Effect of tumor microenvironment on pathogenesis of the head and neck squamous cell carcinoma: a systematic review

The tumor microenvironment (TME) is comprised of many different cell populations, such as cancer-associated fibroblasts and various infiltrating immune cells, and non-cell components of extracellular matrix. These crucial parts of the surrounding stroma can function as both positive and negative regulators of all hallmarks of cancer development, including evasion of apoptosis, induction of angiogenesis, deregulation of the energy metabolism, resistance to the immune detection and destruction, and activation of invasion and metastasis. This review represents a summary of recent studies focusing on describing these effects of microenvironment on initiation and progression of the head and neck squamous cell carcinoma, focusing on oral squamous cell carcinoma, since it is becoming clear that an investigation of differences in stromal composition of the head and neck squamous cell carcinoma microenvironment and their impact on cancer development and progression may help better understand the mechanisms behind different responses to therapy and help define possible targets for clinical intervention.

• Publication year

  2019

• Venue

  Molecular Cancer

• Publication date

  2019-03-30

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1186/s12943-019-0983-5PMID 30927923PMCID 6441173
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• TGF-β1/TβRII/Smad3 signaling pathway promotes VEGF expression in oral squamous cell carcinoma tumor-associated macrophages.

  2018cited by this paper
• TRKB tyrosine kinase receptor is a potential therapeutic target for poorly differentiated oral squamous cell carcinoma

  2018cited by this paper
• High infiltration of CD68+ macrophages is associated with poor prognoses of head and neck squamous cell carcinoma patients and is influenced by human papillomavirus

  2018cited by this paper
• Vimentin and Non-Muscle Myosin IIA are Members of the Neural Precursor Cell Expressed Developmentally Down-Regulated 9 (NEDD9) Interactome in Head and Neck Squamous Cell Carcinoma Cells

  2018cited by this paper
• Cancer-Associated Fibroblasts Drive Glycolysis in a Targetable Signaling Loop Implicated in Head and Neck Squamous Cell Carcinoma Progression.

  2018cited by this paper
• Paracrine and epigenetic control of CAF-induced metastasis: the role of HOTAIR stimulated by TGF-ß1 secretion

  2018cited by this paper
• NEDD9 stimulated MMP9 secretion is required for invadopodia formation in oral squamous cell carcinoma

  2018cited by this paper
• Cancer-associated fibroblasts induce epithelial-mesenchymal transition through secreted cytokines in endometrial cancer cells

  2018cited by this paper
• Factors Secreted by Cancer-Associated Fibroblasts that Sustain Cancer Stem Properties in Head and Neck Squamous Carcinoma Cells as Potential Therapeutic Targets

  2018cited by this paper
• Caspase-1 from Human Myeloid-Derived Suppressor Cells Can Promote T Cell–Independent Tumor Proliferation

  2018cited by this paper
• Overexpression of TRIM24 Stimulates Proliferation and Glucose Metabolism of Head and Neck Squamous Cell Carcinoma

  2018cited by this paper
• Tumor associated macrophages induce epithelial to mesenchymal transition via the EGFR/ERK1/2 pathway in head and neck squamous cell carcinoma

  2018cited by this paper
• CD8+ and CD163+ infiltrating cells and PD‐L1 immunoexpression in oral leukoplakia and oral carcinoma

  2018cited by this paper
• Histomorphometric Analysis of Angiogenesis using CD31 Immunomarker and Mast Cell Density in Oral Premalignant and Malignant Lesions: A Pilot Study.

  2017cited by this paper
• Continuing rise in oropharyngeal cancer in a high HPV prevalence area: A Danish population-based study from 2011 to 2014.

  2017cited by this paper
• CD163+CD204+ tumor-associated macrophages contribute to T cell regulation via interleukin-10 and PD-L1 production in oral squamous cell carcinoma

  2017cited by this paper
• CXCL1 Is Critical for Premetastatic Niche Formation and Metastasis in Colorectal Cancer.

