Rates of change in quantitative traits from fixation of new mutations.

No abstract is available for this paper.

• Publication year

  1982

• Venue

  Proceedings of the National Academy of Sciences of the United States of America

• Publication date

  Unknown publication date

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1073/PNAS.79.1.142PMID 6948296PMCID PMC345678
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Selection experiments in laboratory and domestic animals.

  1981cited by this paper
• Evolution and variation of multigene families

  1980cited by this paper
• Genetic changes with generations of artificial selection.

  1980cited by this paper
• Model of effectively neutral mutations in which selective constraint is incorporated.

  1979cited by this paper
• Unequal crossing over at the rRNA locus as a source of quantitative genetic variation

  1978cited by this paper
• The maintenance of genetic variability by mutation in a polygenic character with linked loci.

  1975cited by this paper
• Mutation rate and dominance of genes affecting viability in Drosophila melanogaster.

  1972cited by this paper
• Selection in finite populations with multiple alleles. II. Centripetal selection, mutation, and isoallelic variation.

  1970cited by this paper
• Evolutionary Rate at the Molecular Level

  1968cited by this paper

• Nucleotide diversity is a poor predictor of short-term adaptive potential

  2026cites this paper
• Quantitative-genetic analysis of directional adaptation suggests low maximum sustainable rates of change in agreement with data from field populations

  2025cites this paper
• Evolution of developmental bias explains divergent patterns of phenotypic evolution in two nematode clades.

  2025cites this paper
• Tissue-specific differences of gene expression variance in mutation accumulation lines of mice

  2025cites this paper
• Genetics and Analysis of Quantitative Traits

  2025cites this paper
• An estimate of fitness reduction from mutation accumulation in a mammal allows assessment of the consequences of relaxed selection

  2024cites this paper
• William George Hill. 7 August 1940—17 December 2021

  2023cites this paper
• Low interspecific variation and no phylogenetic signal in additive genetic variance in wild bird and mammal populations

  2023cites this paper
• A theory of oligogenic adaptation of a quantitative trait

  2023cites this paper
• Polygenic dynamics underlying the response of quantitative traits to directional selection

  2023cites this paper
• The long-term effects of genomic selection: 2. Changes in allele frequencies of causal loci and new mutations

  2023cites this paper
• Pervasive GxE interactions shape adaptive trajectories and the exploration of the phenotypic space in artificial selection experiments

  2023cites this paper
• Phenotypic stasis with genetic divergence

  2023cites this paper
• From Mendel to quantitative genetics in the genome era: the scientific legacy of W. G. Hill

  2022cites this paper
• Can extreme climatic events induce shifts in adaptive potential? A conceptual framework and empirical test with Anolis lizards

  2022cites this paper
• Standing Genetic Diversity and Transmission Bottleneck Size Drive Adaptation in Bacteriophage Qβ

  2022cites this paper
• Variational Approaches to Evolvability: Short- and Long-Term Perspectives

  2021cites this paper
• Animal Breeding Methods and Sustainability

  2021cites this paper
• Allen Orr and the genetics of adaptation

  2021cites this paper
• Interplay between extreme drift and selection intensities favors the fixation of beneficial mutations in selfing maize populations

  2020cites this paper
• Fly wing evolution explained by a neutral model with mutational pleiotropy

  2020cites this paper
• Thinking About the Evolution of Complex Traits in the Era of Genome-Wide Association Studies.

  2019cites this paper
• Why So Variable: Can Genetic Variance in Flowering Thresholds Be Maintained by Fluctuating Selection?

  2019cites this paper
• Selection and drift determine phenotypic stasis despite genetic divergence

  2019cites this paper
• The Impact of Genomic and Traditional Selection on the Contribution of Mutational Variance to Long-Term Selection Response and Genetic Variance

  2019influential citation
• Inferring the distribution of fitness effects of spontaneous mutations in Chlamydomonas reinhardtii

  2019cites this paper
• Direct inference of the distribution of fitness effects of spontaneous mutations in Chlamydomonas reinhardtii

  2019cites this paper
• Costs and benefits of admixture between foreign genotypes and local populations in the field

  2018influential citation
• Host-pathogen coevolution increases genetic variation in susceptibility to infection

  2018cites this paper
• Long-term Response: 2. Finite Population Size and Mutation

  2018influential citation
• Slower environmental change hinders adaptation from standing genetic variation

  2017cites this paper
• Experimental Evolution with Caenorhabditis Nematodes

  2017cites this paper
• Polygenicity and Epistasis Underlie Fitness-Proximal Traits in the Caenorhabditis elegans Multiparental Experimental Evolution (CeMEE) Panel

  2017cites this paper
• Mutation predicts 40 million years of fly wing evolution

  2017cites this paper
• The infinitesimal model: Definition, derivation, and implications.

  2017cites this paper
• Haplotypes Phased from Population Transcriptomes Detecting Selection in the Initial Adaptation of Miscanthus lutarioriparius to Stressful Environments

  2017cites this paper
• How does epistasis influence the response to selection?

  2016cites this paper
• The infinitesimal model

  2016cites this paper
• Joint Prediction of the Effective Population Size and the Rate of Fixation of Deleterious Mutations

  2016cites this paper
• Evidence of concurrent local adaptation and high phenotypic plasticity in a polar microeukaryote.

  2015cites this paper
• Levels and limits in artificial selection of communities.

