this paper
• Bacterial mimicry of eukaryotic HECT ubiquitin ligation

  2023cites this paper
• The ubiquitin-like modifier FAT10 covalently modifies HUWE1 and strengthens the interaction of AMBRA1 and HUWE1

  2023cites this paper
• Investigation of the Binding Interaction of Mfsd2a with NEDD4-2 via Molecular Dynamics Simulations.

  2023cites this paper
• Regulation of Par-4 by Ubiquitinases

  2022cites this paper
• E2-E3 ubiquitin enzyme pairing - partnership in provoking or mitigating cancers.

  2022cites this paper
• Modulation of Ubiquitin Signaling in Innate Immune Response by Herpesviruses

  2022cites this paper
• Display Selection of a Hybrid Foldamer-Peptide Macrocycle.

  2022cites this paper
• Inhibition of the Ubiquitin Transfer Cascade by a Peptidomimetic Foldamer Mimicking the E2 N-Terminal Helix.

  2022cites this paper
• E3 ubiquitin ligases in the acute leukemic signaling pathways

  2022cites this paper
• Redefining the catalytic HECT domain boundaries for the HECT E3 ubiquitin ligase family

  2022cites this paper
• Chemical tools for E3 ubiquitin ligase study

  2022cites this paper
• Quantification and Neutralization of the Interfacial Electrostatic Potential and Visualization of the Dispersion Interaction in Visualization of the Interfacial Electrostatic Complementarity.

  2022cites this paper
• The NEL Family of Bacterial E3 Ubiquitin Ligases

  2022cites this paper
• Acetylation, Phosphorylation, Ubiquitination (Oh My!): Following Post-Translational Modifications on the Ubiquitin Road

  2022cites this paper
• Studying Disease-Associated UBE3A Missense Variants Using Enhanced Sampling Molecular Simulations

  2022cites this paper
• Activation of E6AP/UBE3A-Mediated Protein Ubiquitination and Degradation Pathways by a Cyclic γ-AA Peptide.

  2022cites this paper
• Mechanism and Disease Association With a Ubiquitin Conjugating E2 Enzyme: UBE2L3

  2022influential citation
• Exceptionally versatile take II: post-translational modifications of lysine and their impact on bacterial physiology

  2022cites this paper
• Selective Inhibition of Cysteine-Dependent Enzymes by Bioorthogonal Tethering.

  2022cites this paper
• Structural dynamics of E6AP E3 ligase HECT domain and involvement of flexible hinge loop in ubiquitin chain synthesis mechanism

  2022influential citation
• Insights in Post-Translational Modifications: Ubiquitin and SUMO

  2022cites this paper
• Death of a Protein: The Role of E3 Ubiquitin Ligases in Circadian Rhythms of Mice and Flies

  2022cites this paper
• Adaptors as the regulators of HECT ubiquitin ligases

  2021cites this paper
• Huntingtin Ubiquitination Mechanisms and Novel Possible Therapies to Decrease the Toxic Effects of Mutated Huntingtin

  2021cites this paper
• Identification of disease-linked hyperactivating mutations in UBE3A through large-scale functional variant analysis

  2021cites this paper
• Structural Diversity of Ubiquitin E3 Ligase

  2021cites this paper
• Loss of nuclear UBE3A activity is the predominant cause of Angelman syndrome in individuals carrying UBE3A missense mutations

  2021cites this paper
• Ubiquitination Enzymes

  2021cites this paper
• Functional Significance of the E3 Ubiquitin Ligases in Disease and Therapeutics

  2021cites this paper
• Identification of a peptide that disrupts hADA3-E6 interaction with implications in HPV induced cancer therapy.

  2021cites this paper
• Split chloramphenicol acetyl-transferase assay reveals self-ubiquitylation-dependent regulation of UBE3B.

  2021cites this paper
• Proteasome-associated ubiquitin ligase relays target plant hormone-specific transcriptional activators

  2021cites this paper
• Reconstitution and Structural Analysis of a HECT Ligase-Ubiquitin Complex via an Activity-Based Probe

  2021cites this paper
• The ubiquitin ligation machinery in the defense against bacterial pathogens

  2021cites this paper
• Emerging Gene and Small Molecule Therapies for the Neurodevelopmental Disorder Angelman Syndrome

  2021cites this paper
• Proteasomal Degradation of Zn-Dependent Hdacs: The E3-Ligases Implicated and the Designed Protacs That Enable Degradation

  2021cites this paper
• E3 ubiquitin ligase RNF213 employs a non-canonical zinc finger active site and is allosterically regulated by ATP

  2021cites this paper
• The fellowship of the RING: BRCA1, its partner BARD1 and their liaison in DNA repair and cancer.

  2021cites this paper
• HERC5 and the ISGylation Pathway: Critical Modulators of the Antiviral Immune Response

  2021cites this paper
• Regulation of the endocytosis and prion-chaperoning machineries by yeast E3 ubiquitin ligase Rsp5 as revealed by orthogonal ubiquitin transfer.

  2021cites this paper
• Inhibition of HECT E3 ligases as potential therapy for COVID-19

  2021cites this paper
• Exploring the "other" subfamily of HECT E3-ligases for therapeutic intervention.

  2021cites this paper
• Regulation of p53 by E3s

  2021cites this paper
• Exploring the Roles of HERC2 and the NEDD4L HECT E3 Ubiquitin Ligase Subfamily in p53 Signaling and the DNA Damage Response

  2021cites this paper
• Predicting PY motif-mediated protein-protein interactions in the Nedd4 family of ubiquitin ligases

  2021cites this paper
• The structure and regulation of the E3 ubiquitin ligase HUWE1 and its biological functions in cancer

  2020cites this paper
• Crystal structure of the catalytic C‐lobe of the HECT‐type ubiquitin ligase E6AP

  2020cites this paper
• Rapid Evolution of HERC6 and Duplication of a Chimeric HERC5/6 Gene in Rodents and Bats Suggest an Overlooked Role of HERCs in Mammalian Immunity

  2020cites this paper
• Regulation of E3 ubiquitin ligases by homotypic and heterotypic assembly

  2020cites this paper