  2017cited by this paper
• Natural Killer cells from primary human head and neck squamous cell carcinomas upregulate NKG2A

  2017cited by this paper
• Selective blockade of B7‐H3 enhances antitumour immune activity by reducing immature myeloid cells in head and neck squamous cell carcinoma

  2017cited by this paper
• Forkhead box-P3+ regulatory T cells and toll-like receptor 2 co-expression in oral squamous cell carcinoma.

  2017cited by this paper
• Prometastatic mechanisms of CAF-mediated EMT regulation in pancreatic cancer cells.

  2017cited by this paper
• CXCR2+ MDSCs promote breast cancer progression by inducing EMT and activated T cell exhaustion

  2017cited by this paper
• Cancer-associated fibroblasts induce metalloprotease-independent cancer cell invasion of the basement membrane

  2017cited by this paper
• Immunohistochemical Analysis of Foxp3+, CD4+, CD8+ Cell Infiltrates and PD-L1 in Oral Squamous Cell Carcinoma

  2017cited by this paper
• Monocytic and granulocytic myeloid derived suppressor cells differentially regulate spatiotemporal tumour plasticity during metastatic cascade

  2017cited by this paper
• Impact of human monocyte and macrophage polarization on NLR expression and NLRP3 inflammasome activation

  2017cited by this paper
• Cancer-associated fibroblasts promote directional cancer cell migration by aligning fibronectin

  2017cited by this paper
• TGFβ1 in fibroblasts-derived exosomes promotes epithelial-mesenchymal transition of ovarian cancer cells

  2017cited by this paper
• Glucose transporter 4 promotes head and neck squamous cell carcinoma metastasis through the TRIM24-DDX58 axis

  2017cited by this paper
• Mast cells and angiogenesis in malignant and premalignant oral lesions: An immunohistochemical study

  2017cited by this paper
• Oral squamous cell carcinoma suppressed antitumor immunity through induction of PD-L1 expression on tumor-associated macrophages.

  2017cited by this paper
• Hypoxia promotes migration/invasion and glycolysis in head and neck squamous cell carcinoma via an HIF-1α-MTDH loop.

  2017cited by this paper
• Pre-metastatic niches: organ-specific homes for metastases

  2017cited by this paper
• Blockage of glycolysis by targeting PFKFB3 suppresses tumor growth and metastasis in head and neck squamous cell carcinoma

  2017cited by this paper
• Prognostic significance of tumor infiltrating immune cells in oral squamous cell carcinoma

  2017cited by this paper
• Brain derived neutrophic factor (BDNF) coordinates lympho-vascular metastasis through a fibroblast-governed paracrine axis in the tumor microenvironment

  2017cited by this paper
• CD45RA−Foxp3high regulatory T cells have a negative impact on the clinical outcome of head and neck squamous cell carcinoma

  2017cited by this paper
• Distinct patterns of infiltrating CD8+ T cells in HPV+ and CD68 macrophages in HPV- oropharyngeal squamous cell carcinomas are associated with better clinical outcome but PD-L1 expression is not prognostic

  2017cited by this paper
• Prognostic markers in oropharyngeal squamous cell carcinoma: focus on CD70 and tumour infiltrating lymphocytes.

  2017cited by this paper
• β3 integrin expression is required for invadopodia-mediated ECM degradation in lung carcinoma cells

  2017cited by this paper
• Recruited monocytic myeloid‐derived suppressor cells promote the arrest of tumor cells in the premetastatic niche through an IL‐1β‐mediated increase in E‐selectin expression

  2017cited by this paper
• Loss of GDF10/BMP3b as a prognostic marker collaborates with TGFBR3 to enhance chemotherapy resistance and epithelial‐mesenchymal transition in oral squamous cell carcinoma

  2016cited by this paper
• Secretome profiling of oral squamous cell carcinoma-associated fibroblasts reveals organization and disassembly of extracellular matrix and collagen metabolic process signatures