  2015cites this paper
• Plant-Herbivore Interaction in a Fragmented Landscape: Local Adaptation and Inbreeding

  2015cites this paper
• Dearth of polymorphism associated with a sustained response to selection for flowering time in maize

  2015cites this paper
• Evolutionary inevitability of sexual antagonism

  2014cites this paper
• FISHER'S GEOMETRIC MODEL WITH A MOVING OPTIMUM

  2014cites this paper
• Bayesian analysis of additive epistasis arising from new mutations in mice.

  2014cites this paper
• The relation between the genetic architecture of quantitative traits and long-term genetic response

  2014cites this paper
• Modeling Evolution Using the Probability of Fixation: History and Implications

  2014cites this paper
• High genetic diversity is not essential for successful introduction

  2013cites this paper
• THE OPPORTUNITY FOR BALANCING SELECTION IN EXPERIMENTAL POPULATIONS OF CAENORHABDITIS ELEGANS

  2013cites this paper
• Fitness effects of new mutations and adaptive evolution in house mice

  2013cites this paper
• Formal properties of the probability of fixation: identities, inequalities and approximations.

  2013cites this paper
• Animal Breeding Methods and Sustainability animal breeding sustainability

  2013cites this paper
• 3 Natural Selection and Phenotypic Plasticity in Wildlife Adaptation to Climate Change

  2013cites this paper
• Fisher ’ s geometric model in species with separate sexes

  2013cites this paper
• Experimental evolution.

  2012cites this paper
• Plant‐herbivore coevolution in a changing world

  2012cites this paper
• Experimental evolution Tadeusz

  2012cites this paper
• PLOIDALLY ANTAGONISTIC SELECTION MAINTAINS STABLE GENETIC POLYMORPHISM

  2012cites this paper
• Limits to the Rate of Adaptive Substitution in Sexual Populations

  2012cites this paper
• Dissecting genetic interactions in complex traits

  2012influential citation
• The Quantitative Genetic Theory of Parental Effects

  2012cites this paper
• Variation and constraints of local adaptation of a long‐lived plant, its pollinators and specialist herbivores

  2012cites this paper
• Evolution of adaptive phenotypic variation patterns by direct selection for evolvability

  2011cites this paper
• Repeatability of female preferences in a unisexual–bisexual mating system

  2011cites this paper
• BGI Cognitive Genomics Lab: Proposal for Gene-Trait Association Study of g

  2011cites this paper
• Inbred mouse strains and genetic stability: a review.

  2011cites this paper
• A modelling framework for the analysis of artificial-selection time series.

  2011cites this paper
• Adaptation of Drosophila melanogaster to increased NaCl concentration due to dominant beneficial mutations

  2011cites this paper
• Mutations and quantitative genetic variation: lessons from Drosophila

  2010cites this paper
• Change and maintenance of variation in quantitative traits in the context of the Price equation.

  2010cites this paper
• Population Size and Long‐Term Selection

  2010cites this paper
• Population ‐ and Quantitative‐Genetic Models of Selection Limits

  2010cites this paper
• Habitat fragmentation, climate change, and inbreeding in plants

  2010cites this paper
• Mutational Variation and Long‐Term Selection Response

  2010cites this paper
• Accounting for additive genetic mutations on litter size in Ripollesa sheep.

  2010cites this paper
• The Origin of Conserved Protein Domains and Amino Acid Repeats Via Adaptive Competition for Control Over Amino Acid Residues

  2009cites this paper
• Species' Range: Adaptation in Space and Time

  2009cites this paper
• Emergence of Ultra-Conserved Protein Domains and Amino Acid Repeats: Adaptation, Competition and Thresholds

  2009cites this paper
• Maintaining Genetic Variation in Fitness

  2009cites this paper
• Analysis and implications of mutational variation

  2009influential citation
• Mutational processes in Dictyostelium discoideum: How mutations affect social behaviors and fitness

  2009influential citation
• Adaptation and Fitness in Animal Populations: Evolutionary and Breeding Perspectives on Genetic Resource Management

  2009cites this paper
• A Meta-Analysis of Local Adaptation in Plants

  2008cites this paper
• THE POPULATION GENETICS OF SELECTION AND DRIFT Drift and Selection at a Single Locus

  2008influential citation
• Adaptation from standing genetic variation.

  2008cites this paper
• Within-Generation Mutation Variance for Litter Size in Inbred Mice

  2008influential citation
• Mutation‐Selection Balance for Environmental Variance

  2008cites this paper
• Author ' s personal copy Adaptation from standing genetic variation

  2008cites this paper
• The stochastic model of non-equilibrium mutagen-induced alterations of DNA: Implication to genetic instability in cancer

  2007cites this paper
• Genetic variation in natural populations : linkage mapping of fitness related traits in Soay sheep

  2006cites this paper
• Mutationism and the dual causation of evolutionary change

  2006cites this paper
• Constrained evolution of a quantitative character by pleiotropic mutation.

  2005cites this paper
• Adaptive walks on behavioural landscapes and the evolution of optimal behaviour by natural selection

  2005cites this paper
• Predictions of Patterns of Response to Artificial Selection in Lines Derived From Natural Populations

  2005cites this paper
• The limitations of adaptive dynamics as a model of evolution

  2005cites this paper
• Influence of Dominance, Leptokurtosis and Pleiotropy of Deleterious Mutations on Quantitative Genetic Variation at Mutation-Selection Balance

  2004cites this paper
• Direct and correlated responses to selection for weaning weight, post-weaning weight gain and six-week weight in mice

  2004cites this paper
• Effects on phenotypic variability of directional selection arising through genetic differences in residual variability.

  2004cites this paper
• From plant genomics to breeding practice.

  2003cites this paper