  2016cited by this paper
• Type I IFNs induce anti‐tumor polarization of tumor associated neutrophils in mice and human

  2016cited by this paper
• Involvement of calprotectin (S100A8/A9) in molecular pathways associated with HNSCC

  2016cited by this paper
• Foxp3 overexpression in tumor cells predicts poor survival in oral squamous cell carcinoma

  2016cited by this paper
• Tumor infiltrating lymphocytes and survival in patients with head and neck squamous cell carcinoma

  2016cited by this paper
• Human Head and Neck Squamous Cell Carcinoma–Associated Semaphorin 4D Induces Expansion of Myeloid-Derived Suppressor Cells

  2016cited by this paper
• Prognostic impact of immune microenvironment in laryngeal and pharyngeal squamous cell carcinoma: Immune cell subtypes, immuno-suppressive pathways and clinicopathologic characteristics

  2016cited by this paper
• PHAGOCYTES, GRANULOCYTES, AND MYELOPOIESIS Aged neutrophils contribute to the fi rst line of defense in the acute in fl ammatory response

  2016cited by this paper
• [Corrigendum] Transient transfection of macrophage migration inhibitory factor small interfering RNA disrupts the biological behavior of oral squamous carcinoma cells.

  2016cited by this paper
• Adaptive Characteristics of Innate Immune Responses in Macrophages

  2016cited by this paper
• EGF induces epithelial-mesenchymal transition and cancer stem-like cell properties in human oral cancer cells via promoting Warburg effect

  2016cited by this paper
• Twist1-induced activation of human fibroblasts promotes matrix stiffness by upregulating palladin and collagen α1(VI)

  2016cited by this paper
• Activated tumor cell integrin αvβ3 cooperates with platelets to promote extravasation and metastasis from the blood stream.

  2016cited by this paper
• CD56‐positive lymphocyte infiltration in relation to human papillomavirus association and prognostic significance in oropharyngeal squamous cell carcinoma

  2016cited by this paper
• A specific, transmembrane interface regulates fibroblast activation protein (FAP) homodimerization, trafficking and exopeptidase activity.

  2016cited by this paper
• Identification of neutrophil surface marker changes in health and inflammation using high-throughput screening flow cytometry.

  2016cited by this paper
• Prognostic significance of monocarboxylate transporter expression in oral cavity tumors

  2016cited by this paper
• Evaluation of natural killer cell (CD57) as a prognostic marker in oral squamous cell carcinoma: An immunohistochemistry study

  2016cited by this paper
• Extracellular matrix in oral squamous cell carcinoma: Friend or foe?

  2016cited by this paper
• Correction: Insulin-like growth factor-independent insulin-like growth factor binding protein 3 promotes cell migration and lymph node metastasis of oral squamous cell carcinoma cells by requirement of integrin β1

  2016cited by this paper
• CCL2/EGF positive feedback loop between cancer cells and macrophages promotes cell migration and invasion in head and neck squamous cell carcinoma

  2016cited by this paper
• Tumor-associated macrophages correlate with the clinicopathological features and poor outcomes via inducing epithelial to mesenchymal transition in oral squamous cell carcinoma

  2016cited by this paper
• The role of Tks adaptor proteins in invadopodia formation, growth and metastasis of melanoma

  2016cited by this paper
• Immunohistochemical analysis of angiogenesis by CD34 and mast cells by toluidine blue in different grades of oral squamous cell carcinoma

  2016cited by this paper
• Cancer-Associated Fibroblasts Regulate Tumor-Initiating Cell Plasticity in Hepatocellular Carcinoma through c-Met/FRA1/HEY1 Signaling.

  2016influential reference
• Prognostic significance of macrophage polarization in early stage oral squamous cell carcinomas.

  2016cited by this paper
• Neutrophils Suppress Intraluminal NK Cell-Mediated Tumor Cell Clearance and Enhance Extravasation of Disseminated Carcinoma Cells.

  2016cited by this paper
• NK Cell-Mediated Antibody-Dependent Cellular Cytotoxicity in Cancer Immunotherapy

  2015cited by this paper
• Tumor-associated macrophages in oral premalignant lesions coexpress CD163 and STAT1 in a Th1-dominated microenvironment

  2015cited by this paper
• IL-10 enhances the phenotype of M2 macrophages induced by IL-4 and confers the ability to increase eosinophil migration.

  2015cited by this paper
• Insulin-like growth factor-independent insulin-like growth factor binding protein 3 promotes cell migration and lymph node metastasis of oral squamous cell carcinoma cells by requirement of integrin β1

  2015cited by this paper
• Integrin α3β1 Binding to Fibronectin Is Dependent on the Ninth Type III Repeat*

  2015cited by this paper
• Temporal phenotypic features distinguish polarized macrophages in vitro

  2015cited by this paper
• Myeloid-derived suppressor cells inhibit T cell proliferation in human extranodal NK/T cell lymphoma: a novel prognostic indicator

  2015cited by this paper
• Phenotypic Complexity of the Human Regulatory T Cell Compartment Revealed by Mass Cytometry

  2015cited by this paper
• The role of multipotent cancer associated fibroblasts in hepatocarcinogenesis

  2015cited by this paper
• Expression of cancer-associated fibroblast related proteins in metastatic breast cancer: an immunohistochemical analysis

  2015cited by this paper
• Evaluation of stromal myofibroblasts in oral leukoplakia, oral submucous fibrosis, and oral squamous cell carcinoma--an immunohistochemical study.

  2015cited by this paper
• Transient transfection of macrophage migration inhibitory factor small interfering RNA disrupts the biological behavior of oral squamous carcinoma cells

  2015cited by this paper
• Microlocalization of CD68+ tumor-associated macrophages in tumor stroma correlated with poor clinical outcomes in oral squamous cell carcinoma patients

  2015cited by this paper
• Quality of life of patients with head and neck cancer

  2015cited by this paper
• Secretion of S100A8, S100A9, and S100A12 by Neutrophils Involves Reactive Oxygen Species and Potassium Efflux

  2015cited by this paper
• Immunosuppressive activity of cancer-associated fibroblasts in head and neck squamous cell carcinoma

  2015cited by this paper
• Immunoexpression of tenascin as a predictor of the malignancy potential of oral leukoplakia associated with a tobacco habit

  2015cited by this paper
• TGFβ1 secreted by cancer-associated fibroblasts induces epithelial-mesenchymal transition of bladder cancer cells through lncRNA-ZEB2NAT

  2015cited by this paper
• Biomimetic LBL structured nanofibrous matrices assembled by chitosan/collagen for promoting wound healing.

  2015cited by this paper
• Cd34 and Mast Cell Analysis in Normal Oral Mucosa and Different Grades of Oral Squamous Cell Carcinoma: A Comparative Study.

  2015cited by this paper
• The Regulatory Role of Invariant NKT Cells in Tumor Immunity

  2015cited by this paper
• Larynx carcinoma regulates tumor-associated macrophages through PLGF signaling

  2015cited by this paper
• Macrophages Modulate Migration and Invasion of Human Tongue Squamous Cell Carcinoma

  2015cited by this paper
• Quantification of Extracellular Matrix Proteins from a Rat Lung Scaffold to Provide a Molecular Readout for Tissue Engineering*

  2015cited by this paper
• The master switch: Comparative study of mast cell in oral epithelial dysplasia, oral submucous fibrosis and oral squamous cells carcinoma and their association with inflammation and angiogenesis

  2015cited by this paper
• Fibroblast Growth Factor (FGF-2) and Its Receptors FGFR-2 and FGFR-3 May Be Putative Biomarkers of Malignant Transformation of Potentially Malignant Oral Lesions into Oral Squamous Cell Carcinoma

  2015cited by this paper
• Expression of Cationic Amino Acid Transporter 2 Is Required for Myeloid-Derived Suppressor Cell–Mediated Control of T Cell Immunity

  2015cited by this paper
• Human breast cancer invasion and aggression correlates with ECM stiffening and immune cell infiltration.

  2015cited by this paper
• TNF Counterbalances the Emergence of M2 Tumor Macrophages.

  2015cited by this paper
• Tissue mechanics modulate microRNA-dependent PTEN expression to regulate malignant progression

  2014cited by this paper
• Neutrophils Increase Oral Squamous Cell Carcinoma Invasion through an Invadopodia-Dependent Pathway

  2014cited by this paper

• Diagnostic performance of [18F]F-FAPI-FUSCC-07 PET/CT in characterizing solitary pulmonary nodules: a head-to-head comparison.

  2026cites this paper
• Impaired PD-1 expression in tumor-infiltrating senescent CD8+ T cells is reversed by PD-L1 blockade in a murine squamous cell carcinoma model.

  2026cites this paper
• ANXA2P2 and PA2G4P4 Pseudogenes Are Associated with the Response to Ionizing Radiation and Could Be Used as Potential Biomarkers: In Silico Study

  2026cites this paper
• Characterizing the Head and Neck Cancer Microenvironment: Implications for Immunotherapy and Prognosis.

  2026cites this paper
• Tumors of the head and neck: ways to improve the results of conservative therapy. Part II. Oropharyngeal cancer

  2026cites this paper
• Bridging the Translational Gap in HNSCC Immunotherapy: From Resistance Mechanisms to High-Fidelity Preclinical Models.

  2026cites this paper
• Tissue-based biomarkers of clinical relevance at the invasive tumor front in oral squamous cell carcinoma: a scoping review protocol.

  2026cites this paper
• Ancient and Emerging Nanostructures for Innovations to Fight Head and Neck Cancer.

  2026cites this paper
• Hydrogels in head and neck cancer: Innovations and translational advances in research and therapy.

  2026cites this paper
• Application of radiomics in head and neck squamous cell carcinoma

  2026cites this paper
• Reprogramming the Tumor Microenvironment in Head and Neck Squamous Cell Carcinoma: Therapeutic Targets and Innovations

  2025cites this paper
• Metabolic modulation of the biological effects of ionizing radiation and chemotherapy (review)

  2025cites this paper
• Advances in tumor micro-environment and immunotherapy of squamous cell carcinoma of the tongue.

  2025cites this paper
• Modeling of oral squamous cell carcinoma microenvironment- A 3D bioprinting approach

  2025cites this paper
• Interaction of tumor cells and Cancer-associated fibroblasts in radiation-induced senescence.

  2025cites this paper
• Neutrophils as key regulators of tumor microenvironment in breast cancer: a focus on N1 and N2 polarization

  2025cites this paper
• A novel therapeutic approach targeting PD-L1 in HNSCC and bone marrow-derived mesenchymal stem cells hampers pro-metastatic features in vitro: perspectives for blocking tumor-stroma communication and signaling

  2025cites this paper
• The Prognostic Role of Tumor-Stroma Ratio in Oral Squamous Cell Carcinoma: A Systematic Review and Meta-Analysis

  2025cites this paper
• [18F]-FAPI-04 PET/CT improves metastatic lesions detection for patients with uterine malignancy after radical surgery: prospectively compared with [18F]-FDG PET/CT.

  2025cites this paper
• Tumor–Stroma Ratio in Head and Neck Squamous Cell Carcinoma: A Systematic Review and Meta‐Analysis

  2025cites this paper
• Dysregulated PI3K/AKT signaling in oral squamous cell carcinoma: The tumor microenvironment and epigenetic modifiers as key drivers

  2025cites this paper
• Generating tumor-specific T cells based on a head and neck cancer organoid for adoptive cell therapy

  2025cites this paper
• Immune Evasion in Head and Neck Squamous Cell Carcinoma: Roles of Cancer-Associated Fibroblasts, Immune Checkpoints, and TP53 Mutations in the Tumor Microenvironment

  2025cites this paper
• The Role of Monoclonal Antibodies as Therapeutics in HPV-Related Head and Neck Cancers: An Updated Review

  2025cites this paper
• Targeting the integrin beta 1‐focal adhesion kinase axis with artemisinin: Biophysical disruption of cell adhesion, migration, and invasion in tongue cancer

  2025cites this paper
• Heterogeneity of the tumor immune cell microenvironment revealed by single-cell sequencing in head and neck cancer.

  2025cites this paper
• Immunohistochemical Study of Tumour-Associated Macrophages Using CD68 and CD163 in Oral Squamous Cell Carcinoma

  2025cites this paper
• Advanced Therapeutic Approaches for Metastatic Ovarian Cancer

  2025cites this paper
• Interplay between hypoxia, RNA methylation, and HPV in head and neck squamous cell carcinomas: drivers of oncogenesis and resistance to therapy

  2025cites this paper
• Reactive Oxygen Species-Mediated Oral Cancer Cells Treatment Using Photosensitizer-Combined Carbon Dots via Apoptosis–Ferroptosis Synergistic Therapy

  2025cites this paper
• Tumor-endothelium reciprocal interactions in co-culture: changes of genetics and phenotypic characteristics of endothelial and laryngeal cells

  2025cites this paper
• Development and validation of a glycolysis-associated gene signature for predicting the prognosis, immune landscape, and drug sensitivity in bladder cancer

  2025cites this paper
• Tumor Microenvironment in Cancer Biology: A Comprehensive Review of Stromal, Immune, and Vascular Components Driving Malignancy

  2025cites this paper
• Stiffness-mediated paracrine signaling enhances induction of EMT in oral squamous cell carcinoma

  2025cites this paper
• Targeting Fibroblast-Derived Interleukin 6: A Strategy to Overcome Epithelial-Mesenchymal Transition and Radioresistance in Head and Neck Cancer

  2025cites this paper
• Understanding the Tumor Microenvironment and Therapy Resistance in Head and Neck Squamous Cell Carcinoma

  2025cites this paper
• Impact of ALDH1A1 Expression in Intrahepatic Cholangiocellular Carcinoma

  2025cites this paper
• Mechanisms and strategies of immunosenescence effects on non-small cell lung cancer (NSCLC) treatment: A comprehensive analysis and future directions.

  2025cites this paper
• A comprehensive insights of cancer immunotherapy resistance

  2025cites this paper
• The relationship between gene expression of cytoskeletal protein genes and the epithelial-mesenchymal vimentin marker in squamous cell carcinoma of the larynx

  2025cites this paper
• EGFR-mediated local invasiveness and response to Cetuximab in head and neck cancer

  2025cites this paper
• Prognostic Value of the Immunohistochemical Detection of Cellular Components of the Tumor Microenvironment in Oral Squamous Cell Carcinoma: A Systematic Review

  2025cites this paper
• Association Between HPV Circulating Tumor DNA and Prognostic Inflammatory Indices in Oropharyngeal Squamous Cell Carcinoma: A Pilot Study

  2025cites this paper
• circHIPK2 promotes malignant progression of laryngeal squamous cell carcinoma through the miR-889-3p/MCTS1/IL-6 axis

  2025cites this paper
• An energy metabolism-related signature relevant to the tumor immune microenvironment in HNSCC

  2025cites this paper
• Cucurbitacin B induces oral squamous cell carcinomapyroptosis via GSDME and inhibits tumour growth

  2025cites this paper
• Bibliometric analysis reveals the current status and future trends of cancer associated fibroblasts research in breast cancer

  2025cites this paper
• Hydrogels as advanced drug delivery platforms for cancer immunotherapy: promising innovations and future outlook

  2025cites this paper
• METTL1-driven epitranscriptomic enhancement of TXNDC12 boosts c-Myc stability through USP5 in HNSCC

  2025cites this paper
• Immune-metabolic crosstalk in HNSCC: mechanisms and therapeutic opportunities

  2025cites this paper
• Current nano drug delivery systems for targeting head and neck squamous cell carcinoma microenvironment: a narrative review

  2025cites this paper
• The role of the tumor microenvironment in HNSCC resistance and targeted therapy

  2025cites this paper
• Cancer-associated fibroblasts in hypopharyngeal squamous cell carcinoma: Clinical significance, prognostic impact, and correlation with microvessel density.

  2025cites this paper
• The regulatory role and mechanism of energy metabolism and immune response in head and neck cancer

  2025cites this paper
• Identification of 5mC regulatory factors mediating methylation patterns and prognosis models in head and neck squamous cell carcinoma

  2025cites this paper
• Monocytes and Macrophage-derived mediators influence the behavior of squamous cell carcinoma cell lines

  2025cites this paper
• Cu2+‐Coordinated NLG919: A Drug Delivery Nanoplatform to Activate Antitumor Immunity via Inducing Immunogenic Cell Death and Inhibiting Indoleamine 2,3‐Dioxygenase‐1

  2025cites this paper
• The Targeted Inhibition of Histone Lysine Demethylases as a Novel Promising Anti-Cancer Therapeutic Strategy—An Update on Recent Evidence

  2025cites this paper
• Effect of Oral Peritumoral Tissue on Infiltration and Differentiation of Tumor-Associated Macrophages in Oral Squamous Cell Carcinoma

  2025cites this paper
• Subtype-specific NK cell-TAM interactions drive a novel prognostic signature in HNSCC

  2025cites this paper
• Loss of ZC3H12A Expression Is Linked to Higher Mortality Risk and Increased Lymphatic Metastasis in Oral Squamous Cell Carcinoma

  2025cites this paper
• Profiling of immune cell subsets and functional characteristics of cervical cancer based on single cell RNA sequencing

  2025cites this paper
• Hippo Pathway Dysregulation in Head and Neck Cancer: A Molecular Key To Future Diagnostic System

  2025cites this paper
• Research on the expression, prognostic value, and regulatory effects on immune microenvironment of NETO2 in oral squamous cell carcinoma

  2025cites this paper
• Upregulated BAP31 Links to Poor Prognosis and Tumor Immune Microenvironment in Breast Cancer

  2025cites this paper
• Disulfidptosis-related gene SLC3A2: a novel prognostic biomarker in nasopharyngeal carcinoma and head and neck squamous cell carcinoma

  2025cites this paper
• The role and targeting strategies of non-coding RNAs in immunotherapy resistance in oral squamous cell carcinoma

  2025cites this paper
• Integrated bioinformatics screening and experimental validation: construction of a LUAD prediction model based on Treg-related genes

  2025cites this paper
• IS THERE A PROGNOSTIC ROLE OF FOCAL ADHESION KINASE AND CD8 IN SQUAMOUS CELL HEAD AND NECK CANCER TREATED WITH RADIOTHERAPY?

  2025cites this paper
• Migrasome-related LncRNA features predict immune microenvironment and prognosis in pancreatic cancer

  2025cites this paper
• Profilin-2 promotes tumour aggressiveness in oral squamous cell carcinoma via HDAC1 modulation: implications for EMT and targeted therapy

  2025cites this paper
• The integrin–matrix-FAK–EMT axis in Anoikis resistance: a critical network in tumor progression and therapy

  2025cites this paper
• Dual blockage of P-cadherin and c-Met synergistically inhibits the growth of head and neck cancer

  2025cites this paper
• Tumor-matched and unmatched cancer associated fibroblasts exhibit differential effect on proliferation and FMOD and MMP9 gene expression in head and neck squamous cell carcinoma cells when cocultured in spheroids

  2024cites this paper
• Altered extracellular matrix correlates with an immunosuppressive tumor microenvironment and disease progression in younger adults with oral cavity squamous cell carcinoma

  2024cites this paper
• Metabolic pathway-based subtypes associate glycan biosynthesis and treatment response in head and neck cancer

  2024influential citation
• Nature's Arsenal: Harnessing the Capacity of Phytochemicals to Enhance Immune Checkpoint Inhibitor Therapy of Cancers: An Especial Attention to Brain Malignancies.

  2024cites this paper
• P4HA2 contributes to head and neck squamous cell carcinoma progression and EMT through PI3K/AKT signaling pathway

  2024cites this paper
• Transcript and protein signatures derived from shared molecular interactions across cancers are associated with mortality

  2024cites this paper
• Heterogeneity of cancer-associated fibroblasts and tumor-promoting roles in head and neck squamous cell carcinoma

  2024influential citation
• Macrophages: plastic participants in the diagnosis and treatment of head and neck squamous cell carcinoma

  2024cites this paper
• Stepwise Stiffening/Softening of and Cell Recovery from Reversibly Formulated Hydrogel Double Networks

  2024cites this paper
• Selected miRNAs in oropharyngeal squamous cell carcinoma (OPSCC) with HPV and EBV coinfection

  2024cites this paper
• Identification of an immune-related signature as a prognostic classifier for patients with early-stage head and neck squamous cell carcinoma

  2024cites this paper
• Analysis of the effect of CCR7 on the microenvironment of mouse oral squamous cell carcinoma by single-cell RNA sequencing technology

  2024cites this paper
• High PD-L1 expression on immune cells along with increased density of tumor-infiltrating lymphocytes predicts a favorable survival outcome for patients with loco-regionally advanced head and neck cancer: early results from a prospective study

  2024cites this paper
• Expression of CD4+ and CD8+ Tumor-Infiltrating Lymphocytes in Oral Squamous Cell Carcinoma and Their Relationship With Clinicopathological Parameters: A Cross-Sectional Study

  2024influential citation
• Engineering models of head and neck and oral cancers on-a-chip.

  2024cites this paper
• Local Production of Acute Phase Proteins: A Defense Reaction of Cancer Cells to Injury with Focus on Fibrinogen

  2024cites this paper
• Comparative analysis of the tumor microbiome, molecular profiles, and immune cell abundances by HPV status in mucosal head and neck cancers and their impact on survival

  2024cites this paper
• Deciphering a Prognostic Signature Based on Soluble Mediators Defines the Immune Landscape and Predicts Prognosis in HNSCC.

  2024cites this paper
• Integrative nomogram model based on anoikis-related genes enhances prognostic evaluation in colorectal cancer

  2024cites this paper
• Neutrophils in HNSCC Can Be Associated with Both a Worse or Favorable Prognosis

  2024cites this paper
• Stroma Modulation of radiation response in head and neck squamous cell carcinoma: Insights from zebrafish larvae xenografts.

  2024cites this paper
• EMID2 is a novel biotherapeutic for aggressive cancers identified by in vivo screening

  2024cites this paper
• Matrix stiffness affects tumor-associated macrophage functional polarization and its potential in tumor therapy

  2024cites this paper
• Tumor microenvironment-responsive degradable silica nanoparticles: design principles and precision theranostic applications.

  2024cites this paper
• Interleukins Signature Profile in the Etiopathogenesis of Oral Submucous Fibrosis: A Comprehensive Study

  2024cites this paper
• Biomechanical imaging biomarker during chemoradiotherapy predicts treatment response in head and neck squamous cell carcinoma

  2024cites this paper
• Cancer cell plasticity: from cellular, molecular, and genetic mechanisms to tumor heterogeneity and drug resistance

  2024cites this paper